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| 1 | 5-Hydroxymethylcytosine signatures in cell-free DNA provide information about tumor types and stages显示文摘5-Hydroxymethylcytosine (5hmC ) 是被连接了到基因规定和癌症致病的重要哺乳动物的 DNA epigenetic 修正。这里,我们用定序途径的一枝敏感化学基于标签的低输入的猎枪在传播没有房间的 DNA (cfDNA ) 探索了 5hmC 的诊断潜力。我们从七种不同癌症类型的 49 个病人定序没有房间的 5hmC 并且发现了能被用来与高精确性预言癌症类型和阶段的不同特征。明确地,我们发现肺癌症在 cfDNA 导致 5hmC 的进步全球损失,而 hepatocellular 癌和胰腺的癌症在没有房间的 hydroxymethylome 导致疾病特定的变化。我们的 proof-of-principle 结果建议没有房间的 5hmC 签名可以潜在地被使用不仅识别癌症类型而且在一些癌症追踪肿瘤舞台。 | Chun-Xiao Song Senlin Yin Li Ma Amanda Wheeler Yu Chen Yan Zhang Bin Liu Junjie Xiong Weihan Zhang Jiankun Hu Zongguang Zhou Biao Dong Zhiqi Tian Stefanie S Jeffrey Mei-Sze Chua Samuel So Weimin Li Yuquan Wei Jiajie Diao Dan Xie Stephen R Quake | 2017 | Cell Research2017，27，10： | 17 |
| 2 | Activation of Mitochondrial orf355 Gene Expression by a Nuclear-Encoded DREB Transcription Factor Causes Cytoplasmic Male Sterility in Maize显示文摘Coordination between mitochondria and the nucleus is crucial for fertility determination in plants with cytoplasmic male sterility(CMS).Using yeast one-hybrid screening,we identified a transcription factor,ZmDREB1.7,that is highly expressed in sterile microspores at the large vacuole stage and activates the expression of mitochondria-encoded CMS gene orf355.Δpro,a weak allele of ZmDREB1.7 with the loss of a key unfolded protein response(UPR)motif in the promoter,partially restores male fertility of CMS-S maize.ZmDREB1.7 expression increases rapidly in response to antimycin A treatment,but this response is attenuated in theΔpro allele.Furthermore,we found that expression of orf355 in mitochondria activates mitochondrial retrograde signaling,which in turn induces ZmDREB1.7 expression.Taken together,these findings demonstrate that positive-feedback transcriptional regulation between a nuclear regulator and a mitochondrial CMS gene determines male sterility in maize,providing new insights into nucleus-mitochondria communication in plants. | Senlin Xiao Jie Zang Yuanrong Pei Jie Liu Juan Liu Wei Song Zi Shi Aiguo Su Jiuran Zhao Huabang Chen | 2020 | Molecular Plant2020，13，9： | 10 |
| 3 | Chaotic laser synchronization and its application in optical fiber secure communication显示文摘In this paper, optical fiber chaotic secure communication is proposed by coupling chaotic laser synchronous system with optical fiber propagation channel. Feedback synchronous system of chaotic semiconductor lasers is presented and synchronous error and decoding formulae are demonstrated. Synchronization between two chaotic laser systems with distributed feedback semiconductor lasers at wavelength of 1.31 μm is simulatively achieved with almost zero synchronous error. Parameter mismatch, synchronous transient response and noise effect on the system are studied. Robustness of synchronization and anti-perturbation can increase by increasing the feedback coefficient of the system. Influence of group-velocity-dispersion and self-phase modulation of optical fiber on chaotic laser signal and synchronization are analyzed, and it is found that group-velocity-dispersion affects pulse shape, synchronization and decodin gand limits optical fiber propagation distances, and self-phase modulation does not affect pulse shape, while its product of nonlinear phase shift can affect synchronization and decoding, and restrict propagation distances of optical fiber chaotic communication system and hence the maximum optical power formula is educed. Injecting parameter modulation and amplitude modulation are numerically simulated in long-haul optical fiber secure communication systems. | YAN Senlin CHI Zeying CHEN Wenjian Schoof of Electronic Engineering and Photoelectronic Technology, Nanjing University of Science and Technology, Nanjing 210094, China | 2004 | Science in China(Series F)2004，47，3： | 10 |
| 4 | Unstable unsteady aerodynamic modeling based on least squares support vector machines with general excitation显示文摘Common,unsteady aerodynamic modeling methods usually use wind tunnel test data from forced vibration tests to predict stable hysteresis loop.However,these methods ignore the initial unstable process of entering the hysteresis loop that exists in the actual maneuvering process of the aircraft.Here,an excitation input suitable for nonlinear system identification is introduced to model unsteady aerodynamic forces with any motion in the amplitude and frequency ranges based on the Least Squares Support Vector Machines(LS-SVMs).In the selection of the input form,avoiding the use of reduced frequency as a parameter makes the model more universal.After model training is completed,the method is applied to predict the lift coefficient,drag coefficient and pitching moment coefficient of the RAE2822 airfoil,in sine and sweep motions under the conditions of plunging and pitching at Mach number 0.8.The predicted results of the initial unstable process and the final stable process are in close agreement with the Computational Fluid Dynamics(CFD)data,demonstrating the feasibility of the model for nonlinear unsteady aerodynamics modeling and the effectiveness of the input design approach. | Senlin CHEN Zhenghong GAO Xinqi ZHU Yiming DU Chao PANG | 2020 | Chinese Journal of Aeronautics2020，33，10： | 4 |
| 5 | Dietary L-arginine supplementation reduces lipid accretion by regulating fatty acid metabolism in Nile tilapia(Oreochromis niloticus)显示文摘Background: Excessive white fat accumulation in humans and other animals is associated with the development of multiple metabolic diseases. It is unknown whether dietary L-arginine supplementation reduces lipid deposition in high fat diet-fed Nile tilapia(Oreochromis niloticus).Results: In the present study, we found that dietary supplementation with 1% or 2% arginine decreased the deposition and concentration of fats in the liver;the concentrations of triglycerides, low-density lipoprotein, total cholesterol, and high-density lipoprotein in the serum;and the diameter of adipocytes in intraperitoneal adipose tissue. Compared with the un-supplementation control group, the hepatic activities of alanine aminotransferase,aspartate aminotransferase, and lactate dehydrogenase, and hepatic concentration of malondialdehyde were reduced but these for catalase and superoxide dismutase were enhanced by dietary supplementation with 2% arginine. Arginine supplementation reduced the total amounts of monounsaturated fatty acids, while increasing the total amounts of n-3 and n-6 polyunsaturated fatty acids in the liver. These effects of arginine were associated with reductions in mRNA levels for genes related to lipogenesis(sterol regulatory element-binding protein-1, acetyl-CoA carboxylase α, stearoyl-CoA desaturase, and fatty acid synthase) but increases in mRNA levels for genes involved in fatty acid β-oxidation(carnitine palmitoyltransferase 1α and peroxisome proliferator-activated receptor α). In addition, hepatic mRNA levels for Δ4 fatty acyl desaturase 2 and elongase 5 of very long-chain fatty acids were enhanced by arginine supplementation.Conclusion: These results revealed that dietary L-arginine supplementation to tilapia reduced high fat diet-induced fat deposition and fatty acid composition in the liver by regulating the expression of genes for lipid metabolism. | Senlin Li Yunchang Zhang Ning Liu Jingqing Chen Lina Guo Zhaolai Dai Chao Wang Zhenlong Wu Guoyao Wu | 2021 | Journal of Animal Science and Biotechnology2021，12，1： | 3 |
| 6 | ILK and PRDX1 are prognostic markers in squamous cell/adenosquamous carcinomas and adenocarcinoma of gallbladder显示文摘 | Jinghe Li Zhu-lin Yang Xuebao Ren Qiong Zou Yuan Yuan Lufeng Liang Meigui Chen Senlin Chen | 2013 | Tumor Biology2013，，1： | 3 |
| 7 | Reservoir architecture patterns of sandy gravel braided distributary channel A case study of Triassic Upper Karamay Formation,Xinjiang oilfield显示文摘The purpose of this study was to discuss shape,scale and superimposed types of sandy gravel bodies in sandy-gravel braided distributary channel.Lithofacies analysis,hierarchy bounding surface analysis and subsurface dense well pattern combining with outcrops method were used to examine reservoir architecture patterns of sandy gravel braided distributary channel based on cores,well logging,and outcrops data,and the reservoir architecture patterns of sandy gravel braided distributary channels in different grades have been established.The study shows:(1)The main reservoir architecture elements for sandy gravel braided channel delta are distributary channel and overbank sand,while reservoir flow barrier elements are interchannel and lacustrine mudstone.(2)The compound sand bodies in the sandy gravel braided delta distributary channel take on three shapes:sheet-like distributary channel sand body,interweave strip distributary channel sand body,single strip distributary channel sand body.(3)Identification marks of single distributary channel include:elevation of sand body top,lateral overlaying,“thick-thin-thick”feature of sand bodies,interchannel mudstone and overbank sand between distributary channels and the differences in well log curve shape of sand bodies.(4)Nine lithofacies types were distinguished in distributary channel unit interior,different channel units have different lithofacies association sequence. | Senlin Yin Zhangming Hu Xiang Ren Xiaojun Wu Yanhui Chen Lijun Zheng Zhibin Jiang | 2016 | Petroleum2016，2，2： | 2 |
| 8 | Rigidity of compact minimal submanifolds in a unit sphere显示文摘 | Qing Chen Senlin Xu | 1993 | Geometriae Dedicata1993，，1： | 1 |
| 9 | Minicyclotron-based accelerator mass spectrometry and real 14C measurement 显示文摘 | Chen Maobai Li Deming Xu Senlin | 2000 | Nucl Instr Meth B2000，172，： | 1 |
| 10 | Health Monitoring of Long-Haul Fiber Communication System Using Chaotic OTDR显示文摘A novel chaotic optical time-domain reflectometry(OTDR)-based approach was proposed for monitoring long-haul fiber communication systems with multiple fiber segments. The self-phase modulation and group velocity dispersion effects of the optical cable was considered in demonstrating the proof-of-concept experiment and simulation. In experiments, the correlation peaks are clearly obtained from the correlation trace between the reference and reflected(or scattered) light signals propagating in three optical-fiber segments. The technique affords a high spatial resolution of 2 m, and further long-haul fiber simulations indicate that the sensing distance can be more than 3300 km. Thus, the new proposed technique can be effectively applied for health monitoring of long-haul fiber communication systems. | Mengmeng Chen Mingjiang Zhang Shaoxiang Chen Jianguo Zhang Senlin Yan Yuncai Wang | 2020 | China Communications2020，17，5： | 1 |
| 11 | Cytotoxic T-Lymphocyte Anti- gen-4 + 49G/A Polymorphism and Susceptibility to Pancreatic Cancer 显示文摘 | Cuicui Lang Lei Chen Senlin Li | 2012 | DNA Cell Biol2012，31，5： | 1 |
| 12 | Synthesis of nitrogen-doped carbon spheres using the modified Stober method for supercapacitors显示文摘Nitrogen-doped carbon spheres (NCSs) with uniform and regular morphology were facilely prepared by the modified Stober method. Hexamethylenetetramine (HMT) was selected as the starting material, which decomposed to provide nitrogen and carbon sources for the synthesis of NCSs. The decomposition product formaldehyde polymerized to form carbon skeleton with resorcinol after carbonization, and the in-situ nitrogen doping was achieved with the decomposed nitrogen source. NCSs were obtained with regular spherical morphology, high specific surface area, and suitable nitrogen doping. When used as the electrode material, NCSs exhibited good capacitance and electrochemical stability, indicating that NCSs be the promising candidate for the electrode material of high-performance supercapacitors. | Meng LIU Lei LIU Yifeng YU Haijun LV Aibing CHEN Senlin HOU | 2019 | Frontiers of Materials Science2019，13，2： | 1 |
| 13 | On compact submanifolds in a sphere显示文摘 | Chen Qing Xu Senlin Chen Guanghua | 1992 | Journal of Mathematicial Research & Exposition1992，12，4： | 1 |
| 14 | Phylogenetic Analysis of Morels Based on ITS and LSU Sequences显示文摘[Objectives]Fifty two strains were identified and phylogenetically analyzed to solve the current phenomenon of'synonym and homonym'in morels.[Methods]Based on the ITS and LSU sequences of ribosomal DNA,the collected 52 morel samples were sequenced,and BLAST alignment was performed by NCBI to construct phylogenetic trees.[Results]The collected morel strains were mainly divided into two major groups:namely black morel and yellow morel groups,of which the black morel group was most,mainly including Morchella sextelata,Morchella importuna,Morchella crassipes,and Morchella eximia.There were very few yellow morel strains,including M.crassipes and M.eximia.[Conclusions]This study lays a foundation for the classification and research of morel germplasm resources,and provides a powerful reference value for the research and production of high-quality morel strains. | Senlin ZHU Bo CHEN Fen JIAN Zhun XIANG Qian LUO Xiaomin WANG Xu CHEN Bangxi ZHANG | 2022 | Agricultural Biotechnology2022，11，3： | 1 |
| 15 | The relationship between physicochemical characterization and the potential toxicity of fine particulates (PM 2.5 ) in Shanghai atmosphere显示文摘 | Lu Senlin Yao Zhenkun Chen Xiaohui Wu Minghong Sheng Guoying Fu Jiamo Daly Paul | 2008 | Atmospheric Environment2008，，31： | 1 |
| 16 | CFL1 and Arp3 are Biomarkers for Metastasis and Poor Prognosis of Squamous Cell/Adenosquamous Carcinomas and Adenocarcinomas of Gallbladder显示文摘 | Zhu-Lin Yang Xiongying Miao Li Xiong Qiong Zou Yuan Yuan Jinghe Li Lufeng Liang Meigui Chen Senlin Chen | 2013 | Cancer Investigation2013，，2： | 1 |
| 17 | The introduction of stacking moieties for fabricating stable micellar structure: Formation and dynamics of disklike micelles 显示文摘 | SONG BO WANG ZHIQIANG CHEN SENLIN | 2005 | Angewandte Chemic2005，117，30： | 1 |
| 18 | The expressions and significance of α-,β-catenins and cyclin D1 in breast cancers显示文摘Objective:To study the relationship between expressions of α-,β-catenins and cyclin D1 and the occurrence, infiltration and metastasis of breast cancer. Methods: High sensitive S-P immunohistochemical method was used to detect the protein expressions of α-,β-catenins and cyclin D1 in the 60 cases of breast cancer tissues. Results: Abnormal immu-noreactivities of α-and β-catenins were observed in 37 (61.7%) and 42 (70%) cases of breast cancer tissues, respectively. There were 28 cases (46.7%) who showed cyclin D1 overexpression. The abnormal expression rates of α-and β-catenins in infiltrating lobular carcinoma (ILC) were significantly higher than those in infiltrating ductal carcinoma (IDC) (P<0.05), but they had no relations to the extent of differentiation and lymphatic metastasis of breast cancer (P>0.05). The overexpression rate of cyclin D1 was correlated with tumor stage and lymphatic metastasis of breast cancer (P<0.05), but not with histological type and the extent of differentiation (P>0.05). Cyclin D1 overexpression was observed in 57.1% (24/42) of these cases that showed abnormal staining of β-catenin, but only observed in 22.2% (4/18) of these cases with normal membranous staining of β-catenin. There was a significantly positive correlation between the abnormal expression of β-catenin and overexpression of cyclin D1 (rs=0.321, P<0.05). Conclusion: The abnormal expression of β-catenin may play an important role in the genesis of breast cancer by triggering cyclin D1 overexpression in breast cancer. The abnormal expressions of α-and β-catenins are not a key factor in malignant cell metastasis in breast cancer, but may also involve in the progress. | Liang Zeng Senlin Chen Zhihong Liu Jianfeng Yang | 2008 | The Chinese-German Journal of Clinical Oncology2008，7，6： | 1 |
| 19 | Controlled self- assembly manipulated by charge - transfer interactions: From tubes to vesicles 显示文摘 | WANG CHAO YIN SHOUCHUN CHEN SENLIN | 2008 | Angewandte Chemic2008，120，47： | 1 |
| 20 | Evaluation of a concept-based physical education unit for energy balance education显示文摘Background:Physical education(PE)is a key channel that impacts children's decisions and behaviors for healthful living.This study evaluated the effects of a concept-based PE(CBPE)instructional unit,featured by energy balance(EB)education,on students'knowledge learning,situational interest,cognitive,and physical engagements as well as teachers'perceptions.Methods:Fourth and 5th grade students(n=468)in a mid-western state of the United States were recruited as the participants.Four elementary schools were randomized to the CBPE or control groups.Students'EB knowledge,situational interest,cognitive engagement,and physical engagement were measured by a knowledge test,the Situational Interest Scale—Elementary,written task sheets,and accelerometers,respectively,while teachers'perceptions of the CBPE unit were captured by individual interviews at the end of the experiment.Results:The CBPE group showed a significant increase in EB knowledge,while the control did not.Both groups showed a similar increasing trend for situational interest over time,although the statistical results favored the control group.For physical engagement,the CBPE group demonstrated a statistically different but substantively similar level of in-class physical activity compared to the control group.The CBPE group also showed a moderate level of cognitive engagement throughout the unit.The PE teachers reported overall positive perceptions about teaching the CBPE unit.Conclusion:These results support the utility of the CBPE unit in enhancing EB education along with facilitating positive student interest and engagement as well as positive teaching experiences. | Senlin Chen Xihe Zhu Jared Androzzi Yoon Ho Nam | 2018 | Journal of Sport and Health Science2018，7，3： | 1 |
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