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| 1 | SGLT-2 inhibitors in non-alcoholic fatty liver disease patients with type 2 diabetes mellitus: A systematic review显示文摘BACKGROUND Non-alcoholic fatty liver disease(NAFLD)is a common comorbidity with type 2 diabetes.The existing therapeutic options for NAFLD are not adequate.Hypocaloric diet and exercise is the cornerstone of therapy in NAFLD.Pioglitazone is the only drug recommended in diabetes patients with biopsy proven non-alcoholic steatohepatitis.The frequent coexistence of NAFLD and type 2 diabetes with their combined adverse health consequences and inadequate therapeutic options makes it necessary to search for newer alternatives.AIM To assess the effect of sodium glucose cotransporter-2(SGLT-2)inhibitors on liver enzymes in type 2 diabetes patients with NAFLD.METHODS We searched PubMed/MEDLINE,Cochrane library,Google scholar,and Clinicaltrials.gov for the relevant articles to be included in this systematic review.Human studies done in type 2 diabetes patients with NAFLD treated with SGLT-2 inhibitors for at least 12 wk were included.Data from eight studies(four randomised controlled trials and four observational studies)were extracted and a narrative synthesis was done.A total of 214 patients were treated with SGLT-2 inhibitors in these studies(94 in randomised controlled trials and 120 in observational studies).RESULTS The primary outcome measure was change in serum alanine aminotransferase level.Out of eight studies,seven studies showed a significant decrease in serum alanine aminotransferase level.Most of the studies revealed reduction in serum level of other liver enzymes like aspartate aminotransferase and gamma glutamyl transferase.Five studies that reported a change in hepatic fat exhibited a significant reduction in hepatic fat content in those treated with SGLT-2 inhibitors.Likewise,among the three studies that evaluated a change in indices of hepatic fibrosis,two studies revealed a significant improvement in liver fibrosis.Moreover,there was an improvement in obesity,insulin resistance,glycaemia,and lipid parameters in those subjects taking SGLT-2 inhibitors.The studies disclosed that about 17%(30/176)of the subjects taking SGLT-2 inhibitors developed adverse events and more than 40%(10/23)of them had genitourinary tract infections.CONCLUSION Based on low to moderate quality of evidence,SGLT-2 inhibitors improve the serum level of liver enzymes,decrease liver fat,and fibrosis with additional beneficial effects on various metabolic parameters in type 2 diabetes patients with NAFLD. | Henith Raj Harsh Durgia Rajan Palui Sadishkumar Kamalanathan Sandhiya Selvarajan Sitanshu Sekhar Kar Jayaprakash Sahoo | 2019 | World Journal of Diabetes2019，10，2： | 9 |
| 2 | Low-cost high entropy alloy(HEA)for high-efficiency oxygen evolution reaction(OER)显示文摘Oxygen evolution reaction(OER)is the key step involved both in water splitting devices and rechargeable metal-air batteries,and hence,there is an urgent need for a stable and low-cost material for efficient OER.In the present investigation,Co-Fe-Ga-NiZn(CFGNZ)high entropy alloy(HEA)has been utilized as a low-cost electrocatalyst for OER.Herein,after cyclic voltammetry activation,CFGNZ-nanoparticles(NPs)are covered with oxidized surface and form high entropy(oxy)hydroxides(HEOs),exhibiting a low overpotential of 370 mV to achieve a current density of 10 mA/cm^(2)with a small Tafel slope of 71 mV/dec.CFGNZ alloy has higher electrochemical stability in comparison to state-of-the art RuO2 electrocatalyst as no degradation has been observed up to 10 h of chronoamperometry.Transmission electron microscopy(TEM)studies after 10 h of long-term chronoamperometry test showed no change in the crystal structure,which confirmed the high stability of CFGNZ.The density functional theory(DFT)based calculations show that the closeness of d(p)-band centers to the Fermi level(EF)plays a major role in determining active sites.This work highlights the tremendous potential of CFGNZ HEA for OER,which is the primary reaction involved in water splitting. | Lalita Sharma Nirmal Kumar Katiyar Arko Parui Rakesh Das Ritesh Kumar Chandra Sekhar Tiwary Abhisek K.Singh Aditi Halder Krishanu Biswas | 2022 | Nano Research2022，15，6： | 5 |
| 3 | Ciprofloxacin degradation in photo-Fenton and photo-catalytic processes: Degradation mechanisms and iron chelation显示文摘Ciprofloxacin(CIP)is a broad spectrum synthetic antibiotic drug of fluoroquinolones class.CIP can act as a bidentate ligand forming iron complexes during its degradation in the photoFenton process(PFP).This work investigates on PFP for the degradation of CIP to understand the formation mechanism and stability of iron complexes under ultraviolet(UV)-light illumination.A comparison was made with the UV-photocatalysis(UV/TiO_2)process where CIP doesn't form a complex.In PFP,the optimal dose of Fe^(2+)and H_2O_2were found to be 1.25 and10 mmol/L with pH of 3.5.An optimal TiO_2dose of 1.25 g/L was determined in the UV/TiO_2process.Maximum CIP removal and mineralization efficiency of 93.1%and 47.3%were obtained in PFP against 69.7%and 27.6%in the UV/TiO_2process.The mass spectra could identify seventeen intermediate products including iron-CIP complexes in PFP,and only seven intermediate products were found in the UV/TiO_2process with a majority of common products in both the processes.The proposed mechanism supported by the mass spectra bridged the routes of CIP cleavage in the PFP and UV/TiO_2process,and the decomposition pathway of Fe^(3+)-CIP chelate complexes in PFP was also elucidated.Both in PFP and UV/TiO_2processes,the target site of HO~·radical attack was the secondary-N atom present in the piperazine ring of the CIP molecule.The death of Escherichia coli bacteria was 55.7%and 66.8%in comparison to the control media after 45 min of treatment in PFP and UV/TiO_2process,respectively. | Ardhendu Sekhar Giri Animes Kumar Golder | 2019 | Journal of Environmental Sciences2019，31，6： | 5 |
| 4 | Two Distinct Fluorescent Quantum Clusters of Gold Starting from Metallic Nanoparticles by pH-Dependent Ligand Etching显示文摘Two fl uorescent quantum clusters of gold,namely Au25 and Au8,have been synthesized from mercaptosuccinic acid-protected gold nanoparticles of 45 nm core diameter by etching with excess glutathione.While etching at pH~3 yielded Au_(25),that at pH 7-8 yielded Au_(8).This is the fi rst report of the synthesis of two quantum clusters starting from a single precursor.This simple method makes it possible to synthesize well-defined clusters in gram quantities.Since these clusters are highly fl uorescent and are highly biocompatible due to their low metallic content,they can be used for diagnostic applications. | Madathumpady Abubaker Habeeb Muhammed Subramani Ramesh Sudarson Sekhar Sinha Samir Kumar Pal Thalappil Pradeep | 2008 | Nano Research2008，1，4： | 5 |
| 5 | Identification of Protein-Coding Regions in DNA Sequences Using A Time-Frequency Filtering Approach显示文摘Accurate identification of protein-coding regions (exons) in DNA sequences has been a challenging task in bioinformatics. Particularly the coding regions have a 3-base periodicity, which forms the basis of all exon identification methods. Many signal processing tools and techniques have been applied successfully for the identification task but still improvement in this direction is needed. In this paper, we have introduced a new promising model-independent time-frequency filtering technique based on S-transform for accurate identification of the coding regions. The S-transform is a powerful linear time-frequency representation useful for filtering in time-frequency domain. The potential of the proposed technique has been assessed through simulation study and the results obtained have been compared with the existing methods using standard datasets. The comparative study demonstrates that the proposed method outperforms its counterparts in identifying the coding regions. | Sitanshu Sekhar Sahu Ganapati Panda | 2011 | Genomics, Proteomics & Bioinformatics2011，9，1： | 4 |
| 6 | Graphene sandwiched crumb rubber dispersed hot mix asphalt显示文摘The crumb rubber obtained from discarded vehicle tires and graphene oxide prepared by oxidation of graphite powder in laboratory were used to modify virgin bitumen. Four different hot mix asphalt matrices prepared using virgin bitumen, crumb rubber modified bitumen, graphene oxide modified bitumen and combination of crumb rubber-graphene oxide modified bitumen are compared. The modified bitumen matrices are characterised by Fourier transform infrared spectroscopy and scanning electron microscopy for structural and morphological analysis. Marshall properties along with indirect tensile test and tensile strength ratio tests were carried out to check the resistance towards cracking and moisture susceptibility of matrices. The results show that, crumb rubber and graphene oxide are completely compatible with bitumen. 9.8% crumb rubber content in crumb rubber modified bitumen hot mix asphalt exhibits the optimum result. The performance of graphene oxide modified bitumen hot mix asphalt exhibits superior performance in comparison to control mix and crumb rubber modified bitumen hot mix asphalt samples.The enhanced properties of modified bitumen hot mix asphalt with the combining effect of graphene oxide and crumb rubber, are suitable for road construction. | Bineet Baliyar Singh Fanismita Mohanty Sudhanshu Sekhar Das Sarat Kumar Siuain | 2020 | Journal of Traffic and Transportation Engineering(English Edition)2020，7，5： | 4 |
| 7 | 精神病学与电影:从神奇的画面中我们可以学到什么?(英文)显示文摘概述:电影是一种社会形态的载体,它可展示精神疾病的各个不同方面。由于电影的戏剧性和污蔑性的描述,它有时会传播有关精神疾病的消极影响,给病人带来痛苦。与消极影响相比,虽然它也会有一些正面和鼓舞人心的故事,但却是少之又少。在此,我们将描述电影对精神病学的双重影响。 | Soumitra DAS Nimisha DOVAL Shabna MOHAMMED Neha DUA Seshadri Sekhar CHATTERJEE | 2017 | 上海精神医学2017，29，5： | 3 |
| 8 | Ternary MOF‑Based Redox Active Sites Enabled 3D‑on‑2D Nanoarchitectured Battery‑Type Electrodes for High‑Energy‑Density Supercapatteries显示文摘Designing rationally combined metal-organic frameworks(MOFs)with multifunctional nanogeometries is of significant research interest to enable the electrochemical properties in advanced energy storage devices.Herein,we explored a new class of binderfree dual-layered Ni-Co-Mn-based MOFs(NCM-based MOFs)with three-dimensional(3D)-on-2D nanoarchitectures through a polarityinduced solution-phase method for high-performance supercapatteries.The hierarchical NCM-based MOFs having grown on nickel foam exhibit a battery-type charge storage mechanism with superior areal capacity(1311.4μAh cm^−2 at 5 mA cm^−2),good rate capability(61.8%;811.67μAh cm^−2 at 50 mA cm^−2),and an excellent cycling durability.The superior charge storage properties are ascribed to the synergistic features,higher accessible active sites of dual-layered nanogeometries,and exalted redox chemistry of multi metallic guest species,respectively.The bilayered NCM-based MOFs are further employed as a battery-type electrode for the fabrication of supercapattery paradigm with biomass-derived nitrogen/oxygen doped porous carbon as a negative electrode,which demonstrates excellent capacity of 1.6 mAh cm^−2 along with high energy and power densities of 1.21 mWh cm^−2 and 32.49 mW cm^−2,respectively.Following,the MOF-based supercapattery was further assembled with a renewable solar power harvester to use as a self-charging station for various portable electronic applications. | Goli Nagaraju SChandra Sekhar Bhimanaboina Ramulu SkKhaja Hussain DNarsimulu Jae Su Yu | 2021 | Nano-Micro Letters2021，13，1： | 3 |
| 9 | Influence of dynamic soil-pile raft-structure interaction:an experimental approach显示文摘Traditionally seismic design of structures supported on piled raft foundation is performed by considering fixed base conditions, while the pile head is also considered to be fixed for the design of the pile foundation. Major drawback of this assumption is that it cannot capture soil-foundation-structure interaction due to flexibility of soil or the inertial interaction involving heavy foundation masses. Previous studies on this subject addressed mainly the intricacy in modelling of dynamic soil structure interaction(DSSI) but not the implication of such interaction on the distribution of forces at various elements of the pile foundation and supported structure. A recent numerical study by the authors showed significant change in response at different elements of the piled raft supported structure when DSSI effects are considered. The present study is a limited attempt in this direction, and it examines such observations through shake table tests. The effect of DSSI is examined by comparing dynamic responses from fixed base scaled down model structures and the overall systems. This study indicates the possibility of significant underestimation in design forces for both the column and pile if designed under fixed base assumption. Such underestimation in the design forces may have serious implication in the design of a foundation or structural element. | Rajib Saha Sumanta Haldar Sekhar Chandra Dutta | 2015 | Earthquake Engineering and Engineering Vibration2015，14，4： | 3 |
| 10 | Risk factors for the development of colorectal carcinoma:A case control study from South India显示文摘AIM:To study the association of colorectal carcinoma(CRC) with diet,smoking,alcohol,physical activity,body mass index,family history and diabetes.METHODS: All consecutive patients with CRC confirmed by histopathology diagnosis were included. Age(±5 years) and gender matched controls were selected among the patients admitted in surgery ward for various conditions without any co-existing malignancy. Food frequency questionnaire(FFQ) was developed and validated after pretesting by investigator trained in data col ection techniques. Cases and controls were interviewed ensuring privacy,in similar interview setting,with same duration of time for both cases and controls without any leading question. Biological variables like family history of CRC in first degree relatives,history of diabetes mellitus; behavioral factors like tobacco use both smoking and smokeless form,alcohol consumption and physical activity were recorded. Dietary details were recorded using a FFQ consisting 29 food items with seven categories. Analysis was done using appropriate statistical methods.RESULTS: Ninety-four histopathologically confirmed cases of CRC and equal number of age and gender matched controls treated over a period of two years were studied. Age distribution,mean age,male to female ratio,education level and socioeconomic status were similar in cases and controls. Intake of food items was categorized into tertile due to skewed distribution of subjects as per recommended cut off for consumption of food item. On univariate analysis red meat [OR=7.4(2.935-18.732)],egg [OR=5.1(2.26-11.36)],fish,fried food and oil consumption were found to be risk factors for CRC. On multivariate analysis red meat consumption of more than 2-3 times a month(OR=5.4; 95%CI:1.55-19.05) and egg consumption of more than 2-3 times a week(OR = 3.67; 95%CI:1.23-9.35) were found to be independent risk factors for the development of CRC.CONCLUSION: Egg and red meat consumption found to be independent risk factors for CRC. Smoking,alcohol,physical activity and family history were not associated with increased risk. | Santhana Krishnan Iswarya Kariyarath Cheriyath Premarajan Sitanshu Sekhar Kar Sathasivam Suresh Kumar Vikram Kate | 2016 | World Journal of Gastrointestinal Oncology2016，8，2： | 3 |
| 11 | Effect of crack on rotor system instability显示文摘 | Sekhar A S Dey J K | 2000 | Mechanism and Machine Theory2000，35，12： | 2 |
| 12 | Multifunctional core-shell-like nanoarchitectures for hybrid supercapacitors with high capacity and long-term cycling durability显示文摘Transition metal oxide/hydroxide with multif unctional hierarchical nano structures has attracted widespread attention in supercapacitors(SCs)because of their large accessible surface area,high electrochemical activity and superior redox chemistry.Herein,core-shell-like copper(Cu)hydroxide nano tube arrays grafted nickel aluminum layered double hydroxide n anosheets were facilely synthesized on porous Cu foam(CH NTAs@NiAI LDH NSs)for use as an efficient battery-type electrode in hybrid SCs.With the synergistic effects of NiAl LDH NSs on well-adhered CH NTAs/CF,the core-shell-like composite(prepared for 24 h)delivered a maximum areal capacity of 334.3 pAh/cm2 at a current density of 3 mA/cm2 in 2 M KOH electrolyte,which is comparatively higher than other samples synthesized at different growth times.Moreover,the core-shell-like CH NTAs@NiAI LDH NSs-24 demonstrated an outstanding cycling stability of 134.3%after 10,000 cycles.Utilizing high capacity and stability of CH NTAs@NiAI LDH NSs-24,a pouch-type hybrid SC was further assembled with core-shell-like composite as a positive electrode and reduced graphene oxide as a negative electrode with a filter paper as a separator in aqueous alkaline electrolyte.The hybrid SC showed a high areal capacity of 250 pAh/cm2 at 2 mA/cm2 with maximum areal energy and power densities of 181.9 pWh/cm2 and 24,991.5 pW/cm2,respectively.Successfully harvest!ng the solar energy via solar cell panel and subsequently delivering the stored en ergy to switching and proximity applicati ons also dem on strated the real-time applicability of our hybrid SCs. | S.Chandra Sekhar Goli Nagaraju Bhimanaboina Ramulu Sk.Khaja Hussain D.Narsimulu Jae Su Yu | 2019 | Nano Research2019，12，10： | 2 |
| 13 | PTOX Mediates Novel Pathways of Electron rransport in Etioplasts of Arabidopsis显示文摘Arabidopsis 的 immutans (im ) 上色异种为 PTOX (质体终端 oxidase ) 定义基因,在叶绿体膜的万用的 plastoquinol oxidase。在这份报告,我们使用了 im 在黑暗成年的幼苗的 etioplasts 获得卓见进 PTOX 的功能。我们发现 PTOX 帮助控制 plastoquinone ( PQ )的氧化还原作用状态在这些细胞器的水池,并且它由参予 carotenogenesis 并且在至少一条氧化还原作用小径的 desaturation 反应在 etioplast 新陈代谢起一个必要作用,这由 PGR5 (质子坡度规定 5 )和 NDH ( NAD (P) H 脱氢酶)调停了,哪个是在周期的电子运输的中央播放器。我们建议这些元素从 NAD (P) H 与电子流动联合 PTOX 到氧,并且由到 chlororespiration 的类比(在叶绿体) 并且 chromorespiration (在有色体) ,我们建议他们在我们称为的 etioplasts 定义一个呼吸过程 etiorespiration。我们进一步证明在 etioplasts 的 PQ 水池的氧化还原作用状态可能控制叶绿素生合成,也许由参予机制后退(plastid-to-nucleus ) 表明那并列 biosynthetic 和 photoprotective 活动要求了平衡为轻开发的 etioplast。我们断定 PTOX 是在 etioplasts 察觉到的新陈代谢和氧化还原作用的一个重要部件。 | Sekhar Kambakam Ujjal Bhattacharjee Jacob Petrich Steve Rodermel | 2016 | Molecular Plant2016，9，9： | 2 |
| 14 | Frequency and significance of hepatitis B virus surface gene variant circulating among ‘antiHBc only’ individuals in Eastern India显示文摘 | Arup Banerjee Partha K. Chandra Sibnarayan Datta Avik Biswas Prasun Bhattacharya Subhasis Chakraborty Sekhar Chakrabarti Sujit Kumar Bhattacharya Runu Chakravarty | 2007 | Journal of Clinical Virology2007，，4： | 2 |
| 15 | Prognostically relevant gene signatures of high-grade serous ovarian carcinoma显示文摘 | Verhaak Roel G W Tamayo Pablo Yang Ji-Yeon Hubbard Diana Zhang Hailei Creighton Chad J Fereday Sian Lawrence Michael Carter Scott L Mermel Craig H Kostic Aleksandar D Etemadmoghadam Dariush Saksena Gordon Cibulskis Kristian Duraisamy Sekhar | 2013 | Journal of Clinical Investigation2013，，1： | 2 |
| 16 | Cranial base approaches to intracr-anialaneurysms in the subarachno-id space 显示文摘 | Sekhar LN Kalia KK Yonas H | 1994 | Neurosurgery1994，35，3： | 2 |
| 17 | 搅拌铸造工艺参数对AA6061/TiC铝基复合材料抗拉强度影响的预测(英文)显示文摘采用搅拌铸造工艺制备AA6061/15%TiC(质量分数)铝基复合材料。构建一个经验公式用于预测搅拌铸造工艺参数对AA6061/TiC铝基复合材料极限抗拉强度的影响。采用有4因素、5水平组成的中心旋转组合设计方案来减少搅拌铸造实验次数。实验因素包括搅拌速率、搅拌时间、搅拌叶片角度和铸造温度。采用所建立的经验公式和显微组织观察分析这些因素对AA6061/TiC铝基复合材料极限抗拉强度的影响。分析结果表明:上述各因素均显著影响复合材料的极限抗拉强度。复合材料极限抗拉强度的变化归因于孔隙率、团簇的形成、TiC颗粒在晶界的偏析及其在铝基体中的均匀分布。 | J.JEBEEN MOSES I.DINAHARAN S.JOSEPH SEKHAR | 2016 | Transactions of Nonferrous Metals Society of China2016，26，6： | 2 |
| 18 | Recent developments in self-powered smart chemical sensors for wearable electronics显示文摘The next generation of electronics technology is purely going to be based on wearable sensing systems. Wearable electronic sensors that can operate in a continuous and sustainable manner without the need of an external power sources, are essential for portable and mobile electronic applications. In this review article, the recent progress and advantages of wearable self-powered smart chemical sensors systems for wearable electronics are presented. An overview of various modes of energy conversion and storage technologies for self-powered devices is provided. Self-powered chemical sensors (SPCS) systems with integrated energy units are then discussed, separated as solar cell-based SPCS, triboelectric nano-generators based SPCS, piezoelectric nano-generators based SPCS, energy storage device based SPCS, and thermal energy-based SPCS. Finally, the outlook on future prospects of wearable chemical sensors in self-powered sensing systems is addressed. | Aaryashree Surjit Sahoo Pravin Walke Saroj Kumar Nayak Chandra Sekhar Rout Dattatray J.Late | 2021 | Nano Research2021，14，11： | 2 |
| 19 | Risk factors for endophthalmitis following cataract surgery-our experience at a tertiary eye care centre in India显示文摘AIM: To determine the risk factors for acute endophthalmitis after cataract extraction in a tertiary care centre in India.·METHODS: We performed a nested case control study within a retrospective cohort. The surgical records of all patients with clinically diagnosed endophthalmitis within one month after cataract surgery, performed between January 2006 and December 2009, were reviewed. These were compared with randomly selected age and gender-matched controls, from patients having routine cataract surgery within ±1wk of the endophthalmitis case.Univariable and multivariable analysis were performed to identify risk factors for endophthalmitis.· RESULTS: Of the total 33 856 cataract surgeries performed during this period, there were 57 cases of postoperative acute endophthalmitis that met our study criteria. Thus, the overall incidence of endophthalmitis in our cohort was 1.6 per 1000 cataract extractions performed. Mean age of cases was 55.9y(SD: 10.9y) and for controls was 55.6y(SD: 9.8y). Thirty-five cases(61.4%)and 133 controls(59.6%) were males. Median time of onset of endophthalmitis was 4d(IQR 2-9d; range: 1-30d).Thirty-nine cases(68.4%) presented within 7d and 27 cases(47.4%) were culture positive. Two hundred and twenty-three age and gender matched controls were selected. In multivariate analysis, endophthalmitis was associated with posterior capsular rupture(PCR) during surgery(OR 6.98, 95%CI: 2.22-21.98), phacoemulsification via scleral incision with a foldable intraocular lens(IOL)implantation(OR 3.02, 95%CI: 1.13-8.04) and ocular comorbidity(OR 2.32, 95%CI: 1.11-4.87).·CONCLUSION: PCR, presence of ocular co-morbidity,and phacoemulsification via scleral incision with foldable-IOL were found to be independent risk factors for acute endophthalmitis. | Rohit C.Khanna Vanita Pathak Ray Madhavi Latha Sandra D Cassard Annie Mathai Garudadri C Sekhar | 2015 | International Journal of Ophthalmology(English edition)2015，8，6： | 2 |
| 20 | Exploring the concept of strategic corporate social responsibility for an integrated perspective显示文摘 | Som Sekhar Bhattacharyya | 2010 | European Business Review2010，，1： | 2 |
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