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| 1 | Performance of the Seasonal Forecasting of the Asian Summer Monsoon by BCC_CSM1.1(m)显示文摘This paper provides a comprehensive assessment of Asian summer monsoon prediction skill as a function of lead time and its relationship to sea surface temperature prediction using the seasonal hindcasts of the Beijing Climate Center Climate System Model, BCC CSM1.1(m). For the South and Southeast Asian summer monsoon, reasonable skill is found in the model's forecasting of certain aspects of monsoon climatology and spatiotemporal variability. Nevertheless, deficiencies such as significant forecast errors over the tropical western North Pacific and the eastern equatorial Indian Ocean are also found. In particular, overestimation of the connections of some dynamical monsoon indices with large-scale circulation and precipitation patterns exists in most ensemble mean forecasts, even for short lead-time forecasts.Variations of SST, measured by the first mode over the tropical Pacific and Indian oceans, as well as the spatiotemporal features over the Ni no3.4 region, are overall well predicted. However, this does not necessarily translate into successful forecasts of the Asian summer monsoon by the model. Diagnostics of the relationships between monsoon and SST show that difficulties in predicting the South Asian monsoon can be mainly attributed to the limited regional response of monsoon in observations but the extensive and exaggerated response in predictions due partially to the application of ensemble average forecasting methods. In contrast, in spite of a similar deficiency, the Southeast Asian monsoon can still be forecasted reasonably, probably because of its closer relationship with large-scale circulation patterns and El Nino–Southern Oscillation. | LIU Xiangwen WU Tongwen YANG Song JIE Weihua NIE Suping LI Qiaoping CHENG Yanjie LIANG Xiaoyun | 2015 | Advances in Atmospheric Sciences2015，32，8： | 25 |
| 2 | Herbal decoctosome is a novel form of medicine显示文摘Traditionally, herbal medicine is consumed by drinking decoctions produced by boiling herbs with water. The functional components of the decoction are heat stable. Small RNAs(sRNAs) were reported as a new class of functional components in decoctions. However, the mechanisms by which sRNAs survive heat treatment of the decoction and enter cells are unclear.Previous studies showed that plant-derived exosome-like nanoparticles(ELNs), which we call botanosomes, could deliver therapeutic reagents in vivo. Here, we report that heat-stable decoctosomes(ELNs) from decoctions have more therapeutic effects than the decoctions in vitro and demonstrate therapeutic efficacy in vivo. Furthermore, sRNAs, such as HJT-sRNA-m7 and PGY-sRNA-6, in the decoctosome exhibit potent anti-fibrosis and anti-inflammatory effects, respectively. Decoctosome is comprised of lipids, chemical compounds, proteins, and s RNAs. A medical decoctosome mimic is called bencaosome. A single lipid sphinganine(d22:0) identified in the decoctosome was mixed and heated with the synthesized sRNAs to form the simplest bencaosome. This simple bencaosome structure was identified by critical micelle concentration(cmc) assay that sRNAs coassembled with sphinganine(d22:0) to form the lipid layers of vesicles. The heating process facilitates co-assembly of sRNAs and sphinganine(d22:0) until a steady state is reached. The artificially produced sphinganine-HJT-sRNA-m7 and sphinganinePGY-sRNA-6 bencaosomes could ameliorate bleomycin-induced lung fibrosis and poly(I:C)-induced lung inflammation, respectively, following oral administration in mice. Our study not only demonstrates that the herbal decoctosome may represent a combinatory remedy in precision medicine but also provides an effective oral delivery route for nucleic acid therapy. | Xiaoyun Li Zhu Liang Jianchao Du Zhiqing Wang Song Mei Zhiqing Li Yan Zhao DANDan Zhao Yiming Ma Jun Ye Jiantao Xu Yu Zhao Jiahui Chang Yuhao Qin Lanlan Yu Chenxuan Wang Chengyu Jiang | 2019 | Science China(Life Sciences)2019，62，3： | 26 |
| 3 | Dendritic Cells Transduced with SOCS1 Gene Exhibit Regulatory DC Properties and Prolong Allograft Survival显示文摘SOCS1 is a key regulator of cytokine signaling and is important for maintaining balance in the immune system. It is thought to participate in negative feedback loops in cytokine signaling and may be an important signal for the regulation of dendritic cell (DC) maturation. However, it remains unclear whether DCs transduced with SOCS1 exhibit characteristics of regulatory DCs and induce allogeneic T-cell hyporesponsiveness. In this study, we constructed adenoviral vector coding SOCS1 (Ad-SOCS1) that can efficiently increase SOCS1 gene expression in bone marrow-derived dendritic cells. DCs transduced with Ad-SOCS1 (DC-SOCS1) expressed low levels of costimulatory and MHC molecules, were resistant to maturation and activation stimulation, induced allogeneic T-cell hyporesponsiveness, and promoted the generation of regulatory-like T cells in vitro. DC-SOCS1 pretreatment significantly prolonged the survival of allografts and led to a substantial increase in the generation of regulatory T cells. Our data suggest that SOCS1 inhibits DC maturation and induces regulatory DC generation, therefore possessing therapeutic potential to prevent rejection in organ transplantation. | Hong Fu Shaohua Song Fang Liu Zhijia Ni Xiaoyun Shen Liang Xiao Guoshan Ding Quanxing Wang | 2009 | Cellular & Molecular Immunology2009，6，2： | 20 |
| 4 | Research Developments and Prospects on Microseismic Source Location in Mines显示文摘 | Jiulong Cheng Guangdong Song Xiaoyun Sun Laifu Wen Fei Li | 2018 | Engineering2018，4，5： | 10 |
| 5 | NiTiAl Intermetallic Alloys Strengthened by Mo Replacement显示文摘NiTiAl based alloys have attracted attention as potential high temperature structural materials.Alloying is an effective way to improve their mechanical properties.The microstructures and mechanical properties of Ni50Ti44?xAl6Mox(x = 0,0.5,1,1.5,3) alloys have been investigated by X-ray diffraction(XRD),scanning electron microscope(SEM),transmission electron microscope(TEM) and compressive tests.It is found that Ni50Ti44?xAl6Mox alloy is composed of NiTi(B2) and Ti2Ni(FCC) phases when Mo content is no more than 1 at%.The effect of Mo solid solution hardening at room temperature has been indicated by the rise of yield strength and the fall of plasticity with increasing Mo content.For Ni50Ti42.5Al6Mo1.5 and Ni50Ti41Al6Mo3 alloys,a Mo solid solution appears and increases the yield strength by precipitation strengthening.The maximum yield strength at 600 °C and elevated temperatures is presented in Ni50Ti43Al6Mo1 alloy not in alloys with a higher Mo content,which is possibly due to the softness of Mo-Ti-Ni solid solution phase. | Song Xiaoyun | 2010 | Chinese Journal of Aeronautics2010，23，6： | 9 |
| 6 | Relationships between Interannual and Intraseasonal Variations of the Asian–Western Pacific Summer Monsoon Hindcasted by BCC CSM 1.1(m)显示文摘Using hindcasts of the Beijing Climate Center Climate System Model, the relationships between interannual variability(IAV) and intraseasonal variability(ISV) of the Asian–western Pacific summer monsoon are diagnosed. Predictions show reasonable skill with respect to some basic characteristics of the ISV and IAV of the western North Pacific summer monsoon(WNPSM) and the Indian summer monsoon(ISM). However, the links between the seasonally averaged ISV(SAISV) and seasonal mean of ISM are overestimated by the model. This deficiency may be partially attributable to the overestimated frequency of long breaks and underestimated frequency of long active spells of ISV in normal ISM years, although the model is capable of capturing the impact of ISV on the seasonal mean by its shift in the probability of phases.Furthermore, the interannual relationships of seasonal mean, SAISV, and seasonally averaged long-wave variability(SALWV; i.e., the part with periods longer than the intraseasonal scale) of the WNPSM and ISM with SST and low-level circulation are examined. The observed seasonal mean, SAISV, and SALWV show similar correlation patterns with SST and atmospheric circulation, but with different details. However, the model presents these correlation distributions with unrealistically small differences among different scales, and it somewhat overestimates the teleconnection between monsoon and tropical central-eastern Pacific SST for the ISM, but underestimates it for the WNPSM, the latter of which is partially related to the too-rapid decrease in the impact of El Nino–Southern Oscillation with forecast time in the model. | LIU Xiangwen WU Tongwen YANG Song LI Qiaoping CHENG Yanjie LIANG Xiaoyun FANG Yongjie JIE Weihua NIE Suping | 2014 | Advances in Atmospheric Sciences2014，31，5： | 9 |
| 7 | Effect of Zr addition on microstructures and mechanical properties of Ni-46Ti-4Al alloy显示文摘The microstructures and mechanical properties of Ni-(46-x)Ti-4Al-xZr (x = 0-8, at.%) alloys have been investigated by scanning electron microscopy (SEM), transmission electron microscopy (TEM), and mechanical tests. The results show that the Ni-Ti-Al-Zr alloys are composed of TiNi and (Ti, Al) 2 Ni with Zr as a solid solution element in both phases, and the third phase, (Zr, Ti, Al) 2 Ni, appears in Ni-40Ti-4Al-6Zr and Ni-38Ti-4Al-8Zr alloys. The compressive yield strength at room temperature increases with the increase of Zr content due to the solid-solution strengthening of Zr and precipitation strengthening of (Ti, Al, Zr) 2 Ni phase. However, the Ni-42Ti-4Al-4Zr alloy exhibits the maximum compressive yield strength at 873 and 973 K because of the softening of (Zr, Ti, Al) 2 Ni phase in the alloys with more Zr addition. The tensile stress-strain tests and the SEM fracture surface observations show that the brittle to ductile transition temperature of Ni-42Ti-4Al-4Zr alloy is between 873 and 923 K. | LI Yan YU Kaiyuan SONG Xiaoyun ZHANG Fei | 2011 | Rare Metals2011，30，5： | 6 |
| 8 | Analysis and Suppression of Beat Phenomenon for Railway Traction Converters and Motors显示文摘交直交传动系统广泛应用于高速铁路牵引领域。由于单相脉冲整流器的工作特性,其输出直流电压含有频率为2倍电网频率的脉动分量。该分量在牵引电机侧会引起拍频现象,尤其当牵引逆变器工作频率接近2倍电网频率时最为严重。首先详细分析了直流电压脉动分量的来源和拍频现象产生的本质。然后,在取消LC谐振电路并考虑直流侧脉动电压幅值和相角变化的情况下,研究了一种基于频率补偿的无拍频控制算法,并应用于间接转子磁场定向矢量控制系统。通过在转速环注入脉动分量,补偿牵引逆变器工作频率,抑制牵引电机拍频电流。最后,仿真结果和硬件在回路实验结果验证了该算法的有效性。 | GOU Bin FENG Xiaoyun SONG Wensheng HAN Kun, GE Xinglai | 2013 | 中国电机工程学报2013，33，9： | 5 |
| 9 | Tensile and fracture properties of Ti-62A alloy plate with different microstructures显示文摘Ti-62A alloy plates with three different types of microstructure, fully equiaxed, bimodal, and Widmanst tten, were obtained by various heat treatments to investigate the effects of microstructure on the tensile and fracture properties at room temperature. The results reveal that Widmanst tten microstructure exhibits good damage tolerance behavior considering strength, fracture toughness, and fatigue crack growth behavior, while the bimodal microstructure shows good comprehensive properties considering the plasticity synthetically. Optical microscopy (OM) and scanning electron microscopy (SEM) microstructure analyses on fracture and fatigue crack path demonstrate that the dependence of mechanical properties and fatigue crack growth behavior on microstructural feature are attributed to the α lamellae width and the α colony size. | LIU Rui HUI Songxiao YE Wenjun YU Yang FU Yanyan SONG Xiaoyun DENG Xiguang | 2012 | Rare Metals2012，31，5： | 5 |
| 10 | Martensitic transformation of Ti-18Nb(at.%) alloy with zirconium显示文摘The addition of 3%~9% Zr on the martensitic transformation of Ti-18Nb(at.%) alloy was investigated. The results of microstructure and X-ray diffraction (XRD) analysis show that the phase constitution of as-quenched Ti-18Nb-9Zr(at.%) alloy consists of the retained matrix and martensite, while that of the other three alloys is single martensite. No trace of athermal phase was found in any of the as-quenched alloys. Unlike the effect of Nb addition on the martensitic transformation start temperature Ms of Ti-18Nb(at.%) alloy, Ms de-creased nonlinearly as increasing the Zr addition from 3% to 9% and Ms decreased much more sharply as increasing the Zr addition. The Ms of as-quenched Ti-18Nb-9Zr alloy was around room temperature. The effect of Zr addition on the phase stabilizing in the Ti-18Nb(at.%) alloy was briefly discussed. | Ye, Wenjun Mi, Xujun Song, Xiaoyun | 2012 | Rare Metals2012，31，3： | 4 |
| 11 | Erratum to:Herbal decoctosome is a novel form of medicine显示文摘Following the published article,we noticed an error duplication in Figure 5G“control”and“PGY-6”that was introduced during the revised process,with an attempt to replace it with higher-resolution images.Here we provide the original data in the first submitted manuscript(Figure 5G). | Xiaoyun Li Zhu Liang Jianchao Du Zhiqing Wang Song Mei Zhiqing Li Yan Zhao Dandan Zhao Yiming Ma Jun Ye Jiantao Xu Yu Zhao Jiahui Chang Yuhao Qin Lanlan Yu Chenxuan Wang Chengyu Jiang | 2020 | Science China(Life Sciences)2020，63，9： | 2 |
| 12 | Characterization of insoluble dietary fiber from Pleurotus eryngii and evaluation of its effects on obesity-preventing or relieving effects via modulation of gut microbiota显示文摘The purpose of this study was to evaluate the obesity preventing or relieving effect of insoluble dietary fiber(IDF)from Pleurotus eryngii through its modulations on intestinal microbiota.The IDF was extracted and structurally characterized through FTIR,X-Ray and thermogravimetric(TG)analysis.The mice for in vivo experiments were divided into obesity preventing group(feeding high-fat diet while gavage IDF simultaneously)and obesity relieving group(IDF intervention after the establishment of the obese model)to evaluate its hypolipidemic effect.Results:The yield of P.eryngii IDF extracts was 56.49%(on P.eryngii dry weight base)with IDF content of 85.15%in the extracts.The in vivo results showed that the body weight of the obesity-preventing groups was still increasing after intervention with IDF,but the growth rate was lowered,and the abnormal lipid metabolism and inflammation syndromes were alleviated;the acetic acid content of the medium and low dose dietary fiber intervention groups was significantly higher than that of the normal group,and the structure of the intestinal flora was improved.The mice weight from the obesity-relieving group decreased significantly.The abnormal lipid metabolism and inflammation were alleviated.In conclusion,The IDF intervention decreased the abnormal lipid metabolism and inflammation in both obesity-preventing and relieving experiments.The intestinal flora structure was obviously improved.P.eryngii IDF is a good candidate as hypolipidemic agent. | Xiaoyun Han Duo Yang Song Zhang Xiaoli Liu Yuelong Zhao Chunyue Song Qingshen Sun | 2023 | Journal of Future Foods2023，3，1： | 2 |
| 13 | CUL4B facilitates HBV replication by promoting HBx stabilization显示文摘Objective:Hepatitis B virus(HBV)infection is a major public health problem worldwide.However,the regulatory mechanisms underlying HBV replication remain unclear.Cullin 4 B-RING ubiquitin E3 ligase(CRL4 B)is involved in regulating diverse physiological and pathophysiological processes.In our study,we aimed to explain the role of CUL4 B in HBV infection.Methods:Cul4 b transgenic mice or conditional knockout mice,as well as liver cell lines with CUL4 B overexpression or knockdown,were used to assess the role of CUL4 B in HBV replication.Immunoprecipitation assays and immunofluorescence staining were performed to study the interaction between CUL4 B and HBx.Cycloheximide chase assays and in vivo ubiquitination assays were performed to evaluate the half-life and the ubiquitination status of HBx.Results:The hydrodynamics-based hepatitis B model in Cul4 b transgenic or conditional knockout mice indicated that CUL4 B promoted HBV replication(P<0.05).Moreover,the overexpression or knockdown system in human liver cell lines validated that CUL4 B increased HBV replication in an HBx-dependent manner.Importantly,immunoprecipitation assays and immunofluorescence staining showed an interaction between CUL4 B and HBx.Furthermore,CUL4 B upregulated HBx protein levels by inhibiting HBx ubiquitination and proteasomal degradation(P<0.05).Finally,a positive correlation between CUL4 B expression and HBV pg RNA level was observed in liver tissues from HBV-positive patients and HBV transgenic mice.Conclusions:CUL4 B enhances HBV replication by interacting with HBx and disrupting its ubiquitin-dependent proteasomal degradation.CUL4 B may therefore be a potential target for anti-HBV therapy. | Haixia Shan Bo Wang Xiaodong Zhang Hui Song Xi Li Yongxin Zou Baichun Jiang Huili Hu Hao Dou Changshun Shao Lifen Gao Chunhong Ma Xiaoyun Yang Xiaohong Liang Yaoqin Gong | 2022 | Cancer Biology & Medicine2022，19，1： | 2 |
| 14 | Studies on the Relationship between Neuroendocrine Cellular Differentiation in Gastric Cancers and Post-operative Survival Time显示文摘OBJECTIVE To examine the ultrastructure of gastric cancer cel s by the electron microscope,in order to assess the relationship between neuroendocrine differentiation and post-operative survival time. METHODS NSE,Syn and CgA immunohistochemical labeling was conducted in 168 cases with a common-type of gastric cancer.Electron microscopy was performed in 80 cases with positive immunohistochemical labeling. These cases were fol owed-up for over 5 years and the post-operative survival data analyzed. RESULTS Neuroendocrine granules were found by electron microscopy in 39 cases.The rate of neuroendocrine differentiation found was 23% (39/168),using routine diagnostic criteria and electron microscopy(REM). The post-operative survival time of gastric cancer patients with neuroendocrine differentiation was significantly shorter(P=0.0032)compared to those without neuroendocrine differentiation. CONCLUSION It is of significant clinical importance to determine if the neuroendocrine cells are differentiated in gastric cancers.The gastric cancer patients with neuroendocrine differentiation have a shorter post-operative survival time and a poorer prognosis.Electron microscopy is a reliable method of providing a diagnosis. | Song He Qiao Yan Xudong Chen Jianbing Zhang Xiaoyun Lu Hongjia Pan Li Chen | 2007 | Chinese Journal of Clinical Oncology2007，4，6： | 2 |
| 15 | Pan‐BH3 Mimetic S1 Exhibits Broad‐Spectrum Antitumour Effects by Cooperation between Bax and Bak显示文摘 | Ting Song Zuguang Xue Zhichao Zhang Xiaoyun Shen Xiangqian Li | 2013 | Basic Clin Pharmacol Toxicol2013，，3： | 1 |
| 16 | Synthesis of monodispersed Zn Al2O4nanoparticles and their tribology properties as lubricant additives显示文摘 | Song Xiaoyun Zheng Shaohua Zhang Jun | 2012 | Materials Research Bulletin2012，47，12： | 1 |
| 17 | Nano-carbon/sulfur composite cathode materials with carbon nanofiber as electrical conductor for advanced secondary lithium/sulfur cells显示文摘 | Rao Mumim Song Xiaoyun Cairns E J | 2012 | Journal of Power Sources2012，205，： | 1 |
| 18 | Electrodeposition in organic system and properties of NiO electrochromic films显示文摘By electrodeposition in organic system,NiO films with reversible electrochromic property were fabricated.Fluorine-doped tin oxide glass slices were used as substrates,i.e.cathodes.Cyclic voltammetry and ultraviolet-visible transmission spectroscopy were adopted to study the electrochromic properties of the films.High resolution transmission electron microscopy(HRTEM) was employed to analyze the composition and structure of the films.It is found that the films are composed of fine NiO crystal grains of a few nanometers in diameter,endowing them with large visible light transmittance variation,rapid switch rate(i.e.rapid response time) between the bleached and colored states.Their cycling durability reached 6000 cycles. | SU Ge SONG MeiQin SUN WuZhu CAO LiXin LIU Wei MA DeWen CHEN Na ZHAO LiLi WANG Jing LIU XiaoYun | 2012 | Science China(Technological Sciences)2012，55，6： | 1 |
| 19 | 135 cases of occupational exposure to blood borne pathogens infection显示文摘 | Tang Yanqin Song Xiuchan Wei Xiaoyun | 2012 | Journal Survey2012，23，5： | 1 |
| 20 | The prognostic value of copeptin for acute intracerebral hemorrhagepatients显示文摘 | Aimei Zhang Jun Li Xiaoyun Li Li Song Hongfang Li | 2013 | Experimental and Therapeutic Medicine2013，，2： | 1 |
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