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| 1 | Stress distribution in damaged composite laminates under transverse impact显示文摘 | Dazhi Jiang Dongwei Shu | 2004 | Composite Structures2004，63，34： | 1 |
| 2 | Nonlinear air-beating slider modeling for hard disk drives with ultra-low flying heights显示文摘 | SHI Baojun LI Hongqiu SHU Dongwei | 2009 | Communications in Numerical Methods in Engineering2009，25，10： | 1 |
| 3 | Recent developments in the medicinal chemistry of single boron atom-containing compounds显示文摘Various boron-containing drugs have been approved for clinical use over the past two decades,and more are currently in clinical trials.The increasing interest in boron-containing compounds is due to their unique binding properties to biological targets;for example,boron substitution can be used to modulate biological activity,pharmacokinetic properties,and drug resistance.In this perspective,we aim to comprehensively review the current status of boron compounds in drug discovery,focusing especially on progress from 2015 to December 2020.We classify these compounds into groups showing anticancer,antibacterial,antiviral,antiparasitic and other activities,and discuss the biological targets associated with each activity,as well as potential future developments. | Shu Song Ping Gao Lin Sun Dongwei Kang Jacob Kongsted Vasanthanathan Poongavanam Peng Zhan Xinyong Liu | 2021 | Acta Pharmaceutica Sinica B2021，11，10： | 1 |
| 4 | Buckling analysis of two layer delaminated beams with bridging显示文摘 | MSRao Parlapalli Dongwei Shu | 2005 | European Journal of Mechanics / A Solids2005，，5： | 1 |
| 5 | Shock pulse width effects in operational drop test simulation of a small form factor disk drive with sub-10 nm air bearing slider显示文摘 | Bin Gu Dongwei Shu Yusaku Fujii Koichi Maru Baojun Shi Yan Liu | 2009 | Physics Procedia2009，，1： | 1 |
| 6 | On the performance of 1-3 piezoelectric composites with a passive and active matrix显示文摘 | CHRISTIAN N D SHU Dongwei | 2007 | Sensors and Actuators A2007，140，2： | 1 |
| 7 | Discovery of novel sulfonamide substituted indolylarylsulfones as potent HIV-1 inhibitors with better safety profiles显示文摘Indolylarylsulfones(IASs) are classical HIV-1 non-nucleoside reverse transcriptase inhibitors(NNRTIs) with a unique scaffold and possess potent antiviral activity.To address the high cytotoxicity and improve safety profiles of IASs,we introduced various sulfonamide groups linked by alkyl diamine chain to explore the entrance channel of non-nucleoside inhibitors binding pocket.48 compounds were designed and synthesized to evaluate their anti-HIV-1 activities and reverse transcriptase inhibition activities.Especially,compound R_(10)L_(4) was endowed with significant inhibitory activity towards wild-type HIV-1(EC_(50(WT))=0.007μmol/L,SI=30,930) as well as a panel of single-mutant strains exemplified by L100I(EC_(50)=0.017μmol/L,SI=13,055),E138K(EC_(50)=0.017μmol/L,SI=13,123) and Y181C(EC_(50)=0.045μmol/L,SI=4753) which were superior to Nevirapine and Etravirine.Notably,R_(10)L_(4) was characterized with significantly reduced cytotoxicity(CC_(50)=216.51μmol/L) and showed no remarkable in vivo toxic effects(acute and subacute toxicity).Moreover,the computer-based docking study was also employed to characterize the binding mode between R_(10)L_(4) and HIV-1 RT.Additionally,R_(10)L_(4) presented an acceptable pharmacokinetic profile.Collectively,these results deliver precious insights for next optimization and indicate that the sulfonamide IAS derivatives are promising NNRTIs for further development. | Shenghua Gao Letian Song Yusen Cheng Fabao Zhao Dongwei Kang Shu Song Mianling Yang Bing Ye Wei Zhao Yajie Tang Erik De Clercq Christophe Pannecouque Peng Zhan Xinyong Liu | 2023 | Acta Pharmaceutica Sinica B2023，13，6： | 0 |
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