|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Prevalence of clonorchiasis in patients with gastrointestinal disease: A Korean nationwide multicenter survey显示文摘AIM: To investigate prevalence of Clonorchis sinensis in patients with gastrointestinal symptoms, and the relation of the infection to hepatobiliary diseases in 26 hospitals in Korea.METHODS: Consecutive patients who had been admitted to the Division of Gastroenterology with gastrointestinal symptoms were enrolled from March to April 2005. Of those who had been diagnosed with clonorchiasis, epidemiology and correlation between infection and hepatobiliary diseases were surveyed by questionnaire.RESULTS: Of 3080 patients with gastrointestinal diseases, 396 (12.9%) had clonorchiasis and 1140 patients (37.2%) had a history of eating raw freshwater fish. Of those with a history of raw freshwater fish ingestion, 238 (20.9%) patients had clonorchiasis. Cholangiocarcinoma was more prevalent in C. sinensis-infected patients than non-infected patients [34/396 (8.6%) vs 145/2684 (5.4%), P = 0.015]. Cholangiocarcinoma and clonorchiasis showed statistically significant positive cross-relation (P = 0.008). Choledocholithiasis, cholecystolithiasis, cholangitis, hepatocellular carcinoma, and biliary pancreatitis did not correlate with clonorchiasis.CONCLUSION: Infection rate of clonorchiasis was still high in patients with gastrointestinal diseases in Korea, and has not decreased very much during the last two decades. Cholangiocarcinoma was related to clonorchiasis, which suggested an etiological role for the parasite. | Ho Gak Kim Jimin Han Myung-Hwan Kim Kyu Hyun Cho Im Hee Shin Gwang Ha Kim Jae Seon Kim Jin Bong Kim Tae Nyeun Kim Tae Hyeon Kim Tae Hyo Kim Jae Woo Kim Ji Kon Ryu Young-Soo Moon Jong Ho Moon Sung Jae Park Chan Guk Park Sung-Jo Bang Chang Heon Yang Kyo-Sang Yoo Byung Moo Yoo Kyu Taek Lee Dong Ki Lee Byung Seok Lee Sang Soo Lee Seung Ok Lee Woo Jin Lee Chang Min Cho Young-Eun Joo Gab Jin Cheon Young Woo Choi Jae Bok Chung Yong Bum Yoon | 2009 | World Journal of Gastroenterology2009，15，1： | 15 |
| 2 | Assessment of scoring systems for acute-on-chronic liver failure at predicting short-term mortality in patients with alcoholic hepatitis显示文摘AIM To assess the performance of proposed scores specific for acute-on-chronic liver failure in predicting shortterm mortality among patients with alcoholic hepatitis.METHODS We retrospectively collected data from 264 patients with clinically diagnosed alcoholic hepatitis from January to December 2013 at 21 academic hospitals in Korea. The performance for predicting short-term mortality was calculated for Chronic Liver FailureSequential Organ Failure Assessment(CLIF-SOFA), CLIF Consortium Organ Failure score(CLIF-C OFs), Maddrey'sdiscriminant function(DF), age, bilirubin, international normalized ratio and creatinine score(ABIC), Glasgow Alcoholic Hepatitis Score(GAHS), model for end-stage liver disease(MELD), and MELD-Na.RESULTS Of 264 patients, 32(12%) patients died within 28 d. The area under receiver operating characteristic curve of CLIF-SOFA, CLIF-C OFs, DF, ABIC, GAHS, MELD, and MELD-Na was 0.86(0.81-0.90), 0.89(0.84-0.92), 0.79(0.74-0.84), 0.78(0.72-0.83), 0.81(0.76-0.86), 0.83(0.78-0.88), and 0.83(0.78-0.88), respectively, for 28-d mortality. The performance of CLIF-SOFA had no statistically significant differences for 28-d mortality. The performance of CLIF-C OFs was superior to that of DF, ABIC, and GAHS, while comparable to that of MELD and MELD-Na in predicting 28-d mortality. A CLIF-SOFA score of 8 had 78.1% sensitivity and 79.7% specificity, and CLIF-C OFs of 10 had 68.8% sensitivity and 91.4% specificity for predicting 28-d mortality.CONCLUSION CLIF-SOFA and CLIF-C OF scores performed well, with comparable predictive ability for short-term mortality compared to the commonly used scoring systems in patients with alcoholic hepatitis. | Hee Yeon Kim Chang Wook Kim Tae Yeob Kim Do Seon Song Dong Hyun Sinn Eileen L Yoon Young Kul Jung Ki Tae Suk Sang Soo Lee Chang Hyeong Lee Tae Hun Kim Jeong Han Kim Hyung Joon Yim Sung Eun Kim Soon Koo Baik Byung Seok Lee Jae Young Jang Young Seok Kim Sang Gyune Kim Jin Mo Yang Joo Hyun Sohn Heon Ju Lee Seung Ha Park Eun Hee Choi Dong Joon Kim Korean Acute-on-Chronic Liver Failure Study Group | 2016 | World Journal of Gastroenterology2016，22，41： | 5 |
| 3 | Tissue engineered regeneration of completely transected spinal cord using human mesenchymal stem cells显示文摘 | Kkot Nim Kang Da Yeon Kim So Mi Yoon Ju Young Lee Bit Na Lee Jin Seon Kwon Hyo Won Seo Il Woo Lee Ha Cheol Shin Young Man Kim Hyun Soo Kim Jae Ho Kim Byoung Hyun Min Hai Bang Lee Moon Suk Kim | 2012 | Biomaterials2012，，19： | 1 |
| 4 | Diversity of Rotavirus Strain Circulated in Gwangju, Republic of Korea显示文摘 | Min Ji Kim Hye Sook Jeong Seon Gyeong Kim Se Mi Lee Sun Hee Kim Hye-Young Kee Eun-hye Jo Hye-jung Park Dong-Ryong Ha Eun Sun Kim Kye-Won Seo Jae Keun Chung | 2014 | Osong Public Health and Research Perspectives2014，，： | 1 |
| 5 | Clinical assessment and identification of immuno-oncology markers concerning the 19-gene based risk classifier in stage Ⅳ colorectal cancer显示文摘BACKGROUND Genomic profiling of tumors has contributed to the understanding of colorectal cancer(CRC), facilitating diagnosis, prognosis and selection of treatments,including targeted regimens. A report suggested that a 19-gene-based risk classifier(TCA19) was a prognostic tool for patients with stage III CRC. The survival outcomes in patients with stage IV CRC are still poor and appropriate selection of targeted therapies and immunotherapies is challenging.AIM To assess clinical implication of TCA19 in patients with stage IV CRC, and to identify TCA19 with involvement in immune-oncology.METHODS A retrospective review of the medical records of 60 patients with stage IV CRC was conducted, assessing clinicopathological variables and progression-free survival(PFS). TCA19 gene expression was determined by quantitative polymerase chain reaction(qPCR) in matched normal and tumor tissues taken from the study cohort. Expression of potential immune-oncology regulatory proteins and targets was examined by immunohistochemistry(IHC), western blot, immunofluorescence staining in tissues from a validation cohort of 10 patients, and in CRC cell lines co-cultured with monocyte in vitro.RESULTS In the patients with TCA19 score higher than the median, the PFS rates of eight patients who received the targeted regimens were significantly higher than the PFS rates of four patients who received 5-fluorouracil-based regimen(P = 0.041).In multivariate analysis, expression of signaling lymphocytic activation molecule family, member 7(SLAMF7) and triggering receptor expressed on myeloid cells 1(TREM1) was associated with PFS in the 60-patient cohort. After checking another 10 validate set, the expression of the IHC, the level of real-time qPCR,and the level of western blot were lower for SLAMF7 and higher for TREM7 in primary and metastatic tumors than in normal tissues. In CRC cells expressing SLAMF7 that were co-cultured with a monocytic cell line, levels of CD 68 and CD73 were significantly lower at day 5 of co-culture than at day 0.CONCLUSION The TCA19 score might be prognostic for target-regimen-specific PFS in stage IV CRC. Down-regulation of SLAMF7 and up-regulation of TREM1 occur in primary and metastatic tumor tissues. | Jong Lyul Lee Seon Ae Roh Chan Wook Kim Yi Hong Kwon Ye Jin Ha Seon-Kyu Kim Seon-Young Kim Dong-Hyung Cho Yong Sung Kim Jin Cheon Kim | 2019 | World Journal of Gastroenterology2019，25，11： | 1 |
| 6 | Estrogen receptor beta gene +1730 G/A polymorphism in women with polycystic ovary syndrome 显示文摘 | Jin Ju Kim Young Min Choi Seon Ha Choung | 2010 | Fertility and Sterility2010，93，6： | 1 |
| 7 | Effect of ginsam, a vinegar extract from Panax ginseng, on body weight and glucose homeostasis in an obese insulin-resistant rat model显示文摘 | Soo Lim Ji Won Yoon Sung Hee Choi Bong Jun Cho Jun Tae Kim Ha Soon Chang Ho Seon Park Kyong Soo Park Hong Kyu Lee Young-Bum Kim Hak Chul Jang | 2009 | Metabolism2009，，1： | 1 |
| 8 | Compa- ring the psychometric properties o显示文摘 | Seon Ha Kim Hwa Jung Kimo Sang-il Lee Min-Woo Jo | 2011 | Qual Life Res2011，，9： | 1 |
| 9 | Regulation of DUOX by the Gαq-Phospholipase Cβ-Ca 2+ Pathway in Drosophila Gut Immunity显示文摘 | Eun-Mi Ha Kyung-Ah Lee Seon Hwa Park Sung-Hee Kim Hyuck-Jin Nam Hyo-Young Lee Dongmin Kang Won-Jae Lee | 2009 | Developmental Cell2009，，： | 1 |
| 10 | Effect of a peroxisome proliferator-activated receptor γ sumoylation mutant on neointimal formation after balloon injury in rats显示文摘 | Soo Lim Byung Yong Ahn Sung Soo Chung Ho Seon Park Bong Jun Cho Min Kim Sung Hee Choi In Kyu Lee Sang-Won Lee Soo Joon Choi Chin Ha Chung Young Min Cho Hong Kyu Lee Kyong Soo Park | 2009 | Atherosclerosis2009，，2： | 1 |
| 11 | Propofol protects the autophagic cell death induced by the ischemia/reperfusion injury in rats显示文摘 | Hae Sook Noh Il Woo Shin Ji Hye Ha Young-Sool Hah Seon Mi Baek Deok Ryong Kim | 2010 | Molecules and Cells2010，，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员