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| 1 | Chinese deserts and sand fields in Last Glacial Maximum and Holocene Optimum显示文摘The Last Glacial Maximum (LGM, c. 26-16 ka) and the Holocene Optimum (HO, c. 9-5 ka) were characterized by cold-dry and warm-wet climates respectively in the recently geological Earth. How Chinese deserts and sand fields responded to these distinctive climatic changes is still not clear, however. To reconstruct environments of the deserts and sand fields during the LGM and HO is helpful to understand the forcing mechanisms of environment change in this arid region, and to test paleoclimatic modeling results. Through our long-term field and laboratory investigations, 400 optically stimulated luminescence (OSL) ages and more than 100 depositional records in the Chinese deserts and sand fields were obtained; on the basis of these data, we reconstruct spatial distributions of the deserts and sand fields during the LGM and HO. Our results show that the sand fields of Mu Us, Hunshandake, Horqin and Hulun Buir in northern and northeastern China had expanded 25%, 37%, 38% and 270%, respectively, during the LGM; the sand fields of Gonghe in the northeastern Qinghai-Tibetan Plateau had expanded 20%, and the deserts of Badain Jaran, Tengger in central northern China had expanded 39% and 29% separately during the LGM; the deserts of Taklimakan, Gurbantünggüt and Kumtag in northwestern China had expanded 10%-20% respectively, compared to their modern areas. On the other hand, all of the sand fields were nearly completely covered by vegetation during the HO; the deserts in northwestern and central northern China were reduced by around 5%-20% in area during this time. Lakes in this arid region were probably expanded during the HO but this conclusion needs more investigation. Compared with the geological distributions of deserts and sand fields, human activity has clearly changed (expanded) the area of active sand dunes at the present time. Our observations show that environmental conditions of Chinese deserts and sand fields are controlled by regional climate together with human activity. | LU HuaYu YI ShuangWen XU ZhiWei ZHOU YaLi ZENG Lin ZHU FangYing FENG Han DONG LiNa ZHUO HaiXin YU KaiFeng MASON Joseph WANG XiaoYong CHEN YingYong LU Qi WU Bo DONG ZhiBao QU JianJun WANG XunMing GUO ZhengTang | 2013 | Chinese Science Bulletin2013，58，23： | 40 |
| 2 | Geographical characteristics of China’s wetlands derived from remotely sensed data显示文摘In this paper, we report the first wetland mapping of the entire China using Landsat enhanced thematic mapper plus (ETM+) data. These data were obtained from the Global Land Cover Facility at the University of Maryland spanning from 1999 to 2002. A total of 597 scenes of Landsat images were georeferenced and mosaiced. Manual image interpretation of satellite images was aided with elevation data, soil data, land cover/land use data and Google Earth. The minimum mapping unit is 10 pixel × 10 pixel, equivalent to 9 ha. The aim of our first round of mapping was only targeted at the boundary delineation of any type of wetland except those wetlands that are under agricultural use (i.e., paddy fields), which has already been well mapped by others. Our interpretation results indicate that a total of 359478 km2 of wetlands are of non-agricultural use. Among our preliminarily mapped wetland, 339353 km2 are inland wetland, 2786 km2 are non-agricultural artificial wetland, and 17609 km2 are coastal wetland. Because low-tide is rarely captured in satellite images, an under-estimation of coastal wetland is inevitable. We conducted some statistics based on our mapped wetlands and compared them with those previously obtained from a number of sources including a land cover/land use map made with satellite images during the late 1990s and early 2000s, a marshland map developed in approximately the same period, survey data of coastal wetland in early 1980s, and area data for approximately 400 larger patches of marshland in China compiled in 1996. Because some inconsistencies exist in the guidelines of those different wetland surveys, difference in area is expected. Some further comparison indicates that the wetland distributions derived from the preliminary wetland map are reasonable and more objective than other sources. The mapping process also indicated that the method adopted by us was efficient and cost-effective. We also found that in order to ensure comparability of the wetland maps developed at different times, a set of standard guidelines on the wetland categories to be mapped, and the mapping methods to be used must be well conceived, developed and effectively employed. We carried out some initial geographical analysis on the distribution of wetlands. | NIU ZhenGuo GONG Peng CHENG Xiao GUO JianHong WANG Lin HUANG HuaBing SHEN ShaoQing WU YunZhao WANG XiaoFeng WANG XianWei YING Qing LIANG Lu ZHANG LiNa WANG Lei YAO Qian YANG ZhenZhong GUO ZiQi DAI YongJiu | 2009 | Science China Earth Sciences2009，52，6： | 15 |
| 3 | Protein microarrays for systems biology显示文摘系统生物学为在系统水平上理解生物系统拿钥匙。它最后为象癌症,糖尿病,肥胖,心理混乱,和许多其它那样的复杂疾病的治疗和痊愈拿钥匙。-omics' 技术例如 genomics, transcriptomics, proteomics,和 metabonomics,在系统生物学的主要驱动力之中。是展示了高产量,使小型化,并且能够平行分析,蛋白质 microarrays 已经为系统成为了一个重要技术平台生物学。在这评论,我们将用蛋白质 microarrays 集中于系统水平或生物系统的全球分析。蛋白质 microarrays 的四种主要类型将被讨论:proteome microarrays,抗体 microarrays,反向阶段的蛋白质数组,和 lectin microarrays。我们将也为系统生物学讨论挑战和蛋白质 microarray 技术和他们的应用的未来方向。我们强烈相信蛋白质 microarrays 将很快为系统生物学成为一个不可缺少、无价的工具。 | Lina Yang | 2011 | Acta Biochimica et Biophysica Sinica2011，43，3： | 9 |
| 4 | The wheat MYB-related transcription factor TaMYB72 promotes flowering in rice显示文摘Through large-scale transformation analyses, Ta MYB72 was identified as a flowering time regulator in wheat. Ta MYB72 is a MYB family transcription factor localized to the nucleus. Three Ta MYB72 homologs,Ta MYB72-A, Ta MYB72-B and Ta MYB72-D, cloned from hexaploid wheat were mapped to the short arm of the group 6 chromosomes. Under the long-day conditions,over-expression of the Ta MYB72 in rice shortened the flowering time by approximately 12 d. Expression analyses suggest that Ta MYB72 may function through upregulation of florigen genes Hd3 a and RFT1. | Lichao Zhang Guoxiang Liu Jizeng Jia Guangyao Zhao Chuan Xia Lina Zhang Fu Li Qiang Zhang Chunhao Dong Shuangcheng Gao Longzhi Han Xiuping Guo Xin Zhang Jinxia Wu Xu Liu Xiuying Kong | 2016 | Journal of Integrative Plant Biology2016，58，8： | 8 |
| 5 | Influence of mechanical alloying time on the properties of Fe_3Al intermetallics prepared by spark plasma sintering显示文摘The Fe3Al-based intermetallics were prepared by mechanical alloying and spark plasma sintering (SPS), and the influence of milling time on the properties of materials was investigated. The phase identification was investigated by X-ray, and the surface morphology and fractography were observed by scanning electron microscope (SEM). The mechanical properties such as bending strength, strain, and microhardness were tested. The results show that Fe reacts with Al completely to form Fe3Al during short SPS processing time. The relative densities of the sintered samples were nearly 100/. The mechanical properties of the sintered samples can be improved along with the milling time. The representative values are the bend strength of 1327 MPa and the microhardness of 434. | Chengchang Jia Qing He Jie Meng Lina Guo | 2007 | Journal of University of Science and Technology Beijing2007，14，4： | 6 |
| 6 | Effect of interaction between different CeO_(2)plane and platinum nanoparticles on catalytic activity of Pt/CeO_(2)in toluene oxidation显示文摘The plane exposure of support vitally affects the catalytic performance of the catalyst.In this work,CeO_(2)nanorods((110)plane exposure),nano-octahedrons((111)plane exposure)and nano-cubes((100)plane exposure)were prepared as the supports of Pt/CeO_(2)samples to investigate the effect of CeO_(2)plane exposure on total toluene oxidation.Characterizations reveal that the(110)plane of CeO_(2)is more helpful to the dispersion of Pt species,followed by(111)face.The improved dispersion of Pt species can enhance the metal-supports interaction,which promotes the electron transfer of CeO_(2)carrier to Pt nanoparticles and the adsorption-activation of O_(2),thereby facilitating the total oxidation of toluene via the Langmuir-Hinshelwood(L-H)mechanism.Therefore,Pt/CeO_(2)-r(nanorods)sample expresses excellent catalytic performance of toluene oxidation.Finally,the procedure of toluene total oxidation was studied by in-situ diffuse reflectance infrared Fourier transform(DRIFT)spectroscopy.We expect that this work can contribute to the development of an effective sample for the decomposition of volatile organic compounds(VOCs). | Shengsheng Chang Yong jia Yiqing Zeng Fuping Qian Lina Guo Shenghua Wu Jinli Lu Yunlong Han | 2022 | Journal of Rare Earths2022，40，11： | 6 |
| 7 | Single track and single layer formation in selective laser melting of niobium solid solution alloy显示文摘Selective laser melting(SLM) was employed to fabricate Nb-37 Ti-13 Cr-2 Al-1 Si(at%)alloy, using pre-alloyed powders prepared by plasma rotating electrode processing(PREP). A series of single tracks and single layers under different processing parameters was manufactured to evaluate the processing feasibility by SLM, including laser power, scanning speed, and hatch distance.Results showed that continuous single tracks could be fabricated using proper laser powers and scanning velocities. Both the width of a single track and its penetration depth into a substrate increased with an increase of the linear laser beam energy density(LED), i.e., an increase of the laser power and a decrease of the scanning speed. Nb, Ti, Si, Cr, and Al elements distributed heterogeneously over the melt pool in the form of swirl-like patterns. An excess of the hatch distance was not able to interconnect neighboring tracks. Under improper processing parameters, a balling phenomenon occurred, but could be eliminated with an increased LED. This work testified the SLMprocessing feasibility of Nb-based alloy and promoted the application of SLM to the manufacture of niobium-based alloys. | Yueling GUO Lina JIA Bin KONG Na WANG Hu ZHANG | 2018 | Chinese Journal of Aeronautics2018，31，4： | 6 |
| 8 | Clinical effects of Xingnao Kaiqiao acupuncture on neurological impairment following cerebral infarction显示文摘BACKGROUND: Although the curative effects of acupuncture have been confirmed by various treatments of cerebral infarction, few studies have investigated when acupuncture can attain the best clinical effect. OBJECTIVE: Four different time points were selected for acupuncture treatment of cerebral infarction to evaluate the appropriate time course for Xingnao Kaiqiao therapy in terms of improved neurological function. DESIGN: Controlled observation. SETTING: Department of Traditional Chinese Medicine Rehabilitation and Physiotherapy of the Affiliated Hospital of Medical College of Chinese Armed Police Forces. PARTICIPANTS: A total of 120 inpatients with cerebral infarction of different stages, including 75 males and 45 females, aged 41-75 years, were selected from November 2005 to December 2006 at the Department of Traditional Chinese Medicine Rehabilitation and Physiotherapy in Affiliated Hospital of Medical College of Chinese Armed Police Forces. Diagnostic criteria: in accordance with 'main points of diagnosis on different cerebrovascular disease' secondly revised in the Second Cerebrovascular Disease Academic Meeting of Chinese Medicine Association in 1986. All accepted subjects provided confirmed consent, and the experiment received ethical permission from the hospital’s ethics committee. METHODS: ① Experiment grouping: All inpatients were divided into four groups with non-stochastic concurrent control method according to the disease course: Group I (onset within 7 hours), group Ⅱ (onset from 7 hours to 3 days), group Ⅲ (onset within 4-7 days), and group Ⅳ (onset within 21-180 days). On the basis of symptomatic treatment with western medicine, each group received Xingnao Kaiqiao therapy after onset within 7 hours, 7 hours to 3 days, 4 to 7days, and 21 to 180 days. ② The principal acupoints were Neiguan, Renzhong, and Sanyinjiao. ③ The auxiliary acupoints were Jiquan, Chize, and Weizhong. ④Acupuncture manipulations: initially, Neiguan (PC6, bilateral) was needled at 0.5-1.0 cun vertically with a reducing technique achieved by rotating-swirling and lifting-inserting for 1 minute. Subsequently, Renzhong (GV26) was needled at 0.3-0.5 cun obliquely towards the nasal septum, with a heavy bird-pecking method until eyeballs were moist or shed tears. Sanyinjiao (SP6, affected limb) was needled at 1.0-1.5 cun obliquely along the medial border of the tibia with a 45° angle between the needle and skin. The technique of reinforcing was achieved by a lifting-inserting method until the affected lower limb twitched three times. The auxiliary acupoint, Jiquan, was selected when the patient extended the affected upper limb abduction. Jiquan was along the downward channel, 1 cun from the quondam Jiquan (HT1) acupoint; the armpit hair was avoided. Jiquan (affected limb) was needled vertically at 1.0-1.5 cun. The technique of reduction was achieved by lifting-inserting until the affected upper limb twitched three times. Chize (LU5) was selected when the patient flexed the elbow at 120°. Chize was vertically needled at 1 cun with a lifting-inserting reducing technique until the affected forearm and fingers twitched three times. Weizhong (BL40) was selected when the patient’s leg was raised straight in a supine position. Weizhong was vertically needled at 0.5-1.0 cun with a lifting-inserting reducing technique until the affected lower limb twitched three times. ⑤ Acupuncture manipulations were achieved by the doctor who is an associate chief physician and doctor of acupuncture and moxibustion and has aptitude for the post’s specification. ⑥One course of treatment lasted for 10 days and each group was treated for two courses of treatment. ⑦Experiment evaluation: To apply neurological impairment scores for evaluating clinical curative effects before and after treatment with Xingnao Kaiqiao therapy on day 7, 14, and 21(range of 0-45; decreasing score indicates functional improvement).To evaluate clinical curative effect by clinical effective power:Basic recovery: equal to ormore than 81%; significant improvement: 56% to 81% (including 56%); Improvement: between 36% to 56% (including 36%); Slight Improvement: 11% to 36% (including 11%); No change: less than 11%; Aggravation (including death): negative value. Total effective rate was computed at the same time. MAIN OUTCOME MEASURES: The total effective rate and amelioration of neurological impairment of the patients after treatment. RESULTS: All 120 patients with cerebral infarction were included in the final analysis, without deletion. ① Comparison of the total effective rate: the total effective rate of group Ⅰ, group Ⅱ, group Ⅲ, and group Ⅳ was 97%, 93%, 93%, and 67%, respectively. There were significant differences of interclass synthetic curative effects (χ2 = 36.351 7, P < 0.01). ② Amelioration of neurological impairment: A decreased neurological impairment score was observed in group I on day 7, 14, and 21 after Xingnao Kaiqiao therapy. The differences between group IV and the remaining three groups were significant (P < 0.05). CONCLUSION: Xingnao Kaiqiao therapy is helpful for amelioration of neurological impairment in patients during the acute stage cerebral infarction. | Jie Xiong Lina Ning Jinling Bian Jun Li Junfeng Xu Zhilong Zhang Jiakui Guo YadongLi Xuemin Shi | 2008 | Neural Regeneration Research2008，3，3： | 5 |
| 9 | Distribution pattern of Caragana species under the influence of climate gradient in the Inner Mongolia region, China显示文摘There is a strong climate gradient in the Inner Mongolia region, China, with solar radiation and air temperature increasing but precipitation decreasing gradually from the northeast to the southwest. Sixteen Cara- gana species exist in the Inner Mongolia region. These Caragana species exhibit a distribution pattern across moisture zones and form a geographical replacement series. In order to examine the mechanisms responsible for Caragana species distribution pattern, we selected 12 Caragana species that exhibit a distinct distribution pattern across multiple moisture zones in the Inner Mongolia region, and determined the relationships between the leaf ecological and physiological traits of these Caragana species and the aridity index and solar radiation. Along with the climatic drought gradient and the solar radiation intensification from the northeast to the southwest, leaf eco- logical characteristics of Caragana species changed drastically, i.e. the leaf shape gradually turned from flat into tegular or tubbish; the leaf hair became denser, longer and lighter in color; the leaf area, leaf biomass and specific leaf area(SLA) decreased significantly; the leaf thickness and the ratio of leaf thickness to leaf area increased sig- nificantly; and the leaf chlorophyll content decreased significantly. As the climatic drought stress increased, osmotic potentials of the main osmotic adjustment substances and the cytoplasmic ion concentration of Caragana species increased significantly. Meanwhile, the total and free water contents and water potential of leaves decreased sig- nificantly; the ratio of bound to free water increased significantly; the stomatal conductance and transpiration rate reduced significantly; and the water use efficiency(WUE) increased significantly. In addition, with the intensification of climatic drought stress, peroxidase(POD) and superoxide dismutase(SOD) activities in leaves increased sig- nificantly. As a result, the malondialdehyde(MDA) content increased while the oxygen free radical content decreased. Our results showed that most of the leaf ecological and physiological traits of the 12 Caragana species varied in ac- cordance with the climatic drought gradient in the Inner Mongolia region, which reflected the adaptation of the Cara- gana species to the local climate conditions. With relatively more active metabolism and faster growth, the Caragana species in the northeast had strong competitive abilities; on the other hand, with stronger resistance to climatic drought stress, the Caragana species in the southwest could survive in harsh environments. Based on our results, we con- cluded that both the environmental gradients and the adaptive responses of Caragana species to their environments played important roles in the formation of the Caragana species distribution pattern across the Inner Mongolia region. | LiNa XIE ChengCang MA HongYu GUO QingFang LI YuBao GAO | 2014 | Journal of Arid Land2014，6，3： | 5 |
| 10 | Construction of controllable size silver nanoparticles immobilized on nanofibers of chitin microspheres via green pathway显示文摘在现在的工作, nanofibrous 几丁质 microsphere (NCM ) 从在低温度在一个 NaOH/urea 水的系统溶解的一个几丁质解决方案经由大音阶的第五音胶化转变被准备。Ag nanoparticles (AgNPs ) 被综合经由一在里面用 trisodium 柠檬酸盐的银硝酸盐的 situ 减小使脱水并且在几丁质 nanofibers 上被使不能调动获得合成 microspheres 由 nanofibers 和 AgNPs (NCM-Ag ) 组成。AgNPs 的尺寸能在 10 ~ 70 nm 的范围被控制,取决于 AgNO 3 的集中。X 光检查光电子光谱学(XPS ) 和 Fourier 变换红外线(英尺红外) 分析证明几丁质 nanofibers 向 AgNPs 有一种强壮的亲密关系,源于在几丁质和 AgNPs 的 acetamino 组之间的相互作用。NCM-Ag 展出了完美的 nanoporous 结构和高表面在器官的溶剂的区域,以及高稳定性。而且,在石蜡的催化 epoxidation (特别地,到苯乙烯 epoxide 的苯乙烯的变换) , NCM-Ag 展出了多达 90% 的一种优秀选择。用一种环境地友好的技术把几丁质粉末变换成几丁质 microspheres 是一个绿过程,它为工业产品的大规模合成是有益的。更重要地,这个工作为在 nanofiber 支持上使不能调动的控制尺寸的高贵金属 nanoparticles 的构造提供一条绿合成小径,它有大量潜在的应用。 | Lin Guo Bo Duan Lina Zhang | 2016 | Nano Research2016，9，7： | 5 |
| 11 | Construction of a metabolomics profile of arsenic trioxide effect in gastric carcinoma cell line SGC7901显示文摘砷三氧化物(ATO ) 为对待尖锐 promyelocytic 白血病是高度有效的。它也为治疗稳固的肿瘤保持诺言,包括胃的癌。然而,到稳固的肿瘤的 ATO 的有效性的分子的机制仍然糟糕被理解。在这研究,我们 chosed 是的胃的癌一个例子并且试着通过 metabolomics 揭示 antitumor 机制。胃的癌房间线 SGC7901 为 6, 12,和 24 h 与 ATO 被对待。全球代谢物侧面被 metabolomics 分析用气体监视层析(GC )/mass spectrometry (MS ) 和液体层析 /MS/MS。281 的一个总数证明代谢物可靠地被检测。生物信息学分析证明那 glycerophospholipid 合成,一个碳合成,和谷胱甘肽合成戏剧性地被影响。被影响了的另外的细胞的功能 / 小径包括了煽动性的反应,菸碱腺嘌 dinucleotide (NAD +), 和 polyamine 生合成小径。在有以前的 transcriptomics 和 proteomics 数据的联合,从这研究的 metabolomics 数据能为 ATO 处理的特定的 antitumor 机制的理解用作珍贵资源。 | Ziqing Chen Hainan Zhang Lina Yang Hewei Jiang Shujuan Guo Yang Li Shengce Tao | 2016 | Acta Biochimica et Biophysica Sinica2016，48，5： | 5 |
| 12 | Effects of grazing intensity on seed production of Caragana stenophylla along a climatic aridity gradient in the Inner Mongolia Steppe,China显示文摘As the increases of climatic aridity and grazing intensity,shrubs play an increasingly important role in grassland ecosystem in arid and semi-arid regions,and its abundance also generally increases.However,the effects of climatic aridity and grazing intensity on sexual reproduction of shrubs in grassland remain largely unclear.In order to understand the effects of grazing intensity and climatic drought stress,and their interaction on seed production of shrub species,we examined the seed number,seed weight and seed yield of Caragana stenophylla under three grazing intensities(fenced,mild grazing and severe grazing) across a climatic aridity gradient(semi-arid,arid,very arid and intensively arid zones) in the Inner Mongolia Steppe,northern China during 2012–2013.The seed number,seed weight and seed yield gradually increased from the semi-arid to the very arid zones,but decreased from the very arid to the intensively arid zones in fenced plots.The seed number and seed yield decreased from the semi-arid to the intensively arid zones in mild and severe grazing treatment plots,therefore,grazing enhanced the suppression effect of climatic aridity on seed production of C.stenophylla.The seed number and seed yield gradually decreased as grazing intensity increased.The seed weight was highest in severe grazing plots,followed by the mild grazing plots and then the fenced plots.Precipitation varied interannually during the study period.We observed that the seed number,seed weight and seed yield were lower in the low precipitation year(2013) than in the high precipitation year(2012).As climatic drought stress increased,the negative effects of grazing on seed production of C.stenophylla also gradually increased.Our results indicated that climatic drought stress may contribute to the encroachment of C.stenophylla shrub in arid zones by promoting its seed production.However,grazing had negative effects on sexual reproduction of C.stenophylla,and the combined effects of drought stress and grazing seriously suppressed sexual reproduction of C.stenophylla in the intensively arid zone. | XIE Lina CHEN Weizhong Christopher A GABLER HAN Lei GUO Hongyu CHEN Qing MA Chengcang GU Song | 2016 | Journal of Arid Land2016，8，6： | 5 |
| 13 | Serine metabolism orchestrates macrophage polarization by regulating the IGF1–p38 axis显示文摘Serine metabolism is reportedly involved in immune cell functions, but whether and how serine metabolism regulates macrophage polarization remain largely unknown. Here, we show that suppressing serine metabolism, either by inhibiting the activity of the key enzyme phosphoglycerate dehydrogenase in the serine biosynthesis pathway or by exogenous serine and glycine restriction, robustly enhances the polarization of interferon-γ-activated macrophages (M(IFN-γ)) but suppresses that of interleukin-4-activated macrophages (M(IL-4)) both in vitro and in vivo. Mechanistically, serine metabolism deficiency increases the expression of IGF1 by reducing the promoter abundance of S-adenosyl methionine-dependent histone H3 lysine 27 trimethylation. IGF1 then activates the p38-dependent JAK–STAT1 axis to promote M(IFN-γ) polarization and suppress STAT6-mediated M(IL-4) activation. This study reveals a new mechanism by which serine metabolism orchestrates macrophage polarization and suggests the manipulation of serine metabolism as a therapeutic strategy for macrophage-mediated immune diseases. | Xiao Shan Penghui Hu Lina Ni Long Shen Yanan Zhang Zemin Ji Yan Cui Meihua Guo Haoan Wang Liyuan Ran Kun Yang Ting Wang Lei Wang Bin Chen Zhi Yao Vingjie Wu Qiujing Yu | 2022 | Cellular & Molecular Immunology2022，19，11： | 5 |
| 14 | Relationship of gelatinases-tight junction proteins and blood-brain barrier permeability in the early stage of cerebral ischemia and reperfusion显示文摘Gelatinases matrix metalloproteinase-2 and matrix metalloproteinase-9 have been shown to mediate claudin-5 and occludin degradation, and play an important regulatory role in blood-brain barrier permeability. This study established a rat model of 1.5-hour middle cerebral artery occlusion with reperfusion. Protein expression levels of claudin-5 and occludin gradually decreased in the early stage of reperfusion, which corresponded to the increase of the gelatinolytic activity of matrix metalloproteinase-2 and matrix metalloproteinase-9. In addition, rats that received treatment with matrix metalloproteinase inhibitor N-[(2R)-2-(hydroxamidocarbonylmethyl)-4-methylpenthanoyl]-L- tryptophan methylamide (GM6001) showed a significant reduction in Evans blue leakage and an inhibition of claudin-5 and occludin protein degradation in striatal tissue. These data indicate that matrix metalloproteinase-2 and matrix metalloproteinase-9-mediated claudin-5 and occludin degradation is an important reason for blood-brain barrier leakage in the early stage of reperfusion. The leakage of the blood-brain barrier was present due to gelatinases-mediated degradation of claudin-5 and occludin proteins. We hypothesized that the timely closure of the structural component of the blood-brain barrier (tight junction proteins) is of importance. | Haolin Xin Wenzhao Liang Jing Mang Lina Lin Na Guo Feng Zhang Zhongxin Xu | 2012 | Neural Regeneration Research2012，7，31： | 4 |
| 15 | Effect of newly identified hTERT-interacting proteins on telomerase activity显示文摘在 telomerestelomerase 和年龄相关的疾病之间有一种靠近的关系。人的 telomerase 颠倒 transcriptase (hTERT ) 两个都是人的 telomerase 和 telomerase 活动的限制率的决定因素的催化部件。Itstranscriptional 规定是 telomerase 活动的控制的主要模式。为探索 hTERT 表示和 telomerase 活动的规章的机制发现蛋白质 interactingwith hTERT 是批评的。在这研究, theyeast 二混血儿的系统被用来屏蔽 hTERT 的潜在的交互蛋白质。六蛋白质被获得, amongwhich T 星, LOXL3, HKR3,和 Par-4 被 co-immunoprecipitation.Then 进一步作为 hTERT 的交往的蛋白质证实感觉和 antisense 基因包含这四基因的真核细胞的表示向量被构造, transfectedinto 肿瘤房间排队。在这四蛋白质, hTERT 的表示水平,和 telomerase 活动的表示层次之中的关联被分析。结果证明 T 星表示和 down-regulationof HKR3 表示的起来规定导致了 hTERT 表示和 telomerase 活动的增加,当 LOXL3and Par-4 表情的起来规定和下面规定没有明显的效果时。当 HKR3 可以是一个否定管理者时,我们的结果建议 T 星与 telomeraseactivity 有积极关联。这个结论是重要的进一步探索人的 telomerase 活动的影响因素 orregulation 小径,它可能为潜在的临床的申请是很重要的。 | Lina Zhou Bing Chen Xing Hua Ping Zhou Lian Guo Yong Peng Kunhua Qiu | 2013 | Acta Biochimica et Biophysica Sinica2013，45，8： | 4 |
| 16 | 用粘结剂-处理工艺制备高性能钢粉混合粉显示文摘FLOMET工艺是一种粘结剂-处理混合技术,其是用固态有机粘结剂将细小的石墨粉、金属添加剂及润滑剂颗粒粘结在较粗的铁粉颗粒上。和常规混合粉相比,粘结剂-处理混合粉的主要好处是,流动性较好,可提高生产率与零件的一致性,以及减小扬尘(dusting)与偏聚。这些特性都使粘结剂-处理的混合粉很适于生产高性能粉末冶金制品,以及其他各种用途需要优异充填特性的混合粉。QMP在20世纪90年代中期提出了一系列粘结剂-处理的混合粉。此后,为改进这类混合粉的性能和开发能用于特殊用途的粘结剂-处理混合粉一直在进行不懈的努力。本文评述了粘结剂-处理材料的物理性能,生坯与烧结体的性能。特别关注的是这些材料的生产工艺特性。 | Sylvain St-Laurent Claude Gélinas Ray Guo Yannig Thomas Lhoucine Azzi | 2007 | 粉末冶金工业2007，17，1： | 4 |
| 17 | Building Hot Snapshot Copy Based on Windows File System显示文摘This paper describes a method for building hot snapshot copy based on windows-file system (HSCF). The architecture and running mechanism of HSCF are discussed after giving a comparison with other on-line backup technology. HSCF, based on a file system filter driver, protects computer data and ensures their integrity and consistency with following three steps:access to open files, synchronization and copy-on-write. Its strategies for improving system performance are analyzed including priority setting, incremental snapshot and load balance. HSCF is a new kind of snapshot technology to solve the data integrity and consistency problem in online backup, which is different from other storage-level snapshot and Open File Solution. | WANG Lina GUO Chi WANG Dejun ZHU Qin | 2006 | Wuhan University Journal of Natural Sciences2006，11，6： | 4 |
| 18 | A New Time-Aware Collaborative Filtering Intelligent Recommendation System显示文摘Aiming at the problem that the traditional collaborative filtering recommendation algorithm does not fully consider the influence of correlation between projects on recommendation accuracy,this paper introduces project attribute fuzzy matrix,measures the project relevance through fuzzy clustering method,and classifies all project attributes.Then,the weight of the project relevance is introduced in the user similarity calculation,so that the nearest neighbor search is more accurate.In the prediction scoring section,considering the change of user interest with time,it is proposed to use the time weighting function to improve the influence of the time effect of the evaluation,so that the newer evaluation information in the system has a relatively large weight.The experimental results show that the improved algorithm improves the recommendation accuracy and improves the recommendation quality. | Weijin Jiang Jiahui Chen Yirong Jiang Yuhui Xu Yang Wang Lina Tan Guo Liang | 2019 | Computers, Materials & Continua2019，，8： | 3 |
| 19 | Layered MoS2@graphene functionalized with nitrogen-doped graphene quantum dots as an enhanced electrochemical hydrogen evolution catalyst显示文摘A novel three-dimensional (3D) layered MoS2@graphene functionalized with nitrogen-doped graphene quantum dots (MoS2@N-GQDs-GR) composites as an enhanced electrochemical hydrogen evolution catalyst. The few layered MoS2 nanoflowers supported on N-GQDs-GR surface were elaborately fabricated by one-pot hydrothermal method, which MoS2 and N-GQDs-GR exist in a bonding manner of Mo-N. In addition, due to the layered MoS2 sheet edge exposes more hydrogen evolution active sites and N-GQDs-GR have high conductivity, the composites exhibit prominent electrocatalytic activity with a low overpotential 99 mV, a small Tafel slope 49.3 mV/dec. Therefore, that the current work will develop HER catalysts may replace Pt. | Tong Guo Lina Wang Sen Sun Yan Wang Xiaoling Chen Kangning Zhang Dongxia Zhang Zhonghua Xue Xibin Zhou | 2019 | Chinese Chemical Letters2019，30，6： | 3 |
| 20 | Dietary L-arginine supplementation reduces lipid accretion by regulating fatty acid metabolism in Nile tilapia(Oreochromis niloticus)显示文摘Background: Excessive white fat accumulation in humans and other animals is associated with the development of multiple metabolic diseases. It is unknown whether dietary L-arginine supplementation reduces lipid deposition in high fat diet-fed Nile tilapia(Oreochromis niloticus).Results: In the present study, we found that dietary supplementation with 1% or 2% arginine decreased the deposition and concentration of fats in the liver;the concentrations of triglycerides, low-density lipoprotein, total cholesterol, and high-density lipoprotein in the serum;and the diameter of adipocytes in intraperitoneal adipose tissue. Compared with the un-supplementation control group, the hepatic activities of alanine aminotransferase,aspartate aminotransferase, and lactate dehydrogenase, and hepatic concentration of malondialdehyde were reduced but these for catalase and superoxide dismutase were enhanced by dietary supplementation with 2% arginine. Arginine supplementation reduced the total amounts of monounsaturated fatty acids, while increasing the total amounts of n-3 and n-6 polyunsaturated fatty acids in the liver. These effects of arginine were associated with reductions in mRNA levels for genes related to lipogenesis(sterol regulatory element-binding protein-1, acetyl-CoA carboxylase α, stearoyl-CoA desaturase, and fatty acid synthase) but increases in mRNA levels for genes involved in fatty acid β-oxidation(carnitine palmitoyltransferase 1α and peroxisome proliferator-activated receptor α). In addition, hepatic mRNA levels for Δ4 fatty acyl desaturase 2 and elongase 5 of very long-chain fatty acids were enhanced by arginine supplementation.Conclusion: These results revealed that dietary L-arginine supplementation to tilapia reduced high fat diet-induced fat deposition and fatty acid composition in the liver by regulating the expression of genes for lipid metabolism. | Senlin Li Yunchang Zhang Ning Liu Jingqing Chen Lina Guo Zhaolai Dai Chao Wang Zhenlong Wu Guoyao Wu | 2021 | Journal of Animal Science and Biotechnology2021，12，1： | 3 |
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