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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Therapeutic and prophylactic thalidomide in TNBS-induced colitis: Synergistic effects on TNF-α, IL-12 and VEGF production显示文摘AIM: To evaluated the therapeutic and prophylactic effect of thalidomide on 2, 4, 6-trinitrobenzene sulfonic acid (TNBS)-induced colitis. Thalidomide has been reported to downregulate the expression of tumor necrosis factor a (TNF-α), IL-12, and vascular endothelial growth factor (VEGF), hallmarks of intestinal inflammation in Crohn's disease (CD). METHODS: Male Wistar rats were divided in five groups of ten animals each. Four groups received a rectal infusion of TNBS in ethanol. The first group was sacrificed 7 d after colitis induction. The second and third groups received either thalidomide or placebo by gavage and were sacrificed at 14 d. The fourth group received thalidomide 6 h before TNBS administration, and was sacrificed 7 d after induction. The fifth group acted as the control group and colitis was not induced. Histological inflammatory scores of the colon were performed and lamina propria CD4+ T cells, macrophages, and VEGF+ cells were detected by immunohistochemistry. TNF-a and IL-12 were quantified in the supernatant of organ cultures by ELISA. RESULTS: Significant reduction in the inflammatory score and in the percentage of VEGF+ cells was observed in the group treated with thalidomide compared with animals not treated with thalidomide. Both TNF-αand IL-12 levels were significantly reduced among TNBS induced colitis animals treated with thalidomide compared with animals that did not receive thalidomide. TNF-αlevels were also significantly reduced among the animals receiving thalidomide prophylaxis compared with untreated animals with TNBS-induced colitis. Intestinal levels of TNF-αand IL-12 were significantly correlated with the inflammatory score and the number of VEGF+ cells. CONCLUSION: Thalidomide significantly attenuates TNBS-induced colitis by inhibiting the intestinal production of TNF-α, IL-12, and VEGF. This effect may support the use of thalidomide as an alternate approach in selected patients with CD. | Ana Teresa Carvalho Heitor Souza Antonio Jose Carneiro Morgana Castelo-Branco Kalil Madi Alberto Schanaider Flavia Silva Fernando Antonio Pereira Júnior Márcia G Pereira Cláudio Tortori Ilana Dines Jane Carvalho Eduardo Rocha Celeste Elia | 2007 | World Journal of Gastroenterology2007，13，15： | 6 |
| 3 | 涂层和未涂层铝基体上接触应力的有限元模拟显示文摘基于对涂层/基体系统上产生的接触应力的分析,研究了软基体上薄膜的磨损行为。应用有限元法对由压头向涂层或未涂层铝基体施加正压力的情况进行模拟。先在没有薄膜的系统上对模型的精确性进行检验。然后通过改变薄膜的弹性模量比,开发出适用于铝基体上有两层硬薄膜试样的模型。同时还研究了薄膜厚度和载荷的影响。较厚的薄膜降低了模型上某些点的应力,但是增加了另一些点的应力。从弹性模量的角度来说,薄膜内的计算应力主要与薄膜的弹性模量有关,而通过改变薄膜的弹性模量比几乎不会使应力产生差异。 | J J Moore R M Souza G G W Mustoe 徐桂珍 | 2000 | 中国表面工程2000，13，1： | 4 |
| 4 | Effect of hard second phase on cavitation erosion of Fe-Cr-Ni-C alloys显示文摘 | Cuppari V Souza R M | 2005 | Wear2005，258，： | 1 |
| 5 | Prediction of radiation pneumonitis by dose-volume histogram parameters in lung cancer-asystematic review显示文摘 | Rodrigues G Cock M D'souza | 2004 | Radiother Oncol2004，71，2： | 1 |
| 6 | TL, EPR and optical absorption studies on natural alexandrite compared to natural chrysoberyl 显示文摘 | Ferraz G M Watanabe S Souza S O | 2002 | Radiation Protection Dosimetry2002，100，14： | 1 |
| 7 | Dyschromatosis universalis hereditaria 显示文摘 | Sethuraman G Srinivas CR D'Souza M | 2002 | Clin Exp Dermatol2002，27，6： | 1 |
| 8 | Supply chain coordination for false failure returns显示文摘 | Ferguson M Guide V D R Souza G C | 2006 | Manufacturing & Service Operations Management2006，8，4： | 1 |
| 9 | Mesoporous silica-magnetite nanocomposite synthesized by using a neutral surfactant显示文摘 | Souza K C Salazar-Alvarez G Ardisson J D Macedo W A A Sousa E M B | 2008 | Nanotechnology2008，19，18： | 1 |
| 10 | Esterase enzymes involved in pyrethroid and organophosphate resistance in a Brazilian population of Riphicephalltts (Boophilus) microplus(Aeari, Ixodidae) 显示文摘 | Baffi M A Souza G R L Sousa C S | 2008 | Molecular & Biochemical Parasitology2008，160，： | 1 |
| 11 | Wavelet shrinkage: High frequency multipath reduction from GPS relative positioning显示文摘 | Souza E M Monico J F G | 2004 | GPS Solutions2004，8，3： | 1 |
| 12 | A new and efficient procedure for preparing 1,2,3-triazoles 显示文摘 | Romeiro G A Cecilia M de Souza B V | 1997 | Tet- rahedron Letters1997，38，29： | 1 |
| 13 | Supply chain coordination for false failure returns显示文摘 | Ferguson M Guide V Souza G | | 0，，04： | 1 |
| 14 | Validation of a matrix solid phase dispersion (MSPD) technique for determination of pesticides in lyophilized eggs of the chicken Gallus gallus domesticus显示文摘 | dos Reis Souza M K Moreira C O de Lima T G | 2013 | Microchem J2013，110，： | 1 |
| 15 | Note: An application of the EOQ model with nonlinear holding cost to i ventory management of perishables显示文摘 | FERGUSON M JAYARAMAN V SOUZA G C | 2007 | European Journal of Op erational Research2007，，1： | 1 |
| 16 | The σ phase formation in annealed UNS S31803 duplex stainless steel: Texture aspects显示文摘 | Souza C M Abreu H F G Tavares S S M | 2008 | Materials Characterization2008，59，9： | 1 |
| 17 | Genotypic stability and adaptability in tropical maize based on AMMI and GGE biplot analysis 显示文摘 | BALESTRE M VON PINHO R G SOUZA J C | 2009 | Genetics and Molecular Research2009，8，4： | 1 |
| 18 | ICP OES simultaneous determination of Ca, Cu, Fe, Mg, Mn, Na, and P inbiodiesel by axial and radial inductively coupled plasma-optical emission spectrometry显示文摘 | de SOUZA R M LEOCADIO L G da SILVEIRA C L P | 2008 | Analytical Letter2008，41，9： | 1 |
| 19 | Antioxidant ac- tivity and total phenolic content of Agaricus brasiliensis ( Agari- cus blazei Murril) in two stages of maturity 显示文摘 | Soares A A Souza C G M Daniel F M | 2009 | Food Chemis- try2009，112，4： | 1 |
| 20 | Textural features of highly ordered Al-MCM-41 molecular sieve studied by X-ray diffraction, nitrogon adsorption and transmission electron microscopy显示文摘 | Souza M J B Araujo A S Pedrosa A M G | 2006 | Materials Letters2006，60，2122： | 1 |
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