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| 1 | Orbit determination and time synchronization for a GEO/IGSO satellite navigation constellation with regional tracking network显示文摘Aiming at regional services,the space segment of COMPASS (Phase I) satellite navigation system is a constellation of Geostationary Earth Orbit (GEO),Inclined Geostationary Earth Orbit (IGSO) and Medium Earth Orbit (MEO) satellites.Precise orbit determination (POD) for the satellites is limited by the geographic distribution of regional tracking stations.Independent time synchronization (TS) system is developed to supplement the regional tracking network,and satellite clock errors and orbit data may be obtained by simultaneously processing both tracking data and TS data.Consequently,inconsistency between tracking system and TS system caused by remaining instrumental errors not calibrated may decrease navigation accuracy.On the other hand,POD for the mixed constellation of GEO/IGSO/MEO with the regional tracking network leads to parameter estimations that are highly correlated.Notorious example of correlation is found between GEO's orbital elements and its clock errors.We estimate orbital elements and clock errors for a 3GEO+2IGSO constellation in this study using a multi-satellite precise orbit determination (MPOD) strategy,with which clock error elimination algorithm is applied to separate orbital and clock estimates to improve numerical efficiency.Satellite Laser Ranging (SLR) data are used to evaluate User Ranging Error (URE),which is the orbital error projected on a receiver's line-of-sight direction.Two-way radio-wave time transfer measurements are used to evaluate clock errors.Experimenting with data from the regional tracking network,we conclude that the fitting of code data is better than 1 m in terms of Root-Mean-Square (RMS),and fitting of carrier phase is better than 1 cm.For orbital evaluation,difference between computed receiver-satellite ranging based on estimated orbits and SLR measurements is better than 1 m (RMS).For clock estimates evaluation,2-hour linear-fitting shows that the satellite clock rates are about 1.E-10 s/s,while receiver clock rates are about 1×10 13-1×10 12 s/s.For the 72-hour POD experiment,the average differences between POD satellite clock rates estimates and clock measurements based on TS system are about 1×10 13 s/s,and for receiver clock rates,the differences are about 1×10 15 s/s. | ZHOU ShanShi HU XiaoGong WU Bin LIU Li QU WeiJing GUO Rui HE Feng CAO YueLing Wu XiaoLi ZHU LingFeng SHI Xin TAN HongLi | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，6： | 44 |
| 2 | Far-field coseismic displacements associated with the 2011 Tohoku-oki earthquake in Japan observed by Global Positioning System显示文摘Analysis of GEONET observations covering the entire territory of Japan shows that the great Tohoku-oki earthquake that occurred on March 11, 2011 off the east coast of Honshu in Japan caused an eastward movement of the northern part of the island by as much as 5.3 m. The GPS data from TEONET in China were used to derive far-field coseismic displacements and to assess the impact of the Tohoku-oki earthquake on crustal deformation in eastern China. The results reveal that the coseismic horizontal displacements induced by the earthquake are the level of millimeters to centimeters in North and Northeast China, with a maximum of 35 mm. Strain analysis also indicates that the earthquake resulted in an increase in the tensile strain on the north-northeast trending faults in North and Northeast China. The tensile strain imposed on the Yilan-Yitong and Dunhua-Mishan faults is more significant than that imposed on the faults in North China; the maximum normal strain reaches about 40 nano-strain. Considering that the static Coulomb stress loaded on the faults is limited, its effect on the regional seismic activity may not be significant. | WANG Min LI Qiang WANG Fan ZHANG Rui WANG YanZhao SHI HongBo ZHANG PeiZhen SHEN ZhengKang | 2011 | Chinese Science Bulletin2011，56，23： | 34 |
| 3 | Association of serum uric acid with different levels of glucose and related factors显示文摘以前的研究表明了的背景那浆液尿酸(UA ) 在一般人口是事件类型 2 糖尿病 mellitus (T2DM ) 的一个独立预言者。试图在 946 的一个总数使遭到的中国 population.Methods 调查在 UA 和血葡萄糖和另外的风险因素之间的 UA 和它的关系的特定的特征的这研究在这研究被包括。 UA ,葡萄糖,胰岛素, UA ( FEua )的部分排泄, creatinine 清理率( Ccr ),血红素 A1c ( HbA1c ), fructosamine ( FA ),在病人二星期联合 therapeutics.Results UA 经历了层次以后,血压和类脂化合物被学习并且也再考在有损害葡萄糖规定( IGR )的题目是最高的,与 T2DM 由题目与 normoglycemia ( NGT )并且最后由题目列在后面。在为胰岛素(AUCins ) 的曲线下面的 2 小时的饭后的胰岛素和区域的水平显示出一个类似的趋势。UA 层次开始与增加 fasting 血葡萄糖(FBG ) 和饭后的血葡萄糖(PPBG ) 层次增加了,直到 7 mmol/L,分别地, 10 mmol/L 在更高的 FBG 和 PPBG 层次减少了。与在更低的浆液 UA 的题目相比方照,题目在上面更高有的浆液 UA 层次方照象更低的 Ccr 和 FEua 层次一样的重量, triglyceride 层次,和 creatinine 层次。与女人的组相比, UA 层次更高,并且 FEua 层次在男人的组是更低的。性,身体团索引(BMI ) ,吝啬的动脉的血压(地图) ,浆液 triglycerides (TG ) , FA 和 Ccr 是 UA 的独立关联因素。在病人经历了开始增加然后当葡萄糖层次与 NGT 和 T2DM 从 NGT 增加了到 IGR 和 T2DM.Compared,减少了的联合 treatment.Conclusions UA 以后, UA 减少了, FEua 增加了, IGR 题目有更高的 SUA 层次,它与它胰岛素的高水平有关。在 T2DM,男性, BMI,地图, Ccr, TG 和 FA 下面是 UA 的独立关联因素。葡萄糖阴沉, antihypertensive,联合治疗具有优点 T2DM 的 SUA 衰退的调整 lipemia。 | YUAN Hui-juan YANG Xu-guang SHI Xiao-yang TIAN Rui ZHAO Zhi-gang | 2011 | Chinese Medical Journal2011，，10： | 29 |
| 4 | Inhibition of survivin expression and mechanisms of reversing drug-resistance of human lung adenocarcinoma cells by siRNA显示文摘背景 Survivin, apoptosis 的禁止者的一个成员蛋白质(国际机场) 家庭,在肿瘤房间并且不的 overexpresses 在严重地区分的成年纸巾表示。试图在 vitro 并且在 vivo 在房间增长, apoptosis 和 chemosensitivity 上调查 survivin 特定的 siRNA 的效果到 cisplatin 并且在颠倒癌症房间抵抗到化学疗法的 drug.Methods 关于 survivin 的减少的表示探索机制的这研究 Survivin 特定的 siRNA 是进 A549/DDP 房间的 transfected。抵抗相关的蛋白质( LRP ) mRNA 铺平的 survivin 和肺的表示被 RT-PCR 决定,到 cisplatin 的 A549/DDP ( cisplatin )房间的 chemosensitivity 被 MTT 试金决定,并且 apoptosis 和房间骑车被流动 cytometry ( FCM )决定 survivin 的 .The 蛋白质表示层次, LRP , cyclin-D1 , caspase-3 和 bcl-2 被西方的弄污的分析决定。肿瘤生长上的 survivin siRNA 抑制的效果在 vivo.Results 在 athymic 裸体人老鼠被学习 Survivin 特定的 siRNA 高效地下面调整的 survivin 表示。房间周期在 G2/M 阶段被逮捕,并且 apoptosis 显然被发现。survivin 表示的抑制能让 IC50 和 cisplatin 的药抵抗的索引减少,并且提高癌症房间敏感到 cisplatin。在由 survivin 特定的 siRNA 的 transfection 以后, LRP 和 cyclin-D1 的表示是 downregulated, caspase-3 表示是 upregulated,有的 bcl-2 表示没有明显的变化。survivin 击倒的证实的动物实验能禁止肿瘤 growth.Conclusions Survivin 特定的 siRNA 罐头高效地压制 survivin 的表示,增加 apoptosis,禁止细胞增长并且提高到在 vitro 并且在 vivo 的 cisplatin 的 chemosensitivity。survivin 表示帮助颠倒药抵抗的抑制可以与 LRP 的 downregulation 有关系, caspase-3.Anti-tumor 策略的 upregulation 可能在指向肺腺癌基于 survivin 的抑制是有用的。 | LIU Jing-lei WANG Yan JIANG Ji KONG Rui YANG Yan-mei JI Hong-fei SHI Yu-zhi | 2010 | Chinese Medical Journal2010，，20： | 22 |
| 5 | Epidemiology of Diabetes in Adults Aged 35 and Older from Shanghai,China显示文摘Objective This study aimed to investigate the epidemiology of diabetes in adults from Shanghai, aged 35 and older, in 2013. Methods We estimated the diabetes prevalence in a representative sample of 18,736 adults who were selected through a multistage stratified cluster sampling process. A standard questionnaire containing questions about demographic characteristics and lifestyle factors was distributed. After an overnight fast of at least 10 hours, a venous blood sample was collected from each participant. For each patient without a history of diabetes, another blood sample was drawn 120 min after an oral glucose tolerance test to identify undiagnosed diabetes and prediabetic condition. Results Among Shanghai residents aged 35 and above, the overall weighted prevalence of diabetes was 17.6% [95% confidence interval(CI): 16.4%-18.8%]. The prevalences were 19.3% in men and 15.8% in women as well as 19.1%, 15.4%, and 16.1% in urban, suburban, and rural residents, respectively. In addition, the weighted prevalence of prediabetes was 16.5%(95% CI: 15.3%-17.8%), with the prevalences of 16.5% in men, 16.6% in women, 15.2% in urban residents, 18.0% in suburban residents, and 18.5% in rural residents. Among all patients with diabetes, 68.1%(95% CI: 64.3%-71.6%) were aware of their status, 63.5%(95% CI: 60.0%-66.9%) received diabetes treatment, but only 35.1%(95% CI: 32.4%-37.8%) had adequate glycemic control. Conclusion In Shanghai, diabetes and prediabetes are highly prevalent. However, 1/3rd of diabetes cases are undiagnosed, and the rate of glycemic control is low. | RUAN Ye YAN Qing Hua XU Ji Ying YANG Qun Di YAO Hai Hong LI Rui SHI Yan | 2016 | Biomedical and Environmental Sciences2016，29，6： | 22 |
| 6 | Development of mechatronic driving system for seed meters equipped on conventional precision corn planter显示文摘Precision planters are more and more widely used for planting corn in China.Seed meters of conventional precision corn planters are usually driven by ground wheel and chain and sprocket system at present.Because of the slippage of ground wheels and vibration of chains,planting accuracy cannot be ensured,especially at higher forward speed.To improve the planting performance of precision planters,a mechatronic driving system was designed and its field working performance was evaluated in this research.A two-row pneumatic precision planter was modified to allow simultaneously using two different driving systems,i.e,with one row unit equipped with the newly designed mechatronic driving system and the other row unit equipped with conventional mechanical driving system,and used for planting at three forward speeds(9,11 and 12 km/h)on no-tillage and rotary-tillage lands.The distances between adjacent seeds in each plot were measured and the indices of uniformity in seed spacing,quality of feeding index(QFI),missing-seeding index and precision index were analyzed.With the average 4.70%increase of QFI and 3.54%decrease of missing-seeding index,the mechatronic driving system performed better than the mechanical driving system both on no-tillage and rotary-tillage lands at each forward speed.The values of QFI,missing-seeding index and precision index of the mechatronic driving system on rotary-tillage land are comparable to those on no-tillage land,by contrast,these indices of the mechanical driving system on rotary-tillage land are significantly worse than those on no-tillage land.The result indicates that the mechatronic driving system can eliminate the effect of ground wheel slippage on planting quality and maintain the uniformity of seed distribution.Although the QFI,missing-seeding index and precision index become worse with the increase of forward speed,with the worst values of QFI of 89.93%,missing-seeding index of 5.08%and precision index of 18.92%at the highest forward speed of 12 km/h,the mechatronic driving system can reduce the effect of forward speed on planting accuracy effectively.The result indicates that planters equipped with the mechatronic driving system are suitable for high speed planting.As compared to the mechanical driving system,the advantage of the mechatronic driving system is more noticeable especially when the forward speed is more than 11 km/h. | Yang Li He Xiantao Cui Tao Zhang Dongxing Shi Song Zhang Rui Wang Mantao | 2015 | International Journal of Agricultural and Biological Engineering2015，8，4： | 22 |
| 7 | The ChinaMAP analytics of deep whole genome sequences in 10,588 individuals显示文摘Metabolic diseases are the most common and rapidly growing health issues worldwide.The massive population-based human genetics is crucial for the precise prevention and intervention of metabolic disorders.The China Metabolic Analytics Project(ChinaMAP)is based on cohort studies across diverse regions and ethnic groups with metabolic phenotypic data in China.Here,we describe the centralized analysis of the deep whole genome sequencing data and the genetic bases of metabolic traits in 10,588 individuals from the ChinaMAP.The frequency spectrum of variants,population structure,pathogenic variants and novel genomic characteristics were analyzed.The individual genetic evaluations of Mendelian diseases,nutrition and drug metabolism,and traits of blood glucose and BMI were integrated.Our study establishes a large-scale and deep resource for the genetics of East Asians and provides opportunities for novel genetic discoveries of metabolic characteristics and disorders. | Yanan Cao Lin Li Min Xu Zhimin Feng Xiaohui Sun Jieli Lu Yu Xu Peina Du Tiange Wang Ruying Hu Zhen Ye Lixin Shi Xulei Tang Li Yan Zhengnan Gao Gang Chen Yinfei Zhang Lulu Chen Guang Ning Yufang Bi Weiqing Wang The ChinaMAP Consortium | 2020 | Cell Research2020，30，9： | 20 |
| 8 | Cloning, expression, and protective immunity in mice of a gene encoding the diagnostic antigen P-29 of Echinococcus granulosus显示文摘Taeniid 绦虫包虫 granulosus 是包虫病的原因的代理人,有世界范围的分发的重要动物病。在这研究,诊断抗原 P-29 从 E 被克隆。granulosus 并且在 Escherichia 表示了 coli。顺序分析证明 EgP-29 包含 717-bp 开的读框架并且与 27.1 kDa 的预言的分子的重量编码 238 氨基酸残余的蛋白质。recombinant EgP-29 (rEgP-29 ) 能在西方的弄污与反老鼠 sera 被认出。特定的抗体被连接酶的 immunosorbent 试金检测。老鼠与 rEgP-29 种牛痘并且与 E intraperitoneally 质问了。granulosus protoscoleces 揭示了 96.6% 的重要保护的免疫(P < 0.05 ) ,与控制组相比。因此, rEgP-29 蛋白质是一个有希望的候选人让一支有效疫苗阻止第二等的包虫病。 | Zhiyun Shi Yana Wang Zongji Li Zhaoyu Li Yang Bo Rui Ma Wei Zhao | 2009 | Acta Biochimica et Biophysica Sinica2009，41，1： | 19 |
| 9 | Improvement of orbit determination for geostationary satellites with VLBI tracking显示文摘China’s COMPASS satellite navigation system consists of five or more geostationary (GEO) satellites.The roles of GEO satellites are to improve the regional user’s positioning accuracy and provide the continuous Radio Determination Satellite Service.The motion of GEO satellites relative to a ground tracking station is almost fixed,and regular orbit maneuvers are necessary to maintain the satellites’ allocated positions above the equator.These features present difficulties in precise orbit determination (POD).C-band ranging via onboard transponders and the L-band pseudo-ranging technique have been used in the COMPASS system.This paper introduces VLBI tracking,which has been successfully employed in the Chinese lunar exploration programs Chang’E-1 and Chang’E-2,to the POD of GEO satellites.In contrast to ranging,which measures distances between a GEO satellite and an observer,VLBI is an angular measurement technique that constrains the satellite’s position errors perpendicular to the satellite-to-observer direction.As a demonstration,the Chinese VLBI Network organized a tracking and orbit-determination experiment for a GEO navigation satellite lasting 24 h.This paper uses the VLBI delay and delay-rate data,in combination with C-band ranging data,to determine the GEO satellite’s orbit.The accuracies of the VLBI delay and delay rate data are about 3.6 ns and 0.4 ps/s,respectively.Data analysis shows that the VLBI data are able to calibrate systematic errors of the C-band ranging data,and the combination of the two observations improves orbit prediction accuracy with short-arc data,which is important for orbital recovery after maneuvers of GEO satellites.With the implementation of VLBI2010,it is possible for VLBI to be applied in the COMPASS satellite navigation system. | HUANG Yong HU XiaoGong ZHANG XiuZhong JIANG DongRong GUO Rui WANG Hong SHI ShanBin | 2011 | Chinese Science Bulletin2011，56，26： | 18 |
| 10 | Early changes of procalcitonin predict bacteremia in patients with intensive care unit-acquired new fever显示文摘 | SHI Yan DU Bin XU Ying-chun RUI Xi DU Wei WANG Yao | 2013 | Chinese Medical Journal2013，，10： | 18 |
| 11 | Hidden policy ciphertext-policy attribute-based encryption with keyword search against keyword guessing attack显示文摘Attribute-based encryption with keyword search(ABKS) enables data owners to grant their search capabilities to other users by enforcing an access control policy over the outsourced encrypted data. However,existing ABKS schemes cannot guarantee the privacy of the access structures, which may contain some sensitive private information. Furthermore, resulting from the exposure of the access structures, ABKS schemes are susceptible to an off-line keyword guessing attack if the keyword space has a polynomial size. To solve these problems, we propose a novel primitive named hidden policy ciphertext-policy attribute-based encryption with keyword search(HP-CPABKS). With our primitive, the data user is unable to search on encrypted data and learn any information about the access structure if his/her attribute credentials cannot satisfy the access control policy specified by the data owner. We present a rigorous selective security analysis of the proposed HP-CPABKS scheme, which simultaneously keeps the indistinguishability of the keywords and the access structures. Finally,the performance evaluation verifies that our proposed scheme is efficient and practical. | Shuo QIU Jiqiang LIU Yanfeng SHI Rui ZHANG | 2017 | Science China(Information Sciences)2017，60，5： | 18 |
| 12 | Diurnal variation of number concentration and size distribution of ultrafine particles in the urban atmosphere of Beijing in winter显示文摘在尺寸的在空中的粒子的数字集中和分发变化 5.6 ~ 560 nm 直径在冬季 2005 为一个 15-d 时期在北京被测量。成核模式(5.6 20 nm ) 的每天平均的数字集中,艾特肯模式(20 100 nm ) ,和累积模式(100 560 nm ) 粒子,和全部的粒子是 17500, 32000, 4000,和 53500 厘米(? 3 ) 分别地。平均颗粒大小分发是单音的与在夜里和与大约 10 和大约 40 nm 的模式直径形式的双性人的大约 40 nm 的一条模式直径形式在白天期间。新粒子形成事件,它被连接到日报成核模式粒子的变化,被观察在多于观察天的一半。事件经常在 10:00 11:00 汉语标准时间(CST ) 附近开始了并且在 3 4 h 以后结束了。艾特肯和累积模式粒子的集中从午夜增加了并且在大约 10:00 CST 到达了他们的最大值,然后减少并且在下午变得最低。分析日报在交通体积和气象学的参数的周期表明在艾特肯的粒子和在早上的累积模式的累积被在车辆排放的倒置和增加的形成影响,并且在下午的如此的粒子的分散与更有效的垂直混合和更高的风速度被联系。 | SHI Zong-bo HE Ke-bin YU Xue-chun YAO Zhi-liang YANG Fu-mo MA Yong-liang MA Rui JIA Ying-tao ZHANG Jie | 2007 | Journal of Environmental Sciences2007，19，8： | 16 |
| 13 | Electroacupuncture activates enteric glial cells and protects the gut barrier in hemorrhaged rats显示文摘AIM:To investigate whether electroacupuncture ST36 activates enteric glial cells,and alleviates gut inflammation and barrier dysfunction following hemorrhagic shock.METHODS:Sprague-Dawley rats were subjected to approximately 45% total blood loss and randomly divided into seven groups:(1) sham:cannulation,but no hemorrhage;(2) subjected to hemorrhagic shock(HS);(3) electroacupuncture(EA) ST36 after hemorrhage;(4) vagotomy(VGX)/EA:VGX before hemorrhage,then EA ST36;(5) VGX:VGX before hemorrhage;(6) a-bungarotoxin(BGT)/EA:intraperitoneal injection of a-BGT before hemorrhage,then EA ST36; and(7) a-BGT group:a-BGT injection before hemorrhage.Morphological changes in enteric glial cells(EGCs) were observed by immunofluorescence,and glial fibrillary acidic protein(GFAP; a protein marker of enteric glial activation) was evaluated using reverse transcriptase polymerase chain reaction and western blot analysis.Intestinal cytokine levels,gut permeability to 4-k Da fluorescein isothiocyanate(FITC)-dextran,and the expression and distribution of tight junction protein zona occludens(ZO)-1 were also determined.RESULTS:EGCs were distorted following hemorrhage and showed morphological abnormalities.EA ST36 attenuated the morphological changes in EGCs at 6 h,as compared with the VGX,a-BGT and HS groups.EA ST36 increased GFAP expression to a greater degree than in the other groups.EA ST36 decreased intestinal permeability to FITC-dextran(760.5 ± 96.43 ng/m L vs 2466.7 ± 131.60 ng/m L,P < 0.05) and preserved ZO-1 protein expression and localization at 6 h afterhemorrhage compared with the HS group.However,abdominal VGX and a-BGT treatment weakened or eliminated the effects of EA ST36.EA ST36 reduced tumor necrosis factor-a levels in intestinal homogenates after blood loss,while vagotomy or intraperitoneal injection of a-BGT before EA ST36 abolished its antiinflammatory effects.CONCLUSION:EA ST36 attenuates hemorrhageinduced intestinal inflammatory insult,and protects the intestinal barrier integrity,partly via activation of EGCs. | Sen Hu Zeng-Kai Zhao Rui Liu Hai-Bin Wang Chun-Yu Gu Hong-Min Luo Huan Wang Ming-Hua Du Yi Lv Xian Shi | 2015 | World Journal of Gastroenterology2015，21，5： | 15 |
| 14 | 3D Positional and Quantitative Prediction of the Xiaoqinling Gold Ore Belt in Tongguan, Shaanxi, China显示文摘Quantitative prediction of deep orebody based on 3D visualization technology is of great significance in mineral exploration. Based on the 2D traditional quantitative predicting method, the geoanomaly theory and the mineral exploration model idea, we constructed 3D models of the topography, strata, structure, magmatite and prospecting engineering of the study area using the commercial 3D modeling software Micromine, delineated eight prospective areas and estimated the gold resources amount with methods of Abundance Estimation and Volume Estimation. Then, we compared and counted the known ore blocks and the predicted blocks, which quantitatively explains this prediction's validity. The results show that Xiaoqinling gold belt in Tongguan has convincing potential for gold development and utilization and the prediction method based on 3D visualization technology proves to be effective. | CHEN Jianping SHI Rui CHEN Zhenping WANG Limei SUN Yan | 2012 | Acta Geologica Sinica(English Edition)2012，86，3： | 14 |
| 15 | Single and competitive adsorption affinity of heavy metals toward peanut shell-derived biochar and its mechanisms in aqueous systems显示文摘Converting peanut shells into biochar by pyrolysis was considered an environmentally friendly and efficient method for agricultural solid waste disposal.The properties of peanut shell-derived biochar(PBC)under different temperature and its adsorption capacity of heavy metals were investigated.It was found that PBC400 exhibited the highest cumulative capability for heavy metals elimination in single solute because of its high specific surface area and rich functional groups.Furthermore,the competitive adsorption revealed that PBC had a substantial difference in adsorption affinity from diverse heavy metal ions,sorption capacity decreased as Pb2+>Cu2+>Cd2+>Ni2+>Zn2+,which was lower than in a single solute.The adsorption process using selected biochar was optimized with respect to p H,reaction time,adsorbent dose,and initial concentration of heavy metals.The kinetic data was well fitted with PSO model,and the Langmuir model was adopted for adsorption equilibrium data in both cases of single solutes and mixed solutes for all heavy metals,which indicated that the removal course was primarily explained by monolayer adsorption,and chemical adsorption occupied an important role.Therefore,peanut shells derived biochar could be a potential and green adsorbent for wastewater treatment. | Rui Shan Yueyue Shi Jing Gu YazhuoWang Haoran Yuan | 2020 | Chinese Journal of Chemical Engineering2020，28，5： | 14 |
| 16 | Boron neutron capture therapy for malignant melanoma: first clinical case report in China显示文摘A phase Ⅰ/Ⅱ clinical trial for treating malignant melanoma by boron neutron capture therapy(BNCT) was designed to evaluate whether the world's first in-hospital neutron irradiator(IHNI) was qualified for BNCT. In this clinical trial planning to enroll 30 patients, the first case was treated on August 19, 2014. We present the protocol of this clinical trial, the treating procedure, and the clinical outcome of this first case. Only grade 2 acute radiation injury was observed during the first four weeks after BNCT and the injury healed after treatment. No late radiation injury was found during the 24-month follow-up. Based on positron emission tomography-computed tomography(PET/CT) scan, pathological analysis and gross examination, the patient showed a complete response to BNCT,indicating that BNCT is a potent therapy against malignant melanoma and IHNI has the potential to enable the delivery of BNCT in hospitals. | Zhong Yong Zewen Song Yongmao Zhou Tong Liu Zizhu Zhang Yanzhong Zhao Yang Chen Congjun Jin Xiang Chen Jianyun Lu Rui Han Pengzhou Li Xulong Sun Guohui Wang Guangqing Shi Shaihong Zhu | 2016 | Chinese Journal of Cancer Research2016，28，6： | 13 |
| 17 | Seasonal variations in the occurrence and distribution of estrogens and pharmaceuticals in the Zhangweinanyun River System显示文摘The report describes the use of solid-phase extraction(SPE)and LC/MS/MS to investigate the occurrence and distribution of 4 estrogens(estrone,17 β-estradiol,estriol,and 17 α-ethynylestradiol)and 3 anti-inflammatories(ibuprofen,ketoprofen and naproxen)in the Zhangweinanyun River System(China).Relatively higher concentrations were observed for estrone,17 α-ethynylestradiol,and ketoprofen in the Wei Canal than in the Wei River and in the Zhangweixin River.The study suggested that there is a potential ecological risk of male fish feminization from estrogens in the Zhangweinanyun River System. | CAO JinLing SHI JiangHong HAN Rui LI YingXia YANG ZhiFeng | 2010 | Chinese Science Bulletin2010，55，27： | 13 |
| 18 | Prostate cancer in Asia:A collaborative report显示文摘The incidence of prostate cancer(PCa)within Asian population used to be much lower than in the Western population;however,in recent years the incidence and mortality rate of PCa in some Asian countries have grown rapidly.This collaborative report summarized the latest epidemiology information,risk factors,and racial differences in PCa diagnosis,current status and new trends in surgery management and novel agents for castration-resistant prostate cancer.We believe such information would be helpful in clinical decision making for urologists and oncologists,health-care ministries and medical researchers. | Rui Chen Shancheng Ren 无 Ming Kwong Yiu Ng Chi Fai Wai Sam Cheng Lap Hong Ian Seiji Naito Tadashi Matsuda Elijah Kehinde Ali Kural Jason Yichun Chiu Rainy Umbas Qiang Wei Xiaolei Shi Liqun Zhou Jian Huang Yiran Huang Liping Xie Lulin Ma Changjun Yin Danfeng Xu Kexin Xu Zhangqun Ye Chunxiao Liu Dingwei Ye Xin Gao Qiang Fu Jianquan Hou Jianlin Yuan Dalin He Tiejun Pan Qiang Ding Fengshuo Jin Benkang Shi Gongxian Wang Xiuheng Liu Dongwen Wang Zhoujun Shen Xiangbo Kong Wanhai Xu Yaoliang Deng Haibo Xia Alexa NCohen Xu Gao Chuanliang Xu Yinghao Sun | 2014 | Asian Journal of Urology2014，1，1： | 13 |
| 19 | Humoral immune response to circulating SARS-CoV-2 variants elicited by inactivated and RBD-subunit vaccines显示文摘SARS-CoV-2 variants could induce immune escape by mutations on the receptor-binding domain(RBD)and N-terminal domain(NTD).Here we report the humoral immune response to circulating SARS-CoV-2 variants,such as 501Y.V2(B.1.351),of the plasma and neutralizing antibodies(NAbs)elicited by CoronaVac(inactivated vaccine),ZF2001(RBD-subunit vaccine)and natural infection.Among 86 potent NAbs identified by high-throughput single-cell VDJ sequencing of peripheral blood mononuclear cells from vaccinees and convalescents,near half anti-RBD NAbs showed major neutralization reductions against the K417N/E484K/N501Y mutation combination,with E484K being the dominant cause.VH3-53/VH3-66 recurrent antibodies respond differently to RBD variants,and K417N compromises the majority of neutralizing activity through reduced polar contacts with complementarity determining regions.In contrast,the 242–244 deletion(242–244Δ)would abolish most neutralization activity of anti-NTD NAbs by interrupting the conformation of NTD antigenic supersite,indicating a much less diversity of anti-NTD NAbs than anti-RBD NAbs.Plasma of convalescents and CoronaVac vaccinees displayed comparable neutralization reductions against pseudo-and authentic 501Y.V2 variants,mainly caused by E484K/N501Y and 242–244Δ,with the effects being additive.Importantly,RBD-subunit vaccinees exhibit markedly higher tolerance to 501Y.V2 than convalescents,since the elicited anti-RBD NAbs display a high diversity and are unaffected by NTD mutations.Moreover,an extended gap between the third and second doses of ZF2001 leads to better neutralizing activity and tolerance to 501Y.V2 than the standard three-dose administration.Together,these results suggest that the deployment of RBD-vaccines,through a third-dose boost,may be ideal for combating SARS-CoV-2 variants when necessary,especially for those carrying mutations that disrupt the NTD supersite. | Yunlong Cao Ayijiang Yisimayi Yali Bai Weijin Huang Xiaofeng Li Zhiying Zhang Tianjiao Yuan Ran An Jing Wang Tianhe Xiao Shuo Du Wenping Ma Liyang Song Yongzheng Li Xiang Li Weiliang Song Jiajing Wu Shuo Liu Xuemei Li Yonghong Zhang Bin Su Xianghua Guo Yangyang Wei Chuanping Gao Nana Zhang Yifei Zhang Yang Dou Xiaoyu Xu Rui Shi Bai Lu Ronghua Jin Yingmin Ma Chengfeng Qin Youchun Wang Yingmei Feng Junyu Xiao Xiaoliang Sunney Xie | 2021 | Cell Research2021，31，7： | 12 |
| 20 | 102例慢性乙型肝炎肝细胞脂肪变患者肝纤维化进展的研究显示文摘目的 探讨肝细胞脂肪变对慢性乙型肝炎(chb)患者肝纤维化进展的影响.方法 对2007年1月至8月未经治疗的562例chb患者进行肝组织穿刺活检,同时记录人口学资料并留取空腹静脉血样,分析肝组织纤维化程度与炎性反应程度、脂肪变、人口学特征、hbv dna以及生化学指标间关系.结果 在562例chb患者中,男405名,女157名,平均年龄(31.3±9.6)岁,体质量指数(bmi)为(22.2±3.1)kg/m2.hbeag(+)和hbv dna(+)分别为394例和494例.组织病理显示肝细胞脂肪变发生率为18.15%(102/562),多元回归分析表明chb患者肝细胞脂肪变的发生与bmi、tg、载脂蛋白(apo-b)、尿酸(ua)和空腹血糖(fsg)密切相关.炎性反应、肝细胞脂肪变、年龄、hbv dna拷贝量、bmi、ua、谷氨酰转移酶(ggt)是chb患者肝组织纤维化进展的相关因素.结论 代谢紊乱是chb患者肝细胞脂肪变发生的主要原因,而肝细胞脂肪变是chb患者肝组织纤维化进展相关的独立危险因素.
abstract:
objective to evaluate the prevalence of hepatic steatosis in patients with chronic hepatitis b (chb) and the impact of hepatic steatosis on the progress of fibrosis. methods five hundred and sixty two untreated chb patients (405 males and 157 females) with an average age of 31.3 underwent liver biopsy from january to august 2007. on the day of liver biopsy, a questionnaire was completed and a blood sample was obtained for laboratory analysis. the degree of liver steatosis, necroinflammation and fibrosis was assessed; demographic information and clinical data including age, gender, body mass index (bmi), history of diabetes mellitus, hypertension, dyslipidemia, and hbeag status, hbv dna viral load were documented. results in 562 patients, 102 (18. 2% ) had steatosis. multivariate analysis demonstrated that liver steatosis was associated with the levels of tg, apo-b, ua, fsg, and higher bmi; and the progress of fibrosis was associated with high degree of hepatic steatosis and necroinflammation, age over 35 years, hbv dna > 103 copies/l, high bmi and ggt. conclusions the results show that obesity and dyslipidemia in chb patients are associated with the hepatic steatosis, and the latter seems to be an important determinant for fibrosis. | shi jun-ping 范建高 wu rui 张莉 xun yun-hao 娄国强 | 2008 | 中华临床感染病杂志2008，1，2： | 12 |
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