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| 1 | New vacuum solar telescope and observations with high resolution显示文摘The New Vacuum Solar Telescope(NVST) is a one meter vacuum solar telescope that aims to observe fine structures on the Sun. The main goals of NVST are high resolution imaging and spectral observations, including measurements of the solar magnetic field. NVST is the primary ground-based facility used by the Chinese solar research community in this solar cycle. It is located by Fuxian Lake in southwest China, where the seeing is good enough to perform high resolution observations. We first introduce the general conditions at the Fuxian Solar Observatory and the primary science cases of NVST. Then, the basic structures of this telescope and instruments are described in detail. Finally, some typical high resolution data of the solar photosphere and chromosphere are also shown. | Zhong Liu Jun Xu Bo-Zhong Gu Sen Wang Jian-Qi You Long-Xiang Shen Ru-Wei Lu Zhen-Yu Jin Lin-Fei Chen Ke Lou Zhi Li Guang-Qian Liu Zhi Xu Chang-Hui Rao Qi-Qian Hu Ru-Feng Li Hao-Wen Fu Feng Wang Men-Xian Bao Ming-Chan Wu Bo-Rong Zhang | 2014 | Research in Astronomy and Astrophysics2014，14，6： | 37 |
| 2 | Biomarkers for individualized dosage adjustments in immunosuppressive therapy using calcineurin inhibitors after organ transplantation显示文摘Calcineurin inhibitors (CNIs), such as cyclosporine A and tacrolimus, are widely used immunosuppressive agents for the prevention of post-transplantation rejection and have improved 1-year graft survival rates by up to 90%. However, CNIs can induce severe reactions, such as acute or chronic allograft nephropathy, hypertension, and neurotoxicity. Because CNIs have varied bioavailabilities, narrow therapeutic ranges, and individual propensities for toxic effects, therapeutic drug monitoring is necessary for all CNIs. Identifying the genetic polymorphisms in drug-metabolizing enzymes will help to determine personalized dosage regimens for CNIs, as CNIs are substrates for CYP3A5 and P-glycoprotein (P-gp, MDR1). CNIs are often concomitantly administered with voriconazole or proton pump inhibitors (PPIs), giving rise to drug interaction problems. Voriconazole and PPIs can increase the blood concentrations of CNIs, and both are primarily metabolized by CYP2C19. Thus, it is expected that interactions between CNIs and voriconazole or PPI would be affected by CYP2C19 and CYP3A5 polymorphisms. CNI-induced acute kidney injury (AKI) is a serious complication of transplantations. Neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule 1 (KIM-1) are noninvasive urinary biomarkers that are believed to be highly sensitive to CNI-induced AKI. In this article, we review the adverse events and pharmacokinetics of CNIs and the biomarkers related to CNIs, including CYP3A5, CYP2C19, MDR1, NGAL, and KIM-1. We hope that these data will help to identify the optimal biomarkers for monitoring CNI-based immunosuppressive therapy after organ transplantation. | Rao Fu Soichiro Tajima Kimitaka Suetsugu Hiroyuki Watanabe Nobuaki Egashira Satohiro Masuda | 2019 | Acta Pharmacologica Sinica2019，40，2： | 10 |
| 3 | MicroTom Metabolic Network: Rewiring Tomato Metabolic Regulatory Network throughout the Growth Cycle显示文摘Tomato(Solanum lycopersicum)is a major horticultural crop worldwide and has emerged as a preeminent model for metabolic research.Although many research efforts have focused on the analysis of metabolite differences between varieties and species,the dynamics of metabolic changes during the tomato growth cycle and the regulatory networks that underlie these changes are poorly understood.In this study,we integrated high-resolution spatio-temporal metabolome and transcriptome data to systematically explore the metabolic landscape across 20 major tomato tissues and growth stages.In the resulting MicroTom Metabolic Network,the 540 detected metabolites and their co-expressed genes could be divided into 10 distinct clusters based on their biological functions.Using this dataset,we constructed a global map of the major metabolic changes that occur throughout the tomato growth cycle and dissected the underlying regulatory network.In addition to verifying previously well-established regulatory networks for important metabolites,we identified novel transcription factors that regulate the biosynthesis of important secondary metabolites such as steroidal glycoalkaloids and flavonoids.Our findings provide insights into spatiotemporal changes in tomato metabolism and generate a valuable resource for the study of metabolic regulatory processes in model plants. | Yan Li Yang Chen Lu Zhou Shengjie You Heng Deng Ya Chen Saleh Alseekh Yong Yuan Rao Fu Zixin Zhang Dan Su Alisdair R.Fernie Mondher Bouzayen Tao Ma Mingchun Liu Yang Zhang | 2020 | Molecular Plant2020，13，8： | 10 |
| 4 | Spatial Properties of Mismatch Negativity in Patients with Disorders of Consciousness显示文摘In recent decades, event-related potentials have been used for the clinical electrophysiological assessment of patients with disorders of consciousness(DOCs). In this paper, an oddball paradigm with two types of frequencydeviant stimulus(standard stimuli were pure tones of 1000 Hz; small deviant stimuli were pure tones of 1050 Hz; large deviant stimuli were pure tones of 1200 Hz) was applied to elicit mismatch negativity(MMN) in 30 patients with DOCs diagnosed using the JFK Coma Recovery ScaleRevised(CRS-R). The results showed that the peak amplitudes of MMN elicited by both large and small deviant stimuli were significantly different from baseline.In terms of the spatial properties of MMN, a significant interaction effect between conditions(small and large deviant stimuli) and electrode nodes was centered at the frontocentral area. Furthermore, correlation coefficients were calculated between MMN amplitudes and CRS-R scores for each electrode among all participants to generate topographic maps. Meanwhile, a significant negative correlation between the MMN amplitudes elicited by large deviant stimuli and the CRS-R scores was also found at the frontocentral area. In consequence, our results combine the above spatial properties of MMN in patients with DOCs,and provide a more precise location(frontocentral area) at which to evaluate the correlation between clinical electrophysiological assessment and the level of consciousness. | Xiaoyu Wang Rao Fu Xiaoyu Xia Xueling Chen Han Wu Nicole LANDi Ken Pugh Jianghong He Fengyu Cong | 2018 | Neuroscience Bulletin2018，34，4： | 9 |
| 5 | Next-Generation Plant Metabolic Engineering, Inspired by an Ancient Chinese Irrigation System显示文摘专业化第二等的代谢物服务不仅保护植物免于不能生活、关於生命的挑战,而且也有由人广泛地使用与疾病作斗争。由于 ? 为健康的药用的植物的大重要性,我们需要发现改进 ?的生产的新、持续的方法专业化代谢物。除了直接抽取,在植物的新陈代谢的工程的最近的进步提供一种其他的供应选择。我们主张为在植物生产第二等的代谢物的新陈代谢的工程可以比微生物引起的生产平台有明显的优点,并且因此建议新途径种新陈代谢的工程,它被一个古老的中国灌溉系统启发。新陈代谢的工程策略在三个层次工作:介绍 biosynthetic 基因,用抄写因素,并且改进新陈代谢的流动包括增加先锋,精力,和减少的电源的供应。另外,在生物工学的最近的进步显著地作出贡献到更好设计,例如特定的倡导者的使用 ? 并且竞争分支小径的删除。我们建议那家下一代的工厂新陈代谢的设计将改进当前的工程策略,为生产在工厂的珍贵代谢物的目的 ? 在工业规模上。 | Rao Fu Cathie Martin Yang Zhang | 2018 | Molecular Plant2018，11，1： | 7 |
| 6 | MCP-1-induced protein-1,an immune regulator显示文摘MCP-1-induced protein-1(MCPIP1)is a newly identified protein that is crucial to immune regulation.Mice lack-ing MCPIP1 gene suffer from severe immune disorders,and most of them cannot survive longer than 12 weeks.Considerable progress has been made in revealing the mechanism underlying the immune regulatory function of MCPIP1.MCPIP1 can act as an RNase to promote the mRNA degradation of some inflammatory cytokines,such as IL-6 and IL-1.Pre-microRNAs are also confirmed to be the substrate of MCPIP1 RNase.The structure of MCPIP1 N-terminal conserved domain shows a PilT N-terminus-like RNase structure,further supporting the notion that MCPIP1 has RNase activity.MCPIP1 can also deubiquitinate TNF receptor-associated factor family proteins,which are known to mediate immune and inflammatory responses.In this review,we summarize recent progress on the immune regulatory role of MCPIP1 and discuss the mechanisms underlying its function. | Jiwei Xu Sheng Fu Wei Peng Zihe Rao | 2012 | Protein & Cell2012，3，12： | 6 |
| 7 | Fabrication of scaffolds in tissue engineering: A review显示文摘 | Peng ZHAO Haibing GU Haoyang MI Chengchen RAO Jianzhong FU Lih-sheng TURNG | 2018 | Frontiers of Mechanical Engineering2018，13，1： | 5 |
| 8 | Zero-order-free meta-holograms in a broadband visible range显示文摘The unwanted zero-order light accompanied by the birth of diffractive optical elements and caused mainly by fabrication errors and wavelength variations is a key factor that deteriorates the performance of diffraction-related optical devices such as holograms,gratings,beam shapers,beam splitters,optical diffusers,and diffractive microlenses.Here,inspired by the unique characteristic of nano-polarizer-based metasurfaces for both positive and negative amplitude modulation of incident light,we propose a general design paradigm to eliminate zero-order diffraction without burdening the metasurface design and fabrication.The experimentally demonstrated metahologram,which projects a holographic image with a wide angle of 70°×70°in the for field,presents a very low zero-order intensity(only 0.7%of the total energy of the reconstructed image).More importantly,the zero-orderfree meta-hologram has a large tolerance limit for wavelength variations(under a broadband illumination from520 to 660 nm),which brings important technical advances.The strategy proposed could significantly relieve the fabrication difficulty of metasurfaces and be viable for various diffractive-optics-related applications includingholography,laser beam shaping,optical data storage,vortex beam generation,and so on. | RAO FU LIANGUI DENG ZHIQIANG GUAN SHENG CHANG JIN TAO ZILE LI GUOXING ZHENG | 2020 | Photonics Research2020，8，5： | 5 |
| 9 | A New Species of Japalura(Squamata, Agamidae) from the Nu River Valley in Southern Hengduan Mountains, Yunnan, China显示文摘A population of Japalura from Yunnan Province, China, previously assigned to Japalura splendida, is described as a new species. The new species has been recorded between 1 138–2 500 m in the Nu River drainage between the towns of Liuku and Binzhongluo, and on the lower western slopes of the Nushan and eastern slopes of the Goaligongshan. The new species can be distinguished from other species of Japalura, except J. dymondi, by the following combination of characters: exposed tympani, prominent dorso-lateral stripes, and small gular scales. It is very similar with but differs from J. dymondi by having smooth or feebly keeled dorsal head scales, three relatively enlarged spines on either side of the post-occiput area, strongly keeled and mucronate scales on occiput area and within the lateral stripes, back of arm and leg green, higher number of dorsal-ridge scales(DS) and fourth toe subdigital scales(T4S). A principal component analysis of body measurements of adult male specimens of the new species and J. dymondi showed principal component 1 loading highest for upper arm length, fourth toe length and snout to eye length and principal component 2 loading highest for head width, head length and fourth toe length. | Dingqi RAO Jens V.VINDUM Xiaohui MA Mingxia FU Jeffery A.WILKINSON | 2017 | Asian Herpetological Research2017，18，2： | 3 |
| 10 | Pharmacokinetics of PEGylated recombinant human endostatin (M2ES) in rats显示文摘 | Zuo-gang LI Lin JIA Li-fang GUO Min YU Xu SUN Wen NIE Yan FU Chun-ming RAO Jun-zhi WANG Yong-zhang LUO | 2015 | Acta Pharmacologica Sinica2015，36，7： | 3 |
| 11 | Crystal structure of the African swine fever virus structural protein p35 reveals its role for core shell assembly显示文摘Dear Editor,The African swine fever(ASF)is a highly contagious hemorrhagic and lethal disease in domestic pigs.The ASF outbreaks of in many Asia countries,including China,Vietnam,Mongolia,and South Korea,have posed a huge threat to the pig indusry.In the attempt to stop ASF from spreading further in China's Mainland,more than 10 million pigs have been culled since August 2018.The causative agent for ASF is a DNA virus,African swine fever virus(ASFV).Although this deadly disease has been reported in Kenya nearly one hundred years ago,there has been no vaccine for protection from ASFV infection or effective treatments to cure ASF until now. | Guobang Li Dan Fu Guangshun Zhang Dongming Zhao Mingyu Li Xue Geng Dongdong Sun Yuhui Wang Cheng Chen Peng Jiao Lin Cao Yu Guo Zihe Rao | 2020 | Protein & Cell2020，11，8： | 3 |
| 12 | Structure of African swine fever virus p15 reveals its dual role for membrane-association and DNA binding显示文摘Dear Editor, African swine fever (ASF) is a highly contagious disease of domestic pigs caused by African swine fever virus (ASFV),with mortality rates approaching 90%-100%.The first ASF case was described in 1921 in Kenya.Over the past decades, ASF has spread from Sub-Saharan Africa to Europe and Asia, and pose a huge threat to global food safety.Since the first ASF case reported in August 2018, more than 10 million pigs had been culled in China at an enormous economic loss.The risk of ASFV mutating to infect humans is extremely low.However, ASF not only threatens food security but also severely strikes the world economy in many fields, such as the global supply of the blood thinner heparin,most of which is produced from pigs.Hence, ASF is a strictly monitored infectious animal disease by OIE (World Organization for Animal Health), unfortunately, there is no approved drug or vaccine against this lethal viral disease. | Dan Fu Dongming Zhao Wei Zhang Guangshun Zhang Mingyu Li Zheng Zhang Yuhui Wang Dongdong Sun Peng Jiao Cheng Chen Yu Guo Zihe Rao | 2020 | Protein & Cell2020，11，8： | 3 |
| 13 | First light for the sodium laser guide star adaptive optics system on the Lijiang 1.8 m telescope显示文摘A first generation sodium Laser Guide Star Adaptive Optics System(LGS-AOS) was developed and integrated into the Lijiang 1.8 m telescope in 2013. The LGS-AOS has three sub-systems:(1) a 20 W long pulsed sodium laser,(2) a 300-millimeter-diameter laser launch telescope, and(3) a 37-element compact adaptive optics system. On 2014 January 25, we obtained high resolution images of an mV8.18 star,HIP 43963, during the first light of the LGS-AOS. In this paper, the sodium laser, the laser launch telescope,the compact adaptive optics system and the first light results will be presented. | Kai Wei Min Li Shan-Qiu Chen Yong Bo Feng Chen Jun-Wei Zuo Qi Bian Ji Yao Lu-Chun Zhou Lin Wei Dong-Hong Chen Yang Gao KaiJin Xiao-Lin Dai Han-Chu Fu Chang Xu Zhi-Chao Wang Xiang-Hui Xue Xue-Wu Chen Xian-Mei Qian Yu Zhou Hao Xian Qin-Jun Peng Chang-Hui Rao Zu-Yan Xu Yu-Dong Zhang | 2016 | Research in Astronomy and Astrophysics2016，16，12： | 2 |
| 14 | Crystal structure of a bacterial homolog to human lysosomal transporter,spinster显示文摘Lysosomes break down various biomolecules and spinster is one of the major efflux carriers removing degradation products from lysosomal lumen to keep it in healthy size and proper function.Although it is well established that a dysfunctional spinster will cause enlarged lysosomes and in turn lead to developmental defects and abnormal behavior in animals,little was known about the transportation mechanism and substrate specificity of spinster.Here,we report a crystal structure of spinster homolog from Hyphomonas neptunium,HnSPNS,in its inward-facing conformation with and without substrate bound.HnSPNS is crystallized in a monomer and a substrate-binding cavity was formed in the center of its transmembrane helices.A blob of electron density corresponding to its substrate was found in the cavity near a conserved residue,R42,which is locked in position by the interactions with conserved residues E129 and R122.Our results suggest that human spinster serves as a transporter translocating negativelycharged lipophilic small molecules and E129 might serve as a switch to control the conformational change via its protonation-deprotonation cycle. | Fu Zhoua Deqiang Yao Bing Rao Li Zhang Wang Nie Yan Zou Jie Zhao Yu Cao | 2019 | Science Bulletin2019，64，18： | 2 |
| 15 | Fiber Bragg Grating Strain Sensors for Marine Engineering显示文摘 | Tingting WANG Zilin YUAN Yuan GONG Yu WU Yunjiang RAO Lili WEI Peng GUO Junpu WANG Fu WAN | 2013 | Photonic Sensors2013，3，3： | 2 |
| 16 | Effect of heat treatment on microstructures and properties of a novel Al-Zn-Mg-Cu alloy for oil drilling显示文摘In view of the special requirements for strength, heat resistance and corrosion resistance of Al-Zn-Mg-Cu alloy for oil drilling, the Al-6.2 Zn-2.5 Mg-1.6 Cu alloy was prepared by increasing Cu content on basis of Russian Series 1953 alloy. The effect of heat treatment on the microstructures and properties of the alloy was characterized by optical microscope(OM), scanning electron microscope(SEM) and transmission electron microscope(TEM), and investigated by tensile test at room temperature, thermal exposure test and corrosion test. The results show that the strength after T6 aging treatment exhibit a decrease trend as an increase of the solution temperature from465 ℃ to 480 ℃. After the solution treated by the rate of 470 ℃/1 h, second phases dissolve into the matrix very well and the strength property reaches optimum. The alloy has better comprehensive properties treated by a solution treatment of 470 ℃/1 h and then followed by an aging treatment of 120 ℃/24 h + 170 ℃/1 h + 120 ℃/24 h. Under the aging state, the precipitated phases inside the grains are suitable in size, while on the grain boundary distribute discontinuously and the precipitate-free zone is obvious. Besides, the alloy still maintain high tensile properties. The yield strength, tensile strength and elongation are 650 MPa, 686 MPa,12.0%, respectively. The yield strength retention after heat exposure is 92%. The alloy has good corrosion resistance and the exfoliation corrosion degree. The average corrosion rate in the H2S and CO2 environment is 0.0024 mm/a, which is far less than the required 0.12 mm/a. It is insensitive to H2S and CO2 environments. | Yanjun Fu Xiwu Li Kai Wen Shuhui Huang Yang Dong Mao Rao Fubo Yang Yugang Wang Baiqing Xiong Zhihui Li | 2019 | Progress in Natural Science:Materials International2019，29，2： | 2 |
| 17 | Frontier research of ultra-high-speed ultra-large-capacity and ultra-long-haul optical transmission显示文摘极端高速度, ultra-large-capacity 和 ultra-long-haul (3U ) 是光通讯的永久追求。作为光通讯的一个新模式, 3U 传播能极大地支持下一代光因特网和宽带活动通讯网络开发和工艺的进步,因此,它变得国际高技术知识产权竞争的焦点扎根。这篇论文在 3U 传播研究引入科学问题,关键技术和重要成就。 | Daojun XUE Shaohua YU Qi YANG Nan CHI Lan RAO Xiangjun XIN Wei LI Songnian FU Sheng CUI Demin LIU Zhuo LI Aijun WEN Chongxiu YU Xinmei WANG | 2016 | Frontiers of Optoelectronics2016，9，2： | 2 |
| 18 | Appropriate choice of collision-induced dissociation energy for qualitative analysis of notoginsenosides based on liquid chromatography hybrid ion trap time-of-flight mass spectrometry显示文摘Liquid chromatography hybrid ion trap/time-of-flight mass spectrometry possesses both the MS^n ability of ion trap and the excellent resolution of a time-of-flight and has been widely used to identify drug metabolites and determine trace multi-components in natural products. Collision energy, one of the most important factors in acquiring MS^n information, could be set freely in the range of 10%–400%. Herein, notoginsenosides were chosen as model compounds to build a novel methodology for the collision energy optimization. Firstly, the fragmental patterns of the representatives for the authentic standards of protopanaxadiol-type and protopanaxatriol-type notoginsenosides were obtained based on accurate MS^2 and MS^3 measurements via liquid chromatography hybrid ion trap/time-of-flight mass spectrometry. The extracted ion chromatograms of characteristic product ions of notoginsenosides in Panax Notoginseng Extract were produced under a series of collision energies and compared to screen the optimum collision energies values for MS^2 and MS^3. The results demonstrated that the qualitative capability of liquid chromatography hybrid ion trap/time-of-flight mass spectrometry was greatly influenced by collision energies, and 50% of MS^2 collision energy was found to produce the highest collision-induced dissociation efficiency for notoginsenosides. Addtionally, the highest collision-induced dissociation efficiency appeared when the collision energy was set at 75% in the MS^3 stage. | WANG Guang-Ji FU Han-Xu XIAO Jing-Cheng YE Wei RAO Tai SHAO Yu-Hao KANG Dian XIE Lin LIANG Yan | 2016 | Chinese Journal of Natural Medicines2016，14，4： | 2 |
| 19 | Sorption Kinetics of Organic Contaminants by Sandy Aquifer and Its Kerogen Isolate 显示文摘 | Ran Yong Xing Bao-shaaa Rao P S C Sheng Guo-ying Fu Jia-mo | 2005 | Environ Sci Technol2005，39，16： | 1 |
| 20 | Copper-catalyzed arylation of amines using diphenyl pyrrolidine-2-phosphonate as the new ligand显示文摘 | RAO H FU H JIANG Y | 2005 | J Org Chem2005，70，： | 1 |
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