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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy显示文摘 | Vijay K Kuchroo Mercy Prabhu Das Julia A Brown Ann M Ranger Scott S Zamvil Raymond A Sobel Howard L Weiner Nasrin Nabavi Laurie H Glimcher | 1995 | Cell1995，，5： | 2 |
| 3 | Prognostically relevant gene signatures of high-grade serous ovarian carcinoma显示文摘 | Verhaak Roel G W Tamayo Pablo Yang Ji-Yeon Hubbard Diana Zhang Hailei Creighton Chad J Fereday Sian Lawrence Michael Carter Scott L Mermel Craig H Kostic Aleksandar D Etemadmoghadam Dariush Saksena Gordon Cibulskis Kristian Duraisamy Sekhar | 2013 | Journal of Clinical Investigation2013，，1： | 2 |
| 4 | Pore-Scale Investigation of Biomass Plug Development and Propagation in Porous Media显示文摘 | TERRI L STEWART FOGLER H SCOTT | 2002 | Biotechnology and Bioengineering2002，77，5： | 2 |
| 5 | Gold and trace element zonation in pyrite using a laser imaging technique: Implications for the timing of gold in orogenic and Carlin- style sediment- hosted deposits 显示文摘 | R R Large L Danyushevsky C Hollit V Maslennikov S Meffer S Gilbert S Bull R Scott P Emsbo H Thomas B Singh J Foster | 2009 | Economic Geology2009，104，5： | 1 |
| 6 | Calcium anidotrihydroborate:a hydrogen storage material显示文摘 | Diyabalanage H V K Shrestha R P Semelsberger TA Scott B L Bowden M E Davis B L Burrell A K | | 0，，47： | 1 |
| 7 | Treatment with interferon-a2b and ribavirin improves outcome in MERS-CoV-infected rhesus macaques 显示文摘 | Falzarano D de Wit E Rasmussen AL Feldmann F Oku- mura A Scott DP Brining D Bushmaker T Martellaro C Baseler L Benecke AG Katze MG Munster VJ Feldma- nn H | 2013 | Nat Med2013，19，10： | 1 |
| 8 | Plastic hinge integration methods for forced-based beam column elements显示文摘 | Scott M H Fenves G L | 2006 | Journal of Structural Engineering2006，132，2： | 1 |
| 9 | Plastic hinge integration methods for force-based beam-column elements 显示文摘 | Scott M H Fenves G L | 2006 | Journal of Structural Engineering ASCE2006，132，2： | 1 |
| 10 | Molecular and phenotypic characterization of Als1 and Als2 mutations conferring tolerance to acetolactate synthase herbicides in soybean显示文摘 | Kay L Walter Stephen D Strachan Nancy M Ferry Henrik H Albert Linda A Castle Scott A Sebastian | 2014 | Pest. Manag. Sci2014，，12： | 1 |
| 11 | Improving water flood recovery of viscous crude oils by chemical control显示文摘 | Scott G R Collins H N Flock D L | 1965 | J Can Petrol Technol1965，4，4： | 1 |
| 12 | An algorithm for associating the features of two patterns显示文摘 | G L Scott H C Longuet-Higgins | 1991 | Proc Royal Society London1991，224，： | 1 |
| 13 | The distribution of some fungal and bacterial endophytes in maize显示文摘 | Fisher P J Pertin O Scott H M L | 1992 | New Phytologist1992，12，2： | 1 |
| 14 | The systemic inflammatory response, weight loss, performance status and survival in patients with inoperable non-small cell lung cancer 显示文摘 | Scott H R McMillan D C Forrest L M | 2002 | BrJ Cancer2002，87，3： | 1 |
| 15 | Failure of lymphopoiesis after adoptive transfer of NF-kappaB-deficient fetal liver cells显示文摘 | Horwitz B H Scott M L Cherry S R | 1997 | Immunity1997，6，6： | 1 |
| 16 | Plastic: hinge integration methods for force-based beam-column elements 显示文摘 | Scott M H Fenves G L | 2006 | Journal of Structural Engineering2006，132，2： | 1 |
| 17 | Multiple Shear Key Connections for Preeast Shear Wall Panels显示文摘 | RIZKALLA Sami H SERRETTE Reynaud L HEUVEL J Scott | 1989 | PCI Journal1989，34，2： | 1 |
| 18 | Tmprss3, a transmembrane serine protease deficient in human DFNB8/IO deafness, is critical for cochlear hair cell survival at the onset of hearing显示文摘 | Fasquelle L Scott H S Lenoir M | 2011 | J Biol Chem2011，286，17： | 1 |
| 19 | Syndromes and consti tutional chromosomal abnormalities associated with Wilms tumour显示文摘 | Scott R H Stiller C A Walker L | 2006 | J Med Genet2006，43，9： | 1 |
| 20 | The growth of word trade:Tariffs,transport costs and income similarities显示文摘 | Scott L B Jeffrey H B | | 0，，01： | 1 |
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