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| 1 | Antigenic variation of the human influenza A(H3N2) virus during the 2014–2015 winter season显示文摘The human influenza A(H3N2) virus dominated the 2014–2015 winter season in many countries and caused massive morbidity and mortality because of its antigenic variation. So far, very little is known about the antigenic patterns of the recent H3N2 virus. By systematically mapping the antigenic relationships of H3N2 strains isolat ed since 2010, we discov ered that two groups with obvious antigenic divergence, named SW13(A/Switzerland/9715293/2013-like strains) and HK14(A/Hong Kong/5738/2014-like strains), co-circulated during the 2014–2015 winter season. HK14 group co-circulated with SW13 in Europe and the United States during this season, while there were few strains of HK14 in China's Mainland, where SW13 has dominated since 2012. Furthermore, we found that substitutions near the receptor-binding site on hemagglutinin played an important role in the antigenic variation of both the groups. These findings provide a comprehensive understanding of the recent antigenic evolution of H3N2 virus and will aid in the selection of vaccine strains. | HUA Sha LI XiYan LIU Mi CHENG YanHui PENG YouSong HUANG WeiJuan TAN MinJu WEI HeJiang GUO JunFeng WANG DaYan WU AiPing SHU YueLong JIANG TaiJiao | 2015 | Science China(Life Sciences)2015，58，9： | 17 |
| 2 | ZmCOL3, a CCT gene represses flowering in maize by interfering with the circadian clock and activating expression of ZmCCT显示文摘Flowering time is a trait vital to the adaptation of flowering plants to different environments.Here, we report that CCT domain genes play an important role in flowering in maize(Zea mays L.).Among the 53 CCT family genes we identified in maize, 28 were located in flowering time quantitative trait locus regions and 15 were significantly associated with flowering time, based on candidate-gene association mapping analysis.Furthermore, a CCT gene named ZmCOL3 was shown to be a repressor of flowering.Overexpressing ZmCOL3 delayed flowering time by approximately 4 d, in either long-day or short-day conditions.The absence of one cytosine in the ZmCOL3 3'UTR and the presence of a 551 bp fragment in the promoter region are likely the causal polymorphisms contributing to the maize adaptation from tropical to temperate regions.We propose a modified model of the maize photoperiod pathway, wherein ZmCOL3 acts as an inhibitor of flowering either by transactivating transcription of ZmCCT, one of the key genes regulating maize flowering, or by interfering with the circadian clock. | Minliang Jin Xiangguo Liu Wei Jia Haijun Liu Wenqiang Li Yong Peng Yanfang Du Yuebin Wang Yuejia Yin Xuehai Zhang Qing Liu Min Deng Nan Li Xiyan Cui Dongyun Hao Jianbing Yan | 2018 | Journal of Integrative Plant Biology2018，60，6： | 14 |
| 3 | Thermodynamic analysis of the simple microstructure of AlCrFeNiCu high-entropy alloy with multi-principal elements显示文摘AlCrFeNiCu high-entropy alloy (THA) was synthesized by the arc melting and casting method. The alloy exhibits simple FCC and BCC solid solution phases rather than intermetallic compounds. The reason is that the Gibbs free energy of mixing of the equimolar AlCrFeNiCu alloy is smaller than that of inter-metallic compounds by calculation according to the Miedema model. | Anmin LI Xiyan ZHANG | 2009 | Acta Metallurgica Sinica(English Letters)2009，22，3： | 6 |
| 4 | Epidemiological and Virological Surveillance of Seasonal Influenza Viruses—China,2020–2021显示文摘Introduction:During the coronavirus disease 2019(COVID-19)pandemic,the circulation of seasonal influenza virus declined globally and remained below previous seasonal levels.We analyzed the results of the epidemiology,antigenic,and genetic characteristics,and antiviral susceptibilities of seasonal influenza viruses isolated from the mainland of China during October 5,2020 through September 5,2021,to better assess the risk of influenza during subsequent influenza season in 2021–2022.Methods:Positive rates of influenza virus detection during this period were based on real-time polymerase chain reaction(PCR)detection by the Chinese National Influenza Surveillance Network laboratories,and isolated viruses from influenza positive samples were submitted to the Chinese National Influenza Center.Antigenic analyses for influenza viruses were conducted using the hemagglutination inhibition assay.Next-generation sequencing was used for genetic analyses.Viruses were tested for resistance to antiviral medications using a phenotypic assay and next-generation sequencing.Results:In southern China,the influenza positivity rate was elevated especially after March 2021 and was higher than the same period the previous year with the COVID-19 pandemic.In northern China,influenza positive rate peaked at Week 18 in 2021 and has declined since then.Nearly all isolated viruses were B/Victoria lineage viruses during the study period,and 37.3%of these viruses are antigenically similar to the reference viruses representing the vaccine components for the 2020–2021 and 2021–2022 Northern Hemisphere influenza season.All seasonal influenza viruses were susceptible to neuraminidase inhibitors and endonuclease inhibitors.Conclusions:Influenza activity has gradually increased in the mainland of China in 2021,although the intensity of activity is still lower than before the COVID-19 pandemic.The diversity of circulating influenza types/subtypes decreased,with the vast majority being B/Victoria lineage viruses.The surveillance data from this study suggest that we should strengthen influenza surveillance during the upcoming traditional influenza season.It also provided evidence for vaccine recommendations and prevention and control of influenza and clinical use of antiviral drugs. | Weijuan Huang Xiyan Li Minju Tan Yanhui Cheng Tao Chen Hejiang Wei Xiaoxu Zeng Yiran Xie Jia Liu Ning Xiao Lei Yang Dayan Wang | 2021 | China CDC weekly2021，3，44： | 4 |
| 5 | Least-Squares Mirrorsymmetric Solution for Matrix Equations(AX=B,XC=D)显示文摘In this paper, least-squaxes mirrorsymmetric solution for matrix equations (AX = B, XC = D) and its optimal approximation is considered. With special expression of mirrorsymmetric matrices, a general representation of solution for the least-squares problem is obtained. In addition, the optimal approximate solution and some algorithms to obtain the optimal approximation are provided. | Fanliang Li Xiyan Hu Lei Zhang | 2006 | Numerical Mathematics A Journal of Chinese Universities(English Series)2006，15，3： | 3 |
| 6 | Reduced graphene oxide decorated with Bi2O2.33 nanodots for superior lithium storage显示文摘 | Haichen Liang Xiyan Liu Dongliang Gao Jiangfeng Ni Yan Li | 2017 | Nano Research2017，10，11： | 3 |
| 7 | Parenting stress and affective symptoms in parents of autistic children显示文摘We examined parenting stress and mental health status in parents of autistic children and assessed factors associated with such stress. Participants were parents of 188 autistic children diagnosed with DSM-IV criteria and parents of 144 normally developing children. Parents of autistic children reported higher levels of stress, depression, and anxiety than parents of normally developing children. Mothers of autistic children had a higher risk of depression and anxiety than that did parents of normally developing children. Mothers compared to fathers of autistic children were more vulnerable to depression. Age, behavior problems of autistic children, and mothers' anxiety were significantly associated with parenting stress. | GONG Yun DU YaSong LI HuiLin ZHANG XiYan AN Yu WU Bai-Lin | 2015 | Science China(Life Sciences)2015，58，10： | 3 |
| 8 | Patterning catalyst via inkjet printing to grow single-walled carbon nanotubes显示文摘Controlled growth of patterned single-walled carbon nanotubes (SWNTs) is an important issue in many applications. Herein, we demonstrated a method to pattern catalyst via inkjet printing for the growth of SWNTs, using metal salt solutions as the inks and an ordinary office-use printer. We printed water solutions of cobalt acetate on hydrophilic Si substrates and grew high quality SWNT films. The composition of the precursor solutions and the hydrophilicity of the substrates were crucial factors to the patterning. | Zeyao Zhang Yitan Li Sheng Zhu Xiyan Liu Xiulan Zhao Meihui Li Haoyu Li Feng Yang Yan Li | 2019 | Chinese Chemical Letters2019，30，2： | 3 |
| 9 | Silica Nanoparticles-mediated Stable Genetic Transformation in Nicotiana tabacum显示文摘 | FU Yuqin LI Luhua WANG Hui JIANG Yuan LIU Huijing CUI Xiyan WANG Piwu LU Changli | 2015 | Chemical Research in Chinese Universities2015，31，6： | 3 |
| 10 | Single‑Layer ZnO Hollow Hemispheres Enable High‑Performance Self‑Powered Perovskite Photodetector for Optical Communication显示文摘The carrier transport layer with reflection reduction morphology has attracted extensive attention for improving the utilization of light.Herein,we introduced single-layer hollow ZnO hemisphere arrays(ZHAs)behaving light trapping effect as the electron transport layer in perovskite photodetectors(PDs).The singlelayer hollow ZHAs can not only reduce the reflection,but also widen the angle of the effective incident light and especially transfer the distribution of the optical field from the ZnO/FTO interface to the perovskite active layer confirmed by the 3D finitedifference time-domain simulation.These merits benefit for the generation,transport and separation of carriers,improving the light utilization efficiency.Finally,our optimized FTO/ZHA/CsPbBr3/carbon structure PDs showed high self-powered performance with a linear dynamic range of 120.3 dB,a detectivity of 4.2×10^(12) Jones,rise/fall time of 13/28μs and the f_(−3) dB of up to 28 kHz.Benefiting from the high device performance,the PD was demonstrated to the application in the directional transmission of encrypted files as the signal receiving port with super high accuracy.This work uniquely utilizes the features of high-performance self-powered perovskite PDs in optical communication,paving the path to wide applications of all-inorganic perovskite PDs. | Xiyan Pan Jianqiang Zhang Hai Zhou Ronghuan Liu Dingjun Wu Rui Wang Liangping Shen Li Tao Jun Zhang Hao Wang | 2021 | Nano-Micro Letters2021，13，4： | 3 |
| 11 | Five Independent Cases of Human Infection with Avian Influenza H5N6—Sichuan Province,China,2021显示文摘Summary What is known about this topic?The emerging H5Ny lineages of the avian influenza virus(AIV)with genomic reassortments have posed a continuous threat to animals and human beings.Since the first case of avian influenza A(H5N6)virus infection in 2014,the World Health Organization has reported a total of 38 cases by August 6,2021. | Chongkun Xiao Jianan Xu Yu Lan Zhongping Huang Lijun Zhou Yaxin Guo Xiyan Li Lei Yang George F.Gao Dayan Wang William J.Liu Xingyu Zhou Huiping Yang | 2021 | China CDC weekly2021，3，36： | 2 |
| 12 | Characterization of Influenza Viruses-China, 2019−2020显示文摘Introduction:Influenza surveillance is necessary for detection of emerging variants of influenza viruses and determining their epidemiological and clinical significance.Vaccination and antiviral drugs remain the most useful ways to protect against seasonal influenza and its potentially severe consequences.This study describes the epidemiology,antigenic and genetic characteristics,and antiviral susceptibilities of influenza viruses isolated from the mainland of China during the April 1,2019 through October 4,2020.Methods:All viruses analyzed were isolated and submitted by Chinese National Influenza Surveillance Network laboratories.The Chinese National Influenza Center performed antigenic analysis,sequencing,and antiviral resistance testing after propagation of the viruses.Antigenic characterizations were determined by hemagglutinin inhibition assay;next-generation sequencing was used for genetic analyses;phenotypic assay and next-generation sequencing were used for determining antiviral resistance.Results:The influenza positivity rate declined significantly starting in late January 2020 and has remained low.There was no summer influenza peak season in south China.Influenza A(H3N2)and B/Victoria lineage viruses were the dominant subtype/lineage during April 1,2019 through October 4,2020.The majority of influenza viruses were antigenically and genetically similar to reference viruses representing components of vaccines for the 2020–2021 northern hemisphere influenza season.Nearly all seasonal influenza viruses were susceptible to oseltamivir and zanamivir.Conclusions and Implications for Public Health Practice:Since the outbreak of COVID-19,the influenza positivity rate declined with implementation of strong COVID-19 control measures.The majority of circulating viruses are well matched with the current 2020–2021 northern hemisphere influenza vaccine viruses.Circulating seasonal influenza viruses were sensitive to neuraminidase inhibitors and Baloxavir marboxil.This study provided evidence for World Health Organization(WHO)recommendations for vaccine viruses,for prevention and control of influenza,and for clinical use of antiviral medications. | Weijuan Huang Yanhui Cheng Tao Chen Xiyan Li Minju Tan Hejiang Wei Xiaoxu Zeng Yiran Xie Jia Liu Ning Xiao Lei Yang Dayan Wang | 2020 | China CDC weekly2020，2，44： | 2 |
| 13 | Pulse radiolysis and laser flash photolysis study of balofloxacin显示文摘 | XU Yulie LIU Yancheng LI Haixia ZHANG Peng TANG Ruizhi CAO Xiyan WANG Wenfeng | 2013 | Nuclear Science and Techniques2013，24，B12： | 2 |
| 14 | Economic burden of inpatients with viral hepatitis B-related diseases and the influencing factors显示文摘Objective:The purpose of this study was to analyze the economic burden of inpatients with hepatitis B virus(HBV)-related diseases and the influencing factors so as to provide an effective basis for the development of health prevention and control strategies.Methods:The patients were selected by means of successive sampling in the period between August and December 2012 from those who were diagnosed with HBV-related diseases and hospitalized in countylevel medical institutions of Jiangsu Province.One hundred ninety-six patients were studied,including 3 patients with acute HBV,141 with chronic HBV,18 with compensatory cirrhosis,22 with decompensated cirrhosis,and 12 with liver cancer.This study adopted a questionnaire method to investigate and calculate the direct and indirect economic burden of the subjects according to disease economic burden theories and methods.Multiple linear stepwise regression was used for analysis of the influencing factors for economic burden of inpatients with HBV-related diseases.Results:The average economic burden for the 196 inpatients investigated was RMB 28,971.The direct economic burden was RMB 19,916(68.7%),including direct medical costs(RMB 19,087;95.8%)and direct non-medical costs(RMB 829;4.2%).The indirect economic burden was RMB 9055(31.3%),including patient-related expenses(RMB 6348;70.1%)and nursing expenses(RMB 2707;29.9%).According to the multiple linear stepwise regression analysis results,the hospital stay,proportion of medicine,age,and disease type affected the economic burden of the patients(P<0.05).Conclusion:Patients with HBV-related diseases undertake a heavy economic burden for hospitalization,especially the direct economic burden.Therefore,the inpatients’economic burden can be reduced by shortening the hospital stay,reducing the medical expenses reasonably,and delaying the progression of disease as far as possible according to medical standards. | Hua Zhang Jianqian Chao Liguo Zhu Long Song Xiyan Li Pei Liu | 2013 | Family Medicine and Community Health2013，1，4： | 2 |
| 15 | Fe3O4@SiO2@TiO2@Pt Hierarchical Core-Shell Microspheres:Controlled Synthesis,Enhanced Degradation System,and Rapid Magnetic Separation to Recycle显示文摘 | LI Xiyan LIU Dapeng SONG Shuyan | 2014 | Crystal Growth Design2014，14，11： | 1 |
| 16 | The S190R mutation in the hemagglutinin protein of pandemic H1N1 2009 influenza virus increased its pathogenicity in mice显示文摘Human influenza viruses preferentially bind to sialic acid-α2,6-galactose (SAα2,6Gal) receptors, which are predominant in human upper respiratory epithelia, whereas avian influenza viruses preferentially bind to SAα2,3Gal receptors. However, variants with amino acid substitutions around the receptor-binding sites of the hemagglutinin (HA) protein can be selected after several passages of human influenza viruses from patients’ respiratory samples in the allantoic cavities of embryonated chicken eggs. In this study, we detected an egg-adapted HA S190R mutation in the pandemic H1N1 virus 2009 (pdmH1N1), and evaluated the effects of this mutation on receptor binding affinity and pathogenicity in mice. Our results revealed that residue 190 is located within the pocket structure of the receptor binding site. The single mutation to arginine at position 190 slightly increased the binding affinity of the virus to the avian receptor and decreased its binding to the long human α2,6-linked sialic acid receptor. Our study demonstrated that the S190R mutation resulted in earlier death and higher weight loss in mice compared with the wild-type virus. Higher viral titers at 1 dpi (days post infection) and diffuse damage at 4 dpi were observed in the lung tissues of mice infected with the mutant virus. | Yongkun Chen Tian Bai Wenfei Zhu Rongbao Gao Zhihong Deng Yi Shi Shumei Zou Yiwei Huang Xiyan Li Fangcai Li Zhaomin Feng Tao Chen Jing Yang Dayan Wang Lidong Gao Yuelong Shu | 2018 | Science China(Life Sciences)2018，61，7： | 1 |
| 17 | The nearness problems for special submatrix constraint显示文摘 | Li Jiaofen Hu Xiyan Zhang Lei | 2010 | Numerical Algorithms2010，，： | 1 |
| 18 | Single-step-fabricated disordered metasurfaces for enhanced light extraction from LEDs显示文摘While total internal reflection(TIR)lays the foundation for many important applications,foremost fibre optics that revolutionised information technologies,it is undesirable in some other applications such as light-emitting diodes(LEDs),which are a backbone for energy-efficient light sources.In the case of LEDs,TIR prevents photons from escaping the constituent high-index materials.Advances in material science have led to good efficiencies in generating photons from electron–hole pairs,making light extraction the bottleneck of the overall efficiency of LEDs.In recent years,the extraction efficiency has been improved,using nanostructures at the semiconductor/air interface that outcouple trapped photons to the outside continuum.However,the design of geometrical features for light extraction with sizes comparable to or smaller than the optical wavelength always requires sophisticated and timeconsuming fabrication,which causes a gap between lab demonstration and industrial-level applications.Inspired by lightning bugs,we propose and realise a disordered metasurface for light extraction throughout the visible spectrum,achieved with single-step fabrication.By applying such a cost-effective light extraction layer,we improve the external quantum efficiency by a factor of 1.65 for commercialised GaN LEDs,demonstrating a substantial potential for global energy-saving and sustainability. | Peng Mao Changxu Liu Xiyan Li Mengxia Liu Qiang Chen Min Han Stefan A.Maier Edward H.Sargent Shuang Zhang | 2021 | Light(Science & Applications)2021，10，10： | 1 |
| 19 | Least-squares mirrosymmetric solution for matrix equations (AX=B,XC=D) 显示文摘 | Li Fanliang Hu Xiyan Zhang Lei | 2006 | Numerical Mathematics: A Journal of Chinese Universities2006，15，3： | 1 |
| 20 | Hierarchically structured Fe3 04 microspheres: morphology control and their application in wastewater treatment显示文摘 | Li Xiyan Si Zhenjun Lei Yangqian | 2011 | Cryst Engcomm2011，13，2： | 1 |
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