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| 1 | 儿童功能性胃肠病罗马Ⅳ标准显示文摘罗马标准是目前关于功能性胃肠病( FGID)分类最全面且不断更新的标准。罗马Ⅰ、Ⅱ标准分别于1994年、1999年发布。罗马Ⅱ标准开始单列儿童FGID分类。2006年,根据年龄不同,婴幼儿(0-36个月)和儿童(〉36个月) FGID的罗马Ⅲ诊断标准发布,但相关的流行病学、病理生理学、诊断检查、治疗策略以及预后等资料都很少。 | Marc A. Benninga Samuel Nurko Christophe Faure Paul E. Hyman Ian St. James Roberts Neil L. Schechter Jeffrey S. Hyams Carlo Di Lorenzo Miguel Saps Robert J. Shulman Annamaria Staiano Miranda van Tilburg | 2017 | 中华儿科杂志2017，55，1： | 108 |
| 2 | Acute calculous cholecystitis: Review of current best practices显示文摘Acute calculous cholecystitis(ACC) is the most frequent complication of cholelithiasis and represents one-third of all surgical emergency hospital admissions, many aspects of the disease are still a matter of debate. Knowledge of the current evidence may allow the surgical team to develop practical bedside decision-making strategies, aiming at a less demanding procedure and lower frequency of complications. In this regard, recommendations on the diagnosis supported by specific criteria and severity scores are being implemented, to prioritize patients eligible for urgency surgery. Laparoscopic cholecystectomy is the best treatment for ACC and the procedure should ideally be performed within 72h. Early surgery is associated with better results in comparison to delayed surgery. In addition, when to suspect associated common bile duct stones and how to treat them when found are still debated. The antimicrobial agents are indicated for high-risk patients and especially in the presence of gallbladder necrosis. The use of broad-spectrum antibiotics and in some cases with antifungal agents is related to better prognosis. Moreover, an emerging strategy of not converting to open, a difficult laparoscopic cholecystectomy and performing a subtotal cholecystectomy is recommended by adept surgical teams. Some authors support the use of percutaneous cholecystostomy as an alternative emergency treatment for acute Cholecystitis for patients with severe comorbidities. | Carlos Augusto Gomes Cleber Soares Junior Salomone Di Saveiro Massimo Sartelli Michel Denis Kelly Camila Couto Gomes Felipe Couto Gomes Lívia Dornellas Correa Camila Brandao Alves Samuel de Fádel Guimaraes | 2017 | World Journal of Gastrointestinal Surgery2017，9，5： | 18 |
| 3 | High-Resolution Crystal Structure and Redox Properties of Chloroplastic Triosephosphate Isomerase from Chlamydomonas reinhardtii显示文摘Triosephosphate isomerase (TPI ) 催化 glyceraldehyde-3-phosphate 的互变现象到 dihydroxyacetone 磷酸盐。光合的有机体通常包含位于细胞质和叶绿体的 TPI 的二 isoforms。当细胞质的 TPI 涉及 glycolysis 时, chloroplastic isoform 参予 CalvinBenson 周期,为碳固定负责的一个关键光合的过程。与它的细胞质的对应物相比, chloroplastic TPI 的功能的特征糟糕被调查了,它的三维的结构没被解决。最近,几研究包括 dithiol/disulfide 交换, glutathionylation,和 nitrosylation 作为不同氧化还原作用修正的一个潜在的目标建议了 TPI。然而,在蛋白质活动的既不效果也不位于这些氧化还原作用修正下面的分子的机制被调查了。这里,我们 recombinantly 生产了并且从单细胞的绿水藻 Chlamydomonas reinhardtii (Cr ) 净化了 TPI。酶的生物化学的性质被描出,它的结晶的结构在 1.1 的一个决定是坚定的 ? 。CrTPI 是有包含典型(/)8 桶褶层的子单元的 homodimer。尽管为 TRX 规定的证据都没被获得, CrTPI 被发现由 nitrosoglutathione 由氧化谷胱甘肽和 trans-nitrosylation 经历 glutathionylation,证实它到多重氧化还原作用修正的敏感。 | Mirko Zaffagnini Laure Michelet Chiara Sciabolini Nastasia Di Giacinto Samuel Morisse Christophe H. Marchand Paolo Trost Simona Fermani Stephane D Lemaire | 2014 | Molecular Plant2014，7，1： | 4 |
| 4 | Telbivudine Improves Renal Function in Patients With Chronic Hepatitis B显示文摘 | Edward J. Gane Gilbert Deray Yun-Fan Liaw Seng Gee Lim Ching-Lung Lai Jens Rasenack Yuming Wang George Papatheodoridis Adrian Di Bisceglie Maria Buti Didier Samuel Alkaz Uddin Sophie Bosset Aldo Trylesinski | 2014 | Gastroenterology2014，，1： | 2 |
| 5 | A Multicenter Study on Childhood Constipation and Fecal Incontinence: Effects on Quality of Life显示文摘 | Katja Kovacic Manu R. Sood Suzanne Mugie Carlo Di Lorenzo Samuel Nurko Nicole Heinz Ananthasekar Ponnambalam Christina Beesley Rina Sanghavi Alan H. Silverman | 2015 | The Journal of Pediatrics2015，，6： | 1 |
| 6 | Hybrid Aortic Arch Debranching With Staged Endovascular Completion in DeBakey Type I Aortic Dissection显示文摘 | Antonino G.M. Marullo Samuele Bichi Rocco A. Pennetta Gerardo Di Matteo Antonio M. Cricco Luigi Specchia Fausto Castriota Giampiero Esposito | 2010 | The Annals of Thoracic Surgery2010，，6： | 1 |
| 7 | Six Sigma can meet your revenue- cycle needs显示文摘 | Samuels DI Adomitis FL | 2003 | Healtheare Financial Management2003，57，11： | 1 |
| 8 | The stability ofDSM personality disorders over twelve to eighteen years显示文摘 | Nestadt G Di CZ Samuels JF | 2010 | J Psychiatry Res2010，44，1： | 1 |
| 9 | The Paris Consensus on Childhood Constipation Terminology (PACCT) Group显示文摘 | Marc Benninga David C.A Candy Anthony G Catto-Smith Graham Clayden Vera Loening-Baucke Carlo Di Lorenzo Samuel Nurko Annamaria Staiano | 2005 | Journal of Pediatric Gastroenterology and Nutrition2005，，3： | 1 |
| 10 | The spectrum of pediatric eosinophilic esophagitis beyond infancy: a clinical series of 30 children显示文摘 | Susan R Orenstein Theresa M Shalaby Carlo Di Lorenzo Philip E Putnam Luther Sigurdsson Samuel A Kocoshis | 2000 | The American Journal of Gastroenterology2000，，6： | 1 |
| 11 | Serotonergic regulation of the GABAergic transmission in the rat basal ganglia显示文摘 | DI CARA B SAMUEL D SALIN P | 2003 | Synapse2003，50，2： | 1 |
| 12 | Human Embryonic Stem Cell-Derived Motor Neurons Are Sensitive to the Toxic Effect of Glial Cells Carrying an ALS-Causing Mutation显示文摘 | Francesco Paolo Di Giorgio Gabriella L. Boulting Samuel Bobrowicz Kevin C. Eggan | 2008 | Cell Stem Cell2008，，6： | 1 |
| 13 | Multicenter, Randomized, Placebo-Controlled Trial of Amitriptyline in Children With Functional Gastrointestinal Disorders显示文摘 | Miguel Saps Nader Youssef Adrian Miranda Samuel Nurko Paul Hyman Jose Cocjin Carlo Di Lorenzo | 2009 | Gastroenterology2009，，4： | 1 |
| 14 | Adaptive appearance modeling for video tracking:survey and evaluation显示文摘 | Samuele Salti Andrea Cavallaro Luigi Di Stefano | 2012 | IEEE Transactions on image processing2012，21，10： | 1 |
| 15 | Acute heart failure in the elderly:setting related differences in clinical features and management显示文摘BACKGROUND Administrative data show that acute heart failure(HF)patients are older than those enrolled in clinical registries and frequently admitted to non-cardiological settings of care.The purpose of this study was to describe clinical characteristics of old patients hospitalised for acute HF in Cardiology,Internal Medicine or Geriatrics wards.METHODS Data came from ATHENA(AcuTe Heart failurE in advaNced Age)registry which included elderly patients(≥65 years)admitted to the above mentioned settings of care from December 1,2014 to December 1,2015.RESULTS We enrolled 396 patients,15.4%assigned to Cardiology,69.7%to Internal Medicine,and 14.9%to a Geriatrics ward.Mean age was 83.5±7.6 years(51.8%of patients≥85 years)and was higher in patients admitted to Geriatrics(P<0.001);more than half were females.Medical treatments did not differ significantly among settings of care(in a context of a low prescription rate of renin-angiotensin-aldosterone system inhibitors)whereas significant differences were observed in comorbidity patterns and management guidelines recommendation adherence for decongestion evaluation with comparison of weight and N-terminal pro-B-type natriuretic peptide levels on admission and at discharge(both P=0.035 and P<0.001),echocardiographic evaluation(P<0.001)and follow-up visits planning(P<0.001),all higher in Cardiology.Mean in-hospital length of stay was 9±5.9 days,significantly higher in Geriatrics(13.7±6.5 days)and Cardiology(9.9±6.7 days)compared to Internal Medicine(8±5.2 days),P<0.001.In-hospital mortality was 9.3%,resulting higher in Geriatrics(18.6%)and Cardiology(16.4%)than Internal Medicine(5.8%),P=0.001.CONCLUSIONS In elderly patients hospitalised for acute HF,clinical characteristics and management differ significantly according to the setting of admission. | Francesco Orso Alessandra Pratesi Andrea Herbst Anna Chiara Baroncini Francesca Bacci Gabriele Ciuti Andrea Berni Camilla Tozzetti Carlo Nozzoli Alberto Moggi Pignone Loredana Poggesi Luciano Gabbani Mauro Di Bari Francesco Fattirolli Massimo Milli Andrea Ungar NiccolòMarchionni Samuele Baldasseroni | 2021 | Journal of Geriatric Cardiology2021，18，6： | 0 |
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