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| 1 | Human papillomavirus in squamous cell carcinoma of esophagus in a high-risk population显示文摘AIM: To investigate the relation of human papillomavirus (HPV) and esophageal squamous cell carcinoma (ESCC)in Iranian patients as compared to normal controls.METHODS: Using MY09/MY11 consensus primers, we compared the prevalence of a HPV L1 gene in tumor tissues from 38 ESCC cases and biopsied tissues from 38endoscopically normal Iranian individuals. We also compared the presence of HPV16 and HPV18 in the same samples using type-specific E6/E7 primers.RESULTS: Fourteen (36.8%) of the 38 ESCC samples but only 5 (13.2%) of the 38 control samples were positive for the HPV L1 gene (P = 0.02). Five (13.2%) of the ESCC samples but none of the control samples were positive for the HPV16 E6/E7gene (P = 0.05). Three (7.9%) of the ESCC samples and 5 (13.2%) of the control samples were positive for the HPV18 E6/E7gene (P = 0.71).CONCLUSION: Our data are consistent with HPV DNA studies conducted in other high-risk areas for ESCC. HPV should be considered as a potential factor contributing to the high incidence of ESCC in Iran and other high-incidence areas of the world. | Mohammad Farhadi Zahra Tahmasebi Shahin Merat Farin Kamangar Dariush Nasrollahzadeh Reza Malekzadeh | 2005 | World Journal of Gastroenterology2005，11，8： | 16 |
| 2 | Persistent alanine aminotransferase elevation among the general Iranian population: Prevalence and causes显示文摘AIM: To determine the prevalence and causes of persistently elevated alanine aminotransferase (ALT) levels among the general population in northern Iran. METHODS: A total of 2292 (1376 female, aged 18-75 year), were selected by systematic clustered random sampling from the cities and villages of Gonbad and Kalaleh in Golestan Province and invited to participate in the study. A comprehensive history regarding alcohol drinking and medication was taken. Body mass index (BMI), viral markers and ALT levels were measured. If ALT level was ≥ 40 U/L, it was rechecked twice within 6 mo. Those with ≥ 2 times elevation of ALT were considered as having persistently elevated ALT level. Non-alcoholic fatty liver disease (NAFLD) was diagnosed based on evidence of fatty liver upon sonography and excluding other etiology. RESULTS: A total of 2049 (1351 female) patients participated in the study, 162 (7.9%) had elevated ALT level at the first measurement. Persistently elevated ALT level was detected in 64 (3.1%) participants, with51 (79.6%) with no obvious etiology, six (9.3%) with Hepatitis B, four (6.2%) with Hepatitis C virus (HCV) infection and three (4.6%) with alcoholic hepatitis. The prevalence of NAFLD and alcoholic hepatitis was 2.04% (42 patients) and 0.1% (three), respectively. There was correlation between NAFLD and male gender, overweight, diabetes and living in an urban area [odds ratio = 3.03 (95% CI: 1.6-5.72), 4.21 (95% CI: 1.83-9.68), 2.86 (95% CI: 1.05-7.79) and 2.04 (95% CI: 1.00-4.16) respectively]. CONCLUSION: NAFLD is the most common cause of persistently elevated serum ALT level among the general population of Iran. | Raika Jamali Mahmoodreza Khonsari Shahin Merat Masoud Khoshnia Elham Jafari Alireza Bahram Kalhori Hassan Abolghasemi Sedighe Amini Mahtab Maghsoudlu Mohammad Reza Deyhim Houri Rezvan Akram Pourshams | 2008 | World Journal of Gastroenterology2008，14，18： | 7 |
| 3 | Liver Histology Changes in Nonalcoholic Steatohepatitis after One Year of Treatment with Probucol显示文摘 | Shahin Merat Mohsen Aduli Rozana Kazemi Masoud Sotoudeh Nahid Sedighi Masoud Sohrabi Reza Malekzadeh | 2008 | Digestive Diseases and Sciences2008，，8： | 1 |
| 4 | Liver Histology Changes in Nonalcoholic Steatohepatitis after One Year of Treatment with Probucol显示文摘 | Shahin Merat Mohsen Aduli Rozana Kazemi Masoud Sotoudeh Nahid Sedighi Masoud Sohrabi Reza Malekzadeh | 2008 | Digestive Diseases and Sciences2008，，8： | 1 |
| 5 | Critical role of Helicobacter pylori in the pattern of gastritis and carditis in residents of an area with high prevalence of gastric cardia cancer显示文摘 | Masoud Sotoudeh Mohammad H. Derakhshan Behnoosh Abedi-Ardakani Mehdi Nouraie Abass Yazdanbod Seyyed Mohammad Tavangar Javad Mikaeli Shahin Merat Reza Malekzadeh | 2008 | Digestive Diseases and Sciences2008，，1： | 1 |
| 6 | Liver Histology Changes in Nonalcoholic Steatohepatitis after One Year of Treatment with Probucol显示文摘 | Shahin Merat Mohsen Aduli Rozana Kazemi Masoud Sotoudeh Nahid Sedighi Masoud Sohrabi Reza Malekzadeh | 2008 | Digestive Diseases and Sciences2008，，8： | 1 |
| 7 | The Effect of Enteric-Coated, Delayed-Release Peppermint Oil on Irritable Bowel Syndrome显示文摘 | Shahin Merat Shadi Khalili Pardise Mostajabi Anahita Ghorbani Reza Ansari Reza Malekzadeh | 2010 | Digestive Diseases and Sciences2010，，5： | 1 |
| 8 | Critical role of Helicobacter pylori in the pattern of gastritis and carditis in residents of an area with high prevalence of gastric cardia cancer显示文摘 | Masoud Sotoudeh Mohammad H. Derakhshan Behnoosh Abedi-Ardakani Mehdi Nouraie Abass Yazdanbod Seyyed Mohammad Tavangar Javad Mikaeli Shahin Merat Reza Malekzadeh | 2008 | Digestive Diseases and Sciences2008，，1： | 1 |
| 9 | Ulcerative colitis and irritable bowel syndrome: relationships with quality of life显示文摘 | Reza Ansari Fatemeh Attari Hadi Razjouyan Arash Etemadi Hiva Amjadi Shahin Merat Reza Malekzadeh | 2008 | European Journal of Gastroenterology & Hepatology2008，，： | 1 |
| 10 | Epidemiology of upper gastrointestinal cancers in Iran:A Sub site analysis of 761 cases显示文摘瞄准:在伊朗的三个省定义上面的胃肠的癌症的潜水艇地点分发。方法:学习在伊朗在三个省被执行:Ardabil, Golestan,和德黑兰。在 Arbabil 和 Golestan,数据从胃肠的癌症和本地癌症注册表的唯一的工作分派中心被收集。为德黑兰省,来自二所主要私人医院的数据被使用。从 2000 年 9 月和 2002 年 4 月在时期期间诊断的所有胃、食道的癌症病人在学习被包括。结果:有上面的胃肠的癌症的 761 个病人的一个总数被识别, 314 从 Ardabil, 261 从 Golestan,并且 186 从德黑兰。在德黑兰,癌症的相对的率从上面的食管增加了到远侧的胃。在 Golestan,反向的模式被观察。在 Ardabil,中间的部分(远侧的食管和近似的胃) 最经常被包含。结论:在在学习的三个省的上面的胃肠的癌症的潜水艇地点有可观的变化。我们不能为这个变化提供任何解释。进一步的研究瞄准了解释在上面的胃肠的癌症的潜水艇地点分发的差异可以帮助识别重要风险因素。 | Noushin Taghavi Dariush Nasrollahzadeh Shahin Merat Abbas Yazdanbod Mahshid Hormazdi Masoud Sotoudeh Shahriar Semnani Farhad Eslami Haji-Amin Marjani Saman Fahimi Hooman Khademi Reza Malekzadeh | 2007 | World Journal of Gastroenterology2007，13，40： | 0 |
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