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| 1 | Significant increase in HBV, HCV, HIV and syphilis infections among blood donors in West Bengal, Eastern India 2004-2005: Exploratory screening reveals high frequency of occult HBV infection显示文摘AIM: To evaluate the prevalence of markers of hepatitis B virus (HBV) and hepatitis C virus (HCV) and human immunodeficiency virus (HIV) among blood donors in Kolkata, Eastern India for two consecutive years and to conduct a pilot study to explore the presence of HBV DNA among hepatitis B surface antigen (HBsAg) negative but anti-HBc positive blood donors. METHODS: Seroprevalence of HBsAg, anti-HCV and anti-HIV was studied among 113 051 and 106 695 voluntary blood donors screened in 2004 and 2005, respectively. Moreover, a pilot study on 1027 HBsAg negative donors was carried out for evaluating the presence of HBV DNA by PCR on HBsAg negative/anti- HBc positive donors. RESULTS: A statistically significant increase in the prevalence of HBV (1448 vs 1768, P < 0.001), HIV (262 vs 374, P < 0.001), HCV (314 vs 372, P = 0.003) and syphilis (772 vs 853, P = 0.001) infections was noted among blood donors of Kolkata West Bengal in 2005 as compared to 2004. Moreover, the exploratory study on 1027 HBsAg negative donors revealed that 188 (18.3%)of them were anti-HBc positive out of which 21% were positive for HBV DNA. CONCLUSION: The findings of this study underscore the significantly increasing endemicity of hepatitis viruses, syphilis and HIV among the voluntary blood donors of our community. The pilot study indicates a high rate of prevalence of HBV DNA among HBsAg negative/anti-HBc positive donors and thus emphasizes the need for a more sensitive and stringent screening algorithm for blood donations. | Prasun Bhattacharya Partha Kumar Chandra Sibnarayan Datta Arup Banerjee Subhashish Chakraborty Krishnan Rajendran Subir Kumar Basu Sujit Kumar Bhattacharya Runu Chakravarty | 2007 | World Journal of Gastroenterology2007，13，27： | 9 |
| 2 | Cell-free derivatives from mesenchymal stem cells are effective in wound therapy显示文摘AIM:To compare the efficacy of cell-free derivatives from Bone marrow derived human mesenchymal stem cells(hMSCs) in wound therapy.METHODS:hMSCs have been shown to play an important role in wound therapy.The present study sought to compare efficacy of hMSCs and cell-free derivatives of hMSCs,which may be clinically more relevant as they are easier to prepare,formulate and transport.hMSCs were isolated from human bone marrow and cultured.Multi lineage differentiation of hMSCs was performed to confirm their identity.The ability of hMSCs to migrate was evaluated using in vitro and in vivo migration assays.Cell lysates and conditioned medium concentrate was prepared from hMSCs(see Methods for details).Wounds were induced in mice and wound areas were measure before and after cell and cell-free derivative treatment.RNA and proteins were extracted from the skin and cytokine levels were measured.RESULTS:Co-culture of hMSCs with keratinocytes resulted in increased expression of CXCL-12(SDF1) and ENA78(CXCL-5) in the conditioned media indicating that the hMSCs can respond to signals from keratinocytes.Accelerated wound closure was observed when hMSCs were injected near the site of excisional wounds in athymic as well as NOD/SCID mice.Interestingly,cell-free lysates prepared from hMSCs were also effective in inducing accelerated wound closure and increased expression of SDF1 and CXCL-5 at the wound bed.Additionally,concentrated media from hMSCs as well as an emulsion containing lysates prepared from hMSCs was also found to be more effective in rapid re-epithelialization than fibroblasts or vehicle-alone control.Use of cell-free derivatives may help replace expensive wound care approaches including use of growth factors,epidermal/dermal substitutes,synthetic membranes,cytokines,and matrix components,and most importantly avoid transmission of pathogens from human and animal products.CONCLUSION:These results encourage development of derivatives of hMSCs for wound care and re-epithelialization applications. | Pravin J Mishra Prasun J Mishra Debabrata Banerjee | 2012 | World Journal of Stem Cells2012，4，5： | 3 |
| 3 | Frequency and significance of hepatitis B virus surface gene variant circulating among ‘antiHBc only’ individuals in Eastern India显示文摘 | Arup Banerjee Partha K. Chandra Sibnarayan Datta Avik Biswas Prasun Bhattacharya Subhasis Chakraborty Sekhar Chakrabarti Sujit Kumar Bhattacharya Runu Chakravarty | 2007 | Journal of Clinical Virology2007，，4： | 2 |
| 4 | Polysiloxane-based core-shell microspheres for toughening of epoxy resins显示文摘 | Prasun Kumar Roy Nahid Iqbal Devendra Kumar Chitra Rajagopal | 2014 | Journal of Polymer Research2014，，1： | 1 |
| 5 | CEDAR: a core-extraction distributed Ad hoc routing algorithm 显示文摘 | RAGHUPATHY S PRASUN S VADUVUR B | 1999 | IEEE Journal on Selected Areas in Communication1999，17，8： | 1 |
| 6 | Brain Iron Deposition and Sequence Characteristics in Parkinsonism: Comparison of SWI, T2* Maps, T2-Weighted-, and FLAIR-SPACE显示文摘 | Maija Rossi Hanna Ruottinen Irina Elovaara Pertti Ryymin Seppo Soimakallio Hannu Eskola Prasun Dastidar | 2010 | Investigative Radiology2010，，12： | 1 |
| 7 | Trichoderma research in the genome era显示文摘 | Prasun K M Benjamin A H Alfredo H | 2013 | Annual Review of Phytopathology2013，51，： | 1 |
| 8 | Clinical efficacy of direct-acting antiviral therapy for recurrent hepatitis C virus infection after liver transplantation in patients with hepatocellular carcinoma显示文摘BACKGROUND Recurrent hepatitis C virus(HCV)infection of transplanted liver allografts is universal in patients with detectable HCV viremia at the time of transplantation.Direct-acting antiviral(DAA)therapy has been adopted as the standard of care for recurrent HCV infection in the post-transplant setting.However,there are insufficient data regarding its efficacy in liver transplant(LT)recipients with a history of hepatocellular carcinoma(HCC),and the risk of HCC recurrence after DAA therapy is unknown.predictors of DAA treatment failure and HCC recurrence in LT recipients.METHODS A total of 106 LT recipients given DAAs for recurrent HCV infection from 2015 to 2019 were identified(68 with and 38 without HCC).Descriptive statistics and logistic regression models were used to estimate the multivariate odds ratios and respective 95%confidence intervals for predictors of treatment failure and HCC recurrence.RESULTS Six patients(6%)experienced DAA therapy failure post-LT and 100(94%)had a sustained virologic response at follow-up week 12.A high alanine transaminase level>35 U/L at treatment week 4 was a significant predictor of treatment failure.Relapse to pre-LT DAA therapy is a predictor of post-LT HCC recurrence,P=0.04.DAA relapse post-LT was also associated with post-transplantation HCC recurrence,P=0.05.CONCLUSION DAAs are effective and safe in the treatment of recurrent HCV infection in LT recipients with history of HCC.Relapse to pre-and post-LT DAA therapy is associated with post-transplantation HCC recurrence. | Mohamed Saleh Ismail Manal Hassan Saira Aijaz Khaderi Wael Ahmed Yousry Maha Mohsen Kamal El-Din Mohamed Mohamed Bahaa El-Din Osama Aboelfotoh El Sayed Ahmed Omar Kaseb John Alan Goss FasihaKanwal Prasun Kumar Jalal | 2020 | World Journal of Hepatology2020，12，9： | 1 |
| 9 | A miR-24 microRNA binding-site polymorphism in dihydrofolate reductase gene leads to methotrexate resistance显示文摘 | Prasun JM Rita H Pravin JM | 2007 | Proc Natl Acad Sci USA2007，104，13： | 1 |
| 10 | Inositol polyphosphate multikinase is a transcriptional coactivator required for immediate early gene induction显示文摘 | Risheng Xu Bindu D. Paul Dani R. Smith Richa Tyagi Feng Rao A. Basit Khan Daniel J. Blech M. Scott Vandiver Maged M. Harraz Prasun Guha Ishrat Ahmed Nilkantha Sen Michela Gallagher Solomon H. Snyder | 2013 | Proceedings of the National Academy of Sciences2013，，： | 1 |
| 11 | Sync: A Java framework for mobile collaborative applications显示文摘 | Munson J P Prasun D | 1997 | Computer1997，30，6： | 1 |
| 12 | A general strategy basedon the Newton-Euler approach for the dynamic formulation of parallel manipulators显示文摘 | Bhaskar Dasgupta Prasun Choudhury | 1999 | Mechanisra and Machine Theory1999，34，6： | 1 |
| 13 | Unusual physical features and heat stroke presentation for hypohydrotic ecto-dermal dysplasia显示文摘 | Prasun P Karmarkar SA Agarwal A | | 0，，01： | 1 |
| 14 | Editing soft shadows in a digital photograph显示文摘 | Ankit Mohan Jack Tumblin Prasun Choudhury | | 0，，02： | 1 |
| 15 | Degradable polyethylene:Fantasy or reality显示文摘 | Prasun K Roy Minna Hakkarainen Indra K Varma | 2011 | Environ Sci Technol2011，45，： | 1 |
| 16 | Unusual physical features and heat stroke presentation for hypohydrotic ecto-dermal dysplasia显示文摘 | Prasun P Karmarkar SA Agarwal A | | 0，，01： | 1 |
| 17 | WTCP: A Reliable Transport Protocol for Wireless Wide-Area Networks显示文摘 | Prasun Sinha Thyagarajan Nandagopal Narayanan Venkitaraman Raghupathy Sivakumar Vaduvur Bharghavan | 2002 | Wireless Networks (-)2002，，2： | 1 |
| 18 | Why is end-of-life care delivery sporadic? : A quantitative look at the harriers to and facilitators of providing end-of-life care in the neo- natal intensive care unit显示文摘 | Wright V Prasun MA Hitgenberg C | 2011 | Adv Neonatal Care2011，11，1： | 1 |
| 19 | How Transparent are the Imidazolium Ionic Liquids? A Case Study with l-Methyl-3-butylimidazolium Hexafluorophosphate[bmim]显示文摘 | Aniruddha P Prasun K M Anunay S | | 0，，： | 1 |
| 20 | Turning heterogeneity into an advantage in wireless ad-hoc network routing显示文摘 | Thang Le Prasun Sinha Dong Xuan | 2009 | Ad Hoc Networks2009，，1： | 1 |
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