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| 1 | Failure of P-selectin blockade alone to protect the liver from ischemia-reperfusion injury in the isolated blood-perfused rat liver显示文摘AIM:To determine if blockade of P-selectin in the isolated blood-perfused cold ex vivo rat liver model protects the liver from ischemia-reperfusion injury. METHODS:The effect of P-selectin blockade was assessed by employing an isolated blood-perfused cold ex vivo rat liver with or without P-selectin antibody treatment before and after 6 h of cold storage in University of Wisconsin solution. RESULTS:In our isolated blood-perfused rat liver model,pre-treatment with P-selectin antibody failed to protect the liver from ischemia-reperfusion injury,as judged by the elevated aspartate aminotransferase activity. In addition,P-selectin antibody treatment did not significantly reduced hepatic polymorphonuclear leukocyte accumulation after 120 min of perfusion. Histological evaluation of liver sections obtained at 120 min of perfusion showed significant oncotic necrosis in liver sections of both ischemic control and P-selectin antibody-treated groups. However,total bile production after 120 min of perfusion was signifi cantly greater in P-selectin antibody-treated livers,compared to control livers. No signifi cant difference in P-selectin and ICAM-1 mRNAs and proteins,GSH,GSSG,and nuclear NF-κB was found between control and P-selectin antibody-treated livers. CONCLUSION:In conclusion,we have shown that blockade of P-selectin alone failed to reduced polymorphonuclear leukocyte accumulation in the liver and protect hepatocytes from ischemia-reperfusion injury in the isolated blood-perfused cold-ex vivo rat liver model. | Samuel Wyllie Neal R Barshes Saul J Karpen John A Goss | 2008 | World Journal of Gastroenterology2008，14，44： | 4 |
| 2 | Immune checkpoint inhibitor-mediated colitis in gastrointestinal malignancies and inflammatory bowel disease显示文摘Immune checkpoint inhibitors(ICI)have markedly changed the landscape of cancer therapy.By re-invigorating the immune system against tumors,ICI provide novel therapeutic options for a broad variety of malignancies,including many gastrointestinal(GI)cancers.However,these therapies can also induce autoimmune-like side effects in healthy tissue across the body.One of the most common of these side effects is ICI-mediated colitis and diarrhea(IMC).Here,we review the incidence and risk of IMC in ICI therapy,with a focus on what is known regarding IMC in patients with GI malignancies.We also discuss data available on the use of ICI and risk of IMC in patients with pre-existing inflammatory bowel disease,as these patients may have increased risk of IMC due to their underlying intestinal pathology. | Alexa R Weingarden Samuel J S Rubin John Gubatan | 2021 | World Journal of Gastrointestinal Oncology2021，13，8： | 3 |
| 3 | p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival显示文摘响应 DNA 损坏的房间命运的中央仲裁人是 p53,它调整涉及房间周期拘捕,幸存和 apoptosis 的基因的表示。尽管 DNA 损坏开始的许多回答被描绘了,肌动朊细胞骨架管理者的角色大部分是未知的。我们现在显示出那 RhoC 和秘鲁利玛机场之代号 kinase (LIMK2 ) 2 是 genotoxic 代理人导致的直接 p53 目标基因。尽管 RhoC 和 LIMK2 在肌动朊细胞骨架规定有生长得很好的角色,我们的结果显示 LIMK2 的激活也有支持幸存的功能追随者 DNA 损坏。由调停 siRNA 的击倒或选择的药理学封锁的 LIMK 抑制敏化房间到无线电 -- 或化疗,以便当与 LIMK 抑制结合了时,当单身地管理了时,是尚不致命的治疗导致了房间死亡。我们的调查结果建议把 LIMK 禁止者与 genotoxic 治疗相结合能比单个代理人的管理更有效,并且加亮在肌动朊细胞骨架管理者和 DNA 之间的一个新奇连接导致损坏的房间幸存机制。 | Daniel R Croft Diane Crighton Michael S Samuel Filipe C Lourenco June Munro Jenifer Wood Karim Bensaad Karen H Vousden Owen J Sansom Kevin M Ryan Michael F Olson | 2011 | Cell Research2011，21，4： | 3 |
| 4 | Antimicrobial peptides and the gut microbiome in inflammatory bowel disease显示文摘Antimicrobial peptides(AMP)are highly diverse and dynamic molecules that are expressed by specific intestinal epithelial cells,Paneth cells,as well as immune cells in the gastrointestinal(GI)tract.They play critical roles in maintaining tolerance to gut microbiota and protecting against enteric infections.Given that disruptions in tolerance to commensal microbiota and loss of barrier function play major roles in the pathogenesis of inflammatory bowel disease(IBD)and converge on the function of AMP,the significance of AMP as potential biomarkers and novel therapeutic targets in IBD have been increasingly recognized in recent years.In this frontier article,we discuss the function and mechanisms of AMP in the GI tract,examine the interaction of AMP with the gut microbiome,explore the role of AMP in the pathogenesis of IBD,and review translational applications of AMP in patients with IBD. | John Gubatan Derek R Holman Christopher J Puntasecca Danielle Polevoi Samuel JS Rubin Stephan Rogalla | 2021 | World Journal of Gastroenterology2021，27，43： | 3 |
| 5 | Safety and efficacy of protease inhibitors to treat hepatitis C after liver transplantation: A multicenter experience显示文摘 | Audrey Coilly Bruno Roche Jér?me Dumortier Vincent Leroy Danielle Botta-Fridlund Sylvie Radenne Georges-Philippe Pageaux Si-Nafaa Si-Ahmed Olivier Guillaud Teresa Maria Antonini Stéphanie Ha?m-Boukobza Anne-Marie Roque-Afonso Didier Samuel Jean-Charles Du | 2014 | Journal of Hepatology2014，，1： | 2 |
| 6 | Molecular epidemiology of foot-and-mouth disease virus显示文摘 | Knowles N J Samuel A R | 2003 | Virus Res2003，91，1： | 1 |
| 7 | Neurological outcome after surgical management of adult tethered cord syndrome 显示文摘 | Garces-Ambrossi G L McGirt M J Samuels R | 2009 | JNeurosurgSpine2009，11，3： | 1 |
| 8 | Botryosphaeria and Fusicocctun species associated with ripe fruit rot of Actinidia deliciosa,kiwifruit in New Zealand 显示文摘 | Pennycook S R Samuels G J | 1985 | Mycotaxon1985，24，： | 1 |
| 9 | A randomized phase Ⅱ trial of two schedules of docetaxel in elderly or poor performance status patients with advance non-small cell lung cancer显示文摘 | Lilenbaum R Rubin M Samuel J | 2007 | J Thorac Oncol2007，2，4： | 1 |
| 10 | Electromagnetic aircraft launch system-EMALS显示文摘 | Doyle M R Samuel D J Conway T | 1995 | IEEE Transactions on Magnetics1995，31，2： | 1 |
| 11 | In vitro aerosol delivery and regional airway surface liquid concentration of a liposomal cationic peptide显示文摘 | Lange C F Hancock R E Samuel J | 2001 | J Pharm Sci2001，90，10： | 1 |
| 12 | A photoactivatable push-pull fluorophore for single-molecule imaging in live cells显示文摘 | Lord S J Conley N R Lee H L D Samuel R Liu N Twieg R J Moerner W E | | 0，，29： | 1 |
| 13 | Gnotobiotic zebrafish reveal evolutionarily conserved responses to the gut microbiota显示文摘 | Rawls R F Samuel B S Gordon J I | 2004 | PNAS2004，101，13： | 1 |
| 14 | Foot-and-Mouth disease virus: Cause of the recent crisis for the UK livestock industry显示文摘 | Samuel A R Knowles N J | 2001 | Trends in genetics2001，17，8： | 1 |
| 15 | An Architecture for Semi-Automated Radar Image Exploitation显示文摘 | Keith Sisterson L John R Delaney Samuel J Gravina | 1998 | Lincoln Lab1998，11，2： | 1 |
| 16 | Anaphylaxis after administration of ibritumomab tiuxetan for follicular non-Hodgkin lymphoma显示文摘 | Jankowitz R Judith J Samuel A | 2008 | Clinical Nuclear Medicine2008，22，33： | 1 |
| 17 | Molecular epidemiology of foot- and-mouth disease virus显示文摘 | Knowled H J Samuel A R | 2003 | Virus Res2003，91，： | 1 |
| 18 | Chelated iridium(Ⅲ) bis-carbene complexes as air-stable catalysts for transfer hydrogenation显示文摘 | Albrecht M Miecznikowshi J R Samuel A | 2002 | Organometallics2002，21，： | 1 |
| 19 | ElSe Aircraft Launch System-EMALS显示文摘 | Doyle M R Samuel D J Conway T | 1995 | IEEE Transactions on Magnetics1995，31，1： | 1 |
| 20 | Evaluation Coxiella burnetii antibiotic susceptibilities by real time PCR assay显示文摘 | Brennan R E Samuel J E | 2003 | Journal of clinical microbiology2003，41，5： | 1 |
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