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| 1 | Prognostic nutritional index is an independent prognostic factor for gastric cancer patients with peritoneal dissemination显示文摘Objective: The predictive and prognostic role of prognostic nutritional index(PNI) in gastric cancer patients with peritoneal dissemination remains unclear. This study aims to explore the role of the PNI in predicting outcomes of gastric cancer patients with peritoneal dissemination.Methods: A total of 660 patients diagnosed with gastric adenocarcinoma with peritoneal metastasis between January 2000 and April 2014 at Sun Yat-sen University Cancer Center and the Sixth Affiliated Hospital of Sun Yatsen University were retrospectively analyzed. The clinicopathologic characteristics and clinical outcomes of patients with peritoneal dissemination were analyzed.Results: Compared with PNI-high group, PNI-low group was correlated with advanced age(P=0.036), worse performance status(P<0.001), higher frequency of ascites(P<0.001) and higher frequency of multisite distant metastasis(P<0.001). Kaplan-Meier survival curves showed that PNI-high group had a significantly longer median overall survival than PNI-low group(13.13 vs. 9.03 months, P<0.001). Multivariate survival analysis revealed that Borrmann type IV(P=0.014), presence of ascites(P=0.017) and lower PNI(P=0.041) were independent poor prognostic factors, and palliative surgery(P<0.001) and first-line chemotherapy(P<0.001) were good prognostic factors. For patients receiving palliative surgery, the postoperative morbidity rates in the PNI-low group and PNIhigh group were 9.1% and 9.9%, respectively(P=0.797). The postoperative mortality rate was not significantly different between PNI-low and PNI-high groups(2.3% vs. 0.9%, P=0.362).Conclusions: PNI is a useful and practical tool for evaluating the nutritional status of gastric cancer patients with peritoneal dissemination, and is an independent prognostic factor for these patients. | Runcong Nie Shuqiang Yuan Shi Chen Xiaojiang Chen Yongming Chen Baoyan Zhu Haibo Qiu Zhiwei Zhou Junsheng Peng Yingbo Chen | 2016 | Chinese Journal of Cancer Research2016，28，6： | 19 |
| 2 | Analysis and external validation of a nomogram to predict peritoneal dissemination in gastric cancer显示文摘Objective:Peritoneal dissemination is difficult to diagnose by conventional imaging technologies.We aimed to construct a nomogram to predict peritoneal dissemination in gastric cancer(GC)patients.Methods:We retrospectively analyzed 1,112 GC patients in Sun Yat-sen University Cancer Center between2001 and 2010 as the development set and 474 patients from The Sixth Affiliated Hospital,Sun Yat-sen University between 2010 and 2016 as the validation set.The clinicopathological variables associated with gastric cancer with peritoneal dissemination(GCPD)were analyzed.We used logistic regression analysis to identify independent risk factors for peritoneal dissemination.Then,we constructed a nomogram for the prediction of GCPD and defined its predictive value with a receiver operating characteristic(ROC)curve.External validation was performed to validate the applicability of the nomogram.Results:In total,250 patients were histologically identified as having peritoneal dissemination.Logistic regression analysis demonstrated that age,sex,tumor location,tumor size,signet-ring cell carcinoma(SRCC),T stage,N stage and Borrmann classification IV(Borrmann IV)were independent risk factors for peritoneal dissemination.We constructed a nomogram consisting of these eight factors to predict GCPD and found an optimistic predictive capability,with a C-index of 0.791,an area under the curve(AUC)of 0.791,and a 95%confidence interval(95%CI)of 0.762-0.820.The results found in the external validation set were also promising.Conclusions:We constructed a highly sensitive nomogram that can assist clinicians in the early diagnosis of GCPD and serve as a reference for optimizing clinical management strategies. | Xijie Chen Shi Chen Xinyou Wang Runcong Nie Dongwen Chen Jun Xiang Yijia Lin Yingbo Chen Junsheng Peng | 2020 | Chinese Journal of Cancer Research2020，32，2： | 6 |
| 3 | A nomogram to predict prognosis for gastric cancer with peritoneal dissemination显示文摘Objective: To identify independent prognostic factors to be included in a nomogram to predict the prognosis of gastric cancer patients with peritoneal dissemination.Methods: This is a retrospective study on 684 patients with a histological diagnosis of gastric cancer with peritoneal dissemination from the Sun Yat-sen University Cancer Center as the development set, and 62 gastric cancer patients from the Sixth Affiliated Hospital of Sun Yat-sen University as the validation group. Chi-square test and Cox regression analysis were used to compare the clinicopathological variables and the prognosis of gastric cancer patients with peritoneal dissemination. The Harrell's concordance index(C-index) and calibration curve were determined for comparisons of predictive ability of the nomogram.Results: Univariate and multivariate analyses showed that serum carcinoembryonic antigen(CEA) level(P=0.032), ascites grading(P=0.008), presence of extraperitoneal metastasis(P<0.001), seeding status(P=0.016) and performance status(P=0.009) were independent prognostic factors for gastric cancer patients with peritoneal dissemination in the development set. The nomogram model was constructed using these five factors. Internal validation showed that the C-index of the model was 0.641. For the external validation, the C-index of this model was 0.709.Conclusions: We developed and validated a nomogram to predict the prognosis for gastric cancer patients with peritoneal dissemination. This nomogram may play an important clinical role in guiding palliative therapy for these types of patients, although it may need more data for optimization. | Shi Chen Xijie Chen Runcong Nie Liying Ou Yang Aihong Liu Yuanfang Li Zhiwei Zhou Yingbo Chen Junsheng Peng | 2018 | Chinese Journal of Cancer Research2018，30，4： | 5 |
| 4 | Measurement of sheet resistance of cross microareas using a modified Van der Pauw method 显示文摘 | Sun Yicai Shi Junsheng Meng Qinghao | 1996 | Semieond Sci Technol1996，，11： | 1 |
| 5 | Improved training-set distribution model for the training of BP neural networks in CRT color convertion显示文摘 | Ningfang Liao Junsheng Shi Weiping Yang | | Proc SPIE0，4922，： | 1 |
| 6 | Measurement of sheet resistance of cross microareas using a modified Van der Pauw method显示文摘 | Yicai Sun Junsheng Shi Qinghao Meng | 1996 | Semicondor Science and Technology1996，11，5： | 1 |
| 7 | Sub - hori- zontal reinforcement of weathered granite before tunneling beneath a spillway 显示文摘 | SHI Yufeng YANG Junsheng WANG Shuying | 2014 | International Journal of Rock Me- chanics and Mining Sciences2014，72，： | 1 |
| 8 | Objective evaluation of color fusion of visual and IR imagery by measuring im- age contrast 显示文摘 | SHI JUNSHENG JIN WEIQI WANG LINGXUE | 2005 | Proceedings of SPIE2005，5640，： | 1 |
| 9 | The analysis to crowd-out effects of government expenditure on private invetment inChina显示文摘 | SHI Zhuxian LIU Junsheng JIN Chengxiao | | Journal of Syste0，，： | 1 |
| 10 | Stretchable,skin-conformable neuromorphic system for tactile sensory recognizing and encoding显示文摘Expanding wearable technologies to artificial tactile perception will be of significance for intelligent human-machine interface,as neuromorphic sensing devices are promising candidates due to their low energy consumption and highly effective operating properties.Skin-compatible and conformable features are required for the purpose of realizing wearable artificial tactile perception.Here,we report an intrinsically stretchable,skin-integrated neuromorphic system with triboelectric nanogenerators as tactile sensing and organic electrochemical transistors as information processing.The integrated system provides desired sensing,synaptic,and mechanical characteristics,such as sensitive response(~0.04 kPa^(-1))to low-pressure,short-and long-term synaptic plasticity,great switching endurance(>10000 pulses),symmetric weight update,together with high stretchability of 100%strain.With neural encoding,demonstrations are capable of recognizing,extracting,and encoding features of tactile information.This work provides a feasible approach to wearable,skin-conformable neuromorphic sensing system with great application prospects in intelligent robotics and replacement prosthetics. | Mengge Wu Qiuna Zhuang Kuanming Yao Jian Li Guangyao Zhao Jingkun Zhou Dengfeng Li Rui Shi Guoqiang Xu Yingchun Li Zijian Zheng Zhihui Yang Junsheng Yu Xinge Yu | 2023 | InfoMat2023，5，12： | 0 |
| 11 | Control of vertical phase separation in high performance non-fullerene organic solar cell by introducing oscillating stratification preprocessing显示文摘Non-fullerene organic solar cell(NFOSC)has attracted tremendous attention due to their great potential for commercial applications.To improve its power conversion efficiency(PCE),generally,sequential solution deposition(SSD)methods have been employed to construct the graded vertical phase separation(VPS)of the bulk-heterojunction(BHJ)active layer for efficient exciton separation and charge transition.However,a variety of orthogonal solvents used in the SSD may lead to the unpredicted change in the BHJ morphology and introduce additional defects inside the BHJ bulk thus complicate the fabrication process.Here,a simple oscillating stratification preprocessing(OSP)is developed to facilitate the formation of graded VPS among the BHJ layer.As a result,a significant improvement is obtained in PCE from 10.96%to 12.03%,which is the highest value reported among PBDB-T:ITIC based NFOSC. | Dayong Zhang Pu Fan Jinyu Shi Yifan Zheng Jian Zhong Junsheng Yu | 2021 | Nano Research2021，14，5： | 0 |
| 12 | A New Neutron-deficient Isotope ^(235)Am显示文摘A New Neutron-deficient Isotope ^(235)AmANewNeutron-deficientIsotope^(235)Am￥LiuHongye;GuoJunsheng;GanZaiguo;YangWeifan;ShiLij... | Liu Hongye Guo Junsheng Gan Zaiguo Yang Weifan Shi Lijun Mu Wantong Guo Tianrui Fang Keging Shen Shuifa Yuan Shuanggui Zhang Xueqian Qin Zi Ma Ruichang Zhong Jiquan Wang Shunhong Kong Dengging and Qiao Jimin | 1995 | IMP & HIRFL Annual Report1995，，0： | 0 |
| 13 | Hybrid Neural Network for Automatic Recovery of Elliptical Chinese Quantity Noun Phrases显示文摘In Mandarin Chinese,when the noun head appears in the context,a quantity noun phrase can be reduced to a quantity phrase with the noun head omitted.This phrase structure is called elliptical quantity noun phrase.The automatic recovery of elliptical quantity noun phrase is crucial in syntactic parsing,semantic representation and other downstream tasks.In this paper,we propose a hybrid neural network model to identify the semantic category for elliptical quantity noun phrases and realize the recovery of omitted semantics by supplementing concept categories.Firstly,we use BERT to generate character-level vectors.Secondly,Bi-LSTM is applied to capture the context information of each character and compress the input into the context memory history.Then CNN is utilized to capture the local semantics of n-grams with various granularities.Based on the Chinese Abstract Meaning Representation(CAMR)corpus and Xinhua News Agency corpus,we construct a hand-labeled elliptical quantity noun phrase dataset and carry out the semantic recovery of elliptical quantity noun phrase on this dataset.The experimental results show that our hybrid neural network model can effectively improve the performance of the semantic complement for the elliptical quantity noun phrases. | Hanyu Shi Weiguang Qu Tingxin Wei Junsheng Zhou Yunfei Long Yanhui Gu Bin Li | 2021 | Computers, Materials & Continua2021，，12： | 0 |
| 14 | Augmented reality-based visual-haptic modeling for thoracoscopic surgery training systems显示文摘Background Compared with traditional thoracotomy,video-assisted thoracoscopic surgery(VATS)has less minor trauma,faster recovery,higher patient compliance,but higher requirements for surgeons.Virtual surgery training simulation systems are important and have been widely used in Europe and America.Augmented reality(AR)in surgical training simulation systems significantly improve the training effect of virtual surgical training,although AR technology is still in its initial stage.Mixed reality has gained increased attention in technology-driven modern medicine but has yet to be used in everyday practice.Methods This study proposed an immersive AR lobectomy within a thoracoscope surgery training system,using visual and haptic modeling to study the potential benefits of this critical technology.The content included immersive AR visual rendering,based on the cluster-based extended position-based dynamics algorithm of soft tissue physical modeling.Furthermore,we designed an AR haptic rendering systems,whose model architecture consisted of multi-touch interaction points,including kinesthetic and pressure-sensitive points.Finally,based on the above theoretical research,we developed an AR interactive VATS surgical training platform.Results Twenty-four volunteers were recruited from the First People's Hospital of Yunnan Province to evaluate the VATS training system.Face,content,and construct validation methods were used to assess the tactile sense,visual sense,scene authenticity,and simulator performance.Conclusions The results of our construction validation demonstrate that the simulator is useful in improving novice and surgical skills that can be retained after a certain period of time.The video-assisted thoracoscopic system based on AR developed in this study is effective and can be used as a training device to assist in the development of thoracoscopic skills for novices. | Yonghang TAI Junsheng SHI Junjun PAN Aimin HAO Victor CHANG | 2021 | Virtual Reality & Intelligent Hardware2021，3，4： | 0 |
| 15 | Thin,soft,3D printing enabled crosstalk minimized triboelectric nanogenerator arrays for tactile sensing显示文摘With the requirements of self-powering sensors in flexible electronics,wearable triboelectric nanogenerators(TENGs)have attracted great attention due to their advantages of excellent electrical outputs and low-cost processing routes.The crosstalk effect between adjacent sensing units in TENGs significantly limits the pixel density of sensor arrays.Here,we present a skin-integrated,flexible TENG sensor array with 100 sensing units in an overall size of 7.5 cm×7.5 cm that can be processed in a simple,low-cost,and scalable way enabled by 3D printing.All the sensing units show good sensitivity of 0.11 V/kPa with a wide range of pressure detection from 10 to 65 kPa,which allows to accurately distinguish various tactile formats from gentle touching(as low as 2 kPa)to hard pressuring.The 3D printing patterned substrate allows to cast triboelectric layers of polydimethylsiloxane in an independent sensing manner for each unit,which greatly suppresses the cross talk arising from adjacent sensing units,where the maximum crosstalk output is only 10.8%.The excellent uniformity and reproducibility of the sensor array offer precise pressure mapping for complicated pattern loadings,which demonstrates its potential in tactile sensing and human-machine interfaces. | Jian Li Yiming Liu Mengge Wu Kuanming Yao Zhan Gao Yuyu Gao Xingcan Huang Tsz Hung Wong Jingkun Zhou Dengfeng Li Hu Li Jiyu Li Ya Huang Rui Shi Junsheng Yu Xinge Yu | 2023 | Fundamental Research2023，3，1： | 0 |
| 16 | Effects of Xiaoyao San on exercise capacity and liver mitochondrial metabolomics in rat depression model显示文摘Objective: This study aimed to investigate the therapeutic effects of Xiaoyao San(XYS), a herbal medicine formula, on exercise capacity and liver mitochondrial metabolomics in a rat model of depression induced by chronic unpredictable mild stress(CUMS).Methods: A total of 24 male SD rats were randomly divided into four groups: control group(C), CUMS control group(M), Venlafaxine positive treatment group(V), and XYS treatment group(X). Depressive behaviour and exercise capacity of rats were assessed by body weight, sugar-water preference test, open field test, pole test, and rotarod test. The liver mitochondria metabolomics were analyzed by using liquid chromatography-mass spectrometry(LC-MS) method. TCMSP database and Gene Cards database were used to screen XYS for potential targets for depression, and GO and KEGG enrichment analyses were performed.Results: Compared with C group, rats in M group showed significantly lower body weight, sugar water preference rate, number of crossing and rearing in the open field test, climbing down time in the pole test,and retention time on the rotarod test(P < 0.01). The above behaviors and exercise capacity indices were significantly modulated in rats in V and X groups compared with M group(P < 0.05, 0.01). Compared with C group, a total of 18 different metabolites were changed in the liver mitochondria of rats in M group.Nine different metabolites and six metabolic pathways were regulated in the liver mitochondria of rats in X group compared with M group. The results of network pharmacology showed that 88 intersecting targets for depression and XYS were obtained, among which 15 key targets such as IL-1β, IL-6, and TNF were predicted to be the main differential targets for the treatment of depression. Additionally, a total of 1 553 GO signaling pathways and 181 KEGG signaling pathways were identified, and the main biological pathways were AGE-RAGE signaling pathway, HIF-1 signaling pathway, and calcium signaling pathway.Conclusion: XYS treatment could improve depressive symptoms, enhance exercise capacity, positively regulate the changes of mitochondrial metabolites and improve energy metabolism in the liver of depressed rats. These findings suggest that XYS exerts antidepressant effects through multi-target and multi-pathway. | Weidi Zhao Cui Ji Jie Zheng Shi Zhou Junsheng Tian Yumei Han Xuemei Qin | 2024 | Chinese Herbal Medicines2024，16，1： | 0 |
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