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| 1 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 2 | Prevalence and virological profiles of hepatitis B infection in human immunodeficiency virus patients显示文摘AIM: To determine the prevalence of hepatitis B virus (HBV) in adult human immunodeficiency virus (HIV) patients with CD4+ T-cell count less than 500/mm 3 and without antiretroviral therapy; to describe different HBV-HIV coinfection virological profiles; and to search for factors associated with HBs antigen (HBsAg) presence in these HIV positive patients.METHODS: During four months (June through September 2006), 491 patients were received in four HIV positive monitoring clinical centers in Abidjan. Inclusion criteria: HIV-1 or HIV-1 and 2 positive patients, age ≥ 18 years, CD4+ T-cell count < 500/mL and formal and signed consent of the patient. Realized blood tests included HIV serology, CD4+ T-cell count, quantitative HIV RNA load and HBV serological markers, such as HBsAg and HBc antibody (anti-HBcAb). We performed HBeAg, anti-HBe antibody (anti-HBeAb), anti-HBc IgM and quantitative HBV DNA load in HBsAg positive patients. Anti-HBsAb had been tested in HIV patients with HBsAg negative and anti-HBcAb-positive. HBV DNA was also tested in 188 anti-HBcAb positive patients with HBsAg negative status and without anti-HBsAb. Univariate analysis (Pearsonχ 2 test or Fischer exact test) and multivariate analysis (backward step-wise selection logistic regression) were performed as statistical analysis. RESULTS: Mean age of 491 patients was 36 ± 8.68 years and 73.3% were female. Type-1 HIV was found in 97% and dual-type HIV (type 1 plus type 2) in 3%. World Health Organization (WHO) clinical stage was 1, 2, 3 and 4 respectively in 61 (12.4%), 233 (47.5%), 172 (35%) and 25 patients (5.1%). Median CD4+ T-cell count was 341/mm 3 (interquartile range: 221-470). One hundred and twelve patients had less than 200 CD4+ T-cell/mm 3 . Plasma HIV-1 RNA load was elevated (≥ 5 log 10 copies/mL) in 221 patients (45%). HBsAg and anti-HBcAb prevalence was respectively 13.4% and 72.9%. Of the 66 HBsAg positive patients, 22 were inactive HBV carriers (33.3%), 21 had HBeAg positive hepatitis (31.8%) and 20 had HBeAg negative hepatitis (30.3%). HBeAg and anti-HBeAb were indeterminate in 3 of them. Occult B infection prevalence (HBsAg negative, anti-HBcAb positive, anti-HBsAb negative and detectable HBV DNA) was 21.3%. Three parameters were significantly associated with the presence of HBsAg: male [odds ratio (OR): 2.2;P = 0.005; 95% confidence interval (CI): 1.3-3.8]; WHO stage 4 (OR: 3.2;P = 0.01;95% CI: 1.3-7.9); and aspartate aminotransferase (AST) level higher than the standard (OR: 1.9;P = 0.04; 95% CI: 1.02-3.8). CONCLUSION: HBV infection prevalence is high in HIV-positive patients. HBeAg positive chronic hepatitis and occult HBV infection are more frequent in HIVpositive patients than in HIV negative ones. Parameters associated with HBsAg positivity were male gender, AIDS status and increased AST level. | Koffi Alain Attia Serge Eholié Eugène Messou Christine Danel Sandrine Polneau Henri Chenal Thomas Toni Myreille Mbamy Catherine Seyler Naomi Wakasugi Thérèse N'dri-Yoman Xavier Anglaret | 2012 | World Journal of Hepatology2012，4，7： | 4 |
| 3 | Simultaneous enzymatic kinetic determina- tion of pesticides, carbaryl and phoxim, with the aid of chemometrics显示文摘 | Ni Y N Cao D X Serge K | 2007 | Anal ChimActa2007，588，2： | 1 |
| 4 | Effects of Valsartanon circulating brain natriuretic peptide an norepingphrineinsy NptoNatic chronic heart failure显示文摘 | Robeo L Serge N Inder A | 2002 | Circulation2002，106，19： | 1 |
| 5 | Demonstration of intracellular Staphylococcus aureus in bovine mastitis alveolar cells and macrophages isolated from naturally infected cow milk显示文摘 | Alexandre Hébert Khampoune Sayasith Serge Sénéchal Pascal Dubreuil Jacqueline Lagacé | 2000 | FEMS Microbiology Letters2000，，1： | 1 |
| 6 | Comparison of regularization methods for imagenet classification with deep convolutional neural networks显示文摘 | EVGENY A S DENIS M T and SERGE N A | 2014 | AASRI Procedia2014，6，8： | 1 |
| 7 | Parkinson' s disease: molecular and therapeutic insights from model systems显示文摘 | Richard N Serge P | 2008 | Academic Press2008，，： | 1 |
| 8 | Effect of alkali additives over nanocrystalline Co-Cu-based perovskites as catalysts for higher-alcohol synthesis显示文摘 | NGUYEN T T HASSAN Z N M HOUSHANG A SERGE K | 2007 | J Catal2007，245，2： | 1 |
| 9 | Efects of Valsartan on circulating brain natriuretic peptide an norepingphrine in syNptoNatic chronic heart failure 显示文摘 | Roberto L Serge N Inder A | 2002 | Circulation2002，106，19： | 1 |
| 10 | Jamming phase diagram for attractive particles显示文摘 | Trappe V Prasad V Cipelletti L Serge P N Weitz D A | 2001 | Nature2001，411，： | 1 |
| 11 | Demonstration of intracellular Staphylococcus aureus in bovine mastitis alveolar cells and macrophages isolated from naturally infected cow milk显示文摘 | Alexandre Hébert Khampoune Sayasith Serge Sénéchal Pascal Dubreuil Jacqueline Lagacé | 2000 | FEMS Microbiology Letters2000，，1： | 1 |
| 12 | Classification of aged wine distillates using fuzzy and neural network system 显示文摘 | Ni Y N Chen S H Serge K G | 2002 | Analytiea Chimica Acta2002，463，2： | 1 |
| 13 | Transjugular intrahepatic portosystemic shunts: comparison with paracentesis in patients with cirrhosis and refractory ascites: a randomized trial显示文摘 | Didier Lebrec Nathalie Giuily Antoine Hadengue Valérie Vilgrain Richard Moreau Thierry Poynard Adrián Gadano Claudine Lassen Jean-Pierre Benhamou Serge Erlinger | 1996 | Journal of Hepatology1996，，2： | 1 |
| 14 | Synchronous fluorescence and UV-vis spectrometric study of the competitive interaction of chlorpromazine hydrochloride and Neutral Red with DNA using chemometrics approaches 显示文摘 | NI Y N LIND Q SERGE K | 2005 | Talanta2005，65，5： | 1 |
| 15 | Simultaneous spectrophotometric determination of maltol, ethylmaltol, vaniUin and ethy vanillin in foods by multivariate calibration and art ificial neural networks 显示文摘 | Ni Y N Zhang G W Serge K | 2005 | Food Chemistry2005，89，3： | 1 |
| 16 | Comparison of Regulariza- tion Methods for ImageNet Classification with Deep Convolu- tional Neural Networks 显示文摘 | Evgeny A S Denis M T Serge N A | 2014 | Aasri Procedia2014，6，1： | 1 |
| 17 | Validation of two immunoassay methods for environmental monitoring of carbaryl and 1-naphthol in ground water samples显示文摘 | MARIA-PILAR MARCO SERGE CHIRON JORDI GASCóordi Gascón | 1995 | Analytica Chimica Acta1995，311，3： | 1 |
| 18 | Implant stability measurement of delayed and immediately loaded implants during healing显示文摘 | Mark B Rabah N Serge SM | 2004 | Clin Oral Impl Res2004，15，： | 1 |
| 19 | Demonstration of intracellular Staphylococcus aureus in bovine mastitis alveolar cells and macrophages isolated from naturally infected cow milk显示文摘 | Alexandre Hébert Khampoune Sayasith Serge Sénéchal Pascal Dubreuil Jacqueline Lagacé | 2000 | FEMS Microbiology Letters2000，，1： | 1 |
| 20 | Detection and characterization of hepatitis B virus strains from wild-caught gorillas and chimpanzees in Cameroon,Central Africa显示文摘 | RICHARD N SERGE A S ERIC N | 2010 | Infect Genet Evol2010，10，6： | 1 |
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