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| 1 | Apoptosis and non-alcoholic fatty liver diseases显示文摘The number of patients with nonalcoholic fatty liver diseases(NAFLD) including nonalcoholic steatohepatitis(NASH), has been increasing. NASH causes cirrhosis and hepatocellular carcinoma(HCC) and is one of the most serious health problems in the world. The mechanism through which NASH progresses is still largely unknown. Activation of caspases, Bcl-2 family proteins, and c-Jun N-terminal kinase-induced hepatocyte apoptosis plays a role in the activation of NAFLD/NASH. Apoptotic hepatocytes stimulate immune cells and hepatic stellate cells toward the progression of fibrosis in the liver through the production of inflammasomes and cytokines. Abnormalities in glucose and lipid metabolism as well as microbiota accelerate these processes. The production of reactive oxygen species, oxidative stress, and endoplasmic reticulum stress is also involved. Cell death, including apoptosis, seems very important in the progression of NAFLD and NASH. Recently, inhibitors of apoptosis have been developed as drugs for the treatment of NASH and may prevent cirrhosis and HCC. Increased hepatocyte apoptosis may distinguish NASH from NAFLD, and the improvement of apoptosis could play a role in controlling the development of NASH. In this review, the association between apoptosis and NAFLD/NASH are discussed. This review could provide their knowledge, which plays a role in seeing the patients with NAFLD/NASH in daily clinical practice. | Tatsuo Kanda Shunichi Matsuoka Motomi Yamazaki Toshikatsu Shibata Kazushige Nirei Hiroshi Takahashi Tomohiro Kaneko Mariko Fujisawa Teruhisa Higuchi Hitomi Nakamura Naoki Matsumoto Hiroaki Yamagami Masahiro Ogawa Hiroo Imazu Kazumichi Kuroda Mitsuhiko Moriyama | 2018 | World Journal of Gastroenterology2018，24，25： | 32 |
| 2 | Fusions between dendritic cells and whole tumor cells as anticancer vaccines显示文摘 | Shigeo Koido Sadamu Homma Masato Okamoto Yoshihisa Namiki Kazuki Takakura Kan Uchiyama Mikio Kajihara Seiji Arihiro Hiroo Imazu Hiroshi Arakawa Shin Kan Hideo Komita Masaki Ito Toshifumi Ohkusa Jianlin Gong Hisao Tajiri | 2013 | OncoImmunology2013，，： | 3 |
| 3 | A standardized injection technique and regimen ensures success and safety of N-butyl-2-cyanoacrylate injection for the treatment of gastric fundal varices (with videos)显示文摘 | Stefan Seewald Tiing Leong Ang Hiroo Imazu Mazen Naga Salem Omar Stefan Groth Uwe Seitz Yan Zhong Frank Thonke Nib Soehendra | 2008 | Gastrointestinal Endoscopy2008，，3： | 2 |
| 4 | Esophageal Capsule Endoscopy for Screening Esophageal Varices among Japanese Patients with Liver Cirrhosis显示文摘 | Haruya Ishiguro Shoichi Saito Hiroo Imazu Hiroyuki Aihara Tomohiro Kato Hisao Tajiri Cristiano Spada | 2011 | Gastroenterology Research and Practice2011，，： | 2 |
| 5 | Bcl-2/E1B 19 kDa- interacting protein 3-like protein (Bnip3L) interacts with bcl-2/Bcl-xL and induces apoptosis by altering mitochond- rial membrane permeability 显示文摘 | Imazu T Shimizu S Tagami S | 1999 | Oncogene1999，18，32： | 1 |
| 6 | Hyperinsulina mia for the development of hypertension : data from the Hawaii - Los Angeles-Hiroshima Study显示文摘 | Imazu M Yamamoto H Toyofuku M | 2001 | Hypertens Res2001，24，： | 1 |
| 7 | Tissue inhibitor of metalloproteinases-1 attenuates spontaneous liver fibrosis resolution in the transgenic mouse显示文摘 | Hitoshi Yoshiji Shigeki Kuriyama Junichi Yoshii Yasuhide Ikenaka Ryuichi Noguchi Toshiya Nakatani Hirohisa Tsujinoue Koji Yanase Tadashi Namisaki Hiroo Imazu Hiroshi Fukui | 2002 | Hepatology2002，，4： | 1 |
| 8 | Influence of type 2 diabetes mellitus on cardiovascular disease mortality: findings from the Hawaii-Los Angeles, Hiroshimta Study 显示文摘 | Imazu M Sumii K Yamamoto H | 2002 | Diabetes Res Clin Pract2002，57，1： | 1 |
| 9 | Diagnostic approach using endosonography guided fine needle aspiration for lymphadenopathy in primary sclerosing cholangitis显示文摘We report a case of primary sclerosing cholangitis (PSC) with benign lyphadenopathy which was diagnosed with endosonography guided fine needle aspiration (EUS-FNA). A 65-year-old woman was admitted to Jikei University Hospital with severe jaundice. Although endoscopic retrograde cholangiography and liver biopsy revealed the findings consistent with PSC, abdominal computed tomography revealed numerous large perihepatic lymph nodes with a maximum diameter of more than 3 cm. Therefore, EUS-FNA was done in order to exclude malignant lymphadenopathy, and adequate specimens obtained by EUS-FNA showed reactive hyperplasia of lymphnode. The patients were scheduled to undergo liver transplantation. | Shintaro Tsukinaga Hiroo Imazu Yujiro Uchiyama Hiroshi Kakutani Akira Kuramoti Masayuki Kato Keisuke Kanazawa Tsuyoshi Kobayashi Yasuyuki Searashi Hisao Tajiri | 2007 | World Journal of Gastroenterology2007，13，27： | 1 |
| 10 | Modeling of integrated marine ecosystem including the generation-tracing type scallop growth model显示文摘 | Sato T Imazu Y Sakawa T | 2007 | Ecological Modelling2007，208，24： | 1 |
| 11 | New approach to diagnosing ampullary tumors by magnifying endoscopy combined with a narrow-band imaging system 显示文摘 | Uchiyama Y Imazu H Kakutani H | 2006 | J Gastroentero12006，41，5： | 1 |
| 12 | Immunohistochemical analysis of hepatocyte growth factor in human coronary atherectomy specimens:comparison with trandorming growth factor beta isoforms显示文摘 | Ueda H Imazu M Hayashi Y | 1997 | Virchows Arch1997，430，5： | 1 |
| 13 | Hypertension and insulin disorders显示文摘 | Michinori Imazu MD | 2002 | Current Hypertension Reports2002，，6： | 1 |
| 14 | Pulse Wave Velocity Predicts Cardiovascular Mortality Findings From the Hawaii-LosAn-geles-Hiroshima Study显示文摘 | Tomoki Shokawa Minchinori Imazu | 2005 | Circ J2005，69，3： | 1 |
| 15 | Effect of dimethylformamide on hepatic microsomal monooxygenase system and glutathione metabolism in rats显示文摘 | Imazu K Fujishiro K Inoue N | 1992 | Toxicology1992，72，1： | 1 |
| 16 | Hypertension and irsorders显示文摘 | Imazu M | 2002 | Curr Hypetens Rep2002，4，6： | 1 |
| 17 | Angiotensin II stimulates endothelial NO synthase phosphorylation in thoracic aorta of mice with abdominal aortic banding via type 2 receptor 显示文摘 | Yayama K Hiyoshi H Imazu D | 2006 | Hypertension2006，48，5： | 1 |
| 18 | Hypertension and insulin disorders显示文摘 | Imazu M | 2002 | Curr Hypertens Rep2002，4，6： | 1 |
| 19 | Vascular en- dothelial growth factor and receptor interaction is a prereq-uisite for murine hepatic fibrogenesis 显示文摘 | Yoshiji H Kuriyama S Yoshii J Ikenaka Y Noguchi R Hicklin D J Wu Y Yanase K Namisaki T Yamazaki M Tsujinoue H Imazu H Masaki T Fukui H | 2003 | Gut2003，52，： | 1 |
| 20 | Study on factors controlling catalytic activity for low-temperature water-gas-shift reaction on Cu-based catalysts显示文摘 | Sagata K Imazu N Yahiro H | 2013 | Catalysis Today2013，201，： | 1 |
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