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| 1 | N-acetylcysteine attenuates alcohol-induced oxidative stess in rats显示文摘AIM: To investigate free-radical scavenger effect of nacetylcysteine in rats intragastrically fed with ethanol.METHODS: Twenty-four rats divided into three groups were fed with ethanol (6 g/kg/day, Group 1), ethanol and nacetylcysteine (1 g/kg, Group 2), or isocaloric dextrose (control group, Group 3) for 4 weeks. Then animals were sacrificed under ether anesthesia, and intracardiac blood and liver tissues were obtained. Measurements were made in both serum and homogenized liver tissues.Malondialdehyde (MDA) level was measured by TBARS method. Glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) levels were studied by commercial kits.Kruskal-Wallis test was used for statistical analysis.RESULTS: ALT and AST in Group 1 (154 U/L and 302 U/L,respectively) were higher than those in Group 2 (94 U/L and 155 U/L) and Group 3 (99 U/L and 168 U/L) (P=0.001for both). Serum and tissue levels of MDA in Group 1 (1.84nmol/mL and 96 nmol/100 mg-protein) were higher than that in Group 2 (0.91 nmol/mL and 64 nmol/100 mg protein)and Group 3 (0.94 nmol/mL and 49 nmol/100 mg-protein)(P<0.001 for both). On the other hand, serum GSH-Px level in Group 1 (8.21 U/g Hb) was lower than that in Group 2(16 U/g Hb) and Group 3 (16 U/g-Hb) (P<0.001). Serum and liver tissue levels of SOD in Group 1 (11 U/mL and 26U/100 mg-protein) were lower than that in Group 2 (18 U/mL and 60 U/100 mg protein) and Group 3 (20 U/mL and 60 U/100 mg-protein) (P<0.001 for both).CONCLUSION: Ethanol-induced liver damage was associated with oxidative stress, and co-administration of n-acetylcysteine attenuates this damage effectively in rat model. | Resat Ozaras Veysel Tahan Seval Aydin Hafize Uzun Safiye Kaya Hakan Senturk | 2003 | World Journal of Gastroenterology2003，9，4： | 9 |
| 2 | N-acetylcysteine attenuates alcohol-induced oxidative stress in the rat显示文摘AIM: There is increasing evidence that alcohol-induced liverdamage may be associated with increased oxidative stress.We aimed to investigate free-radical scavenger effect of n-acetylcysteine in rats intragastrically fed with ethanol.METHODS: Twenty-four rats divided into three groups werefed with ethanol (6 g/kg/day, Group 1), ethanol and n-acetylcysteine (1 g/kg, Group 2), or isocaloric dextrose(control group, Group 3) for 4 weeks. Then animals weresacrificed under ether anesthesia, intracardiac blood andliver tissues were obtained. Measurements were performedboth in serum and in homogenized liver tissues.Malondialdehyde (MDA) level was measured by TBARSmethod. Glutathione peroxidase (GSH-Px) and superoxidedismutase (SOD) levels were studied by commercial kits.Kruskal-Wallis test was used for statistical analysis.RESULTS: ALT and AST in Group 1 (154 U/Land 302 U/L,respectively) were higher than those in Group 2 (94 U/L and155 U/L) and Group 3 (99 U/L and 168 U/L) (P=0.001 forboth). Serum and tissue levels of MDA in Group 1 (1.84 nmol/mL and 96 nmol/100 mg-protein) were higher than Group 2(0.91 nmol/mL and 64 nmol/100 mg-protein) and Group 3(0.94 nmol/mL and 49 nmol/100 mg-protein) (P<0.001 forboth). On the other hand, serum GSH-Px level in Group 1(8.21 U/g-Hb) was lower than Group 2 (16 U/g-Hb) andGroup 3 (16 U/g-Hb) (P<0.001). Serum and liver tissue levelsof SOD in Group 1 (11 U/mL and 26 U/100 mg-protein)were lower than Group 2 (18 U/mL and 60 U/100 mg-protein)and Group 3 (20 U/mL and 60 U/100 mg-protein) (P<0.001for both).CONCLUSION: This study demonstrated that ethanol-induced liver damage is associated with oxidative stress,and co-administration of n-acetylcysteine attenuates thisdamage effectively in rat model. | Resat Ozaras Veysel Tahan Seval Aydin Hafize Uzun Safiye Kaya Hakan Senturk | 2003 | World Journal of Gastroenterology2003，9，1： | 7 |
| 3 | Effects of glutamine and curcumin on bacterial translocation in jaundiced rats显示文摘AIM: To investigate the effect of curcumin on bacterial translocation and oxidative damage in an obstructive jaundice model and compare the results to glutamine, an agent known to be effective and clinically used. METHODS: Twenty-four female Wistar-Albino rats, weighing 200-250 g, were randomly divided into three groups (8 in each group). After ligation of the common bile duct in all animals, GroupⅠ received oral normal saline, Group Ⅱ received oral glutamine and Group Ⅲ received oral curcumin for seven days. Blood samples via cardiac puncture, tissue samples (terminal ileum, liver and mesenteric lymph node) and peritoneal fluid were obtained from the animals at the time of death to investigate bacterial translocation and oxidative damage. RESULTS: We observed that both glutamine and curcumin reduced bacterial translocation in blood, hepatocellular damage, plasma cytokine levels, oxidative tissue damage and apoptosis significantly compared to the control group. Additionally, glutamine showed protective effects on ileal epithelium and reduced villus atrophy. CONCLUSION: On the basis of these findings, both curcumin and glutamine are thought to be effective in preventing or reducing bacterial translocation and oxidative damage in obstructive jaundice. | Oguzhan Karatepe Ersin Acet Muharrem Battal Gokhan Adas Ahu Kemik Merih Altiok Gulcin Kamali Safiye Koculu Atahan Catay Sedat Kamali Servet Karahan | 2010 | World Journal of Gastroenterology2010，16，34： | 5 |
| 4 | Quantitative trait loci associated with soybean seed weight and composition under different phosphorus levels显示文摘Seed size and composition are important traits in food crops and can be affected by nutrient availability in the soil. Phosphorus(P) is a non-renewable,essential macronutrient, and P deficiency limits soybean(Glycine max) yield and quality. To investigate the associations of seed traits in low-and high-P environments, soybean recombinant inbred lines(RILs) from a cross of cultivars Fiskeby III and Mandarin(Ottawa) were grown under contrasting P availability environments.Traits including individual seed weight, seed number, and intact mature pod weight were significantly affected by soil P levels and showed transgressive segregation among the RILs. Surprisingly, P treatments did not affect seed composition or weight, suggesting that soybeanmaintains sufficient P in seeds even in low-P soil.Quantitative trait loci(QTLs) were detected for seed weight, intact pods, seed volume, and seed protein,with five significant QTLs identified in low-P environments and one significant QTL found in the optimal-P environment. Broad-sense heritability estimates were0.78(individual seed weight), 0.90(seed protein), 0.34(seed oil), and 0.98(seed number). The QTLs identified under low P point to genetic regions that may be useful to improve soybean performance under limiting P conditions. | Gokhan Hacisalihoglu Amy L.Burton Jeffery L.Gustin Selim Eker Safiye Asikli Elif Hakli Heybet Levent Ozturk Ismail Cakmak Atilla Yazici Kent O.Burkey James Orf A.Mark Settles | 2018 | Journal of Integrative Plant Biology2018，60，3： | 2 |
| 5 | Potential effects of L-NAME on alcohol-induced oxidative stress显示文摘AIM: Nitric oxide (NO) is a highly reactive oxidant synthesized from L-arginine by nitric oxide synthase (NOS). NO may cause injury through the generation of potent radicals. Nwnitro-L-arginine methyl ester (L-NAME) is a non-selective inhibitor of NOS. We aimed to evaluate whether L-NAME treatment had protective effects against oxidative stress in rats intragastrically fed with ethanol during a 4 wk-period.METHODS: Thirty-six male Wistar rats were divided into 3 equal groups: group 1 (control group-isocaloric dextrose was given), group 2 (6 g/kg.d ethanol-induced group) and group 3 (both ethanol 6 g/kg.d and L-NAME 500 mg/L in drinking water-given group). Animals were sacrificed at the end of 4 wk-experimental period, and intracardiac blood and liver tissues were obtained. Biochemical measurements were performed both in plasma and in homogenized liver tissues. Alanine amino transferase (ALT), aspartate amino transferase (AST), malondialdehyde (MDA), NO, superoxide dismutase (SOD), catalase (CAT) and glutathione (GSH) levels were measured by spectrophotometry.RESULTS: ALT and AST in group 2 (62 U/L and 128 U/L,respectively) were higher than those in group 1 (24 U/L and 38 U/L) and group 3 (37 U/L and 81 U/L) (P<0.001 for both).Plasma and tissue levels of MDA in group 2 (4.66 μmol/L and 0.55 nmol/mg protein) were higher than in group 1 (2.65 μmol/L and 0.34 nmol/mg protein) and group 3 (3.43 μmol/L and 0.36 nmol/mg protein) (P<0.001 for both). Plasma and liver tissue levels of NO in group 2 (54.67 μmol/L and 586.50 nmol/mg protein) were higher than in group 1 (34.67 μmol/L and 435.33 nmol/mg protein)and group 3 (27.50 μmol/L and 412.75 nmol/mg protein )(P<0.001 for both). Plasma and liver tissue SOD activities in group 2 (15.25 U/mL and 5.38 U/ mg protein,respectively) were lower than in group 1 (20.00 U/mL and 8.13 U/mg protein) and group 3 (19.00 U/mL and 6.93 U/mg protein) (P<0.001 for both). Plasma and liver tissue CAT activities in group 2 (145 U/mL and 37 U/ mg protein,respectively) were lower than in group 1 (176 U/mL and 73 U/mg protein) and group 3 (167 U/mL and 61 U/mg protein) (P<0.001 for both). Meanwhile, erythrocytes and liver tissue levels of GSH in group 2 (4.12 mg/g Hb and 5.38 nmol/mg protein, respectively) were lower than in group 1 (5.52 mg/g Hb and 4.49 nmol/mg protein) and group 3 (5.64 mg/g Hb and 4.18 nmol/mg protein) (P<0.001 for both).CONCLUSION: Our findings show that L-NAME may produce a restorative effect on ethanol-induced liver damage via decreasing oxidative stress and increasing antioxidant status. | Hafize Uzun Gonul Simsek Seval Aydin Ethem Unal Yesari Karter Nermin Karaturan Yelmen Suphi Vehid Asl Curgunlu Safiye Kaya | 2005 | World Journal of Gastroenterology2005，11，4： | 1 |
| 6 | Fuzzy MCDM framework for locating a nuclear power plant in Turkey显示文摘 | ?smail Erol Safiye Sencer Asl? ?zmen Cory Searcy | 2013 | Energy Policy2013，，： | 1 |
| 7 | Agent-based FMS control显示文摘 | SAFIYE TURGAY | 2009 | Robot- ics and Computer-Integrated Manufacturing2009，25，2： | 1 |
| 8 | Mean platelet volume and D-dimer in patients with suspected deep venous thrombosis显示文摘 | Arzu Canan S?dd?ka Sezgin Hal?c?o?lu Safiye Gürel | 2012 | Journal of Thrombosis and Thrombolysis2012，，2： | 1 |
| 9 | Brucellar Spondylitis: Review of 25 Cases显示文摘 | Emel Yilmaz Mufit Parlak Halis Akalin Yasemin Heper Cuneyt Ozakin Resit Mistik Barbaros Oral Safiye Helvaci Okan T?re | 2004 | JCR: Journal of Clinical Rheumatology2004，，6： | 1 |
| 10 | Silicosis in manufacture of electric cable: Report of four eases显示文摘 | FAHRETTIN T KAMIL G SAFIYE G | 2007 | J Occud Health2007，49，： | 1 |
| 11 | Silicosis in manufacture of electric cable: Report of four cases显示文摘 | FAHRETTIN T KAMIL G SAFIYE G | 2007 | J Occup Health2007，49，： | 1 |
| 12 | The galenic ve- nous system : Surgical anatomy and its angiographic and magnetic res- onance venographic correlations 显示文摘 | Turker Kilic Koray Ozduman Safiye Cavdar | 2005 | European Journal of Radiology2005，，56： | 1 |
| 13 | Glomus Tumor of the Stomach:Case Report显示文摘 | Olcay A N Peyker T Safiye V M | 2010 | Turkish Journal of Pathology2010，26，1： | 1 |
| 14 | Variations in blood lipid profile, thrombotic system, arterial elasticity and psychosexual parame- ters in the cases of surgical and natural menopause显示文摘 | Tuna V Mkis I Safiye AS | 2010 | Aust N Z J Obstet Gynaecol2010，50，2： | 1 |
| 15 | [carbonyl-11C]Desmethyl-WAY-100635 (DWAY) is a potent and selective radioligand for central 5-HT1A receptors in vitro and in vivo显示文摘 | Victor W. Pike Christer Halldin Julie A. McCarron Camilla Lundkvist Ella Hirani Hans Olsson Susan P. Hume Per Karlsson Safiye Osman Carl-Gunnar Swahn H?kan Hall H?kan Wikstr?m Marguerite Mensonidas Keith G. Poole Lars Farde | 1998 | European Journal of Nuclear Medicine1998，，4： | 1 |
| 16 | Macrdlide resistance determinants of group A streptococci in AnKara,Turkey显示文摘 | Ziya CA Safiye G Serdar T | 2003 | Journal of Antimicrobial chemotherapy2003，52，1： | 1 |
| 17 | A new fuzzy multi criteria framework for measuring sustainability performance of a supply chain显示文摘 | Ismail Erola Safiye Sencer Ramazan Sari | | 0，，70： | 1 |
| 18 | Swelling behavior of anionic acrylamide-based hydrogels in aqueous salt solutions: Comparison of experiment with theory 显示文摘 | Oguz Okay Safiye B Sariisik | 1998 | J Appl Polym Sci1998，70，： | 1 |
| 19 | Diagnostic significance of periesophageal fat pad in ultrasonography for sliding hiatal hernias: sonographic fat pad sign显示文摘 | Emin Cakmakci Mehmet Tahtabasi Irfan Celebi Selma Cakmakci Aysel Bayram Safiye Tokgoz Mucahit Dogru Muzaffer Basak | 2013 | Clinical Imaging2013，，： | 1 |
| 20 | Variations in blood lipid profile, thrombotic system, arterial elasticity and psychosexual parameters in the eases of surgical and natural menopause 显示文摘 | Tuna V Alkis I Safiye AS | 2010 | Australian and New Zealand Journal of Obstetrics and Gynecology2010，50，2： | 1 |
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