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| 1 | Clinical investigation of 41 patients with ischemic colitis accompanied by ulcer显示文摘AIM: To investigate the relationship among the presence of ulcer lesions, underlying disease, and clinical course in patients with ischemic colitis. METHODS: The subjects were 41 patients (10 male and 31 female; mean age 70 years) with ischemic colitis who were admitted to and received treatment in our hospital from 2000 to 2006. We compared their characteristics and analyzed the mean lengths of admission and fast- ing for 9 patients with ulcer lesions (ulcer group) and 32 without (non-ulcer group). RESULTS: The groups with presence and absence of ulcer differed significantly only in white blood cell (WBC) count. Lengths of fasting and admission were 7.9 d and 17.9 d for the ulcer group and 4.4 d and 10.7 d for the non-ulcer group, respectively, and significantly longer in the ulcer group (P = 0.0057 and 0.0001). There was no correlation between presence of ulcer and presence of underlying diseases. CONCLUSION: Lengths of fasting and admission were significantly longer in patients with ischemic colitis with ulcer than for those without ulcer. | Satohiro Matsumoto Kenichiro Tsuji Satoshi Shirahama | 2007 | World Journal of Gastroenterology2007，13，8： | 18 |
| 2 | Selection of appropriate endoscopic therapies for duodenal tumors: An open-label study, single-center experience显示文摘AIM:To determine an appropriate compartmentalization of endoscopic submucosal dissection(ESD)or endoscopic mucosal resection(EMR)for duodenal tumors.METHODS:Forty-six duodenal lesions(excluding papillary lesions)from 44 patients with duodenal tumors treated endoscopically between 2005 and 2013 were divided into the ESD and EMR groups for retrospective comparison and analysis.RESULTS:The mean age was 65±9 years(35-79years).There were 24 lesions from men and 22 from women.The lesions consisted of 6 early cancers,31adenomas and 9 neuroendocrine tumors.Lesion location was the duodenal bulb in 15 cases and the descending part of the duodenum in 31 cases.The most common macroscopic morphology was elevated type in 21 cases(45.6%).Mean tumor diameter was 11.9±9.7 mm(3-60 mm).Treatment procedure was ESD(15 cases)vs EMR(31 cases).The examined parameters in the ESD vs EMR groups were as follows:mean tumor diameter,12.9±14.3 mm(3-60 mm)vs 11.4 ±6.7 mm(4-25 mm);en bloc resection rate,86.7%vs 83.9%;complete resection rate,86.7%vs 74.2%;procedure time,86.5±63.1 min(15-217 min)vs 13.2±17.0 min(2-89 min)(P<0.0001);intraprocedural perforation,3 cases vs none(P=0.0300);delayed perforation,none in either group;postprocedural bleeding,1 case vs none;mean postoperative length of hospitalization,8.2±2.9 d(5-16 d)vs 6.1±2.0 d(2-12 d)(P=0.0067);recurrence,none vs 1 case(occurring at 7 mo postoperatively).CONCLUSION:ESD was associated with a longer procedure time and a higher incidence of intraprocedural perforation;EMR was associated with a lower rate of complete resection. | Satohiro Matsumoto Yukio Yoshida | 2014 | World Journal of Gastroenterology2014，20，26： | 17 |
| 3 | Results of mass endoscopic examination for gastric cancer in Kamigoto Hospital,Nagasaki Prefecture显示文摘AIM:To examine how the introduction of endoscopy to gastric cancer screening affected survival prognosis in a regional population. METHODS: The subjects comprised 4261 residents of Kamigoto,Nagasaki Prefecture,who underwent gastric X-ray examination for gastric cancer screening from 1991 to 1995,and all 7178 residents who underwent endoscopic examination for the same purpose from 1996 to 2003. The analysis evaluated trends in age-adjusted gastric cancer mortality rates and standard mortality ratios (SMRs) among the Kamigoto residents. RESULTS: According to demographic statistics,the 1995 and 2000 age-adjusted gastric cancer mortality rates in Nagasaki Prefecture (per 100 000 population) were 42.6 and 37.3 for males and 18.6 and 16.0 for females,while the corresponding rates in Kamigoto before and after the introduction of endoscopic screening were respectively 51.9 and 28.0,and 26.6 and 6.9. The data obtained in this study were divided into those for two periods,1990-1996 and 1997-2006,and SMRs were calculated separately for males and females. For the first period,the SMR was 1.04 (95% CI 0.50-1.58) for males and 1.54 (95% CI 0.71-2.38) for females,while for the second period the SMR was 0.71 (95% CI 0.33-1.10) for males and 0.62 (95% CI 0.19-1.05) for females. CONCLUSION: Following the introduction of endoscopic examination,gastric cancer death rates decreased in Kamigoto. | Satohiro Matsumoto Kazumi Yamasaki Kenichiro Tsuji Satoshi Shirahama | 2007 | World Journal of Gastroenterology2007，13，32： | 13 |
| 4 | Biomarkers for individualized dosage adjustments in immunosuppressive therapy using calcineurin inhibitors after organ transplantation显示文摘Calcineurin inhibitors (CNIs), such as cyclosporine A and tacrolimus, are widely used immunosuppressive agents for the prevention of post-transplantation rejection and have improved 1-year graft survival rates by up to 90%. However, CNIs can induce severe reactions, such as acute or chronic allograft nephropathy, hypertension, and neurotoxicity. Because CNIs have varied bioavailabilities, narrow therapeutic ranges, and individual propensities for toxic effects, therapeutic drug monitoring is necessary for all CNIs. Identifying the genetic polymorphisms in drug-metabolizing enzymes will help to determine personalized dosage regimens for CNIs, as CNIs are substrates for CYP3A5 and P-glycoprotein (P-gp, MDR1). CNIs are often concomitantly administered with voriconazole or proton pump inhibitors (PPIs), giving rise to drug interaction problems. Voriconazole and PPIs can increase the blood concentrations of CNIs, and both are primarily metabolized by CYP2C19. Thus, it is expected that interactions between CNIs and voriconazole or PPI would be affected by CYP2C19 and CYP3A5 polymorphisms. CNI-induced acute kidney injury (AKI) is a serious complication of transplantations. Neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule 1 (KIM-1) are noninvasive urinary biomarkers that are believed to be highly sensitive to CNI-induced AKI. In this article, we review the adverse events and pharmacokinetics of CNIs and the biomarkers related to CNIs, including CYP3A5, CYP2C19, MDR1, NGAL, and KIM-1. We hope that these data will help to identify the optimal biomarkers for monitoring CNI-based immunosuppressive therapy after organ transplantation. | Rao Fu Soichiro Tajima Kimitaka Suetsugu Hiroyuki Watanabe Nobuaki Egashira Satohiro Masuda | 2019 | Acta Pharmacologica Sinica2019，40，2： | 10 |
| 5 | Risk factors for postoperative bleeding after gastric endoscopic submucosal dissection in patients under antithrombotics显示文摘AIM: To evaluate the risk factors for postoperative bleeding after gastric endoscopic submucosal dissection(ESD) based on the latest guidelines.METHODS: A total of 262 gastric neoplasms were treated by ESD at our center during a 2-year period from October 2012. We analyzed the data of these cases retrospectively to identify the risk factors for postESD bleeding.RESULTS: Of the 48(18.3%) cases on antithrombotic treatment, 10 were still receiving antiplatelet drugs perioperatively, 13 were on heparin replacement after oral anticoagulant withdrawal, and the antithrombotic therapy was discontinued perioperatively in 25 cases. Postoperative bleeding occurred in 23 cases(8.8%). The postoperative bleeding rate in the heparin replacement group was 61.5%, significantly higher than that in the non-antithrombotic therapy group(6.1%). Univariate analysis identified history of antithrombotic drug use, heparin replacement, hemodialysis, cardiovascular disease, diabetes mellitus, elevated prothrombin timeinternational normalized ratio, and low hemoglobin level on admission as risk factors for post ESD bleeding. Multivariate analysis identified only heparin replacement(OR = 13.7, 95%CI: 1.2-151.3, P = 0.0329) as a significant risk factor for post-ESD bleeding.CONCLUSION: Continued administration of antiplatelet agents, based on the guidelines, was not a risk factor for postoperative bleeding after gastric ESD; however, heparin replacement, which is recommended after withdrawal of oral anticoagulants, was identified as a significant risk factor. | Yuji Shindo Satohiro Matsumoto Hiroyuki Miyatani Yukio Yoshida Hirosato Mashima | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，7： | 10 |
| 6 | Rebamipide enema therapy for left-sided ischemic colitis patients accompanied by ulcers:Open label study显示文摘AIM: To attempt rectal administration of rebamipide in the treatment of ischemic colitis patients with ulcers, and evaluate its effects. METHODS: We compared 9 ischemic colitis patients (2 men, 7 women) with ulcers treated by bowel rest only from 2000 to 2005 (conventional therapy group), with 6 patients (2 men, 4 women) treated by rebamipide enema therapy in 2006 (rebamipide enema therapy group) and analyzed the mean duration of fasting and hospitalization, degree of ulcer healing, and decrease in WBC count for the two groups. RESULTS: The mean duration of fasting and hos- pitalization were 2.7 ± 1.8 d and 9.2 ± 1.5 d in the rebamipide group and 7.9 ± 4.1 d and 17.9 ± 6.8 d in the control group, respectively, and signifi cantly re- duced in the rebamipide group (t = -2.915; P = 0.0121 and t = -3.054; P = 0.0092). As for the degree of ul- cer healing at 7 d after admission, the ulcer score was reduced by 3.5 ± 0.5 (points) in the rebamipide group and 2.8 ± 0.5 (points) in the control group (t = 1.975; P = 0.0797), while the decrease in WBC count was 120.0 ± 55.8 (× 102/μL) in the rebamipide group and 85.9 ± 56.8 (× 102/μL) in the control group (t = 1.006; P = 0.3360). CONCLUSION: In left-sided ischemic colitis patients with ulcers, rebamipide enema therapy significantly reduced the duration of fasting and hospitalization, recommending its use as a new and effective thera- peutic alternative. | Satohiro Matsumoto Kenichiro Tsuji Satoshi Shirahama | 2008 | World Journal of Gastroenterology2008，14，25： | 5 |
| 7 | Duodenal carcinoid tumors: 5 cases treated by endoscopic submucosal dissection显示文摘 | Satohiro Matsumoto Hiroyuki Miyatani Yukio Yoshida Mitsuhiro Nokubi | 2011 | Gastrointestinal Endoscopy2011，，5： | 4 |
| 8 | Future directions of duodenal endoscopic submucosal dissection显示文摘Endoscopic therapies for lesions of the duodenum are technically more difficult than those for lesions of the other parts of the gastrointestinal tract due to the anatomical features of the duodenum, and the incidence rate of complications such as perforation and bleeding is also higher. These aforementioned trends were especially noticeable for the case of duodenal endoscopic submucosal dissection(ESD). The indication for ESD of duodenal tumors should be determined by assessment of the histopathology, macroscopic morphology, and diameter of the tumors. The three types of candidate lesions for endoscopic therapy are adenoma, carcinoma, and neuroendocrine tumors. For applying endoscopic therapies to duodenal lesions, accurate preoperative histopathological diagnosis is necessary. The most important technical issue in duodenal ESD is the submucosal dissection process. In duodenal ESD, a short needle-type knife is suitable for the mucosal incision and submucosal dissection processes, and the Small-caliber-tip Transparent hood is an important tool. After endoscopic therapies, the wound should be closed by clipping in order to prevent complications such as secondary hemorrhage and delayed perforation. At present, the criteria for selection between ESD and EMR vary among institutions. The indications for ESD should be carefully considered. Duodenal ESD should have limitations, such as the need for its being performed by experts with abundant experience in performing the procedure. | Satohiro Matsumoto Hiroyuki Miyatani Yukio Yoshida | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，4： | 4 |
| 9 | Acquisition of LURE-Binding Activity at the Pollen Tube Tip of Torenia fournieri显示文摘 | Satohiro Okuda Takamasa Suzuki Masahiro M. Kanaoka Hitoshi Moric Narie Sasaki Tetsuya Higashiyama | 2013 | Molecular Plant2013，6，4： | 3 |
| 10 | Efficacy of endoscopic screening in an isolated island: A case–control study显示文摘 | Satohiro Matsumoto Yukio Yoshida | 2014 | Indian Journal of Gastroenterology2014，，1： | 3 |
| 11 | Population pharmacokinetic and pharmacogenomic analysis of tacrolimus in pediatric living-donor liver transplant recipients 显示文摘 | Masahide F Ikuko Y Satohiro M | 2006 | Clin Pharmacol Ther2006，80，： | 1 |
| 12 | Cerebrospinal fluid concentration of gefitinib and erlotinib in patients with non-small cell lung cancer显示文摘 | Yosuke Togashi Katsuhiro Masago Satohiro Masuda Tomoyuki Mizuno Masahide Fukudo Yasuaki Ikemi Yuichi Sakamori Hiroki Nagai Young Kim Toshiya Katsura Michiaki Mishima | 2012 | Cancer Chemotherapy and Pharmacology2012，，3： | 1 |
| 13 | Ulcerative Colitis: Comparison Between Elderly and Young Adult Patients and Between Elderly Patients with Late-Onset and Long-Standing Disease显示文摘 | Satohiro Matsumoto Hiroyuki Miyatani Yukio Yoshida | 2013 | Digestive Diseases and Sciences2013，，： | 1 |
| 14 | Defensin-like polypeptideLUREs are pollen tube attractants secreted from synergid cells显示文摘 | Satohiro O Hiroki T Keiko S | 2009 | Nature2009，458，： | 1 |
| 15 | Sodium tauroursodeoxycholate prevents paraquat-induced cell death by suppressing endoplasmic reticulum stress responses in human lung epithelial A549 cells显示文摘 | Tomohiro Omura Masaru Asari Joe Yamamoto Kumiko Oka Chisato Hoshina Chikatoshi Maseda Toshio Awaya Yoshikazu Tasaki Hiroshi Shiono Atsushi Yonezawa Satohiro Masuda Kazuo Matsubara Keiko Shimizu | 2013 | Biochemical and Biophysical Research Communications2013，，： | 1 |
| 16 | Impact of MDR1 and CYP3A5 on the oral clearance of tacrolimus and tacrolimus-related renal dysfunction in adult living-donor liver transplant patients显示文摘 | Masahide Fukudo Ikuko Yano Atsushi Yoshimura Satohiro Masuda Miwa Uesugi Keiko Hosohata Toshiya Katsura Yasuhiro Ogura Fumitaka Oike Yasutsugu Takada Shinji Uemoto Ken-ichi Inui | 2008 | Pharmacogenetics and Genomics2008，，5： | 1 |
| 17 | CYP3A5*1carrying graft liver reduces the concentration/oral dose ratio of Tacrolimus in recipients of living-donor liver transplantation显示文摘 | Maki G Satohiro M Tetsuya K | 2004 | Pharmacogenetics2004，14，7： | 1 |
| 18 | Effect of intestinal CYP3A5 on postoperative tacrolimus trough levels in living-donor liver transplant recipients显示文摘 | Miwa Uesugi Satohiro Masuda Toshiya Katsura Fumitaka Oike Yasutsugu Takada Ken-ichi Inui | 2006 | Pharmacogenetics and Genomics2006，，2： | 1 |
| 19 | CYP3A5 * 1-carrying graft liver reduces the concentration/ oral dose ratio of tacrolimus in recipients of living-donor liver transplantation 显示文摘 | MAKI GOTOA SATOHIRO MASUDAA TETSUYA KIUCHI | 2004 | Pharmacogenetics2004，14，7： | 1 |
| 20 | Zirconia-supported copper catalysts for NO-CO reaction: Surface copper species on zirconia显示文摘 | Hideki Gotoh Satohiro Yoshida | 1997 | J Chem Soc Farady Trans Phys Chem & Chem Phys1997，93，21： | 1 |
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