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| 1 | A critical role of IFNγ in priming MSC-mediated suppression of T cell proliferation through up-regulation of BT-H1显示文摘 | Huiming Sheng | 2008 | Cell Research2008，18，8： | 55 |
| 2 | Downregulation of CD4+CD25+ regulatory T cells may underlie enhanced Th1 immunity caused by immunization with activated autologous T cells显示文摘规章的 T 房间(Treg ) 在免疫系统动态平衡起重要作用,并且可以被压制涉及反肿瘤免疫的 Th1 免疫反应也涉及肿瘤免疫忍耐。我们以前报导了有稀释激活的自体同源的 T 房间的那免疫导致提高的反肿瘤免疫并且在调整 Th1 回答 invivo 上面。然而,内在的分子的机制很好没被理解。这里,我们证明 Tregfunction 是显著地, down 在老鼠调整了稀释激活的自体同源的 T 房间的那收到的免疫。我们发现那 Foxp3 表情从使免疫的老鼠在 CD4+CD25+ T 房间减少了。而且,从使免疫的老鼠获得的 CD4+CD25+Foxp3+ Treg 从天真的老鼠与那些相比展出了减少的免疫力的抑制能力。进一步的分析证明使免疫的鼠标的浆液包含 anti-CD25 抗体(大约 30 ng/ml, p<0.01 对控制) 的高水平。与在 Treg 的 down 规定的 anti-CD25 反应的一个角色一致,到天真的鼠标的从使免疫的鼠标的浆液的采纳转移在接受者鼠标在 Treg 人口和功能导致了重要减少。在使免疫的老鼠被触发 anti-CD25 反应能被 CD25 在激活的自体同源的 T 房间为免疫使用了的 ConA 被导致到高水平的事实解释。我们的结果第一次证明有稀释激活的自体同源的 T 房间的那免疫唤起 anti-CD25 抗体生产,它导致阻碍的 CD4+CD25+Foxp3+Treg 扩大和功能体内。我们建议那阻抑的 Treg 功能多半在使免疫的老鼠贡献提高的 Th1 反应并且是位于 boostedanti 肿瘤免疫下面的机制的至少部分。 | Qi Cao Li Wang Fang Du Huiming Sheng Yan Zhang Juanjuan Wu Baihua Shen TianweiShen Jingwu Zhang Dangsheng Li Ningli Li | 2007 | Cell Research2007，17，7： | 5 |
| 3 | A Truncated F-Box Protein Confers the Dwarfism in Cucumber显示文摘Dwarfism is an important plant architecture trait in crop breeding(Peng et al.,1999;Sasaki el al.,2002).In cucurbits.the compact plant type was proposed to develop new varieties for the once-over mechanical harvest for concentrated fruit set and higher densities(Li et al.,2011;Mondal et al.,2011).Several recessive genes in cucurbits have been reported to confer the phenotype of short internodes or bushy plant habits,such as compact,cp-2,and dw in cucumber(Cucumis | Tao Lin Shenhao Wang Yang Zhong Dongli Gao Qingzhi Cui Huiming Chen Zhonghua Zhang Huolin Shen Yiqun Weng Sanwen Huang | 2016 | Journal of Genetics and Genomics2016，43，4： | 5 |
| 4 | Immunization with autologous T cells enhances in vivo anti-tumor immune responses accompanied by up-regulation of GADD45β显示文摘Immunization with inactivated autoreactive T cells may induce idiotype anti-idiotypic reactions to deplete autoreac-tire T cells,which are involved in autoimmune diseases.However,it is unknown whether attenuated activated healthyautologous T-cell immunization could increase anti-tumor immune responses.To this end,C57B1/6 mice were immunizedwith attenuated activated autologous T cells.The splenocytes from immunized mice showed a higher proliferative abil-ity than that from naive mice.The special phenotype analysis showed that there were more CDS+T cells and CD62L+T cells in immunized mice after 24 h of culture with 10% fetal calf serum complete medium in vitro(P<0.01).Theseresults demonstrated that this immunization may activate T cells in vivo.Furthermore,the splenocytes from immunizedmice revealed resistance to activation-induced cell death(AICD)in vitro.To further study the relative genes that areresponsible for the higher proliferation and resistance to AICD,the expression of Fas/Fas ligand(FasL)and GADD45βwas measured by real-time PCR.The results indicated that GADD45β transcription was higher in the splenocytes fromimmunized mice than that in the naive mice.In addition,the Fas expression showed a parallel higher,but FasL did notchange obviously.To investigate the biologic functions induced by immunization in vivo,a tumor model was establishedby EL-4 tumor cell inoculation in C57/B1 mice.Mice receiving autologous T-cell immunization had significantly inhibitedtumor growth in vivo(P<0.01).This study implicated that immunization with attenuated activated autologous T cellsenhances anti-tumor immune responses that participate in tumor growth inhibition. | Li Wang~(1,2,*) Fang Du~(1,2,*) Qi Cao~(1,2) Huiming Sheng~(1,2) Baihua Shen~(1,2) Yan Zhang~(1,2) Yingna Diao~(1,2) Jingwu Zhang~(1,2) Ningli Li~(1,2) ~1Shanghai diao Tong UniversiO,School of Medicine,280 Chongqing Road,Shanghai 200025,China ~2Shanghai Institute of Immunology,280 Chongqing Road,Shanghai 200025,China | 2006 | Cell Research2006，16，8： | 5 |
| 5 | Feedforward control for nitrogen removal in a pilot-scale anaerobic-anoxic-oxic plant for municipal wastewater treatment显示文摘To improve the efficiency of nitrogen removalwith lower energy consumption,the study of feedforwardcontrol was carried out on a pilot-scale anaerobic-anoxicoxic(AAO)plant for the treatment of municipal wastewater.The effluent qualities of the pilot plant underdifferent control strategies were investigated.The resultsindicated that the change of external recycle was not asuitable approach to regulate the sludge concentration ofplug-flow reactors;adjusting the aeration valve anddissolved oxygen set-point according to ammonia loadcould overcome the impact of influent fluctuation;and thedenitrification potential could be estimated based on thetransit time of anoxic zone and the relative content ofcarbon resource entering the anoxic zone.Simple feedforwardcontrol strategies for aeration and internal recyclewere subsequently proposed and validated.The nitrogenremoval was successfully improved in the pilot plant.Theeffluent total nitrogen had decreased by 29.9%and wassteadily controlled below 15 mg·L^(-1).Furthermore,approximately 38%of the energy for aeration had beensaved. | Tonggang SHEN Hanchang SHI Huiming SHI He JING Huilei XIONG | 2011 | Frontiers of Environmental Science & Engineering2011，5，1： | 3 |
| 6 | Theoretical design and preparation of high thermal-stable jet fuel显示文摘A high thermal-stable jet fuel design method was developed using composition-properties relations and basic specification properties of jet fuel. Tannery diagrams were provided to visualize relationships among three main components (n-paraffins, iso-paraffins, cycloparaffins, or aromatics) with four major specification properties (density, flash point, freezing point, net heat of combustion) and thermal sta- bility. An optimum chemical composition was established to meet performance requirements: n-paraffins 25%-45%, iso-paraffins 15%-30%, cycloparaffins 30%-50%, and aromatics 5%. The thermal stability test on four fuel samples with and without optimal composition indicated that the thermal stabilities of fuel samples with optimal composition are higher than RP-3 jet fuel, and that the theoretical design method is a reliable method to screen the basic oil for the high thermal-stable jet fuel. | LIU GuoZhu QU HaiJie SHEN HuiMing ZHANG XiangWen MI ZhenTao | 2008 | Science China Chemistry2008，51，2： | 2 |
| 7 | Genomic and Phenotypic Diversity of Carbapenemase-Producing Enterobacteriaceae Isolates from Bacteremia in China: A Multicenter Epidemiological, Microbiological, and Genetic Study显示文摘Carbapenemase-producing Enterobacteriaceae(CPE) isolates are recognized as one of the most severe threats to public health. However, the population structure and genetic characteristics of CPE isolates among bloodstream infections(BSIs) are largely unknown. To address this knowledge gap, in this study,we included patients with clinically significant BSIs due to Enterobacterales isolates, recruited from 26 sentinel hospitals in China(2014–2015). CPE isolates were microbiologically and genomically characterized,including their susceptibility profiles, molecular typing, phylogenetic features, and genetic context analysis of carbapenemase-encoding genes. Of the 2569 BSI Enterobacterales isolates enrolled, 42(1.6%) were carbapenemase-positive. Moreover, among the 2242 investigated isolates, 1111(49.6%) extendedspectrum β-lactamase(ESBL)-producing isolates were identified in Escherichia coli(E. coli), Klebsiella pneumoniae(K. pneumoniae), Proteus mirabilis(P. mirabilis), and Klebsiella oxytoca. Whole genome sequencing analysis showed the clonal spread of K. pneumoniae carbapenemase(KPC)-2-producing K. pneumoniae sequence type(ST) 11 and New Delhi metallo-β-lactamase(NDM)-5-producing E. coli ST167 in our collection. Plasmid analysis revealed that carbapenemase-encoding genes were located on multiple plasmids. A high prevalence of biofilm-encoding type 3 fimbriae clusters and yesiniabactin-associated genes was observed in K. pneumoniae isolates. This work demonstrates the high prevalence of ESBLs and the wide dissemination of CPE among BSI isolates in China, which represent real clinical threats. Moreover, our findings first illustrate a more comprehensive genome scenario of CPE isolates among BSIs. The clonal spread of KPC-2-producing K. pneumoniae ST11 and NDM-5-producing E. coli ST167 needs to be closely monitored. | Beiwen Zheng Hao Xu Lihua Guo Xiao Yu Jinru Ji Chaoqun Ying Yunbo Chen Ping Shen Huiming Han Chen Huang Shuntian Zhang Tao Lv Yonghong Xiao | 2022 | Engineering2022，8，5： | 2 |
| 8 | Effects of space flight on the growth and some cytological characteristics of wheat seedlings显示文摘 | Gu Ruiqi Shen Huiming | 1989 | Acta Photophysiologica Siniea1989，15，4： | 1 |
| 9 | Expression of renal cubilin and its potential role in tubulointerstitial inflammation induced by albumin overload显示文摘 | Jurong Yang Yani He Haiying Shen Hanlu Ding Kailong Li Huiming Wang | 2008 | Frontiers of Medicine in China2008，，1： | 1 |
| 10 | Effects of space flight on the growth and some cytological characteristics of wheat seedlings 显示文摘 | Gu Ruiqi Shen Huiming | 1989 | Acta Hotophysiologica Sinica1989，15，4： | 1 |
| 11 | Amorphous carbon-linked TiO_(2)/carbon nanotube film composite with enhanced photocatalytic performance:The effect of interface contact and hydrophilicity显示文摘Carbon nanotube film(CNTF)can be used for photocatalysis and water treatment due to its porous structure,good stability and excellent electrical properties.In this work,TiO_(2)/amorphous carbon/carbon nanotube film(TCC)composite with uniform structure was prepared by a simple atomization spraying method.Rhodamine B(RhB)was used to test the photocatalytic activity of TCC.TCC composite exhibits good photocatalytic activity under ultraviolet light.In particular,the degradation efficiency of rhodamine B(RhB)by TCC sprayed with 9 layers of TiO_(2)(9 TCC)increased by 1.45 times than of TiO_(2) under ultraviolet light.The enhanced photocatalytic activity of TCC is attributed to the CNTF,which can broaden the light response range of TCC and improve the migration efficiency of electrons.The existence of amorphous carbon will promote these advances.Moreover,the better hydrophilic properties would enhance the catalytic performance happened on the solid-liquid interface.Finally,the photocatalytic mechanism and degradation intermediates of the TCC composite were proposed. | Zekun Xin Xiaodong Zhao Huiming Ji Tianyi Ma Hui Li Shuhui Zhong Zhurui Shen | 2021 | Chinese Chemical Letters2021，32，7： | 1 |
| 12 | FOXP3 Is an X-Linked Breast Cancer Suppressor Gene and an Important Repressor of the HER-2/ErbB2 Oncogene显示文摘 | Tao Zuo Lizhong Wang Carl Morrison Xing Chang Huiming Zhang Weiquan Li Yan Liu Yin Wang Xingluo Liu Michael W.Y. Chan Jin-Qing Liu Richard Love Chang-gong Liu Virginia Godfrey Rulong Shen Tim H.-M. Huang Tianyu Yang Bae Keun Park Cun-Yu Wang Pan Zheng Yan | 2007 | Cell2007，，7： | 1 |
| 13 | FOXP3 Is an X-Linked Breast Cancer Suppressor Gene and an Important Repressor of the HER-2/ErbB2 Oncogene显示文摘 | Tao Zuo Lizhong Wang Carl Morrison Xing Chang Huiming Zhang Weiquan Li Yan Liu Yin Wang Xingluo Liu Michael W.Y. Chan Jin-Qing Liu Richard Love Chang-gong Liu Virginia Godfrey Rulong Shen Tim H.-M. Huang Tianyu Yang Bae Keun Park Cun-Yu Wang Pan Zheng Yan | 2007 | Cell2007，，7： | 1 |
| 14 | DISTRIBUTIONS AND HYDROLOGICAL CHARACTERISTICS OF TROPICAL CYCLONE RAINSTORMS AND FLOODS IN CHINA显示文摘Regional distribution of the rainstorms and floods caused and affected by tropical cyclones are described and the geographicla divisions of China are also given in this paper. The hydrological characteristics of tropical cyclone rainstorms and floods are discussed and compared with that on non-tropical cyclones. | Wang Jiaqi Shen Guochang Geng Leihua Gu Wenyan Yao Huiming(Nanjiang Institute of Hydrology and Water Resources, Nanjing 210244People’s Republic of China) | 1996 | Journal of Geographical Sciences1996，6，3： | 1 |
| 15 | Fiber coupled high count-rate single-photon generated from InAs quantum dots显示文摘In this work,we achieve high count-rate single-photon output in single-mode(SM)optical fiber.Epitaxial and dilute InAs/GaAs quantum dots(QDs)are embedded in a GaAs/AlGaAs distributed Bragg reflector(DBR)with a micro-pillar cavity,so as to improve their light emission extraction in the vertical direction,thereby enhancing the optical SM fiber’s collection capabil-ity(numerical aperture:0.13).By tuning the temperature precisely to make the quantum dot exciton emission resonant to the micro-pillar cavity mode(Q~1800),we achieve a fiber-output single-photon count rate as high as 4.73×10^(6) counts per second,with the second-order auto-correlation g2(0)remaining at 0.08. | Yao Chen Shulun Li Xiangjun Shang Xiangbin Su Huiming Hao Jiaxin Shen Yu Zhang Haiqiao Ni Ying Ding Zhichuan Niu | 2021 | Journal of Semiconductors2021，42，7： | 0 |
| 16 | Two-dimensional g-C_(3)N_(4)nanosheets-based photo-catalysts for typical sustainable processes显示文摘Graphitic carbon nitride(g-C_(3)N_(4))has been widely studied as a visible light responsive photocatalyst in recent years,due to its facile synthesis,low cost,high stability,and appropriate bandgap/band positions.In this review,we firstly introduce and compare various exfoliation approaches of bulk g-C_(3)N_(4)into ultrathin g-C_(3)N_(4)nanosheets.Then,many modification strategies of g-C_(3)N_(4)nanosheets are also reviewed,including heterojunction construction,doping,defect control,and structure design.Thereafter,the charge transfer mechanism in g-C_(3)N_(4)nanosheets based heterojunctions is present,e.g.,Z-scheme,S-scheme and other forms.Besides,the photocatalytic applications of g-C_(3)N_(4)nanosheets based photocatalysts are summarized including environmental remediation,energy generation and storage,organic synthesis,and disinfection.This review ends with a summary and some perspectives on the challenges and new directions in exploring g-C_(3)N_(4)nanosheets-based photocatalysts. | Xiaodong Zhao Qian Liu Xiaolei Li Huiming Ji Zhurui Shen | 2023 | Chinese Chemical Letters2023，34，11： | 0 |
| 17 | Expression of renal cubilin and its potential role in tubulointerstitial inflammation induced by albumin overload显示文摘Sustained proteinuria is an independent risk factor leading to kidney fibrosis and end-stage renal fail-ure.Over-reabsorption of filtered proteins,notably albu-min,has been proved to trigger interstitial inflammation and fibrosis in proteinuric renal disease.Cubilin,an endo-cytic receptor expressed on the renal tubular brush bor-der,is responsible for albumin reabsorption in physiologic condition.However,little is known about whether it is required for activation of tubular cells induced by albu-min overload.In this work,we investigated the change of cubilin expression and its potential role in albumin-induced up-regulation of chemokines synthesis in vivo and in vitro.Twenty-six patients with nephrotic syndrome were enrolled in this study.Proximal tubule uptake of albumin,expression of apical membrane cubilin and infiltrating cells in kidney interstitium were determined by immunocytochemistry.In vitro,the transcription of cubilin in HK2 cells after exposure to albumin was ana-lyzed by real-time PCR.Endocytosis of albumin in HK2 cells was examined by fluorescent microscope.The influ-ence of inhibition of cubilin on albumin-induced expres-sions of monocyte chemoattractant protein 1(MCP-1)and regulated upon activation normal T-cell expressed and secreted(RANTES)was investigated by Western blot.The intensity of luminal cubilin and tubular accu-mulation of albumin were significantly increased in nephrotic kidneys.The expression of MCP-1 and RANTES was up-regulated,and there were spatial rela-tionships in localization between these chemokines and cubilin as well as intracellular albumin in kidney tissues.Infiltration of CD-3 and ED-1-positive cells was predom-inant in tubulointerstitial areas displaying signs of increases of cubilin expression and albumin accumula-tion.In vitro,the transcription of cubilin mRNA in HK2 cells was enhanced after 24 h exposure to albumin in a dose-dependent manner.Inhibition of endocytosis of albumin by antisense cubilin nucleotide markedly reduced expression of MCP-1 and RANTES.Cubilin was required for handling a greater amount of protein in nephrotic status and albumin-induced production of MCP-1 and RANTES by renal tubular cells,which further initiated tubulointerstitial inflammation in proteinuric disease. | Jurong YANG Yani HE Haiying SHEN Hanlu DING Kailong LI Huiming WANG | 2008 | Frontiers of Medicine2008，2，1： | 0 |
| 18 | Broadband Insulator-Based Dynamic Diode with Ultrafast Hot Carriers Process显示文摘The excitation,rebound,and transport process of hot carriers(HCs)inside dynamic diode(DD)based on insulators has been rarely explored due to the original stereotyped in which it was thought that the insulators are nonconductive.However,the carrier dynamics of DD is totally different from the static diode,which may bring a subverting insight of insulators. | Runjiang Shen Yanghua Lu Xutao Yu Qi Ge Huiming Zhong Shisheng Lin | 2023 | Research2023，，2： | 0 |
| 19 | The construction and optimization of engineered yeast chassis for efficient biosynthesis of 8-hydroxygeraniol显示文摘Microbial production of monoterpenoid indole alkaloids(MIAs)provides a sustainable and eco-friendly means to obtain compounds with high pharmaceutical values.However,efficient biosynthesis of MIAs in heterologous microorganisms is hindered due to low supply of key precursors such as geraniol and its derivative 8-hydroxygeraniol catalyzed by geraniol 8-hydroxylase(G8H).In this study,we developed a facile evolution platform to screen strains with improved yield of geraniol by using the SCRaMbLE system embedded in the Sc2.0 synthetic yeast and confirmed the causal role of relevant genomic targets.Through genome mining,we identified several G8H enzymes that perform much better than the commonly used CrG8H for 8-hydroxygeraniol production in vivo.We further showed that the N-terminus of these G8H enzymes plays an important role in cellular activity by swapping experiments.Finally,the combination of the engineered chassis,optimized biosynthesis pathway,and utilization of G8H led to the final strain with more than 30-fold improvement in producing 8-hydroxygeraniol compared with the starting strain.Overall,this study will provide insights into the construction and optimization of yeast cells for efficient biosynthesis of 8-hydroxygeraniol and its derivatives. | Yu Zhang Mengdi Yuan Xinxin Wu Qiuhui Zhang Yuzhu Wang Liming Zheng Tsan-Yu Chiu Huiming Zhang Lei Lan Feng Wang Ying Liao Xuemei Gong Shirui Yan Yun Wang Yue Shen Xian Fu | 2023 | mLife2023，2，4： | 0 |
| 20 | A WO3-CuWO4 nanostructured heterojunction for enhanced n-butanol sensing performance显示文摘Herein,a WO3-CuWO4 nanostructured heteroj unction was prepared by a facile two-step hydrothermal method.It is composed of a WO3 square microplate and CuWO4 nanoparticles.Then,the gas sensing properties were investigated under optimal operating temperature(120℃).The WO3-CuWO4 heterostructure shows good sensing performance towards n-butanol,with a response value up to 9.4 to towards 30 ppm n-butanol,and the response value is about 3 times higher than that of pristine Wo3.Its detection limit for n-butanol is 0.1 ppm,which indicates a potential application in lower concentration detection.Moreover,the response time of Wo3-CuWO4 nanostructured hete rojunction and the pristine WO3 are 21 s and 240 s respectively,revealing that there is a faster gas sensing process in the heterostructure.A possible sensing mechanism was then proposed on the basis of experimental data and band structure analysis.The significant enhancement of WO3-CuWO4 heterostructure could be attributed to the formation of heterojunction,which brings electronic sensitization and electron transport pathway modulation.The work offered a kind of novel and cost-effective sensing materials,and inspired more novel devices based on nanostructured heterojunction mechanism. | Fanpeng Duanmu Qian Liu Shuhui Zhong Huiming Ji | 2020 | Chinese Chemical Letters2020，31，5： | 0 |
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