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| 1 | H pylori infection and other risk factors associated with peptic ulcers in Turkish patients: A retrospective study显示文摘AIM: To identify and evaluate the relative impact of H pylori infection and other risk factors on the occurrence of gastric ulcer (GU), duodenal ulcer (DU) and gastritis in Turkish patients. METHODS: A total of 4471 patients (48.3% female) out of 4863 attended the Samatya hospital in Istanbul (June 1999 - October 2003) were included. The records of H pylori status (CLO-test), endoscopic f indings of GU, DU and gastritis, personal habits (smoking, alcohol intake) and medication [non-steroidal anti-inflammatory drugs (NSAIDs), aspirin intake] were analyzed using multi-way frequency analysis. RESULTS: We have found that GU in the presence of H pylori had significant association with aspirin (P = 0.0001), alcohol (P = 0.0090) and NSAIDs (P = 0.0372). DU on the other hand had significant association with aspirin/ smoking/NSAIDs (P = 0.0259), aspirin/alcohol (P = 0.0002) and aspirin/smoking (P = 0.0233), also in the presence of H pylori. In the absence of H pylori GU had significant association with alcohol/NSAIDs (P = 0.0431), and NSAIDs (P = 0.0436). While DU in the absence of H pylori had significant association with smoking/alcohol/ NSAIDs (P = 0.0013), aspirin/NSAIDs (P = 0.0334), aspirin/alcohol (P = 0.0360). CONCLUSION: In the presence of H pylori, aspirin, alcohol and NSAIDs intake act as an independent risk factors that had an augmenting impact on the occurrence of GU and only together on the occurrence of DU in Turkish patients. | Barik A Salih M Fatih Abasiyanik Nizamettin Bayyurt Ersan Sander | 2007 | World Journal of Gastroenterology2007，13，23： | 11 |
| 2 | Constipation-predominant irritable bowel syndrome: A review of current and emerging drug therapies显示文摘Irritable bowel syndrome(IBS) is a highly prevalent medical condition that adversely affects patient quality of life and constitutes a significant economic burden on healthcare resources. A large proportion of patients suffer from the constipation subtype of IBS(IBS-C), most commonly afflicting older individuals and those with a lower socioeconomic status. Conventional pharmacologic and nonpharmacologic treatment options have limited efficacies and/or significant adverse events, which lead to increased long-term health care expenditures. Failure to effectively treat IBS-C patients over the past decades has largely been due to a poor understanding of disease pathophysiology, lack of a global view of the patient, and an inappropriate selection of patients and treatment endpoints in clinical trials. In recent years, however, more effective and safer drugs have been developed for the treatment of IBS-C. The advancement in the area of pharmacologic treatment is based on new knowledge of the pathophysiologic basis of IBS-C and the development of drugs with increased selectivity within pharmacologic classes with recognized efficacies. This narrative review covers the spectrum of available drugs and their mechanisms of action, as well as the efficacy and safety profiles of each as determined in relevant clinical trials that have investigated treatment options for IBS-C and chronic constipation. A brief summary of laxative-based treatment options is presented, followed by up-to-date assessments for three classes of drugs: prokinetics, prosecretory agents, and bile acid modulators. | Khaled A Jadallah Susan M Kullab David S Sanders | 2014 | World Journal of Gastroenterology2014，20，27： | 9 |
| 3 | Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density显示文摘 | W.S Simonet D.L Lacey C.R Dunstan M Kelley M.-S Chang R Lüthy H.Q Nguyen S Wooden L Bennett T Boone G Shimamoto M DeRose R Elliott A Colombero H.-L Tan G Trail J Sullivan E Davy N Bucay L Renshaw-Gegg T.M Hughes D Hill W Pattison P Campbell S Sander G Van | 1997 | Cell1997，，2： | 6 |
| 4 | Acrylamide formation mechanism in heated foods 显示文摘 | Zyzak D V Sanders R A Stojanovic M | 2003 | Journal of Agricultural and Food Chemistry2003，51，16： | 1 |
| 5 | Complete genomes of two clinical Staphylococcus aureus strains:evidence for the rapid evolution of virulence and drug resistance显示文摘 | Holden MT Feil EJ Lindsay JA Peacock SJ Day NP Enright MC Foster TJ Moore CE Hurst L Atkin R Barron A Bason N Bentley SD Chillingworth C Chillingworth T Churcher C Clark L Corton C Cronin A Doggett J Dowd L Feltwell T Hance Z Harris B Hauser H Holroyd S Jagels K James KD Lennard N Line A Mayes R Moule S Mungall K Ormond D Quail MA Rabbinowitsch E Rutherford K Sanders M Sharp S Simmonds M Stevens K Whitehead S Barrell BG Spratt BG Parkhill J | 2004 | Proc Natl Acad Sci USA2004，101，26： | 1 |
| 6 | Expired PCOz as an index of coronary perfusion pressure显示文摘 | SANDERS A B ATLAS M EWY G A | 1985 | Am J Emerg Med1985，3，2： | 1 |
| 7 | Determination of organic acids in Vaccinium berry standard reference materials显示文摘 | Phillips M M Case R J Rimmer C A Sander L C Sharpless K E Wise S A Yen J H | 2010 | Analytical and Bioanalytical Chemistry2010，398，1： | 1 |
| 8 | Plasticiser effect of oleic acid polyester on polyethylene and polypropyl- ene 显示文摘 | SANDER M M NICOLAU A GUZATTO R | 2012 | PolymTest2012，，8： | 1 |
| 9 | Acrylamide formation mechanism in heated foods显示文摘 | ZYZAK D V SANDERS R A STOJANOVIC M | 2003 | Journal of Agricultural and Food Chemistry2003，51，： | 1 |
| 10 | Diffusion - limited aggregation:A kinetic critical phenomenon显示文摘 | Witten T A Sander L M | 1981 | Phys Rev Lett1981，47，19： | 1 |
| 11 | Upper echelons research revisited: antecedents, elements, and consequences of top management team composition 显示文摘 | Carpenter M A Geletkanycz M A Sanders W G | 2004 | Journal of Management2004，30，6： | 1 |
| 12 | Programmed cell death in developm ent显示文摘 | Sanders E J Wride M A | 1995 | Int Rev Cytol1995，163，： | 1 |
| 13 | Modulation of cardiac ryanodine receptors by sorcin显示文摘 | Lokuta A J Meyers M B Sander P R | 1997 | J Biol Chem1997，272，25： | 1 |
| 14 | Dabco-metalloporphyrin binding: ternary complexes, host-guest chemistry and the mea- surement of 'rr-lr interactions显示文摘 | Hunter C A Meah M N Sanders J K M | 1990 | Journal of the American Chem- ical Society1990，112，15： | 1 |
| 15 | Effects of insulin and insulin-like growth factors oncultured human hair follicles:IGF-1 at physiologicconcentrations is an important regulator of hair folli-cle growth in vitro显示文摘 | PHILPOTT M P SANDERS D A KEALEY T | 1994 | J Invest1994，102，6： | 1 |
| 16 | Efficient isolation of major procyanidin A-type dimers from peanut skins and B- type dimers from grape seeds 显示文摘 | Appeldoorn Maaike M Sanders Mark Vincken Jean- Paul et a/ | 2009 | Food Chemistry2009，117，4： | 1 |
| 17 | Development of the SRK/T intraocular lens implant power calculation formula显示文摘 | Retzlaff J A Sanders D R Kraff M C | 1990 | Cataract Refract Surg1990，16，3： | 1 |
| 18 | Effective harmonic-fluid approach to low-energy properties of one-dimensional quantum fluids 显示文摘 | Witten T A Sander L M | 1981 | PhysRevLet1981，47，25： | 1 |
| 19 | International-isation and Firm Governance:the Roles of CEO Compensation,Top Team Composition and Board Structure显示文摘 | CARPENTER M A | 1998 | Academy of Management Journal1998，41，2： | 1 |
| 20 | Top management team compensation:The missing link between CEO pay and firm performance显示文摘 | Carpenter M A Sanders W G | 2002 | Strategic Management Journal2002，，23： | 1 |
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