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| 1 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 2 | Endoscopic management of polypoid early colon cancer 显示文摘 | Williams C B Saunders B P Talbot I C | 2000 | World J Surg2000，24，9： | 1 |
| 3 | Deinococcus geothermalis:the pool of extreme radiation resistance genes shrinks显示文摘 | Makarova K S Omelchenko M V Gaidamakova E K Matrosova V Y Vasilenko A Zhai M Lapidus A Copeland A Kim E Land M Mavrommatis K Pitluck S Richardson P M Detter C Brettin T Saunders E Lai B Ravel B Kemner K M Wolf Y I Sorokin A Gerasimova A V Gelfand M S Fredrickson J K Koonin E V Daly M J | 2007 | PloS One2007，2，9： | 1 |
| 4 | The effect on thunderstorm charging of the rate of rime accretion by graupel 显示文摘 | Brooks I M Saunders C P R Mitzeva R P | 1997 | Atmos Rea1997，43，： | 1 |
| 5 | Hyperfractionated or accelerated radiotherapy in lung cancer:an individual patient data meta-analysis显示文摘 | MAUGUEN A LE PéCHOUX C SAUNDERS M I | | 0，，22： | 1 |
| 6 | An experimental investigation of the inductive mechanism of thunderstorm electrification 显示文摘 | Brooks I M Saunders C P R | 1994 | Journal of Geophysical Research1994，99，10： | 1 |
| 7 | The effect on thunderstorm charging of the rate of rime accretion by grau- perl显示文摘 | Brooks I M Saunders C P R Mitzeva R P | 1997 | Atmospheric Research1997，43，： | 1 |
| 8 | TRPV1,NK1 re- ceptor and substance Pimmunoreactivity and gene expression in the rat lumbosacral spinal cord and urinary bladder after systemic,low dose vanilloid administration显示文摘 | Heng Y J Saunders C I Kunde D A | 2011 | Regul Pept2011，167，23： | 1 |
| 9 | Polylactones : Sn ( Ⅱ )octoate - initiated polymerization of l - lactide: A mechanistic study显示文摘 | Kricheldod R H Saunders K I Boettcher C | 1995 | Polymer1995，36，6： | 1 |
| 10 | The effect on thunderstorm charging of the rate of rime accretion by graupel显示文摘 | BROOKS I M SAUNDERS C P R MITZEVA R P | 1997 | Atmos Res1997，43，3： | 1 |
| 11 | Towards a physical map of the Drosophila melanogaster genome:Mapping of cosmid clones within defined genomic divisions显示文摘 | Siden-Kiamos I Saunders R D C Spanos L | | 0，，21： | 1 |
| 12 | l-Iyperfractionated or accelerated radiotherapy in lung cancer: an individual patient data meta-analysis显示文摘 | MAUGUEN A LE PECHOUX C SAUNDERS M I | 2012 | JClinOneol2012，30，22： | 1 |
| 13 | A compar-ison of monopolar electrosurgery to a new multipolar electro-surgical system in a rat model显示文摘 | Chinpairoj S Feldman M D Saunders I C | 2001 | Laryngoscope2001，111，2： | 1 |
| 14 | Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus 显示文摘 | Nierman WC Pain A Anderson MJ Wortman JR Kim HS Arroyo J Berriman M Abe K Archer DB Bermejo C Bennett J Bowyer P Chen D Collins M Coulsen R Davies R Dyer PS Farman M Fedorova N Fedorova N Feldblyum TV Fischer R Fosker N Fraser A Garcla JL Garcia MJ Goble A Goldman GH Gomi K Griffith- Jones S Gwilliam R Haas B Haas H Harris D Horiuchi H Huang J Humphray S Jim6nez J Keller N Khouri H Kitamoto K Kobayashi T Konzack S Kulkarni R Kumagai T Lafon A Latgo JP Li W Lord A Lu C Majoros WH May GS Miller BL Mohamoud Y Molina M Monod M Mouyna I Mulligan S Murphy L O'Neil S Paulsen I Pefialva MA Pertea M Price C Pritchard BL Quail MA Rabbinowitsch E Rawlins N Rajandream MA Reichard U Renauld H Robson GD Rodriguez de Cordoba S Rodriguez-Pefia JM Ronning CM Putter S Salzberg SL Sanchez M Sfnchez-Ferrero JC Saunders D Seeger K Squares R Squares S Takeuchi M Tekaia F Turner G Vazquez de Aldana CR Weidman J White O Woodward J Yu JH Fraser C Galagan JE Asai K Machida M Hall N Barrell B Denning DW | 2005 | Nature2005，438，7071： | 1 |
| 15 | Remarkably simple fabrication of superhydrophobic surfaces using electroless galvanic deposition 显示文摘 | LARMOUR I A BELL S E SAUNDERS G C | 2007 | Angewandte Chemie2007，119，10： | 1 |
| 16 | Ab initio study of MF2 (M=Mn, Fe, Co, Ni) rutile-type compounds using the periodic unrestricted Hartree-Fock approach 显示文摘 | MOREIRA I D P R DOVESI R ROETTI C SAUNDERS V R ORLANDO R | 2000 | Phys Rev B2000，62，12： | 1 |
| 17 | J esters containing phosphorus显示文摘 | McCombie I H Saunders B C Stacey G | 1945 | Journal of the Chemical Society1945，，： | 1 |
| 18 | DNA extrac-tion methods for Kelp (Liaminariales) tissue显示文摘 | MAYES C SAUNDERS G W TAN I H | 1992 | J Phycology1992，，28： | 1 |
| 19 | Remarkably simple fabrication of superhydrophobic surfaces using electroless galvanic deposition显示文摘 | Larmour I A Bell S E J Saunders G C | 2007 | Angewandte Chemie International Edition2007，46，10： | 1 |
| 20 | The effect on thunderstorm charging of the rate of rime accretion by graupel 显示文摘 | BROOKS I M SAUNDERS C P R MITZEVA R P | 1997 | AtmosRea1997，43，： | 1 |
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