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| 1 | A randomized controlled clinical trial on the treatment of Thymosin-a1 versus interferon-α in patients with hepatitis B显示文摘INTRODUCTIONChronic hepatitis B virus (HBV) infection is a serious problem because of its world wide distribution and possible adverse sequelae ,such as cirrhosis and hepatocellular carcinoma .The World Health Organization estimates that HBV has infected mord than 350 million people worldwide ,and up to 20% of them will become chromic carricrs and will be at significant risk for cirrhosis and HCC .The ultimate goal of the therapy for chronic hepatitis B is to prevent progression to cirrhosis and to prevent development of HCC. | Jing You Lin Zhuang Bao Zhang Tang Wei Bo Yang Su Ying Ding Wu Li Rong Xue Wu Hong Li Zhang Yan Mei Zhang Shao Ming Yan Lu Zhang ~1Department of Infectious Diseases,The First Affiliated Hospital of Kunming Medical College,Kunming 650032,Yunnan Province,China ~2Departrnent of Hepatology,Kunming Third Municipal People’s Hospital,Kunming 650041,Yunnan Province,China | 2001 | World Journal of Gastroenterology2001，7，3： | 48 |
| 2 | Outbreak of Dengue Fever in Central China,2013显示文摘In 2013,the first dengue fever(DF) outbreak in central China was reported in the central of Henan province,northern temperate regions,although they have been sequentially recorded in Southern China.106 suspected DF cases were reported and 73 patients were confirmed dengue virus type 3(DEN-3) infections.62/392(15.8%) local health persons showed DEN antibodies positive.To this day Henan is the northernmost province in China which has been reported about outbreak of DF and what is important is that it warns us the endemic range of DF has been expanded geographically in China. | HUANG Xue Yong MA Hong Xia WANG Hai Feng DU Yan Hua SU Jia LI Xing Le TANG Xiao Yan MA Hong Peng ZU Bing Can ZHANG Qiao Hong CHEN Hao Min XU Bian Li | 2014 | Biomedical and Environmental Sciences2014，27，11： | 30 |
| 3 | Predicting geological hazards during tunnel construction显示文摘The complicated geological conditions and geological hazards are challenging problems during tunnel construction,which will cause great losses of life and property.Therefore,reliable prediction of geological defective features,such as faults,karst caves and groundwater,has important practical significances and theoretical values.In this paper,we presented the criteria for detecting typical geological anomalies using the tunnel seismic prediction(TSP) method.The ground penetrating radar(GPR) signal response to water-bearing structures was used for theoretical derivations.And the 3D tomography of the transient electromagnetic method(TEM) was used to develop an equivalent conductance method.Based on the improvement of a single prediction technique,we developed a technical system for reliable prediction of geological defective features by analyzing the advantages and disadvantages of all prediction methods.The procedure of the application of this system was introduced in detail.For prediction,the selection of prediction methods is an important and challenging work.The analytic hierarchy process(AHP) was developed for prediction optimization.We applied the newly developed prediction system to several important projects in China,including Hurongxi highway,Jinping II hydropower station,and Kiaochow Bay subsea tunnel.The case studies show that the geological defective features can be successfully detected with good precision and efficiency,and the prediction system is proved to be an effective means to minimize the risks of geological hazards during tunnel construction. | Shucai Li Shuchen Li Qingsong Zhang Yiguo Xue Bin Liu Maoxin Su Zhechao Wang Shugang Wang | 2010 | Journal of Rock Mechanics and Geotechnical Engineering2010，2，3： | 25 |
| 4 | Changing patterns and survival improvements of young breast cancer in China and SEER database, 1999-2017显示文摘Objective: Breast cancer in young females was usually considered more aggressive and requires aggressive therapy. We investigated whether early detection and improved treatments changed the patterns of characteristics,management and outcomes of young breast cancer patients over time.Methods: Females under 40 years of age diagnosed with breast cancer during the periods 1999-2017 and1999-2015 were identified in the Fudan University Shanghai Cancer Center(FUSCC) and the population-based Surveillance, Epidemiology, and End Results(SEER) registry, respectively. Clinicopathologic characteristics and treatment information were collected. Patients diagnosed before 2013 were followed up.Results: The proportions of young breast cancer patients were 15.0% and 5.3% in the FUSCC and SEER cohorts, respectively. In the FUSCC cohort, there was a significant increase in the proportion of ductal carcinoma in situ(DCIS)(from 8.8% to 16.9%;P<0.0001) and it remained stable in SEER cohort. The proportion of T1-stage tumors increased dramatically in the FUSCC cohort(from 35.3% to 41.9%;P=0.008), whereas it decreased in SEER cohort(from 42.4% to 33.0%;P<0.0001). The percentage of estrogen receptor(ER)-positive cancers was consistently increased in both the invasive ductal carcinoma(IDC) and DCIS patients in the two cohorts. Breastconserving surgery and immediate implant reconstruction after mastectomy both exhibited increased use over time in the FUSCC cohort. Both the FUSCC and SEER cohorts showed a significantly better prognosis in the recent time period.Conclusions: With the increased early-stage and ER-positive diseases in young patients as well as better systemic treatment strategies, improved survival has been observed in recent years. There has been a substantial deescalation in surgical therapies in young breast cancer patients. | Rong Guo Jing Si Jingyan Xue Yonghui Su Miao Mo Benlong Yang Qi Zhang Weiru Chi Yayun Chi Jiong Wu | 2019 | Chinese Journal of Cancer Research2019，31，4： | 24 |
| 5 | Chemical characteristics and source apportionment of PM_(2.5) between heavily polluted days and other days in Zhengzhou, China显示文摘PM_(2.5) samples were collected in Zhengzhou during 3 years of observation, and chemical characteristics and source contribution were analyzed. Approximately 96% of the daily PM_(2.5) concentrations and annual average values exceeded the Chinese National Ambient Air Quality Daily and Annual Standards, indicating serious PM_(2.5) pollution. The average concentration of water-soluble inorganic ions was 2.4 times higher in heavily polluted days(daily PM32.5 concentrations > 250 μg/mand visibility < 3 km) than that in other days, with sulfate, nitrate, and ammonium as major ions. According to the ratio of NO-3/SO2-4,stationary sources are still the dominant source of PM_(2.5) and vehicle emission could not be ignored. The ratio of secondary organic carbon to organic carbon indicated that photochemical reactivity in heavily polluted days was more intense than in other days.Crustal elements were the most abundant elements, accounting for more than 60% of 23 elements. Chemical Mass Balance results indicated that the contributions of major sources(i.e., nitrate, sulfate, biomass, carbon and refractory material, coal combustion, soil dust,vehicle, and industry) of PM_(2.5) were 13%, 16%, 12%, 2%, 14%, 8%, 7%, and 8% in heavily polluted days and 20%, 18%, 9%, 2%, 27%, 14%, 15%, and 9% in other days, respectively.Extensive combustion activities were the main sources of polycyclic aromatic hydrocarbons during the episode(Jan 1-9, 2015) and the total benzo[a]pyrene equivalency concentrations in heavily polluted days present significant health threat. Because of the effect of regional transport, the pollution level of PM_(2.5) in the study area was aggravated. | Nan Jiang Qiang Li Fangcheng Su Qun Wang Xue Yu Panru Kang Ruiqin Zhang Xiaoyan Tang | 2018 | Journal of Environmental Sciences2018，30，4： | 22 |
| 6 | Impacts of Forest Gaps on Soil Properties After a Severe Ice Storm in a Cunninghamia lanceolata Stand显示文摘During January–February 2008, a severe ice storm caused significant damages to forests in southern China, creating canopy gaps and changing soil nutrient availability and enzyme activity. To understand the relationships between gap size, changes in the soil environment and the effects that these changes have on soil processes, we investigated the effects of gap size on soil chemical and biological properties in the forest gaps in a Cunninghamia lanceolata stand in northern Guangdong Province, southern China. Ten naturally created gaps, five large(80–100 m^2) and five small(30–40 m^2), were selected in the stand of C.lanceolata. The large gaps showed a significant increase in light transmission ratio and air and soil temperatures and a decline in soil moisture, organic matter,N and P compared with the small gaps and the adjacent canopy-covered plots in the 0–10 cm soil. The differences in organic matter and nutrient levels found between the large and small gaps and the canopy-covered plots may be related to changes in environmental conditions. This indicated rapid litter decomposition and increased nutrient leaching in the large gaps. Moreover, the lowest levels of catalase, acid phosphatase and urease activities occurred in large gaps because of the decline in their soil fertility. Large forest gaps may have a region of poor fertility, reducing soil nutrient availability and enzyme activity within the C.lanceolata stand. | XU Jianxin XUE Li SU Zhiyao | 2016 | Pedosphere2016，26，3： | 19 |
| 7 | Particle size characterization by ultrasonic attenuation spectra显示文摘This paper contributes to extracting information from signals of broadband ultrasonic attenuation spectrum for effective utilization in particle size characterization. The single particle scattering model and the coupled-phase model are formulated simultaneously, the relationship between particle size distribution and ultrasonic spectrum is established, and a convergence criterion for calculation is quantified. Demonstration inversion by the optimum regularization factor method is carried out to yield typical numerical results for discussion. With the experimental set-up developed by the Institute of Particle and Two-Phase Flow Measurement (IPTFM) at the University of Shanghai for Science and Technology, sand sediment particle size is measured by attenuation spectrum and analyzed using the above inversion algorithm and theoretical models. To validate the proposed ultrasonic spectrum particle sizing method, results are compared with those obtained by microscopy. | Mingxu Su, Minghua Xue, Xiaoshu Cai, Zhitao Shang, Feng Xu Institute of Particle and Two-Phase Flow Measurement, University of Shanghai for Science and Technology, Shanghai 200093, China | 2008 | Particuology2008，6，4： | 15 |
| 8 | Super absorbent polymer seed coatings promote seed germinationand seedling growth of Caragana korshinskii in drought显示文摘Coating seeds with water absorbent materials can improve their survival, especially for those planted indrought or barren areas. In this study, effects of five kinds of super absorbent polymers (SAPs) on seed germinationand seedling growth of Caragana korshinskii under drought conditions were investigated. Our results showed that SAPcoatings could significantly improve the percentage and energy of seed germination, as well as reduce the relativeelectrical conductivity (REC), proline, malondialdehyde (MDA), H202 content, and peroxidase (POD) activity duringgermination. These results implied that seeds could uptake moisture from SAP coatings to alleviate drought-inducedoxidative stress and membrane damage, thus exhibiting a better vigor and germination performance. After coating C.korshinskii seeds with SAPs, more seedlings emerged and grew better. Under the combined influence of the waterabsorption capacity of SAP and other factors, the efficiencies of five SAP coatings are in the sequence D〉E〉B〉A〉C.The function of the SAP coating on promoting seedling survival was confirmed in Mu Us Sandy Land in Ordos, InnerMongolia Autonomous Region, China. The average seedling number of SAP D-coated seeds increased twofold on thatof naked seeds. Our results are expected to be helpful in understanding and utilizing SAP seed coatings in improvingplant survival under drought conditions. | Li-qiang SU Jia-guo LI Hua XUE Xiao-feng WANG | 2017 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2017，18，8： | 15 |
| 9 | Expression of interleukin 1β converting enzyme in 5-FU induced apoptosis in esophageal carcinoma cells显示文摘NTRODUCTIONApoptosisisanimportantphysiologicalformofceldeath.Itisstrictlycontroledbygenes.Ithasbeenshowninexperimentsthatexte... | DENG Li Ying 1, ZHANG Yun Han 2, XU Ping 2, YANG Su Min 1 and YUAN Xue Bin 1 | 1999 | World Journal of Gastroenterology1999，5，1： | 13 |
| 10 | A Matched Comparison Study of Uniportal Versus Triportal Thoracoscopic Lobectomy and Sublobectomy for Early-stage Nonsmall Cell Lung Cancer显示文摘 | Ju-Wei Mu Shu-Geng Gao Qi Xue Jun Zhao Ning Li Kun Yang Kai Su Zhu-Yang Yuan Jie He | 2015 | Chinese Medical Journal2015，，20： | 12 |
| 11 | Characteristics of the lunar samples returned by the Chang'E-5 mission显示文摘Forty-five years after the Apollo and Luna missions returned lunar samples,China's Chang’E-5(CE-5)mission collected new samples from the mid-latitude region in the northeastern Oceanus Procellarum of the Moon.Our study shows that 95%of CE-5 lunar soil sizes are found to be within the range of 1.40-9.35μm,while 95%of the soils by mass are within the size range of 4.84-432.27μm.The bulk density,true density and specific surface area of CE-5 soils are 1.2387 g/cm^(3),3.1952 g/cm^(3) and 0.56 m^(2)/g,respectively.Fragments from the CE-5 regolith are classified into igneous clasts(mostly basalt),agglutinate and glass.A few breccias were also found.The minerals and compositions of CE-5 soils are consistent with mare basalts and can be classified as low-Ti/low-Al/low-K type with lower rare-earth-element contents than materials rich in potassium,rare earth element and phosphorus.CE-5 soils have high FeO and low Mg index,which could represent a new class of basalt. | Chunlai Li Hao Hu Meng-Fei Yang Zhao-Yu Pei Qin Zhou Xin Ren Bin Liu Dawei Liu Xingguo Zeng Guangliang Zhang Hongbo Zhang Jianjun Liu Qiong Wang Xiangjin Deng Caijin Xiao Yonggang Yao Dingshuai Xue Wei Zuo Yan Su Weibin Wen Ziyuan Ouyang | 2022 | National Science Review2022，9，2： | 12 |
| 12 | Two Northward Jumps of the Summertime Western Pacific Subtropical High and Their Associations with the Tropical SST Anomalies显示文摘Based on the pentad mean ridgeline index of the western Pacific subtropical high (WPSH), the authors identified the two northward jumps of the WPSH from 1979 to 2008 and revealed their associations with the tropical SST anomalies. The authors show that the northward jumps, especially the second jump, exhibited remarkable interannual variability. In addition, the authors find that the two northward jumps were mutually independent and were influenced by the SST anomalies in the different regions of the tropical Pacific. The first jump was positively correlated with the SST anomalies in the tropical central Pacific from the preceding winter to June. In contrast, the second jump was positively related to ENSO in the preceding winter, but this correlation tended to weaken with the decay of ENSO and disappeared in July. Instead, a positive correlation was found in the Indian Ocean. We therefore suggest that ENSO plays an indirect role in the second jump through the capacitor effect of the Indian Ocean. | SU Tong-Hua XUE Feng | 2011 | Atmospheric and Oceanic Science Letters2011，4，2： | 12 |
| 13 | Effects of endotoxin on expression of ras, p53 and bcl-2 oncoprotein in hepatocarcinogenesis induced by thioacetamide in rats显示文摘Efectsofendotoxinonexpressionofras,p53andbcl2oncoproteininhepatocarcinogenesisinducedbythioacetamideinratsYANGJinMing1,HAN... | YANG Jin Ming 1, HAN De Wu 1, LIANG Quan Chen 2, ZHAO Jia Li 2, HAO Su Yuan 1, MA Xue Hui 1 and ZHAO Yuan Chang 1 | 1997 | World Journal of Gastroenterology1997，3，4： | 11 |
| 14 | Neodymium Oxide Induces Cytotoxicity and Activates NF-κB and Caspase-3 in NR8383 Cells显示文摘我们调查了是否 Nd 2 在 cytotoxicity 的 O 3 处理结果和在老鼠 NR8383 牙槽的巨噬细胞的另外的内在的效果。MTT 试金估计的房间生存能力揭示了那 Nd 2 O 3 以一种剂量依赖者方式,然而并非以一种时间依赖者方式是有毒的。ELISA 分析显示了那暴露到 Nd 2 O 3 引起了房间损坏并且提高了煽动性的 chemokines 的合成和版本。西方的污点分析证明 caspase-3,原子 factor-B (NF-B ) 和它的禁止者 IB 的蛋白质表示层次响应 Nd 2 O 3 处理。NF-B 并且 caspase-3 发信号被激活,建议两条小径涉及 Nd 2 O 3 cytotoxicity。 | HUANG Li Hua YANG Huan SU Xin GAO Yan Rong XUE Hai Nan WANG Su Hua | 2017 | Biomedical and Environmental Sciences2017，30，1： | 11 |
| 15 | Dopamine D2 receptor antagonist sulpiride enhances dexamethasone responses in the treatment of drug- resistant and metastatic breast cancer显示文摘最近的证据证明多巴胺象 D2 一样受体(D2DR ) 对手例如 trifluoperazine 和 thioridazine,为癌症治疗和癌症的抑制是有效的像茎的房间(CSC ) 。在这研究,我们调查了 dexamethasone (DEX ) 和 sulpiride (SUL ) 的联合治疗的反癌症效果,一不正常抑制精神,对药抵抗、变形的乳癌并且进一步探索了内在的机制。SUL 的口头的管理(25, 100 mg ????? | Jian LI Qing-yu YAO Jun-sheng XUE Li-jie WANG Yin YUAN Xiu-yun TIAN Hong SU Si-yuan WANG Wen-jun CHEN Wei LU Tian-yan ZHOU | 2017 | Acta Pharmacologica Sinica2017，38，9： | 11 |
| 16 | Particle sizing in dense two-phase droplet systems by ultrasonic attenuation and velocity spectra显示文摘Size and size distribution of particles in particulate two-phase flow play an important role in a wide variety of industrial areas,while their measurement still remains a hard task till now.Ultrasonic wave as a mechanical vibration contains plenty of information about medium when it passes through.Thus the size distribution could be extracted from the measured ultrasonic attenuation and velocity spectra by means of well established models and data processing techniques.This paper contributes to the extraction of information of droplet size of a two-phase fat emulsion simultaneously from signals of broad-band ultrasonic attenuation and velocity spectra.According to the formulated single particle scattering model,the relationship between particle size distribution and ultrasonic spectrum is estab-lished.The sensitivities of ultrasonic spectra to the variation of particle size are illustrated.Distin-guishing features for attenuation and velocity spectra are summarized.Demonstration calculations of inversion by optimum regularization factor method are carried out to yield the typical numerical results for discussion.Based on the proposed inversion algorithm and theoretical model,a fat emulsion sam-ple with a volume fraction up to 20% is measured and analyzed.To validate the proposed ultrasonic spectrum particle sizing method,the results are compared to those obtained from optical measure-ment. | SU MingXu CAI XiaoShu XUE MingHua DONG LiLi XU Feng | 2009 | Science China(Technological Sciences)2009，52，6： | 11 |
| 17 | Preparation and cytocompatibility of polylactic acid/hydroxyapatite/graphene oxide nanocomposite fibrous membrane显示文摘A series of polylactic acid (PLA) based nanocomposite fibrous membranes,including neat PLA,PLA/hydroxyapatite (HA) and PLA/HA/graphene oxide (GO),were fabricated via electrospinning method.The morphology and composition were investigated by scanning electron microscopy (SEM),X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR) respectively.The thermal stability was determined by thermogravimetric analysis (TGA).To estimate the cytocompatibility of asprepared PLA/HA/GO fibrous membrane,MC3T3-E1 cells were cultured,and the corresponding cell adhesion and differentiation capability were investigated by fluorescence microscopy,SEM and MTT test.The electrospun ternary PLA/HA/GO membrane exhibited three-dimensional fibrous structure with relatively rough surface morphology,which made itself ideal for cell attachment and proliferation in bone tissue regeneration.The fluorescence microscopy,SEM and MTT test confirmed that the PLA/HA/GO nanocomposite fibrous membrane created a proper environment for the seeding and proliferation of MC3T3-E1 cells. | MA HaiBin SU WenXin TAI ZhiXin SUN DongFei YAN XingBin LIU Bin XUE QunJi | 2012 | Chinese Science Bulletin2012，57，23： | 11 |
| 18 | Variational characteristics of shear-wave splitting on the 2001 Shidian earthquakes in Yunnan, China显示文摘In 2001 three earthquakes occurred in Shidian in Yunnan Province, which were the MS=5.2 on April 10, the MS=5.9 on April 12 and the MS=5.3 on June 8. Based on the data from the station Baoshan of Yunnan Telemetry Digital Seismograph Network, the variational characteristics of shear-wave splitting on these series of strong earthquakes has been studied by using the systematic analysis method (SAM) of shear-wave splitting. The result shows the time delays of shear-wave splitting basically increase with earthquake activity intensifying. However the time delays abruptly decrease immediately before strong aftershocks. It accords with the stress relaxation before earthquakes, which was found recently in study on shear-wave splitting. The result suggests it is significant for reducing the harm degree of earthquakes to develop the stress-forecasting on earthquake in strong active tectonic zones and economic developed regions or big cities under the danger of strong earthquakes. | GAO Yuan(高原) LIANG Wei(梁维) DING Xiang(丁香) XUE Yan(薛艳) CAI Ming-jun(蔡明军) LIU Xi-qiang(刘希强) SU You-jin(苏有锦) PENG Li-guo(彭立国) | 2004 | Acta Seismologica Sinica(English Edition)2004，17，6： | 10 |
| 19 | A buried Neolithic paddy soil reveals loss of microbial functional diversity after modern rice cultivation显示文摘It has been documented that human activities are causing the rapid loss of taxonomic, phylogenetic, genetic and functional diversity in soils. However, it remains unclear how modern intensive rice cultivation impacts the soil microbiome and its functionality. Here we examined the microbial composition and function differences between a buried Neolithic paddy soil and an adjacent,currently-cultivated paddy soil using high throughput metagenomics technologies. Our results showed that the currently cultivated soil contained about 10-fold more microbial biomass than the buried one. Analyses based on both 16S rRNA genes and functional gene array showed that the currently cultivated soil had significantly higher phylogenetic diversity, but less functional diversity than the buried Neolithic one. The community structures were significantly different between modern and ancient soils,with functional structure shifting towards accelerated organic carbon(C) degradation and nitrogen(N) transformation in the modern soils. This study implies that, modern intensive rice cultivation has substantially altered soil microbial functional structure, leading to functional homogenization and the promotion of soil ecological functions related to the acceleration of nutrient cycling which is necessary for high crop yields. | Yong-Guan Zhu Jian-Qiang Su Zhihong Cao Kai Xue John Quensen Guang-Xia Guo Yun-Feng Yang Jizhong Zhou Hai-Yan Chu James M.Tiedje | 2016 | Science Bulletin2016，61，13： | 10 |
| 20 | An improved empirical wavelet transform method for rolling bearing fault diagnosis显示文摘Empirical wavelet transform(EWT)based on the scale space method has been widely used in rolling bearing fault diagnosis.However,using the scale space method to divide the frequency band,the redundant components can easily be separated,causing the band to rupture and making it difficult to extract rolling bearing fault characteristic frequency effectively.This paper develops a method for optimizing the frequency band region based on the frequency domain feature parameter set.The frequency domain feature parameter set includes two characteristic parameters:mean and variance.After adaptively dividing the frequency band by the scale space method,the mean and variance of each band are calculated.Sub-bands with mean and variance less than the main frequency band are combined with surrounding bands for subsequent analysis.An adaptive empirical wavelet filter on each frequency band is established to obtain the corresponding empirical mode.The margin factor sensitive to the shock pulse signal is introduced into the screening of empirical modes.The empirical mode with the largest margin factor is selected to envelope spectrum analysis.Simulation and experiment data show this method avoids over-segmentation and redundancy and can extract the fault characteristic frequency easier compared with only scale space methods. | HUANG HaiRun LI Ke SU WenSheng BAI JianYi XUE ZhiGang ZHOU Lang SU Lei PECHT Michael | 2020 | Science China(Technological Sciences)2020，63，11： | 10 |
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