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| 1 | H5N1 influenza viruses: outbreaks and biological properties显示文摘流行性感冒的所有已知的子类型 A 病毒在野水鸟被维持,这些病毒的自然水库。流行性感冒 A 病毒被孤立从许多有改变病态和死亡率的动物种类。更重要地,流行性感冒 A 病毒与潜在地致命的结果在人引起呼吸疾病。在人的本地或全球的爆发被过量住院和死亡典型地描绘。在 1997, H5N1 子类型的高度病原的鸟的流行性感冒病毒在传给人的香港出现了,导致由鸟的流行性感冒病毒感染的人的死亡的首先记录的盒子。在越南,印度尼西亚,和泰国在家禽在 2003 年 7 月开始的新爆发,和高度病原的鸟的 H5N1 流行性感冒病毒后来在整个亚洲并且进欧洲和非洲传播了。这些病毒继续与高死亡率感染人并且引起隐约可见的世界范围的担心流行。而且, H5N1 病毒爆发在整个亚洲在家禽工业上有破坏效果。因为 H5N1 病毒爆发看起来从南部的中国发源,我们这里在中国检验 H5N1 流行性感冒病毒,与他们的生物性质上的一个重音。 | Gabriele Neuman Hualan Chen George F Gao Yuelong Shu Yoshihiro Kawaoka | 2010 | Cell Research2010，20，1： | 19 |
| 2 | Antigenic variation of the human influenza A(H3N2) virus during the 2014–2015 winter season显示文摘The human influenza A(H3N2) virus dominated the 2014–2015 winter season in many countries and caused massive morbidity and mortality because of its antigenic variation. So far, very little is known about the antigenic patterns of the recent H3N2 virus. By systematically mapping the antigenic relationships of H3N2 strains isolat ed since 2010, we discov ered that two groups with obvious antigenic divergence, named SW13(A/Switzerland/9715293/2013-like strains) and HK14(A/Hong Kong/5738/2014-like strains), co-circulated during the 2014–2015 winter season. HK14 group co-circulated with SW13 in Europe and the United States during this season, while there were few strains of HK14 in China's Mainland, where SW13 has dominated since 2012. Furthermore, we found that substitutions near the receptor-binding site on hemagglutinin played an important role in the antigenic variation of both the groups. These findings provide a comprehensive understanding of the recent antigenic evolution of H3N2 virus and will aid in the selection of vaccine strains. | HUA Sha LI XiYan LIU Mi CHENG YanHui PENG YouSong HUANG WeiJuan TAN MinJu WEI HeJiang GUO JunFeng WANG DaYan WU AiPing SHU YueLong JIANG TaiJiao | 2015 | Science China(Life Sciences)2015，58，9： | 17 |
| 3 | Human avian influenza A (H5N1) virus infection in China显示文摘Highly pathogenic influenza A (H5N1) virus causes a widespread poultry deaths worldwide. The first human H5N1 infected case was reported in Hong Kong Special Administrative Region of China in 1997. Since then, the virus re-emerged in 2003 and continues to infect people worldwide. Currently, over 400 human infections have been reported in more than 15 countries and mortality rate is greater than 60%. H5N1 viruses still pose a potential pandemic threat in the future because of the continuing global spread and evolution. Here, we summarize the epidemiological, clinical and virological characteristics of human H5N1 infection in China monitored and identified by our national surveillance systems. | XU CuiLin, DONG LiBo, XIN Li, LAN Yu, CHEN YongKun, YANG LiMei & SHU YueLong State Key Laboratory for Viral Genetic and Engineering, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing 100052, China | 2009 | Science China(Life Sciences)2009，52，5： | 14 |
| 4 | Simultaneous virus identification and characterization of severe unexplained pneumonia cases using a metagenomics sequencing technique显示文摘Many viruses can cause respiratory diseases in humans.Although great advances have been achieved in methods of diagnosis,it remains challenging to identify pathogens in unexplained pneumonia(UP) cases.In this study,we applied next-generation sequencing(NGS) technology and a metagenomic approach to detect and characterize respiratory viruses in UP cases from Guizhou Province,China.A total of 33 oropharyngeal swabs were obtained from hospitalized UP patients and subjected to NGS.An unbiased metagenomic analysis pipeline identified 13 virus species in 16 samples.Human rhinovirus C was the virus most frequently detected and was identified in seven samples.Human measles virus,adenovirus B 55 and coxsackievirus A10 were also identified.Metagenomic sequencing also provided virus genomic sequences,which enabled genotype characterization and phylogenetic analysis.For cases of multiple infection,metagenomic sequencing afforded information regarding the quantity of each virus in the sample,which could be used to evaluate each viruses' role in the disease.Our study highlights the potential of metagenomic sequencing for pathogen identification in UP cases. | Xiaohui Zou Guangpeng Tang Xiang Zhao Yan Huang Tao Chen Mingyu Lei Wenbing Chen Lei Yang Wenfei Zhu Li Zhuang Jing Yang Zhaomin Feng Dayan Wang Dingming Wang Yuelong Shu | 2017 | Science China(Life Sciences)2017，60，3： | 14 |
| 5 | How Shenzhen, China avoided widespread community transmission: a potential model for successful prevention and control of COVID-19显示文摘Shenzhen is a city of 22 million people in south China that serves as a financial and trade center for East Asia.The city has extensive ties to Hubei Province,the first reported epicenter of the coronavirus disease 2019(COVID-19)outbreak in the world.Initial predictions suggested Shenzhen would experience a high number of COVID-19 cases.These predictions have not materialized.As of 31 March 2020 Shenzhen had only 451 confirmed cases of COVID-19.Contact tracing has shown that no cases were the result of community transmission within the city.While Shenzhen did not implement a citywide lockdown like Wuhan,it did put into place a rapid response system first developed after the severe acute respiratory syndrome(SARS)epidemic in 2003.In the wake of the 2003 SARS outbreak,Shenzhen health authority created a network for surveillance and responding to novel respiratory infections,including pneumonia of unknown causes(PUC).The network rapidly detected mass discussion about PUC and immediately deployed emergency preparedness,quarantine for close contacts of PUC.Five early actions(early detection,early reporting,early diagnosis,early isolation,and early treatment)and four centralized responses(centralized coordination by experts,centralized allocation of resources,centralized placement of patients,and centralized provision of treatment)ensured effective prevention and control.Tripartite working teams comprising community cadres,medical personnel and police were formulated to conduct contact tracing at each neighborhood and residential community.Incorporation of mobile technology,big data,and artificial intelligence into COVID-19 response increased accessibility to health services,reduced misinformation and minimized the impact of fake news.Shenzhen’s unique experience in successfully controlling the COVID-19 outbreak may be a useful model for countries and regions currently experiencing rapid spread of the virus. | Huachun Zou Yuelong Shu Tiejian Feng | 2020 | Infectious Diseases of Poverty2020，9，4： | 4 |
| 6 | Pathogenesis and Immunogenicity of an Avian H9N2 Influenza Virus Isolated from Human显示文摘Objective To investigate the pathogenesis and immunogenicity of H9N2 influenza virus A/Guangzhou/333/99 (a reassortant of G1 and G9 viruses isolated from a female patient in 1999) in a mouse model of infection.Methods Mice were infected with increasing virus titers.Viral load in the lungs and trachea was determined by EID50 assay.Pulmonary histopathology was assessed by hematoxylin‐eosin staining.Anti‐HI antibody titers and T‐cell responses to viral HA were determined by ELISPOT and confirmed by flow cytometry.Results Mice presented a mild syndrome after intranasal infection with A/Guangzhou/333/99 (H9N2) influenza virus.Virus was detected in the trachea and lungs of mice harvested on days 3,6,and 9 post‐infection.A T‐cell response to viral HA was detected on day 6 and H9 HA‐specific CD 4+ T‐cells predominated.Seroconversion was detected after 14 days and antibody persisted for at least 28 weeks.Conclusion Our results suggest that H9N2 (A/Guangzhou/333/99) can replicate in the murine respiratory tract without prior adaptation,and both humoral and cell‐mediated immunity play an important role in the immune response. | LIU LiQi Li Zi ZHOU JianFang ZHU Yun DONG Jie ZHAO Xiang GUO JunFeng SHU YueLong | 2011 | Biomedical and Environmental Sciences2011，24，5： | 2 |
| 7 | Serological Investigation of Laboratory-Confirmed and Suspected Ebola Virus Disease Patients During the Late Phase of the Ebola Outbreak in Sierra Leone显示文摘This study aimed to investigate the serological characteristics of Ebola virus(EBOV) infection during the late phase of the Ebola outbreak in Sierra Leone. In total, 877 blood samples from 694 suspected Ebola virus disease(EVD) cases assessed from March to December 2015, were analyzed via real-time reverse transcription polymerase chain reaction(RT-PCR) for viral RNA and enzyme-linked immunosorbent assay(ELISA) and Luminex to detect antibodies against EBOV. Viral load and EBOV-specific IgM/IgG titers displayed a declining trend during March to December 2015. Viral RNA load decreased rapidly at earlier stages after disease onset, while EBOV-specific IgM and IgG still persisted in 58.1%(18/31) and 93.5%(29/31) of the confirmed EVD patients and in 3.8%(25/663) and 17.8%(118/663) of the RNA-negative suspected patients in the later phase, respectively. Dynamic analysis of longitudinally collected samples from eight EVD patients revealed typically reversed trends of declining viral load and increasing IgM and/or IgG titers in response to the EBOV infection.The present results indicate that certain populations of Sierra Leone developed immunity to an EBOV infection in the late phase of the outbreak, providing novel insights into the risk assessment of EBOV infections among human populations. | Yang Liu YuLan Sun Wei Wu AQian Li XianDa Yang Shuo Zhang Chuan Li QiuDong Su ShaoJian Cai DaPeng Sun HaiYang Hu Zhe Zhang XiuXu Yang Idrissa Kamara Sheku Koroma Gerald Bangura Alie Tia Abdul Kamara Matt Lebby Brima Kargbo Jiandong Li Shiwen Wang XiaoPing Dong YueLong Shu WenBo Xu George F. Gao GuiZhen Wu DeXin Li William J. Liu MiFang Liang | 2018 | Virologica Sinica2018，33，4： | 2 |
| 8 | Increased urbanization reduced the efectiveness of school closures on seasonal infuenza epidemics in China显示文摘Background:School closure is a common mitigation strategy during severe infuenza epidemics and pandemics.However,the efectiveness of this strategy remains controversial.In this study,we aimed to explore the efectiveness of school closure on seasonal infuenza epidemics in provincial-level administrative divisions(PLADs)with varying urbanization rates in China.Methods:This study analyzed infuenza surveillance data between 2010 and 2019 provided by the Chinese National Infuenza Center.Taking into consideration the climate,this study included a region with 3 adjacent PLADs in Northern China and another region with 4 adjacent PLADs in Southern China.The efect of school closure on infuenza transmission was evaluated by the reduction of the efective reproductive number of seasonal infuenza during school winter breaks compared with that before school winter breaks.An age-structured Susceptible-Infected-Recovered-Susceptible(SIRS)model was built to model infuenza transmission in diferent levels of urbanization.Parameters were determined using the surveillance data via robust Bayesian method.Results:Between 2010 and 2019,in the less urbanized provinces:Hebei,Zhejiang,Jiangsu and Anhui,during school winter breaks,the efective reproductive number of seasonal infuenza epidemics reduced 14.6%[95%confdential interval(CI):6.2–22.9%],9.6%(95%CI:2.5–16.6%),7.3%(95%CI:0.1–14.4%)and 8.2%(95%CI:1.1–15.3%)respectively.However,in the highly urbanized cities:Beijing,Tianjin and Shanghai,it reduced only 5.2%(95%CI:-0.7–11.2%),4.1%(95%CI:-0.9–9.1%)and 3.9%(95%CI:-1.6–9.4%)respectively.In China,urbanization is associated with decreased proportion of children and increased social contact.According to the SIRS model,both factors could reduce the impact of school closure on seasonal infuenza epidemics,and the proportion of children in the population is thought to be the dominant infuencing factor.Conclusions:Efectiveness of school closure on the epidemics varies with the age structure in the population and social contact patterns.School closure should be recommended in the low urbanized regions in China in the infuenza seasons. | Hao Lei Hangjin Jiang Nan Zhang Xiaoli Duan Tao Chen Lei Yang Dayan Wang Yuelong Shu | 2021 | Infectious Diseases of Poverty2021，10，5： | 2 |
| 9 | Origin and diversity of novel avian influenza A H7N9 viruses causing human infection: phylogenetic, structural, and coalescent analyses显示文摘 | Di Liu Weifeng Shi Yi Shi Dayan Wang Haixia Xiao Wei Li Yuhai Bi Ying Wu Xianbin Li Jinghua Yan Wenjun Liu Guoping Zhao Weizhong Yang Yu Wang Juncai Ma Yuelong Shu Fumin Lei George F Gao | 2013 | The Lancet2013，，9881： | 2 |
| 10 | Epidemiological and Genetic Characteristics of the H3 Subtype Avian Influenza Viruses in China显示文摘Avian influenza viruses(AIVs)are naturally preserved in waterfowls and sometimes spill over to infect humans and mammalian animals.The H3 subtype is one of the most prevalent influenza virus subtypes in waterfowls.Since 2000,H3 subtype AIVs have been continuously isolated from poultry and wild birds in the mainland of China,which implied a dynamic spread in large-scale geography and multiple species.Combinations of H3 with N1–N8 subtypes were reported,among which H3N2 and H3N8 subtypes predominated. | Jiaying Yang Lei Yang Wenfei Zhu Dayan Wang Yuelong Shu | 2021 | China CDC weekly2021，3，44： | 2 |
| 11 | Ultrastructural characterization of avian influenza A(H7N9) virus infecting humans in China显示文摘Dear Editor,In March 2013,the first 3 cases of severe disease dueto a novel avian-origin influenza A(H7N9)virus weredetected in the Chinese provinces of Shanghai and Anhui(Gao R,et al.,2013).A total of 339 laboratory-confirmedcases with 100 deaths were reported until January 142014(WHO,2014).To the best of our knowledge,thisis the first time that human infection with the avian in-fluenza A H7N9 subtype has been detected.Prior to | Rongbao Gao Jingdong Song Ye Zhang Shumei Zou Tian Bai Xiaodan Li Jianguo Qu Jianfang Zhou Tao Hung Yuelong Shu | 2014 | Virologica Sinica2014，29，2： | 2 |
| 12 | Origin and diversity of novel avian influenza A H7N9 viruses causing human infection: phylogenetic, structural, and coalescent analyses显示文摘 | Di Liu Weifeng Shi Yi Shi Dayan Wang Haixia Xiao Wei Li Yuhai Bi Ying Wu Xianbin Li Jinghua Yan Wenjun Liu Guoping Zhao Weizhong Yang Yu Wang Juncai Ma Yuelong Shu Fumin Lei George F Gao | 2013 | The Lancet2013，，9881： | 1 |
| 13 | The S190R mutation in the hemagglutinin protein of pandemic H1N1 2009 influenza virus increased its pathogenicity in mice显示文摘Human influenza viruses preferentially bind to sialic acid-α2,6-galactose (SAα2,6Gal) receptors, which are predominant in human upper respiratory epithelia, whereas avian influenza viruses preferentially bind to SAα2,3Gal receptors. However, variants with amino acid substitutions around the receptor-binding sites of the hemagglutinin (HA) protein can be selected after several passages of human influenza viruses from patients’ respiratory samples in the allantoic cavities of embryonated chicken eggs. In this study, we detected an egg-adapted HA S190R mutation in the pandemic H1N1 virus 2009 (pdmH1N1), and evaluated the effects of this mutation on receptor binding affinity and pathogenicity in mice. Our results revealed that residue 190 is located within the pocket structure of the receptor binding site. The single mutation to arginine at position 190 slightly increased the binding affinity of the virus to the avian receptor and decreased its binding to the long human α2,6-linked sialic acid receptor. Our study demonstrated that the S190R mutation resulted in earlier death and higher weight loss in mice compared with the wild-type virus. Higher viral titers at 1 dpi (days post infection) and diffuse damage at 4 dpi were observed in the lung tissues of mice infected with the mutant virus. | Yongkun Chen Tian Bai Wenfei Zhu Rongbao Gao Zhihong Deng Yi Shi Shumei Zou Yiwei Huang Xiyan Li Fangcai Li Zhaomin Feng Tao Chen Jing Yang Dayan Wang Lidong Gao Yuelong Shu | 2018 | Science China(Life Sciences)2018，61，7： | 1 |
| 14 | A Vero-cell-adapted vaccine donor strain of influenza A virus generated by serial passages显示文摘 | Weibin Hu Hong Zhang Qinglin Han Li Li Yixin Chen Ningshao Xia Ze Chen Yuelong Shu Ke Xu Bing Sun | 2014 | Vaccine2014，，： | 1 |
| 15 | Serologic study for influenza A (HTN9) among high-risk groups in China 显示文摘 | Bai Tian Zhou Jianfang Shu Yuelong | 2013 | N Engl J Med2013，368，24： | 1 |
| 16 | Hemagglutinin and neuraminidase matching patterns of two influenza A virus strains related to the 1918 and 2009 global pandemics显示文摘 | Yonghui Zhang Xiaojing Lin Fengwei Zhang Jia Wu Wenjie Tan Shengli Bi Jianfang Zhou Yuelong Shu Yue Wang | 2009 | Biochemical and Biophysical Research Communications2009，，2： | 1 |
| 17 | Intra-host Ebola viral adaption during human infection显示文摘The onsite next generation sequencing(NGS)of Ebola virus(EBOV)genomes during the 2013–2016 Ebola epidemic in Western Africa provides an opportunity to trace the origin,transmission,and evolution of this virus.Herein,we have diagnosed a cohort of EBOV patients in Sierra Leone in 2015,during the late phase of the outbreak.The surviving EBOV patients had a recovery process characterized by decreasing viremia,fever,and biochemical parameters.EBOV genomes sequenced through the longitudinal blood samples of these patients showed dynamic intra-host substitutions of the virus during acute infection,including the previously described short stretches of 13 serial TNC mutations.Remarkably,within individual patients,samples collected during the early phase of infection possessed Ts at these nucleotide sites,whereas they were replaced by Cs in samples collected in the later phase,suggesting that these short stretches of TNC mutations could emerge independently.In addition,up to a total of 35 nucleotide sites spanning the EBOV genome were mutated coincidently.Our study showed the dynamic intra-host adaptation of EBOV during patient recovery and gave more insight into the complex EBOV-host interactions. | William JLiu Weifeng Shi Wuyang Zhu Cong Jin Shumei Zou Ji Wang Yuehua Ke Xiaofeng Li Mi Liu Tao Hu Hang Fan Yigang Tong Xiang Zhao Wenbin Chen Yuhui Zhao Di Liu Gary Wong Chengchao Chen Chunyu Geng Weiwei Xie Hui Jiang Idrissa Laybor Kamara Abdul Kamara Matt Lebby Brima Kargbo Xiangguo Qiu Yu Wang Xiaofeng Liang Mifang Liang Xiaoping Dong Guizhen Wu George F.Gao Yuelong Shu | 2019 | Biosafety and Health2019，1，1： | 1 |
| 18 | Mutations associated with egg adaptation of influenza A(H1N1)pdm09 virus in laboratory based surveillance in China, 2009–2016显示文摘Mutations of influenza virus associated with adaptation occurring during passage in embryonated chicken eggs could result in antigenic change or reduced vaccine effectiveness.In this study,we investigated the mutations of influenza A(H1N1)pdm09 egg isolates from the Chinese National Influenza Surveillance Network between 2009 and 2016.Thirteen mutations were identified in the hemagglutinin(HA)protein from viruses passaged in eggs,in comparing to those in cells.After scanning public database,four mutations,D127E,L191I,D222G/N and Q223R in HA1,which may alter the receptor-binding specificity,were observed frequently.Although the A(H1N1)pdm09 virus has evolved in human for nearly ten years,most egg-cultured viruses acquired one or more further mutations.Using the egg isolates for influenza surveillance requires extra caution because of these selected mutations,and their impacts on antigenicity and receptor-binding property need further evaluation.Currently,most of the influenza vaccines are produced using egg isolates,particularly in China.Thus,there is an urge to promote the establishment of an alternative influenza vaccine production platform. | Lei Yang Yanhui Cheng Xiang Zhao Hejiang Wei Minju Tan Xiyan Li Wenfei Zhu Weijuan Huang Wenbing Chen Jia Liu Zi Li Yuelong Shu Dayan Wang | 2019 | Biosafety and Health2019，1，1： | 1 |
| 19 | Hemagglutinin stem reactive antibody response in individuals immunized with a seasonal influenza trivalent vaccine显示文摘 | Xiaopeng Zhao Kun Qin Jinlei Guo Donghong Wang Zi Li Wenfei Zhu Liqi Liu Dayan Wang Yuelong Shu Jianfang Zhou | 2015 | Protein & Cell2015，6，6： | 1 |
| 20 | Probable limited per- son-to-person transmission of highly pathogenic avian influenza A (H5N1) virus in China 显示文摘 | Wang Hua Feng Zijian Shu Yuelong | 2008 | Lancet2008，371，9622： | 1 |
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