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| 1 | Therapeutic potential of siRNA-mediated combined knockdown of the lAP genes (Livin, XIAP, and Survivin) on human bladder cancer T24 cells显示文摘Livin, apoptosis (XIAP ) 的 X 连接禁止者,和 Survivin 几乎是 apoptosis 的三个著名禁止者在癌症房间只过去表示并且为癌症治疗被认为有势力目标。在现在的学习,我们发现 Livin, XIAP,和 Survivin 同时在膀胱癌症房间被表示。我们推测了那 Livin, XIAP,和 Survivin 可能在房间生长和 apoptosis 上有 synergistic 效果。我们的结果证实了联合那所有这三基因击倒能 synergistically 禁止增长和高级膀胱癌症 T24 房间的转变能力并且把房间 apoptotic 敏感提升到化疗。而且,联合了 Livin, XIAP,和 Survivin 罐头击倒显著地增加许多活跃 caspase-3,活跃 caspase-7,活跃 caspase-9,和 cytosolic Smac。我们的调查结果暗示 Livin, XIAP,和 Survivin 的那联合 silencing 可以是一个有势力为膀胱癌症的多指向的基因治疗。 | Deyong Yang Xishuang Song Jianing Zhang Lin Ye Shujing Wang Xiangyu Che Jianbo Wang Zhiwei Zhang Lina Wang Wei Shi | 2010 | Acta Biochimica et Biophysica Sinica2010，42，2： | 29 |
| 2 | Transplantation of X-box-binding protein-1 gene-modified neural stem cells in the lateral ventricle of brain ischemia rats显示文摘X-box-binding protein-1 (XBP-1) is an essential transcription factor in endoplasmic reticulum stress. In this study, XBP-1 gene-transfected neural stem cells (NSCs) were transplanted into lesion sites to ensure stability and persistent expression of XBP-1, resulting in the exertion of anti-apoptotic effects. Simultaneously, XBP-1 gene transfection promotes the survival and differentiation of transplanted NSCs. Results from this study demonstrated that survival, proliferation and differentiation of XBP-1 gene-modified NSCs were enhanced when compared to unmodified NSCs at 28 days post-transplantation (P < 0.05). A diminished number of apoptotic neural cells increased Bcl-2 expression and reduced Bax expression, and were observed in the ischemic region of the XBP-1-NSCs group (P < 0.05). These results indicated that modification of the XBP-1 gene enhances the survival and migration of NSCs in vivo and decreases the occurrence of apoptosis. | Yao Wang Xiaokun Gang Qun Liu Lei Song Lina Lin Jia Fan | 2011 | Neural Regeneration Research2011，6，1： | 14 |
| 3 | Modeling CADASIL vascular pathologies with patient-derived induced pluripotent stem cells显示文摘Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy(CADASIL)is a rare hereditary cerebrovascular disease caused by a NOTCH3 mutation.However,the underlying cellular and molecular mechanisms remain unidentified.Here,we generated non-integrative induced pluripotent stem cells(iPSCs)from fibroblasts of a CADASIL patient harboring a heterozygous NOTCH3 mutation(c.3226C>T,p.R1076C).Vascular smooth muscle cells(VSMCs)differentiated from CADASIL-specific iPSCs showed gene expression changes associated with disease phenotypes,including activation of the NOTCH and NF-kB signaling pathway,cytoskeleton disorganization,and excessive cell proliferation.In comparison,these abnormalities were not observed in vascular endothelial cells(VECs)derived from the patients iPSCs.Importantly,the abnormal upregulation of NF-kB target genes in CADASIL VSMCs was diminished by a NOTCH pathway inhibitor,providing a potential therapeutic strategy for CADASIL.Overall,using this iPSCbased disease model,our study identified clues for studying the pathogenic mechanisms of CADASIL and developing treatment strategies for this disease. | Chen Ling Zunpeng Liu Moshi Song Weiqi Zhang Si Wang Xiaoqian Liu Shuai Ma Shuhui Sun Lina Fu Qun Chu Juan Carlos Izpisua Belmonte Zhaoxia Wang Jing Qu Yun Yuan Guang-Hui Liu | 2019 | Protein & Cell2019，10，4： | 7 |
| 4 | FXYD6: a novel therapeutic target toward hepatocellular carcinoma显示文摘FXYD6, FXYD 领域包含离子运输管理者 6,被报导了影响 Na 的活动 < 啜 class= “ a-plus-plus ” >+/K+-ATPase 并且与心理疾病被联系。这里,我们证明 FXYD6 在 hepatocellular 癌(HCC ) 是起来调整的并且提高 HCC 房间的迁居和增长。FXYD6 的起来规定不仅断然随 Na 的增加相关 < 啜 class= “ a-plus-plus ” >+/K 有它发信号的下游的 Src 英皇家空军之阶级最低之兵的激活的 +-ATPase 而且坐标小径。更重要地,显著地由它的功能的抗体堵住 FXYD6 在老鼠禁止 xenografted HCC 肿瘤的生长潜力,显示 FXYD6 代表向 HCC 的一个潜在的治疗学的目标。总的来说,我们的结果在 HCC 前进建立 FXYD6 的一个关键角色并且建议指向 FXYD6 的治疗能向 HCC 病人有益于临床的治疗。 | Qian Gao Xiongfei Chen Hongxia Duan Zhaoqing Wang Jing Feng Dongling Yang Lina Song Ningxin Zhou Xiyun Yan | 2014 | Protein & Cell2014，5，7： | 7 |
| 5 | Impaired tumor angiogenesis and VEGF- induced pathway in endothelial CD146 knockout mice显示文摘 | Qiqun Zeng Zhenzhen Wu Hongxia Duan Xuan Jiang Tao Tu Di Lu Yongting Luo Ping Wang Lina Song Jing Feng Dongling Yang Xiyun Yan | 2014 | Protein & Cell2014，5，6： | 6 |
| 6 | Effects of grazing intensity on seed production of Caragana stenophylla along a climatic aridity gradient in the Inner Mongolia Steppe,China显示文摘As the increases of climatic aridity and grazing intensity,shrubs play an increasingly important role in grassland ecosystem in arid and semi-arid regions,and its abundance also generally increases.However,the effects of climatic aridity and grazing intensity on sexual reproduction of shrubs in grassland remain largely unclear.In order to understand the effects of grazing intensity and climatic drought stress,and their interaction on seed production of shrub species,we examined the seed number,seed weight and seed yield of Caragana stenophylla under three grazing intensities(fenced,mild grazing and severe grazing) across a climatic aridity gradient(semi-arid,arid,very arid and intensively arid zones) in the Inner Mongolia Steppe,northern China during 2012–2013.The seed number,seed weight and seed yield gradually increased from the semi-arid to the very arid zones,but decreased from the very arid to the intensively arid zones in fenced plots.The seed number and seed yield decreased from the semi-arid to the intensively arid zones in mild and severe grazing treatment plots,therefore,grazing enhanced the suppression effect of climatic aridity on seed production of C.stenophylla.The seed number and seed yield gradually decreased as grazing intensity increased.The seed weight was highest in severe grazing plots,followed by the mild grazing plots and then the fenced plots.Precipitation varied interannually during the study period.We observed that the seed number,seed weight and seed yield were lower in the low precipitation year(2013) than in the high precipitation year(2012).As climatic drought stress increased,the negative effects of grazing on seed production of C.stenophylla also gradually increased.Our results indicated that climatic drought stress may contribute to the encroachment of C.stenophylla shrub in arid zones by promoting its seed production.However,grazing had negative effects on sexual reproduction of C.stenophylla,and the combined effects of drought stress and grazing seriously suppressed sexual reproduction of C.stenophylla in the intensively arid zone. | XIE Lina CHEN Weizhong Christopher A GABLER HAN Lei GUO Hongyu CHEN Qing MA Chengcang GU Song | 2016 | Journal of Arid Land2016，8，6： | 5 |
| 7 | The Global Landscape of SARS-CoV-2 Genomes, Variants, and Haplotypes in 2019nCoVR显示文摘On January 22,2020,China National Center for Bioinformation(CNCB)released the 2019 Novel Coronavirus Resource(2019nCoVR),an open-access information resource for the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).2019nCoVR features a comprehensive integration of sequence and clinical information for all publicly available SARS-CoV-2 isolates,which are manually curated with value-added annotations and quality evaluated by an automated in-house pipeline.Of particular note,2019nCoVR offers systematic analyses to generate a dynamic landscape of SARS-CoV-2 genomic variations at a global scale.It provides all identified variants and their detailed statistics for each virus isolate,and congregates the quality score,functional annotation,and population frequency for each variant.Spatiotemporal change for each variant can be visualized and historical viral haplotype network maps for the course of the outbreak are also generated based on all complete and high-quality genomes available.Moreover,2019nCoVR provides a full collection of SARS-CoV-2 relevant literature on the coronavirus disease 2019(COVID-19),including published papers from PubMed as well as preprints from services such as bioRxiv and medRxiv through Europe PMC.Furthermore,by linking with relevant databases in CNCB,2019nCoVR offers data submission services for raw sequence reads and assembled genomes,and data sharing with NCBI.Collectively,SARS-CoV-2 is updated daily to collect the latest information on genome sequences,variants,haplotypes,and literature for a timely reflection,making 2019nCoVR a valuable resource for the global research community.2019nCoVR is accessible at http://gffzzdbc7b6aaae734bdds96xqxvcoxofk6cpq.ffgz.tsg.suse.edu.cn/ncov/. | Shuhui Song Lina Ma Dong Zou Dongmei Tian Cuiping Li Junwei Zhu Meili Chen Anke Wang Yingke Ma Mengwei Li Xufei Teng Ying Cui Guangya Duan Mochen Zhang Tong Jin Chengmin Shi Zhenglin Du Yadong Zhang Chuandong Liu Rujiao Li Jingyao Zeng Lili Hao Shuai Jiang Hua Chen Dali Han Jingfa Xiao Zhang Zhang Wenming Zhao Yongbiao Xue Yiming Bao | 2020 | Genomics, Proteomics & Bioinformatics2020，18，6： | 4 |
| 8 | Nutrient Composition of Different Foxtail Millet Seeds显示文摘Ten millet cultivars from China and abroad were analyzed for their crude fat,amylose and amylopectin,crude protein and amino acid content. A wide variation was observed in amylopectin contain,ranging from 54. 47% to 69. 26%,while amylose content ranged from 11. 26% to 23. 22%. The average crude fat in all cultivates was 3. 46%,and most cultivates ranged from 3. 1% to 3. 7%. Protein contents ranged from 8. 61% to 15. 54% with a mean value of 11. 94%. For amino acid composition,the ten cultivates were particularly rich in leucine,and the mean was 34. 57 mg/g. The millet cultivars were also high in glycine,glutamic acid and cysteine. Millet was known to be limiting in the essential amino lysine,and the mean was 5. 18 mg/g. Other amino acids,tyrosine,histidine and arginine were also very low in the ten cultivars. In general,significant nutrient composition differences were observed between the different millet cultivars,and A2( a kind of mother line of the hybrid millet) and hybrid millet registered a higher level of protein and amino acid composition which would be useful in millet breeding. | Guangyu FAN Jincheng YUAN Lina ZHANG Xiaojie LIU Xiaoming WANG Feng WANG Xiaolei FENG Guoliang SONG Haiying ZHANG Qian WANG Zhihai ZHAO Yinghui LIU | 2018 | Agricultural Biotechnology2018，7，5： | 4 |
| 9 | A temporal gene expression map of Chrysanthemum leaves infected with Alternaria alternata reveals different stages of defense mechanisms显示文摘Chrysanthemum(Chrysanthemum morifolium)black spot disease(CBS)poses a major threat to Chrysanthemum cultivation owing to suitable climate conditions and current lack of resistant cultivars for greenhouse cultivation.In this study,we identified a number of genes that respond to Alternaria alternata infection in resistant and susceptible Chrysanthemum cultivars.Based on RNA sequencing technology and a weighted gene coexpression network analysis(WGCNA),we constructed a model to elucidate the response of Chrysanthemum leaves to A.alternata infection at different stages and compared the mapped response of the resistant cultivar‘Jinba’to that of the susceptible cultivar‘Zaoyihong’.In the early stage of infection,when lesions had not yet formed,abscisic acid(ABA),salicylic acid(SA)and EDS1-mediated resistance played important roles in the Chrysanthemum defense system.With the formation of necrotic lesions,ethylene(ET)metabolism and the Ca^(2+)signal transduction pathway strongly responded to A.alternata infection.During the late stage,when necrotic lesions continued to expand,members of the multidrug and toxic compound extrusion(MATE)gene family were highly expressed,and their products may be involved in defense against A.alternata invasion by exporting toxins produced by the pathogen,which plays important roles in the pathogenicity of A.alternata.Furthermore,the function of hub genes was verified by qPCR and transgenic assays.The identification of hub genes at different stages,the comparison of hub genes between the two cultivars and the highly expressed genes in the resistant cultivar‘Jinba’provide a theoretical basis for breeding cultivars resistant to CBS. | Ye Liu Jingjing Xin Lina Liu Aiping Song Zhiyong Guan Weimin Fang Fadi Chen | 2020 | Horticulture Research2020，7，1： | 4 |
| 10 | Proteome changes in banana fruit peel tissue in response to ethylene and high-temperature treatments显示文摘Banana(Musa AAA group)is one of the most consumed fruits in the world due to its flavor and nutritional value.As a typical climacteric fruit,banana responds to ethylene treatment,which induces rapid changes of color,flavor(aroma and taste),sweetness and nutritional composition.It has also been reported that ripening bananas at temperatures above 24℃ inhibits chlorophyll breakdown and color formation but increases the rate of senescence.To gain fundamental knowledge about the effects of high temperature and ethylene on banana ripening,a quantitative proteomic study employing multiplex peptide stable isotope dimethyl labeling was conducted.In this study,green(immature)untreated banana fruit were subjected to treatment with 10μL L^(−1) of ethylene for 24 h.After ethylene treatment,treated and untreated fruit were stored at 20 or 30℃ for 24 h.Fruit peel tissues were then sampled after 0 and 1 day of storage,and peel color and chlorophyll fluorescence were evaluated.Quantitative proteomic analysis was conducted on the fruit peels after 1 day of storage.In total,413 common proteins were identified and quantified from two biological replicates.Among these proteins,91 changed significantly in response to ethylene and high-temperature treatments.Cluster analysis on these 91 proteins identified 7 groups of changed proteins.Ethylene treatment and storage at 20℃ induced 40 proteins that are correlated with pathogen resistance,cell wall metabolism,ethylene biosynthesis,allergens and ribosomal proteins,and it repressed 36 proteins that are associated with fatty acid and lipid metabolism,redox–oxidative responses,and protein biosynthesis and modification.Ethylene treatment and storage at 30℃ induced 32 proteins,which were mainly similar to those in group 1 but also included 8 proteins in group 3(identified as chitinase,cinnamyl alcohol dehydrogenase 1,cysteine synthase,villin-2,leucine-transfer RNA ligase,CP47 protein and calmodulin)and repressed 43 proteins in 4 groups(groups 4–7),of which 6 were associated with photosynthesis II oxygen-evolving protein,the photosynthesis I reaction center,sugar metabolism,the redox–oxidative system and fatty acid metabolism.Differences in the response to ethylene and holding temperature at 30℃ were also revealed and have been discussed.The identities and quantities of the proteins found were linked with quality changes.This study demonstrates that ethylene and high temperature influence banana fruit ripening and senescence at the proteomic level and reveals the mechanisms by which high temperature accelerates banana fruit ripening. | Lina Du Jun Song Charles Forney Leslie Campbell Palmer Sherry Fillmore ZhaoQi Zhang | 2016 | Horticulture Research2016，3，1： | 3 |
| 11 | Applications and challenges for single-bacteria analysis by flow cytometry显示文摘Flow cytometry(FCM)is a powerful technique for single-bacteria analysis via simultaneous light-scattering and fluorescence measurements.By offering high-throughput,quantitative,and multiparameter analysis at the single-cell level,FCM has gained an increased popularity in microbiological research,food safety monitoring,water quality control,and clinical diagnosis.Here we will review the recent applications of flow cytometry in areas such as(1)total bacterial cell count,(2)bacterial viability analysis,(3)specific bacterial detection and identification,(4)characterization of physiological changes under environmental perturbations,and(5)biological function studies.Nevertheless,despite these widespread applications,challenges still remain for the detection of small sizes of bacteria and biochemical features that cannot be brightly stained via fluorescence.Recent improvement in FCM instrumentation will be discussed,and particularly the development of high sensitivity flow cytometry for advanced analysis of single bacterial cells will be highlighted. | lina wu shuo wang yiyi song xu wang xiaomei yan | 2016 | Science China Chemistry2016，59，1： | 3 |
| 12 | Subjective well-being and its determinants in rural China显示文摘 | John KNIGHT Lina SONG Ramani GUNATILAKA | 2008 | China Economic Review2008，，4： | 3 |
| 13 | Light weight, mechanically strong and biocompatible α-chitin aerogels from different aqueous alkali hydroxide/urea solutions显示文摘Light weight and mechanically strong α-chitin aerogels were fabricated using the sol-gel/self-assembly method from α-chitin in different aqueous alkali hydroxide(KOH, Na OH and Li OH)/urea solutions. All of the α-chitin solutions exhibited temperature-induced rapid gelation behavior. 13 C nuclear magnetic resonance(NMR) spectra revealed that the aqueous alkali hydroxide/urea solutions are non-derivatizing solvents for α-chitin. Fourier transform infrared(FT-IR), X-ray diffraction(XRD) and cross-polarization magic angle spinning(CP/MAS) 13 C NMR confirmed that α-chitin has a stable aggregate structure after undergoing dissolution and regeneration. Subsequently, nanostructured α-chitin aerogels were fabricated by regeneration from the chitin solutions in ethanol and then freeze-drying from t-Bu OH. These α-chitin aerogels exhibited high porosity(87% to 94%), low density(0.09 to 0.19 g/cm^3), high specific surface area(419 to 535 m^2/g) and large pore volume(2.7 to 3.8 cm^3/g). Moreover, the α-chitin aerogels exhibited good mechanical properties under compression and tension models. In vitro studies showed that m BMSCs cultured on chitin hydrogels have good biocompatibility. These nanostructured α-chitin aerogels may be useful for various applications, such as catalyst supports, carbon aerogel precursors and biomedical materials. | Beibei Ding Dan Zhao Jianhui Song Huichang Gao Duoduo Xu Min Xu Xiaodong Cao Lina Zhang Jie Cai | 2016 | Science China Chemistry2016，59，11： | 2 |
| 14 | An RNA-seq-based Gene Expression Profiling of Radiation-induced Tumorigenic Mammary Epithelial Cells显示文摘Immortality and tumorigenicity are two distinct characteristics of cancers. Immortalization has been suggested to precede tumorigenesis. To understand the molecular mechanisms of tumorigenicity and cancer progression in mammary epithelium, we established a tumorigenic cell model by means of heavy-ion radiation of an immortal cell model, which was created by overexpressing the human telomerase reverse transcriptase (hTERT) in normal human mammary epithelial cells. We examined the expression profile of this tumorigenic cell line (T_hMEC) using the hTERT-overexpressing immortal cell line (I_hMEC) as a control. In-depth RNA-seq data was generated by using the next-generation sequencing (NGS) platform (Life Technologies SOLiD3). We found that house-keeping (HK) and tissue-specific (TS) genes were differentially regulated during the tumorigenic process. HK genes tended to be activated while TS genes tended to be repressed. In addition, the HK genes and TS genes tended to contribute differentially to the variation of gene expression at different RPKM (gene expression in reads per exon kilobase per million mapped sequence reads) levels. Based on transcriptome analysis of the two cell lines, we defined 7053 differentially-expressed genes (DEGs) between immortality and tumorigenicity. Differential expression of 20 manually-selected genes was further validated using qRT-PCR. Our observations may help to further our understanding of cellular mechanism(s) in the transition from immortalization to tumorigenesis. | Lina Ma Linghu Nie Jing Liu Bing Zhang Shuhui Song Min Sun Jin Yang Yadong Yang Xiangdong Fang Songnian Hu Yongliang Zhao Jun Yu | 2012 | Genomics, Proteomics & Bioinformatics2012，10，6： | 2 |
| 15 | Optimal Synchronization Control of Heterogeneous Asymmetric Input-Constrained Unknown Nonlinear MASs via Reinforcement Learning显示文摘The asymmetric input-constrained optimal synchronization problem of heterogeneous unknown nonlinear multiagent systems(MASs)is considered in the paper.Intuitively,a state-space transformation is performed such that satisfaction of symmetric input constraints for the transformed system guarantees satisfaction of asymmetric input constraints for the original system.Then,considering that the leader’s information is not available to every follower,a novel distributed observer is designed to estimate the leader’s state using only exchange of information among neighboring followers.After that,a network of augmented systems is constructed by combining observers and followers dynamics.A nonquadratic cost function is then leveraged for each augmented system(agent)for which its optimization satisfies input constraints and its corresponding constrained Hamilton-Jacobi-Bellman(HJB)equation is solved in a data-based fashion.More specifically,a data-based off-policy reinforcement learning(RL)algorithm is presented to learn the solution to the constrained HJB equation without requiring the complete knowledge of the agents’dynamics.Convergence of the improved RL algorithm to the solution to the constrained HJB equation is also demonstrated.Finally,the correctness and validity of the theoretical results are demonstrated by a simulation example. | Lina Xia Qing Li Ruizhuo Song Hamidreza Modares | 2022 | IEEE/CAA Journal of Automatica Sinica2022，9，3： | 2 |
| 16 | Overexpression of LPCAT1 enhances endometrial cancer stemness and metastasis by changing lipid components and activating TGF-β/Smad2/3 signaling pathway显示文摘The incidence of endometrial cancer(EC)increases annually and tends to occur in younger women.A particularly important relationship exists between EC and metabolic disorders.As one of the most important components of lipid metabolism,phospholipids play an indispensable role in metabolic balance.LPCAT1 is a key enzyme regulating phospholipid metabolism.In this study,we perform further investigations to seek mechanistic insight of LPCAT1 in EC.Our results demonstrate that silencing of LPCAT1 inhibits the growth of endometrial cancer,while overexpression of LPCAT1 results in enhanced stemness and metastasis in endometrial cancer cell lines.Meanwhile,the contents of various phospholipids including phosphatidylethanolamine(PE),phosphatidylcholine(PC),and triglyceride(TG)change significantly after overexpression of LPCAT1.In addition,through RNA-sequencing and western blot analysis,we observe that the TGF-β/Smad2/3 signaling pathway is of great importance in the tumor-promoting function of LPCAT1.LPCAT1 promotes the expressions of stem cell-related transcription factors and epithelialmesenchymal transition(EMT)related proteins through the TGF-β/Smad2/3 signaling pathway.Moreover,we find that TSI-01,which can inhibit the activity of LPCAT1,is able to restrain the proliferation of EC cell lines and promote cell apoptosis.Collectively,we demonstrate that LPCAT1 enhances the stemness and metastasis of EC by activating the TGF-β/Smad2/3 signaling pathway and that TSI-01 may have potential use for the treatment of EC. | Tianyi Zhao Rui Sun Xiaohong Ma Lina Wei Yixin Hou Kun Song Jie Jiang | 2022 | Acta Biochimica et Biophysica Sinica2022，54，7： | 2 |
| 17 | Has China crossed the river? The evolution of wage structure in urban China during reform and retrenchment显示文摘 | Simon Appleton Lina Song Qingjie Xia | 2005 | Journal of Comparative Economics2005，，4： | 2 |
| 18 | The Msi1-mTOR pathway drives the pathogenesis of mammary and extramammary Paget’s disease显示文摘Mammary and extramammary Paget’s Diseases(PD)are a malignant skin cancer characterized by the appearance of Paget cells.Although easily diagnosed,its pathogenesis remains unknown.Here,single-cell RNA-sequencing identified distinct cellular states,novel biomarkers,and signaling pathways—including mTOR,associated with extramammary PD.Interestingly,we identified MSI1 ectopic overexpression in basal epithelial cells of human PD skin,and show that Msi1 overexpression in the epidermal basal layer of mice phenocopies human PD at histopathological,single-cell and molecular levels.Using this mouse model,we identified novel biomarkers of Paget-like cells that translated to human Paget cells.Furthermore,single-cell trajectory,RNA velocity and lineage-tracing analyses revealed a putative keratinocyte-to-Paget-like cell conversion,supporting the in situ transformation theory of disease pathogenesis.Mechanistically,the Msi1-mTOR pathway drives keratinocyte-Paget-like cell conversion,and suppression of mTOR signaling with Rapamycin significantly rescued the Paget-like phenotype in Msi1-overexpressing transgenic mice.Topical Rapamycin treatment improved extramammary PD-associated symptoms in humans,suggesting mTOR inhibition as a novel therapeutic treatment in PD. | Yongli Song Christian F.Guerrero-Juarez Zhongjian Chen Yichen Tang Xianghui Ma Cong Lv Xueyun Bi Min Deng Lina Bu Yuhua Tian Ruiqi Liu Ran Zhao Jiuzhi Xu Xiaole Sheng Sujuan Du Yeqiang Liu Yunlu Zhu Shi-jun Shan Hong-duo Chen Yiqiang Zhao Guangbiao Zhou Jianwei Shuai Fazheng Ren Lixiang Xue Zhaoxia Ying Xing Dai Christopher J.Lengner Bogi Andersen Maksim V.Plikus Qing Nie Zhengquan Yu-Show | 2020 | Cell Research2020，30，10： | 2 |
| 19 | Life Satisfaction in Urban China: Components and Determinants显示文摘 | Simon Appleton Lina Song | 2008 | World Development2008，，11： | 2 |
| 20 | Synthesis and characterization of caprolactone based polyurethane with degradable and antifouling performance显示文摘In this work,a degradable polyurethane composed of caprolactone(CL)and L-Lactide(LLA)as soft segments,and 4,40-methylenebis(cyclohexyl isocyanate)(H12 MDI)and polytetramethylene ether glycol(PTMEG)as hard segments,was prepared.Hydrolytic degradation experiment revealed that the degradable polyurethane(PU)could be degraded in artificial seawater.It also showed that caprolactone-copolyurethane(CL-PU)copolymer with higher crystallinity degraded much slower in artificial seawater.However,the introduction of LLA resulted in an increase in the hydrophilicity and reduction in the crystallinity of degradable PU,as demonstrated by the contact angle analysis.The result of the scanning electron microscope showed that the surface of degradable PU renewed under static condition.Moreover,degradable PU was able to be used as a carrier,and it controlled the release rate of 4,5-dichloro-2-octyl-isothiazolone(DCOIT).The anti-diatom(Navicula incerta)test demonstrated that the(caprolactone-co-L-lactide)-co-polyurethane 4(CL/LAx-PU4)with DCOIT contents prevented the adhesion of diatom Navicula incerta(88.37%reduction)due to their self-polishing and the release of antifoulants.Therefore,the degradable PU consisted of CL,LLA,and DCOIT could be a durable resin with good antifouling activity for the application in the marine anti-biofouling field. | Abid Ali Lina Song Jiankun Hu Jingxian Jiang Qingqing Rao Muhammad Shoaib Shah Fahad Yongjie Cai Xiaoli Zhan Fengqiu Chen Qinghua Zhang | 2021 | Chinese Journal of Chemical Engineering2021，34，6： | 2 |
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