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| 1 | Apolipoprotein(apo) E4 enhances amyloid peptide production in cultured neuronalcells:ApoE structure as a potential therapeutic target 显示文摘 | Shiming Ye Yadong Huang Karin Mullendroff | 2005 | PNAS De-cember2005，102，18： | 1 |
| 2 | Variability of Atlantic Meridional Overturning Circulation in FGOALS-g2显示文摘The variability of Atlantic Meridional Overturning Circulation(AMOC) in the pre-industrial control experiment of the Flexible Global Ocean–Atmosphere–Land System model, Grid-point Version 2(FGOALS-g2) was investigated using the model outputs with the most stable state in a 512-yr time window from the total 1500-yr period of the experiment. The period of AMOC in FGOALS-g2 is double peaked at 20 and 32 years according to the power spectrum, and 22 years according to an auto-correlation analysis, which shows very obvious decadal variability. Like many other coupled climate models, the decadal variability of AMOC in FGOALS-g2 is closely related to the convection that occurs in the Labrador Sea region. Deep convection in the Labrador Sea in FGOALS-g2 leads the AMOC maximum by 3–4 years. The contributions of thermal and haline effects to the variability of the convection in three different regions [the Labrador, Irminger and Greenland–Iceland– Norwegian(GIN) Seas] were analyzed for FGOALS-g2. The variability of convection in the Labrador and Irminger Seas is thermally dominant, while that in the colder GIN Seas can be mainly attributed to salinity changes due to the lower thermal expansion. By comparing the simulation results from FGOALS-g2 and 11 other models, it was found that AMOC variability can be attributed to salinity changes for longer periods(longer than 35 years) and to temperature changes for shorter periods. | HUANG Wenyu WANG Bin LI Lijuan DONG Li LIN Pengfei YU Yongqiang ZHOU Tianjun LIU Li XU Shiming XIA Kun PU Ye WANG Lu LIU Mimi SHEN Si HU Ning WANG Yong SUN Wenqi DONG Fang | 2014 | Advances in Atmospheric Sciences2014，31，1： | 1 |
| 3 | Premature infants born after preterm premature rupture of membranes with 24–34 weeks of gestation: a study of factors influencing length of neonatal intensive care unit stay显示文摘 | Guangyong Ye Zhou Jiang Shiming Lu YUANLUO Le | 2011 | Journal of Maternal-Fetal and Neonatal Medicine2011，，7： | 1 |
| 4 | Recent advances and prospects of asymmetric non-fullerene small molecule acceptors for polymer solar cells显示文摘Recently,polymer solar cells developed very fast due to the application of non-fullerence acceptors.Substituting asymmetric small molecules for symmetric small molecule acceptors in the photoactive layer is a strategy to improve the performance of polymer solar cells.The asymmetric design of the molecule is very beneficial for exciton dissociation and charge transport and will also fine-tune the molecular energy level to adjust the open-circuit voltage(Voc)further.The influence on the absorption range and absorption intensity will cause the short-circuit current density(Jsc)to change,resulting in higher device performance.The effect on molecular aggregation and molecular stacking of asymmetric structures can directly change the microscopic morphology,phase separation size,and the active layer's crystallinity.Very recently,thanks to the ingenious design of active layer materials and the optimization of devices,asymmetric non-fullerene polymer solar cells(A-NF-PSCs)have achieved remarkable development.In this review,we have summarized the latest developments in asymmetric small molecule acceptors(A-NF-SMAs)with the acceptor-donor-acceptor(A-D-A)and/or acceptor-donor-acceptor-donor-acceptor(A-D-A-D-A)structures,and the advantages of asymmetric small molecules are explored from the aspects of charge transport,molecular energy level and active layer accumulation morphology. | Liu Ye Weiyu Ye Shiming Zhang | 2021 | Journal of Semiconductors2021，42，10： | 1 |
| 5 | Image editing by object-aware optimal boundary searching and mixed-domain composition显示文摘When combining very different images which often contain complex objects and backgrounds,producing consistent compositions is a challenging problem requiring seamless image editing. In this paper, we propose a general approach, called objectaware image editing, to obtain consistency in structure,color, and texture in a unified way. Our approach improves upon previous gradient-domain composition in three ways. Firstly, we introduce an iterative optimization algorithm to minimize mismatches on the boundaries when the target region contains multiple objects of interest. Secondly, we propose a mixeddomain consistency metric for measuring gradients and colors, and formulate composition as a unified minimization problem that can be solved with a sparse linear system. In particular, we encode texture consistency using a patch-based approach without searching and matching. Thirdly, we adopt an objectaware approach to separately manipulate the guidance gradient fields for objects of interest and backgrounds of interest, which facilitates a variety of seamless image editing applications. Our unified method outperforms previous state-of-the-art methods in preserving global texture consistency in addition to local structure continuity. | Shiming Ge Xin Jin Qiting Ye Zhao Luo Qiang Li | 2018 | Computational Visual Media2018，4，1： | 0 |
| 6 | Hexamerin and allergen are required for female reproduction in the American cockroach,Periplaneta americana显示文摘Reproduction is of great importance for the continuation of the species.In insects,the fat body is the major tissue for nutrient storage and involved in vitellogenesis,which is essential for female reproduction.Here,2 proteins,hexamerin and allergen,were separated from the fat bodies of adult female American cockroaches(Periplaneta americana)and identified as storage proteins,encoding for 733 amino acids with molecular weight of 87.88 kDa and 686 amino acids with molecular weight of 82.18 kDa,respectively.The encoding genes of these 2 storage proteins are mainly expressed in the fat body.RNA interference-mediated knockdown of Hexamerin and Allergen in the early stage of the first reproductive cycle in females suppressed vitellogenesis and ovarian maturation,indicating that these storage proteins are involved in controlling reproduction.Importantly,the expression of Hexamerin and Allergen was repressed by knockdown of the juvenile hormone(JH)receptor gene Met and the primary response gene Kr-h1,and was induced by methoprene,a JH analog,in both in vivo and in vitro experiments.Altogether,we have determined that hexamerin and allergen are identified as storage proteins and play an important role in promoting female reproduction in the American cockroach.The expression of their encoding genes is induced by JH signaling.Our data reveal a novel mechanism by which hexamerin and allergen are necessary for JH-stimulated female reproduction. | Shiming Zhu Xiaoyi Chen Sishi Xia Qin Li Ziqi Ye Shaoting Zhao Kexin Liu Fangfang Liu | 2024 | Insect Science2024，31，1： | 0 |
| 7 | Bilateral Filter for the Optimization of Composite Structures显示文摘In the present study,we propose to integrate the bilateral filter into the Shepard-interpolation-based method for the optimization of composite structures.The bilateral filter is used to avoid defects in the structure that may arise due to the gap/overlap of adjacent fiber tows or excessive curvature of fiber tows.According to the bilateral filter,sensitivities at design points in the filter area are smoothed by both domain filtering and range filtering.Then,the filtered sensitivities are used to update the design variables.Through several numerical examples,the effectiveness of the method was verified. | Yuhang Huo Ye Tian Shiming Pu Tielin Shi Qi Xia | 2021 | Computer Modeling in Engineering & Sciences2021，，6： | 0 |
| 8 | TMEM106A transcriptionally regulated by promoter methylation is involved in invasion and metastasis of hepatocellular carcinoma显示文摘Expression of transmembrane protein 106A(TMEM106A)has been reported to be dysregulated in several types of cancers.However,the role of TMEM106A in hepatocellular carcinoma(HCC)is still unknown.In the present study,we demonstrate that TMEM106A is markedly downregulated in HCC compared with normal liver tissue.In particular,tumor-specific DNA methylation of TMEM106A is frequently observed in tumor tissues from HCC patients.Immunohistochemistry and pyrosequencing reveal a significant relationship between TMEM106A methylation and downregulation of protein expression.Receiver operating characteristic(ROC)curve analysis reveals that methylation of TMEM106A in tumor samples is different from that in non-malignant adjacent tissues of HCC patients.Moreover,HCC patients with TMEM106A hypermethylation have a poor clinical prognosis.5-Aza-2′-deoxycytidin treatment of hypermethylated TMEM106A in highly metastatic HCC cells increases the expression of TMEM106A.Functional assays reveal that overexpression of TMEM106A significantly suppresses the malignant behavior of HCC cells in vitro and decreases tumorigenicity and lung metastasis in vivo.Mechanistically,TMEM106A inhibits epithelial mesenchymal transition(EMT)of HCC cells through inactivation of the Erk1/2/Slug signaling pathway.In conclusion,our findings demonstrate that TMEM106A is an inhibitor of HCC EMT and metastasis,and TMEM106A is often transcriptionally downregulated by promoter methylation,which results in reduced levels of TMEM106A protein and predicts poor survival outcomes for HCC patients. | Shiming Shi Biao Wang Jinglei Wan Lina Song Guiqi Zhu Junxian Du Luxi Ye Qianqian Zhao Jialiang Cai Qing Chen Kun Xiao Jian He Lei Yu Zhi Dai | 2022 | Acta Biochimica et Biophysica Sinica2022，54，7： | 0 |
| 9 | East Asian monsoon intensification promoted weathering of the magnesium-rich southern China upper crust and its global significance显示文摘The Oligocene-Miocene boundary Asian climatic reorganization linked to the northward migration of the East Asian monsoon into subtropical China is a potentially important but poorly constrained atmospheric CO_(2) consumption process.Here,we performed a first-order estimate of the CO_(2) consumption induced by silicate chemical weathering and organic carbon burial in subtropical China related to this climatic reorganization.Our results show that an increase in long-term CO_(2 )consumption by silicate weathering varies from 0.06×10^(12)to 0.87×10^(12)mol yr^(-1)depending on erosion flux reconstructions,with an~50%contribution of Mg-silicate weathering since the late Oligocene.The organic carbon burial flux is approximately 25%of the contemporary CO_(2) consumption by silicate weathering.The results highlight the significant role of weathering of the Mg-rich upper continental crust in East China,which would contribute to the rapid decline in atmospheric CO_(2) during the late Oligocene and the Neogene rise in the seawater Mg content.If this climatic reorganization was mainly induced by the Tibetan Plateau uplift,our study suggests that the growth of the Himalayan-Tibetan Plateau can lead to indirect modification of the global carbon and magnesium cycles by changing the regional hydrological cycle in areas of East Asia that are tectonically less active. | Yibo YANG Albert GALY Xiaomin FANG Christian FRANCE-LANORD Shiming WAN Rongsheng YANG Jian ZHANG Ran ZHANG Song YANG Yunfa MIAO Yudong LIU Chengcheng YE | 2021 | Science China Earth Sciences2021，64，7： | 0 |
| 10 | Stability,encapsulation and large-area fabrication of organic photovoltaics显示文摘Organic photovoltaics(OPVs)have become a timely research topic for their advantages of light weight,low cost,low toxicity,environmental adaptability,flexibility,and large-area manufacture,especially after non-fullerene acceptor ITIC reported in 2015.The highest power conversion efficiency(PCE)is currently above 18%for OPV.However,there are still imparities in the efficiency of OPVs when compared with silicon-based photovoltaics,as well as in their shelf life.Compared with inorganicbased photovoltaics,the efficiency of large-area OPVs is lower and the life time of OPVs is shorter.Therefore,such inferior performance of large-area OPVs restricts the commercial development.Based on these constraints,this paper reviews the research work regarding OPVs into three aspects:stability,encapsulation technology,and recent large-area preparation technologies. | Shan Song Jiaorong Lu Weiyu Ye Bei Zhang Xuan Liu Guichuan Xing Shiming Zhang | 2021 | Science China Chemistry2021，64，9： | 0 |
| 11 | Initial steps on the analysis of the underlying pharmacological mechanisms of Wendan decoction on sudden deafness using network pharmacology and molecular docking显示文摘Background:Despite its widespread therapeutic use and effectiveness,the underlying pharmacologic mechanisms of Wendan decoction(WDD)and how it works to treat sudden deafness(SD)remain unclear.In this study,the pharmacological mechanisms of WDD underlying SD were analyzed using network pharmacology and molecular docking.Methods:The Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP)was employed to identify the active compounds and target genes of WDD,and genes associated with SD were screened on five databases.RGUI conducted Gene Ontology(GO)functional and the Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analyses.A compound-target network was established using Cytoscape,and the STRING database created a protein-protein interaction(PPI)network to identify the key compounds and targets.Subsequently,a network of crucial compound-target was generated for further molecular docking analysis.For molecular docking simulations of the macromolecular target proteins and their matching ligand molecules,AutoDock Vina and AutoDockTool were utilized.Results:TCMSP identified 162 active target genes and 36 active compounds for WDD.The active target genes were compared with the 2271 genes associated with SD to identify 70 intersecting active target genes linked to 34 active compounds.The GO functional enrichment and KEGG pathway enrichment analyses were undertaken,and compound–target,and PPI networks were built.The key compounds and protein targets were identified and integrated to form a key compound–target network.Eventually,molecular docking was performed to investigate the interactions of the protein targets with their respective compounds.Conclusion:This study highlights the mechanisms of multi-compounds,targets,and pathways of WDD acting on SD and provides further evidence of crucial compounds and their matching target proteins of WDD acting on SD. | SHIMING YE YUFENG ZHANG TING LIU CONG WANG ZHENG YAN WANDONG SHE HAIBING HUA | 2023 | BIOCELL2023，47，9： | 0 |
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