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| 1 | Changing patterns and survival improvements of young breast cancer in China and SEER database, 1999-2017显示文摘Objective: Breast cancer in young females was usually considered more aggressive and requires aggressive therapy. We investigated whether early detection and improved treatments changed the patterns of characteristics,management and outcomes of young breast cancer patients over time.Methods: Females under 40 years of age diagnosed with breast cancer during the periods 1999-2017 and1999-2015 were identified in the Fudan University Shanghai Cancer Center(FUSCC) and the population-based Surveillance, Epidemiology, and End Results(SEER) registry, respectively. Clinicopathologic characteristics and treatment information were collected. Patients diagnosed before 2013 were followed up.Results: The proportions of young breast cancer patients were 15.0% and 5.3% in the FUSCC and SEER cohorts, respectively. In the FUSCC cohort, there was a significant increase in the proportion of ductal carcinoma in situ(DCIS)(from 8.8% to 16.9%;P<0.0001) and it remained stable in SEER cohort. The proportion of T1-stage tumors increased dramatically in the FUSCC cohort(from 35.3% to 41.9%;P=0.008), whereas it decreased in SEER cohort(from 42.4% to 33.0%;P<0.0001). The percentage of estrogen receptor(ER)-positive cancers was consistently increased in both the invasive ductal carcinoma(IDC) and DCIS patients in the two cohorts. Breastconserving surgery and immediate implant reconstruction after mastectomy both exhibited increased use over time in the FUSCC cohort. Both the FUSCC and SEER cohorts showed a significantly better prognosis in the recent time period.Conclusions: With the increased early-stage and ER-positive diseases in young patients as well as better systemic treatment strategies, improved survival has been observed in recent years. There has been a substantial deescalation in surgical therapies in young breast cancer patients. | Rong Guo Jing Si Jingyan Xue Yonghui Su Miao Mo Benlong Yang Qi Zhang Weiru Chi Yayun Chi Jiong Wu | 2019 | Chinese Journal of Cancer Research2019，31，4： | 24 |
| 2 | Sedimentology and Sequence Stratigraphy of Marine to Lacustrine Deltaic Deposits in a Craton Basin and Their Controlling Factors: Shan 2 Member–He 8 Member(Guadalupian–Lopingian, Permian), Southeast Ordos Basin, North China显示文摘The Shan 2 Member, Shan 1 Member and He 8 Member of the Mid–Late Permian Shanxi and lower Xiashihezi formations, in the southeastern Ordos Basin, together comprise ~150 m of deltaic deposits. This sequence records an overall evolution from deep marine environment to shallow lake associated with braided river, braided river delta and meandering river delta. Core description, well log interpretation, and stable isotope analysis, including carbon, oxygen and strontium, were conducted to understand the sedimentary evolution of Shan 2 to He 8 Member. The Shanxi Formation, which consists of the Shan 2 and Shan 1 members, is characterized by a tidal-influenced meandering river delta environment and a higher δ^(13)C value and ^(87)Sr?(^(86)Sr) ratio and a lower δ^(18)O value. The He 8 Member, the basal part of the Xiashihezi Formation, is featured by a braided river to braided river delta system and a lower δ^(13)C value, ^(87)Sr?(^(86)Sr) ratio, and a higher δ^(18)O value. Four third-order depositional sequences separated by five sequence boundaries are determined. Coarsening upward sequences of the Shan 2 Member–He 8 Member indicate a general regression trend, which can be correlated to global sea-level fall occurring during the Roadian–Wuchiapingian, as also evidenced by previous published zircon U–Pb results. The coal-bearing sequence(Shanxi Formation) to non-coal-bearing sequence(He 8 Member), as well as a decrease of ^(87)Sr?(^(86)Sr), suggest a trend from humid to arid climates. A combined effect of sea-level drop and a small uplift at the end of Shanxi Formation are proposed. | SHAN Xin YU Xinghe Peter CLIFT LI Yalong JIN Lina SU Dongxu DU Yonghui ZHOU Jinsong HAN Xiaoqin | 2018 | Acta Geologica Sinica(English Edition)2018，92，1： | 4 |
| 3 | Genetic architecture of maize yield traits dissected by QTL mapping and GWAS in maize显示文摘The study of yield traits can reveal the genetic architecture of grain yield for improving maize production.In this study, an association panel comprising 362 inbred lines and a recombinant inbred line population derived from X178 × 9782 were used to identify candidate genes for nine yield traits. High-priority overlap(HPO) genes, which are genes prioritized in a genome-wide association study(GWAS), were investigated using coexpression networks. The GWAS identified 51 environmentally stable SNPs in two environments and 36 pleiotropic SNPs, including three SNPs with both attributes. Seven hotspots containing 41 trait-associated SNPs were identified on six chromosomes by permutation. Pyramiding of superior alleles showed a highly positive effect on all traits, and the phenotypic values of ear diameter and ear weight consistently corresponded with the number of superior alleles in tropical and temperate germplasm. A total of 61 HPO genes were detected after trait-associated SNPs were combined with the coexpression networks. Linkage mapping identified 16 environmentally stable and 16 pleiotropic QTL.Seven SNPs that were located in QTL intervals were assigned as consensus SNPs for the yield traits.Among the candidate genes predicted by our study, some genes were confirmed to function in seed development. The gene Zm00001 d016656 encoding a serine/threonine protein kinase was associated with five different traits across multiple environments. Some genes were uniquely expressed in specific tissues and at certain stages of seed development. These findings will provide genetic information and resources for molecular breeding of maize grain yield. | Xiao Zhang Zhiyong Ren Bowen Luo Haixu Zhong Peng Ma Hongkai Zhang Hongmei Hu Yikai Wang Haiying Zhang Dan Liu Ling Wu Zhi Nie Yonghui Zhu Wenzhu He Suzhi Zhang Shunzong Su Yaou Shen Shibin Gao | 2022 | The Crop Journal2022，10，2： | 2 |
| 4 | Natural multimodal interaction in immersive flow visualization显示文摘In the immersive flow visualization based on virtual reality,how to meet the needs of complex professional flow visualization analysis by natural human–computer interaction is a pressing problem.In order to achieve the natural and efficient human–computer interaction,we analyze the interaction requirements of flow visualization and study the characteristics of four human–computer interaction channels:hand,head,eye and voice.We give out some multimodal interaction design suggestions and then propose three multimodal interaction methods:head&hand,head&hand&eye and head&hand&eye&voice.The freedom of gestures,the stability of the head,the convenience of eyes and the rapid retrieval of voices are used to improve the accuracy and efficiency of interaction.The interaction load is balanced by multimodal interaction to reduce fatigue.The evaluation shows that our multimodal interaction has higher accuracy,faster time efficiency and much lower fatigue than the traditional joystick interaction. | Chengyu Su Chao Yang Yonghui Chen Fupan Wang Fang Wang Yadong Wu Xiaorong Zhang | 2021 | Visual Informatics2021，5，4： | 1 |
| 5 | Dispersion of carbon nanotubes by carbazole-tailed amphiphilic imidazolium ionic liquids in aqueous solutions显示文摘 | Bin Dong Yijin Su Yonghui Liu Jie Yuan Jingkun Xu Liqiang Zheng | 2011 | Journal of Colloid And Interface Science2011，，1： | 1 |
| 6 | Selectivity for and destruction of Salmonella typhimurium via a membrane damage mechanism of a cell-penetrating peptide ppTG20 analogue 显示文摘 | LI Lirong SHI Yonghui SU Guanfang | 2012 | International Journal of Antimicrnbial Agents2012，40，4： | 1 |
| 7 | Geranylated or prenylated flavonoids from Cajanus volubilis显示文摘Five new flavonoid derivatives,cajavolubones A-E(1-5),along with six known analogues(6-11)were isolated from Cajanus volubilis,and their structures were elucidated by spectroscopic analysis and quantum chemical calculations.Cajavolubones A and B(1 and 2)were identified as two geranylated chalcones.Cajavolubone C(3)was a prenylated flavone,while cajavolubones D and E(4 and 5)were two prenylated isoflavanones.Compounds 3,8,9 and 11 displayed cytotoxicity against HCT-116 cancer cell line. | RAO Li SU Yu HE Qian YE Jia LIU Yu FAN Yue HU Feng ZHOU Zhen GAN Lishe ZHANG Yonghui ZHANG Chuanrui | 2023 | Chinese Journal of Natural Medicines2023，21，4： | 0 |
| 8 | A fast on-demand preparation of injectable self-healing nanocomposite hydrogels for efficient osteoinduction显示文摘Injectable hydrogels have been considered as promising materials for bone regeneration,but their osteoinduction and mechanical performance are yet to be improved.In this study,a novel biocompatible injectable and self-healing nano hybrid hydrogel was on-demand prepared via a fast(within 30 s)and easy gelation approach by reversible Schiff base formed between-CH=O of oxidized sodium alginate(OSA)and-NH2 of glycol chitosan(GCS)mixed with calcium phosphate nanoparticles(CaP NPs).Its raw materials can be ready in large quantities by a simple synthesis process.The mechanical strength,degradation and swelling behavior of the hydrogel can be readily controlled by simply controlling the molar ratio of-CH=O and-NH2.This hydrogel exhibits pH responsiveness,good degradability and biocompatibility.The hydrogel used as the matrix for mesenchymal stem cells can significantly induce the proliferation,differentiation and osteoinduction in vitro.These results showed this novel hydrogel is an ideal candidate for applications in bone tissue regeneration and drug delivery. | Panpan Pan Xiao Chen Huaran Xing Yonghui Deng Jingdi Chen Fahad AAlharthi Abdulaziz AAlghamdi Jiacan Su | 2021 | Chinese Chemical Letters2021，32，7： | 0 |
| 9 | A human antibody potently neutralizes RSV by targeting the conserved hydrophobic region of prefusion F显示文摘Respiratory syncytial virus(RSV) continues to pose serious threats to pediatric populations due to the lack of a vaccine and effective antiviral drugs. RSV fusion(F) glycoprotein mediates viral-host membrane fusion and is a key target for neutralizing antibodies. We generated 23 full-human monoclonal antibodies(hm Abs) against prefusion F protein(pre-F) from a healthy adult with natural RSV infection by single B cell cloning technique. A highly potent RSV-neutralizing hm Ab, named as 25-20, is selected, which targets a new site Φ-specific epitope. Site-directed mutagenesis and structural modelling analysis demonstrated that 25-20 mainly targets a highly conserved hydrophobic region located at the a4 helix and a1 helix of pre-F, indicating a site of vulnerability for drug and vaccine design. It is worth noting that 25-20 uses an unreported inferred germline(i GL) that binds very poorly to pre-F, thus high levels of somatic mutations are needed to gain high binding affinity with pre-F. Our observation helps to understand the evolution of RSV antibody during natural infection. Furthermore, by in silico prediction and experimental verification, we optimized 25-20 with KD values as low as picomolar range. Therefore, the optimized 25-20 represents an excellent candidate for passive protection against RSV infection. | Chunyan Yi Caixia Su Xiaoyu Sun Xiao Lu Chuanya Si Caixuan Liu Zhuo Yang Hong Yuan Yuying Huang Jing Wen Yonghui He Yaguang Zhang Liyan Ma Yao Cong Gan Zhao Zhiyang Ling Bin Wang Bing Sun | 2023 | Science China(Life Sciences)2023，66，4： | 0 |
| 10 | 6-31 Progress of Cryogenic System in 2014显示文摘During the year of 2014, the work of cryogenic group was mainly focused on operation of refrigerator system,test of TCM1, design and machining of HCM6. At the end of 2014 refrigerator system has achieved closed-loopoperation and recycle of helium gas, which did great contribution to superconducting cavity and superconductingmagnet test. Since the refrigerator was put into use(Fig. 1), it has operated continuously and reliably for more than5 110 h, reached helium lique ed capacity 270 L/h at 850 W. | Zhang Junhui Guo Xiaohong Jin Tao Zhao Yugang Niu Xiaofei Wan Yuqin Su Hailin Han Yanning Yang Yonghui Bai Feng Jiang Ziyun Hu Chuanfei Zhang Peng Guo Wanhong Yin Yukui Liu Zuohui Hu Yongping Wang Xianjin | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 11 | Exploring the impact of Nafion modifier on electrocatalytic CO_(2) reduction over Cu catalyst显示文摘Nafion as a universal polymer ionomer was widely applied for nanocatalysts electrode preparation.However,the effect of Nafion on electrocatalytic performance was often overlooked,especially for CO_(2)electrolysis.Herein,the key roles of Nafion for CO_(2)RR were systematically studied on Cu nanoparticles(NPs)electrocatalyst.We found that Nafion modifier not only inhibit hydrogen evolution reaction(HER)by decreasing the accessibility of H_(2)O from electrolyte to Cu NPs,and increase the CO_(2)concentration at electrocatalyst interface for enhancing the CO_(2)mass transfer process,but also activate CO_(2)molecule by Lewis acid-base interaction between Nafion and CO_(2)to accelerate the formation of^(*)CO,which favor of C–C coupling for boosting C_(2)product generation.Owing to these features,the HER selectivity was suppressed from 40.6%to 16.8%on optimal Cu@Nafion electrode at-1.2 V versus reversible hydrogen electrode(RHE),and as high as 73.5%faradaic efficiencies(FEs)of C_(2)products were achieved at the same applied potential,which was 2.6 times higher than that on bare Cu electrode(~28.3%).In addition,Nafion also contributed to the long-term stability by hinder Cu NPs morphology reconstruction.Thus,this work provides insights into the impact of Nafion on electrocatalytic CO_(2)RR performance. | Yingshi Su Yonghui Cheng Zhen Li Yanjia Cui Caili Yang Ziyi Zhong Yibing Song Gongwei Wang Lin Zhuang | 2024 | Journal of Energy Chemistry2024，88，1： | 0 |
| 12 | Physico-chemical structure evolution characteristics of coal char during gasification in the presence of iron-based waste catalyst显示文摘The present study aims to explore the physico-chemical structure evolution characteristic during Yangchangwan bituminous coal(YCW)gasification in the presence of iron-based waste catalyst(IWC).The catalytic gasification reactivity of YCW was measured by thermogravimetric analyzer.Scanning electron microscope–energy dispersive system,nitrogen adsorption analyzer and laser Raman spectroscopy were employed to analyze the char physico-chemical properties.The results show that the optimal IWC loading ratio was 5 wt%at 1000°C.The distribution of IWC on char was uneven and Fe catalyst concentrated on the surface of some chars.The specific surface area of YCW gasified semi-char decreased significantly with the increase of gasification time.i.e.,the specific surface area reduced from 382 m2/g(0 min)to 192 m2/g(3 min),meanwhile,the number of micropores and mesopores decreased sharply at the late gasification stage.The carbon microcrystalline structure of YCW gasified semi-char was gradually destroyed with the increase of gasification time,and the microcrystalline structure with small size was gradually generated,resulting in the decreasing order degree of carbon microcrystalline structure.IWC can catalyze YCW gasification which could provide theoretical guidance for industrial solid waste recycling. | Xinsha Zhang Xudong Song Jiaofei Wang Weiguang Su Bing Zhou Yonghui Bai Guangsuo Yu | 2020 | International Journal of Coal Science & Technology2020，7，3： | 0 |
| 13 | High-speed electro-optic modulation in topological interface states of a one-dimensional lattice显示文摘lectro-optic modulators are key components in data communication,microwave photonics,and quantum photonics.Modulation bandwidth,energy efficiency,and device dimension are crucial metrics of modulators.Here,we provide an important direction for the miniaturization of electro-optic modulators by reporting on ultracompact topological modulators.A topological interface state in a one-dimensional lattice is implemented on a thin-film lithium-niobate integrated platform.Due to the strong optical confinement of the interface state and the peaking enhancement of the electro-optic response,a topological cavity with a size of 1.6×140μm^(2)enables a large modulation bandwidth of 104 GHz.The first topological modulator exhibits the most compact device size compared to reported LN modulators with bandwidths above 28 GHz,to the best of our knowledge.100 Gb/s non-return-to-zero and 100 Gb/s four-level pulse amplitude modulation signals are generated.The switching energy is 5.4 fJ/bit,owing to the small electro-optic mode volume and low capacitance.The topological modulator accelerates the response time of topological photonic devices from the microsecond order to the picosecond order and provides an essential foundation for the implementation of large-scale lithium-niobate photonic integrated circuits. | Yong Zhang Jian Shen Jingchi Li Hongwei Wang Chenglong Feng Lei Zhang Lu Sun Jian Xu Ming Liu Ying Wang Yonghui Tian Jianwen Dong Yikai Su | 2023 | Light(Science & Applications)2023，12，9： | 0 |
| 14 | Cooperation between China and Iran in addiction medicine: opportunities, challenges and strategies显示文摘INTRODUCTION Addiction is a major global risk factor for disability and premature death'and has become a public health and social problem worldwide.Despite substantial investments from governments and research institutionsglobally,current addictionmedicine research remains centred in Western countries.However,theories,models and results from western-centric research may not be applicable to different cultures.Non-Western countries such as China and Iran,and Western countries are committed to establishing addiction prevention and treatment tailored to their unique histories and cultures.To foster a global addiction science,it is important to increase the diversity of evidence without preconceived biases. | Gangliang Zhong Hang Su Di Zhao Ji Hu Xing Liu Yonghui Li Saeed Semnanian Abbas Haghparast Ti-Fei Yuan Jiang Du | 2023 | General Psychiatry2023，36，6： | 0 |
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