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| 1 | Recent advances in diagnostic upper endoscopy显示文摘BACKGROUND Esophageo-gastro-duodenoscopy(EGD)is an important procedure used for detection and diagnosis of esophago-gastric lesions.There exists no consensus on the technique of examination.AIM To identify recent advances in diagnostic EGDs to improve diagnostic yield.METHODS We queried the PubMed database for relevant articles published between January 2001 and August 2019 as well as hand searched references from recently published endoscopy guidelines.Keywords used included free text and MeSH terms addressing quality indicators and technological innovations in EGDs.Factors affecting diagnostic yield and EGD quality were identified and divided into the follow segments:Pre endoscopy preparation,sedation,examination schema,examination time,routine biopsy,image enhanced endoscopy and future developments.RESULTS We identified 120 relevant abstracts of which we utilized 67 of these studies in our review.Adequate pre-endoscopy preparation with simethicone and pronase increases gastric visibility.Proper sedation,especially with propofol,increases patient satisfaction after procedure and may improve detection of superficial gastrointestinal lesions.There is a movement towards mandatory picture documentation during EGD as well as dedicating sufficient time for examination improves diagnostic yield.The use of image enhanced endoscopy and magnifying endoscopy improves detection of squamous cell carcinoma and gastric neoplasm.The magnifying endoscopy simple diagnostic algorithm is useful for diagnosis of early gastric cancer.CONCLUSION There is a steady momentum in the past decade towards improving diagnostic yield,quality and reporting in EGDs.Other interesting innovations,such as Raman spectroscopy,endocytoscopy and artificial intelligence may have widespread endoscopic applications in the near future. | Jun-Liang Teh Asim Shabbir Soon Yuen Jimmy Bok-Yan So | 2020 | World Journal of Gastroenterology2020，26，4： | 15 |
| 2 | The success of sleeve gastrectomy in the management of metabolic syndrome and obesity显示文摘The rapid reversal of diabetes,hypertension,hyperlipidaemia and obesity by surgical means has challenged accepted doctrines regarding the management of metabolic syndrome.Sleeve gastrectomy,which developed initially as a preparatory procedure for biliopancreatic diversion with duodenal switch,has seen an exponential rise in popularity as an effective lone laparoscopic bariatric procedure.Superior excess weight loss,a low complication rate,and excellent food tolerance,combined with a short hospital stay,have made this the procedure of choice for patients and surgeons across the globe.High volume centres nurture the ongoing development of experienced and specialized teams,pathways and regimens.Optimum surgical outcomes allow minimization of metabolic syndrome,reducing cardiovascular and cerebrovascular risk. | Asim Shabbir Dallan Dargan | 2015 | The Journal of Biomedical Research2015，29，2： | 11 |
| 3 | Gut microbiome in acute pancreatitis:A review based on current literature显示文摘The gut microbiome is a complex microbial community,recognized for its potential role in physiology,health,and disease.The available evidence supports the role of gut dysbiosis in pancreatic disorders,including acute pancreatitis(AP).In AP,the presence of gut barrier damage resulting in increased mucosal permeability may lead to translocation of intestinal bacteria,necrosis of pancreatic and peripancreatic tissue,and infection,often accompanied by multiple organ dysfunction syndrome.Preserving gut microbial homeostasis may reduce the systemic effects of AP.A growing body of evidence suggests the possible involvement of the gut microbiome in various pancreatic diseases,including AP.This review discusses the possible role of the gut microbiome in AP.It highlights AP treatment and supplementation with prebiotics,synbiotics,and probiotics to maintain gastrointestinal microbial balance and effectively reduce hospitalization,morbidity and mortality in an early phase.It also addresses novel therapeutic areas in the gut microbiome,personalized treatment,and provides a roadmap of human microbial contributions to AP that have potential clinical benefit. | Bharati Kadamb Patel Kadamb H Patel Madhav Bhatia Shridhar Ganpati Iyer Krishnakumar Madhavan Shabbir M Moochhala | 2021 | World Journal of Gastroenterology2021，27，30： | 10 |
| 4 | Pharmacogenomics of Drug Metabolizing Enzymes and Transporters:Relevance to Precision Medicine显示文摘The interindividual genetic variations in drug metabolizing enzymes and transporters influence the efficacy and toxicity of numerous drugs. As a fundamental element in precision medicine, pharmacogenomics, the study of responses of individuals to medication based on their genomic information, enables the evaluation of some specific genetic variants responsible for an individual's particular drug response. In this article, we review the contributions of genetic polymorphisms to major individual variations in drug pharmacotherapy, focusing specifically on the pharmacogenomics of phase-I drug metabolizing enzymes and transporters. Substantial frequency differences in key variants of drug metabolizing enzymes and transporters, as well as their possible functional consequences, have also been discussed across geographic regions. The current effort illustrates the common presence of variability in drug responses among individuals and across all geographic regions. This information will aid health-care professionals in prescribing the most appropriate treatment aimed at achieving the best possible beneficial outcomes while avoiding unwanted effects for a particular patient. | Shabbir Ahmed Zhan Zhou Jie Zhou Shu-Qing Chen | 2016 | Genomics, Proteomics & Bioinformatics2016，14，5： | 7 |
| 5 | Natural Colorants:Historical,Processing and Sustainable Prospects显示文摘With the public’s mature demand in recent times pressurized the textile industry for use of natural colorants,without any harmful effects on environment and aquatic ecosystem,and with more developed functionalities simultaneously.Advanced developments for the natural bio-resources and their sustainable use for multifunctional clothing are gaining pace now.Present review highlights historical overview of natural colorants,classification and predominantly processing of colorants from sources,application on textiles surfaces with the functionalities provided by them.Chemistry of natural colorants on textiles also discussed with relevance to adsorption isotherms and kinetic models for dyeing of textiles. | Mohd Yusuf Mohd Shabbir Faqeer Mohammad | 2017 | Natural Products and Bioprospecting2017，7，1： | 6 |
| 6 | P450基因在氯虫苯甲酰胺不同抗性品系小菜蛾中的表达及功能分析显示文摘【目的】以十字花科蔬菜害虫小菜蛾(Plutella xylostella)为研究对象,筛选参与小菜蛾代谢氯虫苯甲酰胺的主要细胞色素P450解毒基因,为阐明不同抗性水平小菜蛾对氯虫苯甲酰胺的抗性机理提供依据。【方法】利用叶片药膜法测定不同小菜蛾种群3龄幼虫对氯虫苯甲酰的抗性水平,通过转录组测序、insectbase数据库和小菜蛾基因组数据库筛选得到52个细胞色素P450基因。应用MEGA5.10软件对52个细胞色素P450基因进行进化分析,获得与抗药性密切相关的CYP3和CYP4家族P450基因。利用实时荧光定量PCR方法分析目的基因在小菜蛾室内筛选种群(HZY)和田间抗性种群惠州种群(HZ)、连州种群(LZ)、东升种群(DS)、钟落潭种群(ZLT)中的表达量,选用RNA干扰技术,采用注射法,验证在抗性种群中显著上调表达的CYP6BF1V4在小菜蛾抗氯虫苯甲酰胺中的功能。【结果】抗药性测定结果表明,LZ和HZ小菜蛾种群为中等水平抗性,ZLT、DS和HZY小菜蛾种群为高水平抗性。对52个细胞色素P450基因的系统发育树分析发现,小菜蛾拥有10个CYP4家族基因,28个CYP3家族基因,其中2个CYP4家族基因在HZ和HZY种群中的表达量显著高于敏感种群,4个CYP3家族基因表达量与小菜蛾抗性呈正相关,8个基因在中等水平抗性小菜蛾体内的表达量高于在高水平抗性小菜蛾体内的表达量。对田间种群进一步筛选得到6个与小菜蛾抗氯虫苯甲酰胺密切相关,在不同抗性种群中均上调表达的细胞色素P450基因,其中4个为CYP6家族基因(CYP6BF1V4、CYP6BF1V3、CYP6f1和CYP6B6),2个为CYP9家族基因(CYP9G2.1和CYP9G2.2),以CYP6BF1V4的表达量最高,其在抗性种群中的表达量是在敏感种群中表达量的3.5—6.3倍。RNA干扰结果显示,沉默CYP6BF1V4能够显著提高小菜蛾对氯虫苯甲酰胺的敏感性。【结论】CYP6BF1V4、CYP6BF1V3、CYP6f1、CYP6B6、CYP9G2.1和CYP9G2.2可能在小菜蛾体内协同调控多功能氧化酶的表达,从而加快小菜蛾代谢氯虫苯甲酰胺的速度,提高小菜蛾对氯虫苯甲酰胺的抗性。 | 尹飞 李振宇 SAMINA Shabbir 林庆胜 | 2022 | 中国农业科学2022，55，13： | 4 |
| 7 | Cu^2+ reduces hemolytic activity of the antimicrobial peptide HMPI and enhances its trypsin resistance显示文摘Nowadays,drug-resistant microbes are becoming a serious clinical problem threatening people's health and life.An timicrobial peptides(AMPs)are believed to be pote ntial alter natives of con-ventional antibiotics to combat the threat of drug-resistant microbes.However,the susceptibility of AMPs toward proteases is one of the major problems limiting their clinical use.In the present study,we reported the effect of Cu^2+on the bioactivity of AMP HMPI.We found that the addition of Cu^2+could improve the protease resistance of AMP HMPI without affecting its bioactivity.Notably,after the binding of Cu^2+with HMPI,the hemolytic activity of HMPI was greatly decreased.In additi on,our results also demonstrated that the addition of Cu^2+in creased the production of reactive oxygen species in the fun gal cells,which may be a suppleme nt for the antifungal activity of HMPI.In con elusion,the introduction of Cu^2+may provide an inorganic strategy to improve the stability and decrease the hemolytic activity of AMP HMPI,while maintaining its antifungal activity. | Jinxiu Peng Yang Yang Ping Zhao Shuai Qiu Fengjing Jia Jiayi Wang Xiaolei Liang Ahmed Shabbir Chaudhry Peihan Xu Wenjin Yan Zhaoqing Xu Kairong Wang | 2020 | Acta Biochimica et Biophysica Sinica2020，52，6： | 2 |
| 8 | Theoretical investigation of sulfur defects on structural, electronic,and elastic properties of ZnSe semiconductor显示文摘The structural, electronic, and elastic properties of Zn Se1-xSx for the zinc blende structures have been studied by using the density functional theory. The calculations were performed using the plane wave pseudopotential method, as implemented in Quantum ESPRESSO. The exchange-correlation potential is treated with the local density approximation pz-LDA for these properties. Moreover, LDA+U approximation is employed to treat the 'd' orbital electrons properly. A comparative study of the band gap calculated within both LDA and LDA+U schemes is presented. The analysis of results show considerable improvement in the calculation of band gap. The inclusion of compositional disorder increases the values of all elastic constants. In this study, it is found that elastic constants C11, C12, and C44 are mainly influenced by the compositional disorder. The obtained results are in good agreement with literature. | Muhammad Zafar Shabbir Ahmed M.Shakil M.A.Choudhary K.Mahmood | 2015 | Chinese Physics B2015，24，7： | 2 |
| 9 | Prevalence and impact on survival of positive surgical margins in partial nephrectomy for renal cell carcinoma: a population‐based study显示文摘 | Ifeanyi Ani Antonio Finelli Shabbir M.H. Alibhai Narhari Timilshina Neil Fleshner Robert Abouassaly | 2013 | BJU Int2013，，： | 2 |
| 10 | 非贵金属单原子催化剂Co_(1)/MXene(Mo_(2)CS_(2))的CO氧化反应机理研究显示文摘MXene是一类由前过渡态金属碳化物、氮化物或碳氮化物构成的新型二维材料.我们利用量子化学方法研究了单原子Co在新型二维MXene材料Mo2CS2上的吸附构型、稳定性和催化性质.研究发现Co原子可以稳定锚定在MXene材料的表面,形成的单原子催化剂适合于催化低温CO氧化.计算表明,吸附的CO和O2分子与Co_(1)/Mo_(2)CS_(2)催化剂表面之间的电荷转移在活化这些小分子时起着重要作用.我们研究了Co1/Mo2CS2催化氧化CO的三种机理:Eley-Rideal(ER),Langmuir-Hinshelwood(LH)和Termolecular Eley-Rideal(TER),发现在低温下这三种反应机理都是可行的.其中在Co_(1)/Mo_(2)CS_(2)催化剂上TER机理具有最高的催化活性,计算的决速步能垒分别为0.67(TER),0.78(LH)和0.88 eV(ER).我们的研究结果表明,利用二维材料MXene发展和设计经济的、非贵金属单原子催化剂具有重要应用前景. | Shamraiz Hussain Talib Sambath Baskaran 于小虎 于琦 Beenish Bashir Shabbir Mahammad Sajjad Hussain 陈学年 李隽 | 2021 | Science China Materials2021，64，3： | 2 |
| 11 | A new k -? eddy viscosity model for high reynolds number turbulent flows显示文摘 | Tsan-Hsing Shih William W. Liou Aamir Shabbir Zhigang Yang Jiang Zhu | 1995 | Computers and Fluids1995，，3： | 2 |
| 12 | Anisotropic polaritons in van der Waals materials显示文摘Polaritons in two-dimensional(2D)materials continues to garner significant attention due to their favorable ability of field-confinement and intriguing potential for low-loss and ultrafast optical and photonic devices.The recent experimental observation of in-plane anisotropic dispersion in natural van der Waals materials has revealed much richer physics as compared to isotropic plasmonic materials,which provides new insight to manipulate the polaritons and manufacture flat optical devices with unprecedented controls.Herein,we give an overview of the recent progress in in-plane anisotropic polaritons launched and visualized in the near-field range in 2D layered van der Waals materials.Furthermore,future prospects in this promising but emerging field are featured on the basis of its peculiar applications.This review article will stimulate the scientific community to explore other hyperbolic materials and structures in order to develop optical technologies with novel functionalities and further improve the understanding of the exotic photonic phenomena. | Weiliang Ma Babar Shabbir Qingdong Ou Yemin Dong Huanyang Chen Peining Li Xinliang Zhang Yuerui Lu Qiaoliang Bao | 2020 | InfoMat2020，2，5： | 2 |
| 13 | Homozygosity mapping of a consanguineous Pakistani family affected with oculocutaneous albinism to Tyrosinase gene显示文摘Dear Sir,Iam Haiba Kaul,from the Department of Biochemistry,University of Health Sciences,Lahore,Pakistan.I write to present a study of oculocutaneous albinism(OCA)in consanguineous Pakistani families.OCA is a genetic defect of melanin biosynthesis that mainly affects eyes,skin and hair.It is a congenital condition and | Muhammad Shakil Muhammad Ikram Ullah Shabbir Hussain Sabika Firasat Saqib Mahmood Haiba Kaul | 2016 | International Journal of Ophthalmology(English edition)2016，9，5： | 2 |
| 14 | Comfort in urban spaces: defin -ing the boundaries of outdoor thermal comfort for the tropi -cal urban environments显示文摘 | Khandaker Shabbir Ahmed | 2003 | Energy and Buildings2003，，： | 1 |
| 15 | A new κ-ε eddy-viscosity model for high Reynolds number turbulent flowsmodel development and validation显示文摘 | Shih T H Liou W W Shabbir A Zhu J | 1995 | Computers Fluids1995，24，3： | 1 |
| 16 | An examination of the relationship between women’s personal goals and structural factors influencing their decision to start a business: The case of Pakistan显示文摘 | Amama Shabbir Silvana Di Gregorio | 1996 | Journal of Business Venturing1996，，6： | 1 |
| 17 | A New k-εEddy Viscosity Model for High Reynolds Number Turbulent Flows显示文摘 | Tsan-Hsing Shih William Wiou Aamir Shabbir | 1995 | Computers Fluids1995，24，3： | 1 |
| 18 | A New κ-εEddy-Viscosity Model for High Reynolds Number Turbulent Flow Model Development and Validation显示文摘 | Shih T H Liou W W Shabbir A | 1995 | Computer Fluids1995，24，3： | 1 |
| 19 | The role of serotonin (5-hydroxytryptaminelA and 1B) receptors in prostate cancer cell proliferation显示文摘 | Siddiqui E J Shabbir M Mikhailidis DP | 2006 | J Urol2006，176，41： | 1 |
| 20 | A new k - 6 eddy-viscosity model for high Reynolds number turbulent flows-model development and validation 显示文摘 | Shih T H Liou W W Shabbir A | 1995 | Computers & Fluids1995，24，3： | 1 |
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