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| 1 | Clinical implications of fatty pancreas:Correlations between fatty pancreas and metabolic syndrome显示文摘AIM:To investigate the clinical implications of lipid deposition in the pancreas(fatty pancreas). METHODS:The subjects of this study were 293 patients who had undergone abdominal computed tomography(CT)and sonography.Fatty pancreas was diagnosed by sonographic findings and subdivided into mild,moderate,and severe fatty pancreas groups comparing to the retroperitoneal fat echogenicity. RESULTS:Fatty pancreas was associated with higher levels for visceral fat,waist circumference,aspartate aminotransferase(AST),alanine aminotransferase (ALT),total cholesterol,triglyceride,high density lipoprotein,free fatty acid,γ-GTP,insulin,and the homeostasis model assessment of insulin resistance (HOMA-IR)than the control group(P<0.05).HOMAIR,visceral fat,triglyceride,and ALT also tended to increase with the degree of fat deposition in the pancreas on sonography.In a multivariate logistic regression analysis,HOMA-IR,visceral fat,and ALT level were independently related to fatty pancreas after adjustment for age,body mass index,and lipid profile.The incidence of metabolic syndrome in the fatty pancreas group was significantly higher than in the control group,and the numbers of metabolic syndrome parameters were significantly higher in the fatty pancreas group(P<0.05).CONCLUSION:Sonographic fatty pancrease showed higher insulin resistance,visceral fat area,triglyceride, and ALT levels than normal pancreases.Fatty pancreas also showed a strong correlation with metabolic syndrome. | Jun Seok Lee Sang Heum Kim Dae Won Jun Jee Hye Han Eun Chul Jang Ji Young Park Byung Kwan Son Seong Hwan Kim Yoon Ju Jo Young Sook Park Yong Soo Kim | 2009 | World Journal of Gastroenterology2009，15，15： | 40 |
| 2 | Exophytic inflammatory myofibroblastic tumor of the stomach in an adult woman:A rare cause of hemoperitoneum显示文摘Inflammatory myofibroblastic tumor (IMT) of the stomach in adults is extremely rare, with unpredictable prognosis. We present a 55-year-old woman with a gastric IMT. She experienced sudden abdominal pain 4 d previously. Physical examination showed mild abdominal tenderness in the hypogastrium, but no palpable abnormal abdominal mass. Abdominal CT showed a mass of approximately 8 cm in the gastrocolic ligament. On laparoscopic exploration, unexpected hemoperitoneum of approximately 1.5 L of blood was found, and an exophytic gastric mass of approximately 10 cm, appeared from the anterior wall of the gastric body along the greater curvature. Laparoscopy further showed that non-clotting blood in the abdominal cavity seemed to be from the gastric tumor. After conversion to open surgery for more precise evaluation of the cause of hemoperitoneum and the large friable tumor, gastric wedge resection, including the tumor, was conducted. The final diagnosis was consistent with IMT that originated from the gastric wall. | Seong-Heum Park Jong-Han Kim Byung Wook Min Tae Jin Song Gil Soo Son Seung Joo Kim Sang Woo Lee Hwan-Hoon Chung Ju Han Lee Jun Won Um | 2008 | World Journal of Gastroenterology2008，14，1： | 8 |
| 3 | Asymptomatic lymphangioma involving the spleen and retroperitoneum in adults显示文摘Lymphangioma,a benign neoplasm of the lymphatic system,is common in children but rare in adults.Its clinical manifestations include abdominal pain,nausea, vomiting and a palpable mass.However,abdominal sonography or abdominal computed tomography(CT) scan can also incidentally reveal lymphangioma.A larger or symptomatic lymphangioma is treated with total resection to prevent recurrence,infection,torsion and enlargement.Although lymphangioma rarely becomes malignant,its prognosis is generally good. We report a cystic lymphangioma of the spleen and retroperitoneum,which was incidentally found in a 56-year-old man who was hospitalized due to a colon mass.Physical examination showed no specific findings.Abdominal CT revealed a 5.7 cm,non-enhanced multilobulated cystic mass with multiple septa in the spleen and a 10 cm lobulated cystic mass in the paraaortic area.Splenectomy and retroperitoneal resection of the cystic mass were conducted.The endotheliumof splenic and retroperitoneal cyst was immunohisto- chemically stained with D2-40 antibody.The patient was finally diagnosed with splenic cystic and retroperitoneal cavernous lymphangioma. | Sook Hee Chung Young Sook Park Yun Ju Jo Seong Hwan Kim Dae Won Jun Byoung Kwan Son Jun Young Jung Dae Hyun Baek Dong Hee Kim Yoon Young Jung Won Mi Lee | 2009 | World Journal of Gastroenterology2009，15，44： | 7 |
| 4 | 胃肠道胰腺异位及相关癌前和恶性病变:165例系统性病理研究(英)显示文摘胰腺异位(HP)通常是因其伴随症状或行胃肠道肿瘤切除术时偶尔发现。作者比较了手术切除发现的165例胰腺异位临床病理学特征,其中胃部手术57例(35%),十二指手术56例(34%),大网膜手术30例(18%),空肠手术22例(13%)。相对于偶然发现的胰腺异位,有伴随症状的胰腺异位(胃肠道胰腺异位79/135例,87%)占多数(P=0.05),常见于年轻患者及胃部(P〈0.001),且大多伴随淋巴组织增生/淋巴滤泡形成(P=0.03)。 | Jun SY Son D Kiim MJ 曹琪(译) 张建中(校) | 2017 | 诊断病理学杂志2017，24，11： | 6 |
| 5 | Outcome of laparoscopic cholecystectomy is not influenced by chronological age in the elderly显示文摘AIM:To evaluate the outcome of laparoscopic cholecystectomy(LC)in patients aged 80 years and older. METHODS:A total of 353 patients aged 65 to 79 years(group 1)and 35 patients aged 80 years and older(group 2)underwent LC.Patients were further classified into two other groups:those with uncomplicated gallbladder disease(group A)or those with complicated gallbladder disease(group B). RESULTS:There were no significant differences between the age groups(groups 1 and 2)with respect to clinical characteristics such as age,gender,comorbid disease,or disease presentation.Mean operative time,conversion rate,and the incidence of major postoperative complications were similar in groups 1 and 2.However,the percentage of high-risk patients was significantly higher in group 2 than in group 1 (20.0%vs 5.7%,P<0.01).Group A comprised 322 patients with a mean age of 71.0±5.3 years,and group B comprised 51 patients with a mean age of 69.9±4.8 years.In group B,mean operative time (78.4±49.3 min vs 58.3±35.8 min,P<0.01),mean postoperative hospital stay(7.9±6.5 d vs 5.0±3.7 d, P<0.01),and the incidence of major postoperative complications(9.8%vs 3.1%,P<0.05)were significantly greater than in group A.The conversion rate tended to be higher in group B,but this difference was not significant. CONCLUSION:Perioperative outcomes in elderly patients who underwent LC seem to be influenced by the severity of gallbladder disease,and not by chronologic age.In octogenarians,LC should be performed at an earlier,uncomplicated stage of the disease whenever possible to improve perioperative outcomes. | Hyung Ook Kim Jung Won Yun Jun Ho Shin Sang Il Hwang Yong Kyun Cho Byung Ho Son Chang Hak Yoo Yong Lai Park Hungdai Kim | 2009 | World Journal of Gastroenterology2009，15，6： | 5 |
| 6 | Comparing upper gastrointestinal X-ray and endoscopy for gastric cancer diagnosis in Korea显示文摘AIM:To compare the cost and accuracy of upper gastrointestinal(GI)X-ray and upper endoscopy for diagnosis of gastric cancer using data from the 2002-2004 Korean National Cancer Screening Program(NCSP). METHODS:The study population included 1 503 646 participants in the 2002-2004 stomach cancer screening program who underwent upper GI X-ray or endoscopy.The accuracy of screening was defined as the probability of detecting gastric cancer.We calculated the probability by merging data from the NCSP and the Korea Central Cancer Registry.We estimated the direct costs of the medical examination and the tests for up- per GI X-ray,upper endoscopy,and biopsy. RESULTS:The probability of detecting gastric cancervia upper endoscopy was 2.9-fold higher than via upper GI X-ray.The unit costs of screening using upper GI X-ray and upper endoscopy were$32.67 and$34.89, respectively.In 2008,the estimated cost of identifying one case of gastric cancer was$53094.64 using upper GI X-ray and$16 900.43 using upper endoscopy.The cost to detect one case of gastric cancer was the same for upper GI X-ray and upper endoscopy at a cost ratio of 1:3.7. CONCLUSION:Upper endoscopy is slightly more costly to perform,but the cost to detect one case of gastric cancer is lower. | Hoo-Yeon Lee Eun-Cheol Park Jae Kwan Jun Kui Son Choi Myung-Il Hahm | 2010 | World Journal of Gastroenterology2010，16，2： | 5 |
| 7 | Surgical palliation of unresectable pancreatic head cancer in elderly patients显示文摘AIM: To determine if surgical biliary bypass would provide improved quality of residual life and safe palliation in elderly patients with unresectable pancreatic head cancer. METHODS: Nineteen patients, 65 years of age or older, were managed with surgical biliary bypass (Group A). These patients were compared with 19 patients under 65 years of age who were managed with surgical biliary bypass (Group B). In addition, the results for group A were compared with those obtained from 17 patients, 65 years of age or older (Group C), who received percutaneous transhepatic biliary drainage to evaluate the quality of residual life. RESULTS: Five patients (26.0%) in Group A had complications, including one intraabdominal abscess, one pulmonary atelectasis, and three wound infections. One death (5.3%) occurred on postoperative day 3. With respect to morbidity, mortality, and postoperative hospitalization, no statistically significant difference was noted between Groups A and B. The number of readmissions and the rate of recurrent jaundice were lower in Group A than in Group C, to a statistically significant degree (P = 0.019, P = 0.029, respectively). The median hospital-free survival period and themedian overall survival were also signifi cantly longer in Group A (P = 0.001 and P < 0.001, respectively). CONCLUSION: Surgical palliation does not increase the morbidity or mortality rates, but it does increase the survival rate and improve the quality of life in elderly patients with unresectable pancreatic head cancer. | Sang Il Hwang Hyung Ook Kim Byung Ho Son Chang Hak Yoo Hungdai Kim Jun Ho Shin | 2009 | World Journal of Gastroenterology2009，15，8： | 4 |
| 8 | Radial growth response of Pinus densiflora and Quercus spp.to topographic and climatic factors in South Korea显示文摘Aims This study aimed to develop radial growth models and to predict the potential spatial distribution of Pinus densiflora(Japanese red pine)and Quercus spp.(Oaks)in South Korea,considering topographic and climatic factors.Methods We used a dataset of diameter at breast height and radial growth estimates of individual trees,topographic and climatic factors in systematic sample plots distributed over the whole of South Korea.On the basis that radial growth is attributed primarily to tree age,we developed a radial growth model employing tree age as an explanatory variable.We estimated standard growth(SG),defined as radial growth of the tree at age 30,to eliminate the influence of tree age on radial growth.In addition,SG estimates including the Topographic Wetness Index,temperature and precipitation were calculated by the Generalized Additive Model.Important Findings As a result of variogram analysis of SG,we found spatial autocorrelation between SG,topographic and climatic factors.Incremental temperature had negative impacts on radial growth of P.densiflora and positive impacts on that of Quercus spp.Precipitation was associated with positive effects on both tree species.Based on the model,we found that radial growth of P.densiflora would be more vulnerable than that of Quercus spp.to climatic factors.Through simulation with the radial growth model,it was predicted that P.densiflora stands would be gradually replaced with Quercus spp.stands in eastern coastal and southern regions of South Korea in the future.The models developed in this study will be helpful for understanding the impact of climatic factors on tree growth and for predicting changes in distribution of P.densiflora and Quercus spp.due to climate change in South Korea. | Jae Gyun Byun Woo Kyun Lee Moonil Kim Doo Ahn Kwak Hanbin Kwak Taejin Park Woo Hyuk Byun Yowhan Son Jung Kee Choi Young Jin Lee Joachim Saborowski Dong Jun Chung Jin Hyun Jung | 2013 | Journal of Plant Ecology2013，6，5： | 3 |
| 9 | Multi-directionally wrinkle-able textile OLEDs for clothing-type displays显示文摘A clothing-type wearable display can be utilized in fashion,bio-healthcare,and safety industries as well as smart textiles for the internet of things(IoTs)and wearable devices.In response to this trend,we demonstrate a textile display that can endure the active movements of a human body.It can be applied to any kind of textile,and is durable against conditions such as rain,sweat,and washing.As a key technology for realizing the multi-directional wrinkle-able textile display,we fabricated a stress-lowering textile platform with an ultrathin planarization layer replicated from the flat surface of glass.An elastomeric strain buffer for reducing mechanical stress is also inserted into the textile platform.Here,organic light-emitting diodes(OLEDs)with red,green and blue color,thin film transistors(TFTs)fabricated at a low temperature below 150℃,and a washable encapsulation layer blocking both gas and liquid were demonstrated on the textile platform. | Seungyeop Choi Woosung Jo Yongmin Jeon Seonil Kwon Jeong Hyun Kwon Young Hyun Son Junmo Kim Jun Hong Park Hyuncheol Kim Ho Seung Lee Minwoo Nam Eun Gyo Jeong Jeong Bin Shin Taek-Soo Kim Kyung Cheol Choi | 2020 | npj Flexible Electronics2020，4，1： | 3 |
| 10 | Association Between Markers of Glucose Metabolism and Risk for Colorectal Adenoma显示文摘 | Sanjay Rampal Moon Hee Yang Jidong Sung Hee Jung Son Yoon-Ho Choi Jun Haeng Lee Young-Ho Kim Dong Kyung Chang Poong-Lyul Rhee Jong Chul Rhee Eliseo Guallar Juhee Cho | 2014 | Gastroenterology2014，，： | 2 |
| 11 | Laparoscopic-assisted distal gastrectomy versus open distal gastrectomy for advanced gastric cancer显示文摘 | Sang Il Hwang Hyung Ook Kim Chang Hak Yoo Jun Ho Shin Byung Ho Son | 2009 | Surgical Endoscopy2009，，6： | 2 |
| 12 | Ultrafast photonic PCR显示文摘Nucleic acid amplification and quantification via polymerase chain reaction(PCR)is one of the most sensitive and powerful tools for clinical laboratories,precision medicine,personalized medicine,agricultural science,forensic science and environmental science.Ultrafast multiplex PCR,characterized by low power consumption,compact size and simple operation,is ideal for timely diagnosis at the point-of-care(POC).Although several fast/ultrafast PCR methods have been proposed,the use of a simple and robust PCR thermal cycler remains challenging for POC testing.Here,we present an ultrafast photonic PCR method using plasmonic photothermal light-to-heat conversion via photon–electron–phonon coupling.We demonstrate an efficient photonic heat converter using a thin gold(Au)film due to its plasmon-assisted high optical absorption(approximately 65%at 450 nm,the peak wavelength of heat source light-emitting diodes(LEDs)).The plasmon-excited Au film is capable of rapidly heating the surrounding solution to over 150℃ within 3 min.Using this method,ultrafast thermal cycling(30 cycles;heating and cooling rate of 12.7960.93℃ s^(-1) and 6.660.29℃ s^(-1),respectively)from 55℃(temperature of annealing)to 95℃(temperature of denaturation)is accomplished within 5 min.Using photonic PCR thermal cycles,we demonstrate here successful nucleic acid(λ-DNA)amplification.Our simple,robust and low cost approach to ultrafast PCR using an efficient photonic-based heating procedure could be generally integrated into a variety of devices or procedures,including on-chip thermal lysis and heating for isothermal amplifications. | Jun Ho Son Byungrae Cho SoonGweon Hong Sang Hun Lee Ori Hoxha Amanda J Haack Luke P Lee | 2015 | Light(Science & Applications)2015，4，1： | 2 |
| 13 | Comparison of cytological and histological preparations in the diagnosis of pancreatic malignancies using endoscopic ultrasoundguided fine needle aspiration显示文摘BACKGROUND:Endoscopic ultrasound-guided fine needle aspiration(EUS-FNA) has become a crucial diagnostic technique for pancreatic malignancies.The specimen obtained by EUS-FNA can be prepared for either cytological or histological examinations.This study was to compare diagnostic performance of cytological and histological preparations using EUSFNA in the same lesions when pancreatic malignancies were suspected.METHODS:One hundred and eighteen patients who underwent EUS-FNA for suspected pancreatic malignancies were consecutively enrolled.All procedures were conducted by a single echoendoscopist under the same conditions.Four adequate preparations were obtained by 22-gauge needles with 20 to-and-fro movements for each pass.The 4 preparations included 2 cytological and 2 histological specimens.The pathologic reviews of all specimens were conducted independently by a single experienced cytopathologist.Sensitivity,specificity,and accuracy of the 2 preparations were compared.RESULTS:The enrolled patients consisted of 62 males(52.5%),with the mean age of 64.6±10.5 years.Surgery was performed in 23(19.5%) patients.One hundred and sixteen(98.3%) lesions were classified as malignant,while 2(1.7%) were benign.Sensitivity of cytology and histology were 87.9% and 81.9%,respectively,with no significant difference(P=0.190).Accuracy was also not significantly different.Cytological preparation was more sensitive when the size of lesion was <3 cm(86.7% vs 68.9%,P=0.033).CONCLUSIONS:Our results suggested that the diagnostic performances of cytological and histological preparations are not significantly different for the diagnosis of pancreatic malignancies.However,cytological preparation might be more sensitive for pancreatic lesions <3 cm. | Dong Kee Jang Sang Hyub Lee Jun Kyu Lee Woo Hyun Paik Kwang Hyun Chung Ban Seok Lee Jun Hyuk Son Jae Woo Lee Ji Kon Ryu Yong-Tae Kim Kyoung-Bun Lee | 2017 | Hepatobiliary & Pancreatic Diseases International2017，16，4： | 2 |
| 14 | Developmental process of the arcuate fasciculus from infancy to adolescence: a diffusion tensor imaging study显示文摘We investigated the radiologic developmental process of the arcuate fasciculus(AF) using subcomponent diffusion tensor imaging(DTI) analysis in typically developing volunteers. DTI data were acquired from 96 consecutive typically developing children, aged 0–14 years. AF subcomponents, including the posterior, anterior, and direct AF tracts were analyzed. Success rates of analysis(AR) and fractional anisotropy(FA) values of each subcomponent tract were measured and compared. AR of all subcomponent tracts, except the posterior, showed a significant increase with aging(P < 0.05). Subcomponent tracts had a specific developmental sequence: First, the posterior AF tract, second, the anterior AF tract, and last, the direct AF tract in identical hemispheres. FA values of all subcomponent tracts, except right direct AF tract, showed correlation with subject's age(P < 0.05). Increased AR and FA values were observed in female subjects in young age(0–2 years) group compared with males(P < 0.05). The direct AF tract showed leftward hemispheric asymmetry and this tendency showed greater consolidation in older age(3–14 years) groups(P < 0.05). These findings demonstrated the radiologic developmental patterns of the AF from infancy to adolescence using subcomponent DTI analysis. The AF showed a specific developmental sequence, sex difference in younger age, and hemispheric asymmetry in older age. | Hyeong Jun Tak Jin Hyun Kim Su Min Son | 2016 | Neural Regeneration Research2016，11，6： | 2 |
| 15 | DJ-1 mediates paraquat-induced dopaminergic neuronal cell death显示文摘 | Hyun Joo Kwon Jun Young Heo Jung Hee Shim Ji Hoon Park Kang Sik Seo Min Jeong Ryu Jeong Su Han Minho Shong Jin H. Son Gi Ryang Kweon | 2011 | Toxicology Letters2011，，： | 2 |
| 16 | Laparoscopic-assisted distal gastrectomy versus open distal gastrectomy for advanced gastric cancer显示文摘 | Sang Il Hwang Hyung Ook Kim Chang Hak Yoo Jun Ho Shin Byung Ho Son | 2009 | Surgical Endoscopy2009，，6： | 2 |
| 17 | Functional properties of raw and cooked pork patties with added irradiated, freeze-dried green tea leaf extract powder during storage at 4℃显示文摘 | Cheorun Jo Jun Ho Son Cheon Bae Son Myung Woo Byun | 2003 | Meat Science2003，64，1： | 1 |
| 18 | Revision of bilateral self-expandable metallic stents placed using the stent-in-stent technique for malignant hilar biliary obstruction显示文摘Background: Endoscopic biliary decompression using bilateral self-expandable metallic stent(SEMS) placed using the stent-in-stent(SIS) technique is considered favorable for unresectable malignant hilar biliary obstruction(MHBO). However, occlusion of the bilateral SIS placement is frequent and revision can be challenging. This study was performed to investigate the efficacy, the long-term patency and the appropriate approach for revision of occluded bilateral SIS placement in unresectable MHBO. Methods: From January 2011 to July 2016, thirty-eight patients with unresectable MHBO underwent revision of occluded bilateral SIS placement. Clinical data including success rates and patency of revision, were retrospectively analyzed. Results: The technical success rate of revision was 76.3%. The clinical success rate of revision was 51.7% and mean patency of revision was 49.1 days. No significant predictive factor for clinical failure of revision was observed. The cell size of SEMS was not found to have significant effects on clinical success rates or revision patency. Conclusions: Revision of occluded bilateral SIS placement for MHBO showed fair patency and clinical success rate. Revision method and cell size of SEMS were not found to influence clinical outcomes. | Jun Hyuk Son Hee Seung Lee Sang Hyub Lee Seungmin Bang Jinwoo Kang Woo Hyun Paik Ji Kon Ryu Yong-Tae Kim | 2018 | Hepatobiliary & Pancreatic Diseases International2018，17，5： | 1 |
| 19 | Induction of indoleamine 2,3-dioxygenase expression via heme oxygenase-1-dependant pathway during murine dendritic cell maturation显示文摘 | In Duk Jung Jun Sik Lee Chang-Min Lee Kyung Tae Noh Yeong-Il Jeong Won Sun Park Sung Hak Chun Soo Kyung Jeong Jin Wook Park Kwang Hee Son Deok Rim Heo Min-Goo Lee Yong Kyoo Shin Han Wool Kim Cheol-Heui Yun Yeong-Min Park | 2010 | Biochemical Pharmacology2010，，： | 1 |
| 20 | Highly reflective low resistance Ag-based Ohmic contacts on p-type GaN using Mg overlayer显示文摘 | Ho Won Jang Jun Ho Son Jong-Lam Lee | 2007 | Applied Physics Letters2007，90，1： | 1 |
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