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| 1 | A post-GWAS confirming the genetic effects and functional polymorphisms of AGPAT3 gene on milk fatty acids in dairy cattle显示文摘Background: People are paying more attention to the healthy and balanced diet with the improvement of their living standards. Milk fatty acids(FAs) have been reported that they were related to some atherosclerosis and coronary heart diseases in human. In our previous genome-wide association study(GWAS) on milk FAs in dairy cattle, 83 genomewide significant single nucleotide polymorphisms(SNPs) were detected. Among them, two SNPs, ARS-BFGL-NGS-109493 and BTA-56389-no-rs associated with C18 index(P = 0.0459), were located in the upstream of 1-acylglycerol-3-phosphate O-acyltransferase 3(AGPAT3) gene. AGPAT3 is involved in glycerol-lipid, glycerol-phospholipid metabolism and phospholipase D signaling pathways. Hence, it was inferred as a candidate gene for milk FAs. The aim of this study was to further confirm the genetic effects of the AGPAT3 gene on milk FA traits in dairy cattle.Results: Through re-sequencing the complete coding region, and 3000 bp of 5′ and 3′ regulatory regions of the AGPA T3 gene, a total of 17 SNPs were identified, including four in 5′ regulatory region, one in 5′ untranslated region(UTR),three in introns, one in 3′ UTR, and eight in 3′ regulatory region. By the linkage disequilibrium(LD) analysis with Haploview4.1 software, two haplotype blocks were observed that were formed by four and 12 identified SNPs,respectively. Using SAS9.2, we performed single locus-based and haplotype-based association analysis on 24 milk FAs in 1065 Chinese Holstein cows, and discovered that all the SNPs and the haplotype blocks were significantly associated with C6:0, C8:0 and C10:0(P < 0.0001–0.0384). Further, with Genomatix, we predicted that four SNPs in 5′ regulatory region(g.146702957 G > A, g.146704373 A > G, g.146704618 A > G and g.146704699 G > A) changed the transcription factor binding sites(TFBSs) for transcription factors SMARCA3, REX1, VMYB, BRACH, NKX26, ZBED4, SP1, USF1, ARNT and FOXA1. Out of them, two SNPs were validated to impact transcriptional activity by performing luciferase assay that the alleles A of both SNPs, g.146704373 A > G and g.146704618 A > G, increased the transcriptional activities of AGPAT3 promoter compared with alleles G(P = 0.0004).Conclusions: In conclusion, our findings first demonstrated the significant genetic associations of the AGPAT3 gene with milk FAs in dairy cattle, and two potential causal mutations were detected. | Lijun Shi Xin Wu Yuze Yang Zhu Ma Xiaoqing Lv Lin Liu Yanhua Li Feng Zhao Bo Han Dongxiao Sun | 2021 | Journal of Animal Science and Biotechnology2021，12，1： | 3 |
| 2 | Ultrafast polarization-dependent all-optical switching of germanium-based metaphotonic devices显示文摘Metamaterials play an important role in the modulation of amplitude and group delay in the terahertz(THz)regime on account of their optical properties,which are rare in natural materials.Here an ultrafast anisotropic switch of the plasmon-induced transparency(PIT)effect is experimentally and numerically demonstrated by metamaterial devices composed of two pairs of planar split-ring resonators and a pair of closed-ring resonators.By integration with a germanium(Ge)film,a recovery time of 3 ps and a decay constant of 785 fs are realized in the metadevice.Stimulated by the exterior optical pump,the PIT windows at different frequencies are switched off with an excellent property of slow light for vertical and horizontal THz polarizations,realizing an astonishing modulation depth as high as 99.06%.This work provides a new platform for ultrafast anisotropic metadevices tunable for amplitude and group delay. | HAO SUN YUZE HU YUHUA TANG JIE YOU JUNHU ZHOU HENGZHU LIU XIN ZHENG | 2020 | Photonics Research2020，8，3： | 3 |
| 3 | Fast inverse covariance matrix computation based on element-order recursive method for space-time adaptive processing显示文摘Because of large computational complexity in the inverse space-time covariance matrix computation,the conventional space-time adaptive processing(STAP) is unsuitable for practical implementation. According to the block Hermitian matrix property of covariance matrix, a new element-order recursive method is proposed in this paper to calculate the inverse space-time covariance matrix for STAP weight vector. In the proposed method, the inverse space-time covariance matrix of first element-order is initially calculated recursively based on block Hermitian matrix property, and then the inverse space-time covariance matrix of high element-order is correspondingly deduced recursively based on obtained inverse covariance matrix of previous element-order.Finally, STAP weight vector is calculated based on the final inverse covariance matrix. Afterwards, a modified reduced-dimension STAP method is derived by combining the proposed method with the m-Doppler Transformation(m DT-SAP) STAP approach. Based on the simulated and the actual airborne phased array radar data, the proposed method verified that the computational complexity is much smaller than conventional STAP methods. The proposed element-order recursive method for STAP is applicable for practical airborne phased radar system. | YANG XiaoPeng SUN YuZe LIU YongXu ZENG Tao LONG Teng | 2015 | Science China(Information Sciences)2015，58，2： | 2 |
| 4 | University rank and bachelor’s labour market positions in China显示文摘 | Joop Hartog Yuze Sun Xiaohao Ding | 2010 | Economics of Education Review2010，，6： | 1 |
| 5 | Improved eigenanalysis canceler based on data-independent clutter subspace estimation for space-time adaptive processing显示文摘The eigenanalysis canceler(EC)method which is suitable for nonhomogeneous clutter can suppress clutter efectively by discarding the eigenvectors of small eigenvalues,which is a well-known subspace-based space-time adaptive processing(STAP)method.However,the computational complexity of conventional EC STAP method is huge due to the eigenvalue decomposition.Moreover,the corresponding performance would be degraded signifcantly by the subspace leakage phenomenon,since the clutter subspace is not strictly confned to a low-rank subspace any more.Therefore,an improved EC STAP method based on the data-independent clutter subspace estimation is proposed to reduce the computational complexity,where the clutter subspace is rapidly constructed by sampling the prolate spheroidal wave functions(PSWF)non-uniformly.In order to deal with the subspace leakage phenomenon,the proposed EC-PSWF STAP method is modifed based on the covariance matrix taper(CMT)to obtain the covariance matrix by re-establishing the noise floor.The corresponding performance of proposed method is evaluated by using the numerical simulation. | LONG Teng LIU YongXu YANG XiaoPeng SUN YuZe | 2013 | Science China(Information Sciences)2013，56，10： | 1 |
| 6 | Sensitive optical biosensors for unlabeled targets: A review显示文摘 | Xudong Fan Ian M. White Siyka I. Shopova Hongying Zhu Jonathan D. Suter Yuze Sun | 2008 | Analytica Chimica Acta2008，，1： | 1 |
| 7 | Obesity paradox: Clinical benefits not observed in obese patients with ST-segment elevation myocardial infarction: A multicenter, prospective, cohort study of the northern region of China显示文摘 | Yuze Li Chunwei Wu Yujiao Sun Daming Jiang Bo Zhang Lina Ren Yuan Gao Haijie Yu Guang Yang Qigang Guan Wen Tian Haishan Zhang Liang Guo Guoxian Qi | 2013 | International Journal of Cardiology2013，，： | 1 |
| 8 | RANS simulations on combustion and emission characteristics of a premixed NH_(3)/H_(2) swirling flame with reduced chemical kinetic model显示文摘Ammonia(NH_(3))is considered as a potential alternative carbon free fuel to reduce greenhouse gas emission to meet the increasingly stringent emission requirements.Co-burning NH_(3) and H_(2) is an effective way to overcome ammonia’s relative low burning velocity.In this work,3D Reynolds Averaged Navier-Stokes(RANS)numerical simulations are conducted on a premixed NH_(3)/H_(2) swirling flame with reduced chemical kinetic mechanism.The effects of(A)overall equivalence ratio Φ and(B)hydrogen blended molar fraction XH2 on combustion and emission characteristics are examined.The present results show that when 100%NH_(3)-0%H_(2)-air are burnt,the NO emission and unburned NH3 of at the swirling combustor outlet has the opposite varying trends.With the increase of Φ,NO emission is found to be decreased,while the unburnt ammonia emission is increased.NH_(2)→HNO,NH→HNO and HNO→NO sub-paths are found to play a critical role in NO formation.Normalized reaction rate of all these three sub-paths is shown to be decreased with increased Φ.Hydrogen addition is shown to significantly increase the laminar burning velocity of the mixed fuel.However,adding H_(2) does not affect the critical equivalence ratio corresponding to the maximum burning velocity.The emission trend of NO and unburnt NH_(3) with increased Φ is unchanged by blending H_(2).NO emission with increased X_(H2) is increased slightly less at a larger Φ than that at a smaller Φ.In addition,reaction rates of NH_(2)→HNO and HNO→NO sub-paths are decreased with increased X_(H2),when Φ is larger.Under all tested cases,blending H_(2) with NH_(3) reduces the unburned NH_(3) emission,especially for rich combustion conditions.In summary,the present work provides research finding on supporting applying ammonia with hydrogen blended in low-emission gas turbine engines. | Yuze SUN Tao CAI Mohammad SHAHSAVARI Dakun SUN Xiaofeng SUN Dan ZHAO Bing WANG | 2021 | Chinese Journal of Aeronautics2021，34，12： | 1 |
| 9 | Aging Behavior and Creep Characteristics of CACB显示文摘Cement asphalt composite binder(CACB)is a type of composite binder composed of cement,asphalt,water,and various additives through curing,whose creep properties are influenced by asphalt aging.By CACB creep tests at various aging times,the creep compliance curves of the material were obtained.Curves of the test results were fitted by the creep compliance of Burgers model revised by fractional derivative,and the effects of asphalt aging and mix proportions on the CACB creep properties were analyzed.This study demonstrates that as aging time increased,the ability of the CACB to resist instant elastic deformation and viscous flow deformation was enhanced,the amount of its elastic components increased but the viscous components were reduced,and the material deformability decreased,exhibiting deforming properties similar to elastic materials.The effects of asphalt aging on the CACB viscoelastic mechanical properties were great during the initial aging stage(within 12 h)and became weaker during the later aging stage(over 12 h).During the initial aging stage,the CACB creep deformability could be enhanced by increasing asphalt application.However,during the later aging stage,asphalt application had little effect on creep deformability. | Yunliang Li Yuze Liu Lei Xu Xin He Haijiao Sun | 2020 | Journal of Harbin Institute of Technology(New Series)2020，27，2： | 0 |
| 10 | Robust and fast iterative sparse recovery method for space-time adaptive processing显示文摘Conventional space-time adaptive processing(STAP) requires large numbers of independent and identically distributed(i.i.d) training samples to ensure the performance of clutter suppression, which is hard to be achieved in practical complex nonhomogeneous environment. In order to improve the performance of clutter suppression with small training sample support, a robust and fast iterative sparse recovery method for STAP is proposed in this paper. In the proposed method, the sparse recovery of clutter spatial-temporal spectrum and the calibration of space-time overcomplete dictionary are achieved iteratively. Firstly, the robust solution of sparse recovery is derived by regularized processing, which can be calculated recursively based on the block Hermitian matrix property, afterwards the mismatch of space-time overcomplete dictionary is calibrated by minimizing the cost function. The proposed method can not only alleviate the effect of noise and dictionary mismatch, but also reduce the computational cost caused by direct matrix inversion. Finally, the proposed method is verified based on the simulated and the actual airborne phased array radar data, which shows that the proposed method is suitable for practical complex nonhomogeneous environment and provides better performance compared with conventional STAP methods. | Xiaopeng YANG Yuze SUN Tao ZENG Teng LONG | 2016 | Science China(Information Sciences)2016，59，6： | 0 |
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