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| 1 | CONSORT 2010说明与详述:报告平行对照随机临床试验指南的更新显示文摘大量证据显示随机对照临床试验(randomised controlled trial,RCT)的报告质量不理想。报告不透明,则读者既不能评判试验结果是否真实可靠,也不能从中提取可用于系统综述的信息。最近的方法学分析表明,报告不充分和设计不合理与对治疗效果产生评价偏倚有关。这种系统误差对RCT损害严重,而RCT正是以其能减少或避免偏倚而被视为评价干预措施的金标准。为了提高RCT的报告质量,一个由专家和编辑组成的工作组制定了临床试验报告的统一标准(Consolidated Standards of Reporting Trials,CONSORT)声明。CONSORT声明于1996年首次发表,并于2001年更新。声明由对照检查清单和流程图组成,供作者在报告RCT时使用。许多核心医学期刊和主要国际性编辑组织都已认可CONSORT声明。该声明促进了对RCT的严格评价和解释。2001年,在对CONSORT进行修订时,人们就已经清楚地认识到,解释和说明制定CONSORT声明的原理,有助于研究人员等撰写或评价临床试验报告。一篇CONSORT说明与详述文章于2001年同2001版CONSORT声明一起发表。2007年1月的专家会议之后,对CONSORT声明作了进一步修订并已发表,即'CONSORT2010声明'。这次更新对原版对照检查清单作了文字上的修改,使其更为明晰,并收入了与一些新近才认识到的主题相关的建议,如选择性报告结局产生的偏倚。说明与详述文件旨在加强人们对CONSORT声明的理解、应用和传播,这次也作了大量修订,对每一项新增或更新的清单条目的含义和增改理由进行了解释,提供了优秀的报告实例,还尽可能地提供了相关的经验性研究的参考文献。文中收入了若干流程图实例。'CONSORT2010声明'、其说明与详述文件,以及相关网站(www.consort-statement.org),对于改进随机临床试验报告必将有所裨益。 | David Moher Sally Hopewell Kenneth F Schulz Victor Montori Peter C Gφtzsche P J Devereaux Diana Elbourne Matthias Egger Douglas G Altman 周庆辉 卞兆祥 刘建平 | 2010 | 中西医结合学报2010，8，8： | 318 |
| 2 | Overexpression of Slug is associated with malignant progression of esophageal adenocarcinoma显示文摘AIM: To characterise expression of known E-cadherin repressors; Snail, Slug and Twist in the development of esophageal adenocarcinoma. METHODS: E-cadherin, Slug, Snail and Twist mRNA expression in Barrett's metaplasia and esophageal adenocarcinoma specimens was examined by real-time reverse transcription-polymerase chain reaction (RT-PCR). Semi-quantitative immunohistochemistry was used to examine cellular localisation and protein levels. The effect of Slug on epithelial mesenchymal transition (EMT) markers was examined by transfection of Slug into an adenocarcinoma line OE33.RESULTS: Cellular localisation of Slug in Barrett's metaplasia was largely cytoplasmic whilst in adenocarcinoma it was nuclear. Semi-quantitative analysis indicated that Slug was more abundant in adenocarcinoma compared to matched Barrett's metaplastic specimens. Snail and Twist were expressed in adenocarcinoma but were cytoplasmic in location and not induced compared to Barrett's mucosa. These observations were supported by mRNA studies where only Slug mRNA was shown to be over-expressed in adenocarcinoma and inversely correlated to E-cadherin expression. Overexpression of Slug in OE33 mediated E-cadherin repression and induced the mesenchymal markers vimentin and fibronectin.CONCLUSION: Progression to adenocarcinoma is associated with increased Slug expression and this may represent a mechanism of E-cadherin silencing. | Paras Jethwa Mushal Naqvi Robert G Hardy Neil A Hotchin Sally Roberts Robert Spychal Chris Tselepis | 2008 | World Journal of Gastroenterology2008，14，7： | 24 |
| 3 | Tumor necrosis factor-α-G308A polymorphism is associated with liver pathological changes in hepatitis C virus patients显示文摘AIM To investigate the association of tumor necrosis factor alpha(TNFα)-G308 A polymorphism with different liver pathological changes in treatment-na?ve Egyptian patients infected with hepatitis C virus(HCV) genotype 4.METHODS This study included 180 subjects,composed of 120 treatment-na?ve chronic HCV patients with different fibrosis grades(F0-F4) and 60 healthy controls. The TNFα-G308 A region was amplified by PCR and the different genotypes were detected by restriction fragment length polymorphism analysis. The TNFα protein was detected by enzyme-linked immunosorbent assay. The influence of different TNFα-G308 A genotypes on TNFα expression and liver disease progression were statistically analyzed. The OR and 95%CI were calculated to assess the relative risk confidence.RESULTS Current data showed that the TNFα-G308 A SNP frequency was significantly different between controls and HCV infected patients(P = 0.001). Both the AA genotype and A allele were significantly higher in late fibrosis patients(F2-F4,n = 60) than in early fibrosis patients(F0-F1,n = 60)(P = 0.05,0.04 respectively). Moreover,the GA or AA genotypes increased the TNFα serum level greater than the GG genotype(P = 0.002). The results showed a clear association between severe liver pathological conditions(inflammation,steatosis and fibrosis) and(GA + AA) genotypes(P = 0.035,0.03,0.04 respectively). The stepwise logistic regression analysis showed that the TNFα genotypes(GA + AA) were significantly associated with liver inflammation(OR = 3.776,95%CI: 1.399-10.194,P = 0.009),severe steatosis(OR = 4.49,95%CI: 1.441-14.0,P = 0.010) and fibrosis progression(OR = 2.84,95%CI: 1.080-7.472,P = 0.034). Also,the A allele was an independent risk factor for liver inflammation(P = 0.003),steatosis(P = 0.003) and fibrosis(P = 0.014). CONCLUSION TNFα SNP at nucleotide-308 represents an important genetic marker that can be used for the prognosis of different liver pathological changes in HCV infected | Noha G Bader El Din Sally Farouk Reem El-Shenawy Marwa K Ibrahim Reham M Dawood Mostafa M Elhady Ahmed M Salem Naglaa Zayed Ahmed Khairy Mostafa K El Awady | 2016 | World Journal of Gastroenterology2016，22，34： | 3 |
| 4 | Survival rates in patients with primary malignant brain tumors ratified by patient age and tumor histological type:an analysis based on Surveillance,epidemicology,and end results(SEER)data,1973-1991显示文摘 | Faith GD Sally F Tames G | 1998 | J Neurosurg1998，88，1： | 1 |
| 5 | After the Women' Health Initiative:Postmenopausal women' experience with discontinuing estrogen replacement therapy显示文摘 | Sally G Haskell | 2004 | Journal of Women'' Health2004，13，4： | 1 |
| 6 | BAI 3, CDX 2 and VIL 1: a panel of three antibodies to distinguish small cell from large cell neuroendocrine lung carcinomas显示文摘 | Muhammad F Bari Helen Brown Andrew G Nicholson Keith M Kerr John R Gosney William A Wallace Irshad Soomro Salli Muller Danielle Peat Jonathan D Moore Lesley A Ward Maxim B Freidin Eric Lim Manu Vatish David R J Snead | 2014 | Histopathology2014，，： | 1 |
| 7 | Choline Acetyltransferase Activity in Vascular Dementia and Stroke显示文摘 | Sharp Sally I Francis Paul T Elliott Mark S J Kalaria Rajesh N Bajic Natasha Hortobagyi Tibor Ballard Clive G | 2009 | Dementia and Geriatric Cognitive Disorders2009，，3： | 1 |
| 8 | Improved split feed anaerobic baffled reactor(SFABR) for shorter start-up period and higher process performance 显示文摘 | Uyanik S Sallis P J Anderson G K | 2002 | Water Sci Technol2002，46，4： | 1 |
| 9 | The lawyer's response to or- ganizational professional conflict: an empirical study of the ethical decision making of in--house counsel 显示文摘 | Hugh P G Sally P G | 2002 | America Business Law Journal2002，39，： | 1 |
| 10 | Effect of biosolids processing on the bioavailability of lead in an urban soil显示文摘 | Sally Brown Rufus L Chancy Judith G Hallfrisch Qi Xue | 2003 | Journal of Environmental Quality2003，32，： | 1 |
| 11 | The effect of polymer addition on granulation in an anaerobic baffled reactor(ABR) 显示文摘 | SALLIS P J ANDERSON G K | 2002 | Water Research2002，36，： | 1 |
| 12 | A Time Course for the Focal Elevation of Synthesis of Basic Fibroblast Growth Factor and One of Its High-Affinity Receptors (flg) following a Localized Cortical Brain Injury 显示文摘 | Ann L Sally AF Ana-Maria G | 1992 | J Neurosci1992，12，10： | 1 |
| 13 | Psychosocial and environmental correlates of adolescent sedentary behaviors显示文摘 | Norman G J Schmid B A Sallis J F | 2005 | Pediatrics2005，116，4： | 1 |
| 14 | Insertion of DNA sequences into the human chromosomal B - globin locus by homologous recombination 显示文摘 | Smithies Ronald G Gregg Sallie S | 1985 | Nature1985，317，： | 1 |
| 15 | A time course for the focal elevation of synthesis of basic fibroblast growth factor and one of its high-affinity receptors (fig) following a localized cortical brain injury显示文摘 | Ann L Sally AF Ana-Maria G | 1992 | J Neurosci1992，12，10： | 1 |
| 16 | The effect of Polymer addition on granulation in an anaerobic baffled reactor (ABR) 显示文摘 | Uyanik S Sallis P J Anderson G K | 2002 | Water Res2002，36，4： | 1 |
| 17 | A Review of studies on the effect of iron deficiency on cognitive development in children 显示文摘 | SALLY G M ANI C | 2001 | J Nutr2001，131，： | 1 |
| 18 | The pains of discography 显示文摘 | James W Willam C Sally G | 1988 | Spine1988，13，： | 1 |
| 19 | The effect of polymer addition on granulation in a anaerobic baffled reactor,part Ⅱ : compartmentalization of baterial populations显示文摘 | UYANIK S SALLIS P J ANDERSON G K | 2002 | Water Research2002，36，： | 1 |
| 20 | Automated tree recognition in old growth conifer stands with high resolution digital imagery显示文摘 | Donald G Leckie Francois A Gougeon Sally Tinis | 2005 | Remote Sensing of Environment2005，94，： | 1 |
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