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| 1 | Thymosin alpha 1:A comprehensive review of the literature显示文摘Thymosin alpha 1 is a peptide naturally occurring in the thymus that has long been recognized for modifying,enhancing,and restoring immune function.Thymosin alpha 1 has been utilized in the treatment of immunocompromised states and malignancies,as an enhancer of vaccine response,and as a means of curbing morbidity and mortality in sepsis and numerous infections.Studies have postulated that thymosin alpha 1 could help improve the outcome in severely ill corona virus disease 2019 patients by repairing damage caused by overactivation of lymphocytic immunity and how thymosin alpha 1 could prevent the excessive activation of T cells.In this review,we discuss key literature on the background knowledge and current clinical uses of thymosin alpha 1.Considering the known biochemical properties including antibacterial and antiviral properties,timehonored applications,and the new promising findings regarding the use of thymosin,we believe that thymosin alpha 1 deserves further investigation into its antiviral properties and possible repurposing as a treatment against severe acute respiratory syndrome coronavirus-2. | Asimina Dominari Donald Hathaway III Krunal Pandav Wanessa Matos Sharmi Biswas Gowry Reddy Sindhu Thevuthasan Muhammad Adnan Khan Anoopa Mathew Sarabjot Singh Makkar Madiha Zaidi Michael Maher Mourad Fahem Renato Beas Valeria Castaneda Trissa Paul John Halpern Diana Baralt | 2020 | World Journal of Virology2020，9，5： | 11 |
| 2 | A Neuro-genetic Based Short-term Forecasting Framework for Network Intrusion Prediction System显示文摘Information systems are one of the most rapidly changing and vulnerable systems, where security is a major issue. The number of security-breaking attempts originating inside organizations is increasing steadily. Attacks made in this way, usually done by 'authorized' users of the system, cannot be immediately traced. Because the idea of filtering the traffic at the entrance door, by using firewalls and the like, is not completely successful, the use of intrusion detection systems should be considered to increase the defense capacity of an information system. An intrusion detection system (IDS) is usually working in a dynamically changing environment, which forces continuous tuning of the intrusion detection model, in order to maintain sufficient performance. The manual tuning process required by current IDS depends on the system operators in working out the tuning solution and in integrating it into the detection model. Furthermore, an extensive effort is required to tackle the newly evolving attacks and a deep study is necessary to categorize it into the respective classes. To reduce this dependence, an automatically evolving anomaly IDS using neuro-genetic algorithm is presented. The proposed system automatically tunes the detection model on the fly according to the feedback provided by the system operator when false predictions are encountered. The system has been evaluated using the Knowledge Discovery in Databases Conference (KDD 2009) intrusion detection dataset. Genetic paradigm is employed to choose the predominant features, which reveal the occurrence of intrusions. The neuro-genetic IDS (NGIDS) involves calculation of weightage value for each of the categorical attributes so that data of uniform representation can be processed by the neuro-genetic algorithm. In this system unauthorized invasion of a user are identified and newer types of attacks are sensed and classified respectively by the neuro-genetic algorithm. The experimental results obtained in this work show that the system achieves improvement in terms of misclassification cost when compared with conventional IDS. The results of the experiments show that this system can be deployed based on a real network or database environment for effective prediction of both normal attacks and new attacks. | Siva S. Sivatha Sindhu S. Geetha M. Marikannan A. Kannan | 2009 | International Journal of Automation and computing2009，6，4： | 7 |
| 3 | Iron deficiency anemia in inflammatory bowel disease显示文摘Anemia is a common extraintestinal manifestation of inflammatory bowel disease(IBD) and is frequently overlooked as a complication. Patients with IBD are commonly found to have iron deficiency anemia(IDA) secondary to chronic blood loss, and impaired iron absorption due to tissue inflammation. Patients with iron deficiency may not always manifest with signs and symptoms; so, hemoglobin levels in patients with IBD must be regularly monitored for earlier detection of anemia. IDA in IBD is associated with poor quality of life, necessitating prompt diagnosis and appropriate treatment. IDA is often associated with inflammation in patients with IBD. Thus, commonly used labora-tory parameters are inadequate to diagnose IDA, and newer iron indices, such as reticulocyte hemoglobin content or percentage of hypochromic red cells or zinc protoporphyrin, are required to differentiate IDA from anemia of chronic disease. Oral iron preparations are available and are used in patients with mild disease activity. These preparations are inexpensive and con-venient, but can produce gastrointestinal side effects, such as abdominal pain and diarrhea, that limit their use and patient compliance. These preparations are partly absorbed due to inflammation. Non-absorbed iron can be toxic and worsen IBD disease activity. Although cost-effective intravenous iron formulations are widely available and have improved safety profiles, physicians are reluctant to use them. We present a review of the pathophysiologic mechanisms of IDA in IBD, improved diagnostic and therapeutic strategies, efficacy, and safety of iron replacement in IBD. | Sindhu Kaitha Muhammad Bashir Tauseef Ali | 2015 | World Journal of Gastrointestinal Pathophysiology2015，6，3： | 3 |
| 4 | In vitro antioxidant activity and scavenging effects of Cinnamomum verum leaf extract assayed by different methodologies显示文摘 | Sindhu Mathew T. Emilia Abraham | 2005 | Food and Chemical Toxicology2005，，2： | 2 |
| 5 | Ferulic Acid: An Antioxidant Found Naturally in Plant Cell Walls and Feruloyl Esterases Involved in its Release and Their Applications显示文摘 | Sindhu Mathew T. Emilia Abraham | 2004 | 2004 (2-3)2004，，2： | 2 |
| 6 | Synthesis, spectroscopic characterization, and thermal decomposition kinetics of some lanthanide(III) nitrate complexes of 2-(N-o-hydroxyacetophenone) amino-3-carboxyethyl-4,5,6,7-tetrahydrobenzo[b]thiophene显示文摘Complexes of La(III), Ce(III), Pr(III), Nd(III), Sm(III), Eu(III), Gd(III), Dy(III), Yb(III), and Lu(III) with 2-(N-o-hydroxyacetophenone)amino-3-carboxyethyl-4,5,6,7-tetrahydrobenzo[b]thiophene (HAAT) formed by the condensation of o-hydroxyacetophenone and 2-amino-3-carboxyethyl-4,5,6,7-tetrahydrobenzo[b]thiophene were synthesized and characterized on the basis of elemental analyses, molar conductance measurements, magnetic susceptibility data, UV-Visible, IR, and NMR spectral studies. The spectral data revealed that the ligand acted as a neutral tridentate coordinating to the metal ion through ONO donor sequence. A coordination number nine was proposed for the complexes. Thermal decomposition studies of the ligand and lanthanum(III) complex were carried out and kinetic parameters were calculated using Coats-Redfern equation. The decomposition reactions followed random nucleation mechanism with one nucleus on each particle. | K. Mohanan M. Thankamony B. Sindhu Kumari | 2008 | Journal of Rare Earths2008，26，4： | 2 |
| 7 | Carotenoid lutein protects rats from gastric ulcer induced by ethanol显示文摘 | Edakkadath R. Sindhu Ramadasan Kuttan | 2012 | Journal of Basic and Clinical Physiology and Pharmacology2012，，1： | 1 |
| 8 | Statistical studies on high molecular weight pullulan production in solid state fermentation using jack fruit seed 显示文摘 | Sugumaran K R Sindhu R V Sukanya S | 2013 | Carbohydrate Polymers2013，98，1： | 1 |
| 9 | Studies on the antioxidant activities of cinnamon ( Cinnamomum verum) bark extracts, through various in vitro models 显示文摘 | Sindhu Emilia T | 2006 | Food Chemistry2006，94，： | 1 |
| 10 | Effectiveness and Safety of Indomethacin versus Ibuprofen for the Treatment of Patent Ductus Arteriosus in Preterm Infants显示文摘 | Sindhu Sivanandan Varun Bali Amuchou Soraisham Andrei Harabor Majeeda Kamaluddeen | 2013 | Amer J Perinatol2013，，： | 1 |
| 11 | Potassium solubilization by rhizosphere bacteria:Influence of nutritional and environmental conditions显示文摘 | PARMAR P SINDHU S S | 2013 | Journal of microbiology research2013，3，1： | 1 |
| 12 | Swim- test as a function of moto impairment in MPTP model of Par- kinson's disease: a comparative study in two mouse strains 显示文摘 | HAOBAM R SINDHU K M CHANDRA G | 2005 | Behavioural Brain Research2005，63，2： | 1 |
| 13 | Effect of chemical phosphorylation on solubility of buffalo milk proteins显示文摘 | NAYAK S ARORA S SINDHU J | 2006 | International Dairy Journal2006，16，3： | 1 |
| 14 | Biomarkers of inflammation and placental dysfunction are associated with subsequent preterm birth显示文摘 | Jamie A. Bastek Amy G. Brown Lauren Anton Sindhu K. Srinivas Antonietta D’addio Michal A. Elovitz | 2011 | Journal of Maternal-Fetal and Neonatal Medicine2011，，4： | 1 |
| 15 | Passive Steganalysis Based on Higher Order Image Statistics of Curvelet Transform显示文摘Steganographic techniques accomplish covert communication by embedding secret messages into innocuous digital images in ways that are imperceptible to the human eye.This paper presents a novel passive steganalysis strategy in which the task is approached as a pattern classification problem.A critical part of the steganalyser design depends on the selection of informative features.This paper is aimed at proposing a novel attack with improved performance indices with the following implications:1) employing higher order statistics from a curvelet sub-band image representation that offers better discrimination ability for detecting stego anomalies in images,as compared to other conventional wavelet transforms;2) increasing the sensitivity and specificity of the system by the feature reduction phase;3) realizing the system using an efficient classification engine,a neuro-C4.5 classifier,which provides better classification rate.An extensive experimental evaluation on a database containing 5600 clean and stego images shows that the proposed scheme is a state-of-the-art steganalyser that outperforms other previous steganalytic methods. | S.Geetha Siva S.Sivatha Sindhu N.Kamaraj | 2010 | International Journal of Automation and computing2010，7，4： | 1 |
| 16 | Bioethanol production from rice straw: An overview显示文摘 | Binod P Sindhu R Singhania RR Vikram S Devi L Nagalakshmi S Kurien N Sukumaran RK Pandey A | 2010 | Bioresource Technology2010，101，13： | 1 |
| 17 | Effect of Bi2O3 content on the optical band gap,density and electrical conductivity ofMO · Bi2O3 · B2O3(M=Ba,Sr) glasses显示文摘 | Sindhu S Sanghi S Agarwal A | | 0，，01： | 1 |
| 18 | Short duration microwave assisted pretreatment enhances the enzymatic saccharification and fermentable sugar yield from sugarcane bagasse显示文摘 | Binod P Satyanagalakshmi K Sindhu R | 2012 | Renewable Energy2012，37，1： | 1 |
| 19 | Bioethanol production from rice straw:An overview显示文摘 | Binod P Sindhu R Singhania R R | 2010 | Bioresource Technology2010，101，9： | 1 |
| 20 | Incorporation of liquid fillers into silicone foams to enhance the electro-mechanical properties显示文摘Silicone foams with and without liquid fillers(silicone oils of various types and glycerol,respectively)are synthesized and analyzed to be used as dielectric layers in capacitive sensors.A simple fabrication technique involving only four components i.e.Sylgard 184,glycerol,sodium hydroxide and ethanol is used to make these silicone foams after which they are filled with silicone oil or glycerol by soaking the foam in respective liquid.Mechanical and dielectric properties of the foams are examined.The oil reinforces the foam’s dielectric properties,softens the foam and improves its capacitive response,making it a very good dielectric material for fabricating capacitive pressure sensors.Compared to dry silicone foams,foams filled with-and swollen by-chloropropyl-functional silicone oil,show a low Young’smodulus(31 kPa),a high and stable relative dielectric permittivity of around 5,and a high capacitive response of 132%for an appliedpressureof 12 kPa.Thepresence of oil stabilizes the soft foam and ensures that it does not buckle under high pressure. | Min Liu Liyun Yu Sindhu Vudayagiri Anne Ladegaard Skov | 2020 | International Journal of Smart and Nano Materials2020，11，1： | 1 |
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