|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Plant-derived anticancer agents: A green anticancer approach显示文摘Cancer is a frightful disease and represents one of the biggest health-care issues for the human race and demands a proactive strategy for cure. Plants are reservoirs for novel chemical entities and provide a promising line for research on cancer. Hitherto, being effective, chemotherapy is accompanied by certain unbearable side effects. Nevertheless,plants and plant derived products is a revolutionizing field as these are Simple, safer, ecofriendly, low-cost, fast, and less toxic as compared with conventional treatment methods.Phytochemicals are selective in their functions and acts specifically on tumor cells without affecting normal cells. Carcinogenesis is complex phenomena that involves many signaling cascades. Phytochemicals are considered suitable candidates for anticancer drug development due to their pleiotropic actions on target events with multiple manners. The research is in progress for developing potential candidates(those can block or slow down the growth of cancer cells without any side effects) from these phytochemicals. Many phytochemicals and their derived analogs have been identified as potential candidates for anticancer therapy. Effort has been made through this comprehensive review to highlight the recent developments and milestones achieved in cancer therapies using phytomolecules with their mechanism of action on nuclear and cellular factors. Furthermore, drugs for cancer treatment and their limitations have also been discussed. | Javed Iqbal Banzeer Ahsan Abbasi Tariq Mahmood Sobia Kanwal Barkat Ali Sayed Afzal Shah Ali Talha Khalil | 2017 | Asian Pacific Journal of Tropical Biomedicine2017，7，12： | 8 |
| 2 | Role of dietary phytochemicals in modulation of miRNA expression:Natural swords combating breast cancer显示文摘The National Cancer Institute had projected breast cancer(BC) as one of the topmost prevalent malignancies around the globe.In many cases,BC becomes resistant to chemotherapy,radiation and hormonal therapies.Traditional BC therapies are associated with adverse side effects,drug resistance and recurrence.Extensive research work has shown that these dietary phytochemicals(DPs) may exert therapeutic effects by regulating the miRNA expression.A large number of DPs have been researched as miRNA regulatory agents against BC and some other DPs have not yet been tested against BC.We have discussed the effects of curcumin,diallyl disulphide,3,3′ diindolylmethane,ellagic acid,genistein,indole-3-carbinol,quercetin,resveratrol,and sulforaphane on regulation of expression of BC miRNAs in a wide range of in vitro and in vivo models.We have also shown some of the possible DPs(Oleanolic acid,capsaicin,benzyl isothiocyanate,epigallocatechin gallate,phenethyl isothiocyanate and ursolic acid) that have shown miRNA regulatory activities and have not yet been tested against BC miRNAs.Finally,current limitations,challenges,future perspectives of DPs and BC research are also critically discussed. | Banzeer Ahsan Abbasi Javed Iqbal Tariq Mahmood Ali Talha Khalil Barkat Ali Sobia Kanwal Sayed Afzal Shah Riaz Ahmad | 2018 | Asian Pacific Journal of Tropical Medicine2018，11，9： | 3 |
| 3 | Sequence and the developmental and tissue-specific regulation of the first complete vitellogenin messenger RNA from ticks responsible for heme sequestration显示文摘 | Deborah M. Thompson Sayed M.S. Khalil Laura A. Jeffers Daniel E. Sonenshine Robert D. Mitchell Christopher J. Osgood R. Michael Roe | 2007 | Insect Biochemistry and Molecular Biology2007，，4： | 1 |
| 4 | Limonoids from citrus reticulata显示文摘 | Ashraf T Khalil Galal T Maatooq Khalid A El Sayed | 2002 | Natarforsch2002，58，3： | 1 |
| 5 | Fault location scheme for combined overhead line with underground power cable 显示文摘 | El Sayed Tag El Din Mohamed Mamdouh Abdel Aziz Doaa khalil Ibrahim | 2006 | Electric Power Systems Re- search2006，76，11： | 1 |
| 6 | Traveling-Wave-Based Fault-Location Scheme for Multiend-Aged Underground Cable System显示文摘 | Mahmoud Gilany Doaa khalil Ibrahim El Sayed Tag Eldin | 2007 | IEEE Transactions on Power Delivery2007，1，22： | 1 |
| 7 | Traveling-wave-based Fault-location Scheme for Multiend-aged Underground Cable System显示文摘 | Mahmoud Gilany Doaa khalil Ibrahim EI Sayed Tag Eldin | 2007 | IEEE Transactions on Power Delivery2007，22，1： | 1 |
| 8 | Sulforaphane increases the survival rate in rats with fulminant hepatic failure induced by D-galactosamine and lipopolysaccharide显示文摘 | Rabab H. Sayed Wagdy K.B. Khalil Hesham A. Salem Sanaa A. kenawy Bahia M. El-Sayeh | 2014 | Nutrition Research2014，，： | 1 |
| 9 | Increasing bandwidth with single sensor seismic data-the Lehib oilfield case study显示文摘 | Abdul Baset Refae Sayed Khalil Bob Vincent | 2008 | First Break2008，26，： | 1 |
| 10 | Synthesis and reactions of some 6-aryl and 2,6-diaryl-4-(4'-antipyrinyl)-2,3,4,5-tetrahydropyridasin-3-ones and screening for their antibacterial activities显示文摘Some new pyridazinone derivatives(3) were synthesized through addition of antipyrin to β-aroylacrylic acids (1) followed by cyclization of the adducts. Reactions of 3 with ethyl bromoacetate,benzenesulfonyl chloride, benzoyl chloride and POCl3 give N-substituted products and monochlorosub-stituted pyridazines (4), respectively. The reactions of the latter with thiourea give unexpected dithio-derivatives(5), which react with phenylhydrazine to give pyrazolopyridazino pyridazine derivatives (6).Reactions of 2 with NH2OH in ethanol and pyridine afford oxime and oxazinone derivatives 7 and 8,tespectively. The antibacterial activities of several compounds were screened. | SAYED G. H. SHIBA S. A. RADWAN A. MOHAMED S. M. KHALIL M. | 1992 | Chinese Journal of Chemistry1992，10，5： | 0 |
| 11 | Predictors of graft function and survival in second kidney transplantation: A single center experience显示文摘BACKGROUND The increasing kidney retransplantation rate has created a parallel field of research,including the risk factors and outcomes of this advanced form of renal replacement therapy.The presentation of experiences from different kidney transplantation centers may help enrich the literature on kidney retransplantation,as a specific topic in the field of kidney transplantation.AIM To identify the risk factors affecting primary graft function and graft survival rates after second kidney transplantation(SKT).METHODS The records of SKT cases performed between January 1977 and December 2014 at a European tertiary-level kidney transplantation center were retrospectively reviewed and analyzed.Beside the descriptive characteristics,the survivals of patients and both the first and second grafts were described using Kaplan-Meier curves.In addition,Kaplan-Meier analyses were also used to estimate the survival probabilities at 1,3,5,and 10 post-operative years,as well as at the longest followup duration available.Moreover,bivariate associations between various predictors and the categorical outcomes were assessed,using the suitable biostatistical tests,according to the predictor type.RESULTS Out of 1861 cases of kidney transplantation,only 48 cases with SKT were eligible for studying,including 33 men and 15 women with a mean age of 42.1±13 years.The primary non-function(PNF)graft occurred in five patients(10.4%).In bivariate analyses,a high body mass index(P=0.009)and first graft loss due to acute rejection(P=0.025)were the only significant predictors of PNF graft.The second graft survival was reduced by delayed graft function in the first(P=0.008)and second(P<0.001)grafts.However,the effect of acute rejection within the first year after the first transplant did not reach the threshold of significance(P=0.053).The mean follow-up period was 59.8±48.6 mo.Censored graft/patient survival rates at 1,3,5 and 10 years were 90.5%/97.9%,79.9%/95.6%,73.7%/91.9%,and 51.6%/83.0%,respectively.CONCLUSION Non-immediate recovery modes of the first and second graft functions were significantly associated with unfavorable second graft survival rates.Patient and graft survival rates of SKT were similar to those of the first kidney transplantation. | Mahmoud Khalil Rabea Ahmed Gadelkareem Medhat Ahmed Abdallah Mohamed Abdel-Basir Sayed FathyGaber Elanany Paolo Fornara Nasreldin Mohammed | 2023 | World Journal of Transplantation2023，13，6： | 0 |
| 12 | Dietary isoflavones,the modulator of breast carcinogenesis:Current landscape and future perspectives显示文摘Breast cancer is a frightful disease and serious concern in women around the world causing significant health care burden in both developed and developing countries. Extensive research work has shown that breast cancer provides strong resistance to chemical agents, U V radiation,and hormonal treatments. It is generally accepted that cell genetics is not the only main reason for breast cancer and genetic risk factors, for example, mutations in RRCAI and BRCA2 genes constitute 5%-10% of all breast cancer rates. Other related factors include age, gender,race, ethnicity, weight, reproductive factors, exo-and endogenous hormonal exposures, oral contraceptives use, ultraviolet radiation, diet, and night work(circadian disruption). Many studies have revealed that dietary isoflavones regulate breast cancer occurrence, recurrence and prognosis. Dietary isoflavones have long been part of Asian population diet and there is a significant increase as compared to dietary isoflavones intake among other populations. Dietary isoflavones are natural phytoestrogens having both estrogenic and anti-estrogenic potentials on breast cancer cells in culture, animal models and in experimental trials. This literature survey provides a comprehensive overview on the tumor preventive and tumor promoting potentials of dietary isoflavones on breast cancer. In addition, this paper provides a literature review of dietary isoflavones and their effects on up-regulation and down-regulation of different signaling pathways, genes and proteins. Finally, future perspectives of dietary isoflavones and breast cancer researchers are also critically discussed, which will provide a deeper insight regarding the inner molecular mechanisms of action. | Javed Iqbal Banzeer Ahsan Abbasi Ali Talha Khalil Barkat Ali Tariq Mahmood Sobia Kanwal Sayed Afzal Shah Wajid Ali | 2018 | Asian Pacific Journal of Tropical Medicine2018，11，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员