|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Ectopic osteogenesis and angiogenesis regulated by porous architecture of hydroxyapatite scaffolds with similar interconnecting structure in vivo显示文摘The macro-pore sizes of porous scaffold play a key role for regulating ectopic osteogenesis and angiogenesis but many researches ignored the influence of interconnection between macro-pores with different sizes.In order to accurately reveal the relationship between ectopic osteogenesis and macro-pore sizes in dorsal muscle and abdominal cavities of dogs,hydroxyapatite(HA)scaffolds with three different macro-pore sizes of 500–650,750–900 and 1100–1250 mm were prepared via sugar spheres-leaching process,which also had similar interconnecting structure determined by keeping the d/s ratio of interconnecting window diameter to macro-pore size constant.The permeability test showed that the seepage flow of fluid through the porous scaffolds increased with the increase of macro-pore sizes.The cell growth in three scaffolds was not affected by the macro-pore sizes.The in vivo ectopic implantation results indicated that the macro-pore sizes of HA scaffolds with the similar interconnecting structure have impact not only the speed of osteogenesis and angiogenesis but also the space distribution of newly formed bone.The scaffold with macro-pore sizes of 750–900 mm exhibited much faster angiogenesis and osteogenesis,and much more uniformly distribution of new bone than those with othermacro-pore sizes.This work illustrates the importance of a suitable macro-pore sizes in HA scaffolds with the similar interconnecting structure which provides the environment for ectopic osteogenesis and angiogenesis. | Jinyu Li Wei Zhi Taotao Xu Feng Shi Ke Duan JianxinWang Yandong Mu Jie Weng | 2016 | Regenerative Biomaterials2016，3，5： | 16 |
| 2 | Nonlinear regression model for peak-failure strength of rockfill materials in general stress space显示文摘A nonlinear regression model for peak-failure strength prediction of rockfill materials is proposed. It is based on the relationship between the peak-failure stress ratio and the normalized confining pressure as well as the relationship between the normalized peak-failure stress ratio and the exponent function of the intermediate principal stress ratio. This model can well predict the variations of the peak-failure stress ratio with the initial confining pressure and the intermediate principal stress ratio for different rockfill materials under different general stress paths. Comparisons of the measured and predicted results show that the peak-failure strength under the constant-p' and constant-b path is larger than that under the constant-σ'_3 and constant-b path. The predictive capacity of the proposed model for the peakfailure stress ratio is better than that for the peak-failure friction angle. | Yang Xiao Minqiang Meng Hui Chen Xiang He Jinyu Ran Weicheng Shi | 2018 | Geoscience Frontiers2018，9，6： | 6 |
| 3 | Whole Genome Analyses of Chinese Population and De Novo Assembly of A Northern Han Genome显示文摘To unravel the genetic mechanisms of disease and physiological traits,it requires comprehensive sequencing analysis of large sample size in Chinese populations.Here,we report the primary results of the Chinese Academy of Sciences Precision Medicine Initiative(CASPMI)project launched by the Chinese Academy of Sciences,including the de novo assembly of a northern Han reference genome(NH1.0)and whole genome analyses of 597 healthy people coming from most areas in China.Given the two existing reference genomes for Han Chinese(YH and HX1)were both from the south,we constructed NH1.0,a new reference genome from a northern individual,by combining the sequencing strategies of PacBio,10×Genomics,and Bionano mapping.Using this integrated approach,we obtained an N50 scaffold size of 46.63 Mb for the NH1.0 genome and performed a comparative genome analysis of NH1.0 with YH and HX1.In order to generate a genomic variation map of Chinese populations,we performed the whole-genome sequencing of 597 participants and identified 24.85 million(M)single nucleotide variants(SNVs),3.85 M small indels,and 106,382 structural variations.In the association analysis with collected phenotypes,we found that the T allele of rs1549293 in KAT8 significantly correlated with the waist circumference in northern Han males.Moreover,significant genetic diversity in MTHFR,TCN2,FADS1,and FADS2,which associate with circulating folate,vitamin B12,or lipid metabolism,was observed between northerners and southerners.Especially,for the homocysteine-increasing allele of rs1801133(MTHFR 677T),we hypothesize that there exists a “comfort”zone for a high frequency of 677T between latitudes of 35–45 degree North.Taken together,our results provide a high-quality northern Han reference genome and novel population-specific data sets of genetic variants for use in the personalized and precision medicine. | Zhenglin Du Liang Ma Hongzhu Qu Wei Chen Bing Zhang Xi Lu Weibo Zhai Xin Sheng Yongqiao Sun Wenjie Li Meng Lei Qiuhui Qi Na Yuan Shuo Shi Jingyao Zeng Jinyue Wang Yadong Yang Qi Liu Yaqiang Hong Lili Dong Zhewen Zhang Dong Zou Yanqing Wang Shuhui Song Fan Liu Xiangdong Fang Hua Chen Xin Liu Jingfa Xiao Changqing Zeng | 2019 | Genomics, Proteomics & Bioinformatics2019，17，3： | 4 |
| 4 | Influence of confi ning pressure and impact loading on mechanical properties of amphibolite and sericite-quartz schist显示文摘In order to investigate the dynamic mechanical properties of amphibolite and sericite-quartz schist under confi ning pressure, two rocks are subjected to impact loadings with different strain rates and confi ning pressures by using split Hopkinson pressure bar equipment with a confi ning pressure device. Based on the experimental results, the stress-strain curves are analyzed and the effects of confi ning pressure and strain rates on the dynamic compressive strength, peak strain and failure mode are summarized. The results show that:(1) The characteristics of two rocks in the ascent stage of the stressstrain curve are basically the same, but in the descent stage, the rocks gradually show plastic deformation characteristics as the confi ning pressure increases.(2) The dynamic compressive strength and peak strain of two rocks increase as the strain rate increases and the confi ning pressure effects are obvious.(3) Due to the effect of confi ning pressure, the normal stress on the damage surface of the rock increases correspondingly, the bearing capacity of the crack friction exceeds the material cohesion and the slippage of the fractured rock is controlled, which all lead to the compression and shear failure mode of rock. The theoretical analysis and experimental methods to study the dynamic failure mode and other related characteristics of rock are useful in developing standards for engineering practice. | Liu Shi Xu Jinyu Lv Xiaocong | 2014 | Earthquake Engineering and Engineering Vibration2014，13，2： | 4 |
| 5 | Family-level diversity of extracellular proteases of sedimentary bacteria from the South China Sea显示文摘Protease-producing bacteria and their extracellular proteases are key players in degrading organic nitrogen to drive marine nitrogen cycling and yet knowledge on both of them is still very limited. This study screened protease-producing bacteria from the South China Sea sediments and analyzed the diversity of their extracellular proteases at the family level through N-terminal amino acid sequencing. Results of the 16 S rRNA gene sequence analysis showed that all screened protease-producing bacteria belonged to the class Gammaproteobacteria and most of them were affiliated with different genera within the orders Alteromonadales and Vibrionales. The Nterminal amino acid sequence analysis for fourteen extracellular proteases from fourteen screened bacterial strains revealed that all these proteases belonged to the M4 family of metalloproteases or the S8 family of serine proteases. This study presents new details on taxa of marine sedimentary protease-producing bacteria and types of their extracellular proteases, which will help to comprehensively understand the process and mechanism of the microbial enzymatic degradation of marine sedimentary organic nitrogen. | Jinyu Yang Yangyang Feng Xiulan Chen Binbin Xie Yuzhong Zhang Mei Shi Xiying Zhang | 2019 | Acta Oceanologica Sinica2019，38，12： | 3 |
| 6 | Genomic Variations in the Tea Leafhopper Reveal the Basis of Its Adaptive Evolution显示文摘Tea green leafhopper(TGL),Empoasca onukii,is of biological and economic interest.Despite numerous studies,the mechanisms underlying its adaptation and evolution remain enigmatic.Here,we use previously untapped genome and population genetics approaches to examine how the pest adapted to different environmental variables and thus has expanded geographically.We complete a chromosome-level assembly and annotation of the E.onukii genome,showing notable expansions of gene families associated with adaptation to chemoreception and detoxification.Genomic signals indicating balancing selection highlight metabolic pathways involved in adaptation to a wide range of tea varieties grown across ecologically diverse regions.Patterns of genetic variations among 54 E.onukii samples unveil the population structure and evolutionary history across different tea-growing regions in China.Our results demonstrate that the genomic changes in key pathways,including those linked to metabolism,circadian rhythms,and immune system functions,may underlie the successful spread and adaptation of E.onukii.This work highlights the genetic and molecular basis underlying the evolutionary success of a species with broad economic impacts,and provides insights into insect adaptation to host plants,which will ultimately facilitate more sustainable pest management. | Qian Zhao Longqing Shi Weiyi He Jinyu Li Shijun You Shuai Chen Jing Lin Yibin Wang Liwen Zhang Guang Yang Liette Vasseur Minsheng You | 2022 | Genomics, Proteomics & Bioinformatics2022，20，6： | 1 |
| 7 | Study on dynamic characteristics of marble under impact loading and high temperature 显示文摘 | Shi Liu Jinyu Xu | 2013 | International Journal of Rock Mechanics and Mining Sci- ences2013，62，： | 1 |
| 8 | Study on dynamic characteristics of marble under impact loading and high temperature 显示文摘 | Shi Liu Jinyu Xu | 2013 | International Journal of Rock Mechanics & Mining Sci- ences2013，62，： | 1 |
| 9 | Intonation and respiration:apreliminary analysis显示文摘 | Shi Feng Zhang Jinyu Bai Xuejun | 2010 | Journal of Chinese Linguistics2010，38，2： | 1 |
| 10 | Study on dynamic characteristics of marble under impact loading and high temperature 显示文摘 | Liu Shi Xu Jinyu | 2013 | International journal of rock mechanics and min- ing sciences2013，62，： | 1 |
| 11 | Study on dynamic characteristics of marble under impact loading and high temperature显示文摘 | Shi Liu Jinyu Xu | 2013 | International Journal of Rock Mechanics and Mining Sciences2013，，： | 1 |
| 12 | Study on dynamic characteristics of marble under impact loading and high temperature显示文摘 | LIU Shi XU Jinyu | 2013 | International Journal of Rock Mechanics and Mining Sciences2013，62，9： | 1 |
| 13 | Intonation and Respiration: a Preliminary Analysis 显示文摘 | FENG SHI XUEJUN BAI JINYU ZHANG | 2010 | Journal of Chinese Linguistics2010，38，2： | 1 |
| 14 | Adiponectin and Endometrial Cancer :A Systematic Review and Meta-Analysis显示文摘 | Fangxin Zeng Jinyu Shi Yang Long | 2015 | Cell Physiol Biochem2015，36，4： | 1 |
| 15 | Study on dynamic characteristics of marble under impact loading and high temperature显示文摘 | Shi Liu Jinyu Xu | 2013 | International Journal of Rock Mechanics and Mining Sciences2013，，： | 1 |
| 16 | Research progress on vanadium oxides for potassium-ion batteries显示文摘Potassium-ion batteries(PIBs)have been considered as promising candidates in the post-lithium-ion battery era.Till now,a large number of materials have been used as electrode materials for PIBs,among which vanadium oxides exhibit great potentiality.Vanadium oxides can provide multiple electron transfers during electrochemical reactions because vanadium possesses a variety of oxidation states.Meanwhile,their relatively low cost and superior material,structural,and physicochemical properties endow them with strong competitiveness.Although some inspiring research results have been achieved,many issues and challenges remain to be further addressed.Herein,we systematically summarize the research progress of vanadium oxides for PIBs.Then,feasible improvement strategies for the material properties and electrochemical performance are introduced.Finally,the existing challenges and perspectives are discussed with a view to promoting the development of vanadium oxides and accelerating their practical applications. | Yuhan Wu Guangbo Chen Xiaonan Wu Lin Li Jinyu Yue Yinyan Guan Juan Hou Fanian Shi Jiyan Liang | 2023 | Journal of Semiconductors2023，44，4： | 1 |
| 17 | A functional BRCA1 coding sequence genetic variant contributes to risk of esophageal squamous cell carcinoma显示文摘 | Xiaojiao Zhang Jinyu Wei Liqing Zhou Changchun Zhou Juan Shi Qipeng Yuan Ming Yang Dongxin Lin | 2013 | Carcinogenesis2013，，10： | 1 |
| 18 | Study on dynamic characteristics of marble under impact loading and high temperature 显示文摘 | Shi Liu Jinyu Xu | 2013 | International Journal of Rock Mechanics & Mining Sci- ences2013，62，： | 1 |
| 19 | On Designs of Decentralized Reputation Management for Permissioned Blockchain Networks显示文摘In permissioned blockchain networks,the Proof of Authority(PoA)consensus,which uses the election of authorized nodes to validate transactions and blocks,has beenwidely advocated thanks to its high transaction throughput and fault tolerance.However,PoA suffers from the drawback of centralization dominated by a limited number of authorized nodes and the lack of anonymity due to the round-robin block proposal mechanism.As a result,traditional PoA is vulnerable to a single point of failure that compromises the security of the blockchain network.To address these issues,we propose a novel decentralized reputation management mechanism for permissioned blockchain networks to enhance security,promote liveness,and mitigate centralization while retaining the same throughput as traditional PoA.This paper aims to design an off-chain reputation evaluation and an on-chain reputation-aided consensus.First,we evaluate the nodes’reputation in the context of the blockchain networks and make the reputation globally verifiable through smart contracts.Second,building upon traditional PoA,we propose a reputation-aided PoA(rPoA)consensus to enhance securitywithout sacrificing throughput.In particular,rPoA can incentivize nodes to autonomously form committees based on reputation authority,which prevents block generation from being tracked through the randomness of reputation variation.Moreover,we develop a reputation-aided fork-choice rule for rPoA to promote the network’s liveness.Finally,experimental results show that the proposed rPoA achieves higher security performance while retaining transaction throughput compared to traditional PoA. | Jinyu Chen Long Shi Qisheng Huang Taotao Wang Daojing He | 2024 | Computer Modeling in Engineering & Sciences2024，139，5： | 0 |
| 20 | Observation of the early blood vessels of cutaneous malignant melanoma using Swept Source Optical Coherence Tomography A ngiography(SS-OCTA)显示文摘Melanoma,characterized by high mortality,rapid development and accompanied with angio-genesis is the most typical malignant tumor in skin cancer.Hence,the detection of blood vessels is of much significanoe.The early vascular network has small scale.If we remove the tumor early and biopsy it,it will increase the spread of the cancer cells and infection and bleeding.In this case,we presented a new angiography method.A high-resolution OCT system for noninvasive an-giographic imaging of early skin melanoma-Swept Source Optical Coberence Tomography Angiography(SS-OCTA)is proposed.With a high lateral resolution of 10pm in vrivo tomographic angiography,SS-OCTA is used to image and identify the morphology of the early tumor blood vessels.In addition,a control group experiment is conducted to observe the growth of melanoma in the process of rupture,malormation of micro-vessels.The results of the analysis and statistical test(P<0.05)are statistically signifcant. | Jingxuan Liu Jinyu Fan Quan Wang Wen He Caihua Dong Minxuan Sun Guohua Shi | 2019 | Journal of Innovative Optical Health Sciences2019，，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员