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| 1 | Glacier retreat and its effect on stream flow in the source region of the Yangtze River显示文摘在冰河上在气候变化的效果上正在种担心融化并且水文学。在这篇文章,我们在长江的来源区域使用了二自然的小规模的盆, Tuotuo 河和 Buqu 河,中国,到表演,冰河的影响融化在溪流流动上。在在 1970, 1992 和 2009 的冰河和冰体积的程度的变化用遥感图象被评估。在一样的时间间隔上的冰河表面区域的变化用 Landsat TM/ETM+ 形象通过冰河轮廓和位置的描述被估计。在 2009,冰河表面区域分别地在 Tuotuo 河和 Baqu 河盆由 1970 价值中的 20.83% 个和 34.81% 减少了。在每盆的全部的 meltwater 供应被估计是 2.56 ?? | WU Shanshan YAO Zhijun HUANG Heqing LIU Zhaofei CHEN Yuansheng | 2013 | Journal of Geographical Sciences2013，23，5： | 13 |
| 2 | Spatial-temporal patterns of major ion chemistry and its controlling factors in the Manasarovar Basin, Tibet显示文摘因为它的唯一的地理环境,在南部的西藏的 Manasarovar 盆,在佛教被认为一块神圣陆地,引起了国际学术注意。在这研究,基于 43 水里的主要离子集中的实际大小,样品在年期间收集了 2005 和 2012,我们全身地在湖和 inflowing 河分析了水化学和它的控制因素的空间时间的模式。结果表明在 Manasarovar 盆的水是稍微碱的,与在 7.47.9 之间变化的 pH。分别地,在湖和河水的全部的溶解固体(TDS ) 的数量是约 325.4 和 88.7 mg/l 在西藏的高原在大多数表面水里比那降低。因为成为蒸气的结晶化的长期的效果,在湖, Na <啜class=“ a-plus-plus ”>+和 HCO <潜水艇class=“ a-plus-plus ”> 3 <啜class=“ a-plus-plus ”>有最高的集中,为全部的阳离子和阴离子内容中的46.8%个和86.8%的财务。在 inflowing 河里,然而,主导的离子是 Ca < 啜 class= “ a-plus-plus ” >2+ 和 HCO < 潜水艇 class= “ a-plus-plus ” > 3 < 啜 class= “ a-plus-plus ” > 为全部的阳离子和阴离子内容中的 59.6% 个和 75.4% 的 , 财务。水交换为如此的一个大湖是不够的,导致离子作文的一个显著空间变化。分别地湖,离子集中在湖的另外的方面上在比那显著地高的北方方面上有几条大 inflowing 河,与 468.9 和 254.9 mg/l 的 TDS。在复杂环境的影响下面,在水化学的空间变化在河里是甚至更重要的,与展出一个更高离子的内容的 upstreams。臼齿的比率在之间( Ca <啜class=“ a-plus-plus ”>2+ +Mg2+)并且( Na <啜class=“ a-plus-plus ”>+ +K+)比 1.0 高得多,表明水里的离子的主要来源是捱过的碳酸盐。尽管自然过程例如捱过的摇滚乐,是在盆控制主要离子化学的主要因素,在未来,我们需要对人为的影响给予更多的注意。 | YAO Zhijun WANG Rui LIU Zhaofei WU Shanshan JIANG Liguang | 2015 | Journal of Geographical Sciences2015，25，6： | 11 |
| 3 | Effects of freeze-thaw on soil erosion processes and sediment selectivity under simulated rainfall显示文摘The freeze-thaw(FT) processes affect an area of 46.3% in China. It is essential for soil and water conservation and ecological construction to elucidate the mechanisms of the FT processes and its associated soil erosion processes. In this research, we designed the control simulation experiments to promote the understanding of FT-water combined erosion processes. The results showed that the runoff of freeze-thaw slope(FTS) decreased by 8% compared to the control slope(CS), and the total sediment yield of the FTS was 1.10 times that of the CS. The sediment yield rate from the FTS was significantly greater than that from the CS after 9 min of runoff(P<0.01). Both in FTS and CS treatments, the relationships between cumulative runoff and sediment yield can be fitted well with power functions(R2>0.98, P<0.01). Significant differences in the mean weight diameter(MWD) values of particles were observed for washed particles and splashed particles between the CS and the FTS treatments in the erosion process(P<0.05). The mean MWD values under CS were smaller than those under FTS for both washed and splashed particles. The ratio of the absolute value of a regression coefficient between the CS and the FTS was 1.15, being roughly correspondent with the ratio of K between the two treatments. Therefore, the parameter a of the power function between cumulative runoff and sediment yield could be an acceptable indicator for expressing the soil erodibility. In conclusion, the FTS exhibited an increase in soil erosion compared to the CS. | WANG Tian LI Peng REN Zongping XU Guoce LI Zhanbin YANG Yuanyuan TANG Shanshan YAO Jingwei | 2017 | Journal of Arid Land2017，9，2： | 8 |
| 4 | Mathematical Model and Experiment Validation of Fluid Torque by Shear Stress under Influence of Fluid Temperature in Hydro-viscous Clutch显示文摘The current design of hydro-viscous clutch(HVC)in tracked vehicle fan transmission mainly focuses on high-speed and high power.However,the fluid torque under the influence of fluid temperature can not be predicted accurately by conventional mathematical model or experimental research.In order to validate the fluid torque of HVC by taking the viscosity-temperature characteristic of fluid into account,the test rig is designed.The outlet oil temperature is measured and fitted with different rotation speed,oil film thickness,oil flow rate,and inlet oil temperature.Meanwhile,the film torque can be obtained.Based on Navier-Stokes equations and the continuity equation,the mathematical model of fluid torque is proposed in cylindrical coordinate.Iterative method is employed to solve the equations.The radial and tangential speed distribution,radial pressure distribution and theoretical flow rate are determined and analyzed.The models of equivalent radius and fluid torque of friction pairs are introduced.The experimental and theoretical results indicate that tangential speed distribution is mainly determined by the relative rotating speed between the friction plate and the separator disc.However,the radial speed distribution and pressure distribution are dominated by pressure difference at the lower rotating speed.The oil film fills the clearance and the film torque increases with increasing rotating speed.However,when the speed reaches a certain value,the centrifugal force will play an important role on the fluid distribution.The pressure is negative at the outer radius when inlet flow rate is less than theoretical flow,so the film starts to shrink which decreases the film torque sharply.The theoretical fluid torque has good agreement with the experimental data.This research proposes a new fluid torque mathematical model which may predict the film torque under the influence of temperature more accurately. | CUI Hongwei YAO Shouwen YAN Qingdong FENG Shanshan LIU Qian | 2014 | Chinese Journal of Mechanical Engineering2014，27，1： | 6 |
| 5 | Ultrasound-triggered noninvasive regulation of blood glucose levels using microgels integrated with insulin nanocapsules显示文摘Diabetes is a serious public health problem affecting 422 million people worldwide. Traditional diabetes management often requires multiple daily insulin injections, associated with pain and inadequate glycemia control. Herein, we have developed an ultrasound-triggered insulin delivery system capable of pulsatile insulin release that can provide both long-term sustained and fast on-demand responses. In this system, insulin-loaded poly(lactic-co-glycolic acid) (PLGA) nanocapsules are encapsulated within chitosan microgels. The encapsulated insulin in nanocapsules can passively diffuse from the nanoparticle but remain restricted within the microgel. Upon ultrasound treatment, the stored insulin in microgels can be rapidly released to regulate blood glucose levels. In a chemically-induced type 1 diabetic mouse model, we demonstrated that this system, when activated by 30 s ultrasound administration, could effectively achieve glycemic control for up to one week in a noninvasive, localized, and pulsatile manner. | Jin Di Jicheng Yu Qun Wang Shanshan Yao Yanqi Ye Matthew Pless Yong Zhu Yun Jing Zhen Gu | 2017 | Nano Research2017，10，4： | 6 |
| 6 | Additivity of pore structural parameters of granular activated carbons derived from different coals and their blends显示文摘A series of granular activated carbons(GACs) were prepared by briquetting method from Chinese coals of different ranks and their blends,with coal pitch as the binder.Pore structural parameters including BET specific surface area(SBET),total pore volume(VT) and average pore diameter(da) were measured and calculated as well as process parameters such as yield of char(CY) and burn-off(B).The relationship between the pore structural parameters of the GAC from coal blend(BC-GAC) and the ones of the GACs from corresponding single coals(SC-GACs) was analyzed,in which an index,the relative error(d),was presented to define the bias between fitted values and experimental values of these parameters of the BC-GACs.The results show that the BC-GAC keeps qualitatively the pore structural features of the SC-GACs;as concerned as the quantitative relationship,the pore structural parameters of the BC-GAC from coal blend consisting of non-caking coals can be obtained by adding proportionally the pore structural parameters of the SC-GACs with d less than 10%.Meanwhile,for the BC-GAC from coal blend containing weak caking bituminous coal,the d increases up to 25% and the experimental pore size distribution differs greatly from the fitted one. | Yao Xin Xie Qiang Yang Chuan Zhang Bo Wan Chaoran Cui Shanshan | 2016 | International Journal of Mining Science and Technology2016，26，4： | 6 |
| 7 | Biocompatibility of nano-hydroxyapatite/Mg-Zn-Ca alloy composite scaffolds to human umbilical cord mesenchymal stem cells from Wharton's jelly in vitro显示文摘Seeding cells and scaffolds play pivotal roles in bone tissue engineering and regenerative medicine.Wharton’s jelly-derived mesenchymal stem cells(WJCs)from human umbilical cord represent attractive and promising seeding cells in tissue regeneration and engineering for treatment applications.This study was carried out to explore the biocompatibility of scaffolds to seeding cells in vitro.Rod-like nano-hydroxyapatite(RN-HA)and flake-like micro-hydroxyapatite(FM-HA)coatings were prepared on Mg-Zn-Ca alloy substrates using micro-arc oxidation and electrochemical deposition.WJCs were utilized to investigate the cellular biocompatibility of Mg-Zn-Ca alloys after different surface modifications by observing the cell adhesion,morphology,proliferation,and osteoblastic differentiation.The in vitro results indicated that the RN-HA coating group was more suitable for cell proliferation and cell osteoblastic differentiation than the FM-HA group,demonstrating better biocompatibility.Our results suggested that the RN-HA coating on Mg-Zn-Ca alloy substrates might be of great potential in bone tissue engineering. | GUAN FangXia MA ShanShan SHI XinYi MA Xun CHI LianKai LIANG Shuo CUI YuanBo WANG ZhiBin YAO Ning GUAN ShaoKang YANG Bo | 2014 | Science China(Life Sciences)2014，57，2： | 4 |
| 8 | Modeling of Cross-Spring Pivots Subjected to Generalized Planar Loads显示文摘Cross-spring pivots, formed by crossing two identical flexural beams at their midpoint, have been broadly used in precision engineering and aerospace fields. Many researches have been conducted on modeling and analysis of cross-spring pivots. However the influence of application position and magnitude of the external loads on the load-rotation and parasitic motion characteristics has not yet been discussed. In order to reveal the effect of the external loads, this paper develops the accurate load-rotation and center shift models of cross-spring pivots, with generalized planar loads applied including bending moment, horizontal and vertical forces. Firstly, by using the energy method, the load-displacement models of the pivot are derived with the assumption of small rotational angles. Based on the models, the influence of generalized planar loads on the load-rotation relationship is discussed, which shows that both application position and magnitude of the vertical and horizontal forces influence the load-rotation behaviors. Then the accurate center shift expressions of the pivot with generalized planar loads are developed, which shows that the rotational angle is the dominant term for both components of the center shift while the vertical and horizontal forces are small. Finally, the accuracy of the proposed model is validated by finite element analysis(FEA). Comparing the model data with the results obtained from FEA, the relative error of the load-rotation is less than 6% even if the rotational angle reaches 20°; the relative errors of the two components of center shift are less than 5% and 10% respectively when the rotational angle reaches 10°. The proposed model and analytical conclusions can be used to analyze and preliminarily design the compliant mechanisms containing cross-spring pivots. | BI Shusheng YAO Yanbin ZHAO Shanshan YU Jingjun | 2012 | Chinese Journal of Mechanical Engineering2012，25，6： | 4 |
| 9 | The genome of Magnolia biondii Pamp. provides insights into the evolution of Magnoliales and biosynthesis of terpenoids显示文摘Magnolia biondii Pamp.(Magnoliaceae,magnoliids)is a phylogenetically,economically,and medicinally important ornamental tree species widely grown and cultivated in the north-temperate regions of China.Determining the genome sequence of M.biondii would help resolve the phylogenetic uncertainty of magnoliids and improve the understanding of individual trait evolution within the Magnolia genus.We assembled a chromosome-level reference genome of M.biondii using~67,~175,and~154Gb of raw DNA sequences generated via Pacific Biosciences single-molecule real-time sequencing,10X Genomics Chromium,and Hi-C scaffolding strategies,respectively.The final genome assembly was~2.22Gb,with a contig N50 value of 269.11 kb and a BUSCO complete gene percentage of 91.90%.Approximately 89.17%of the genome was organized into 19 chromosomes,resulting in a scaffold N50 of 92.86Mb.The genome contained 47,547 protein-coding genes,accounting for 23.47%of the genome length,whereas 66.48%of the genome length consisted of repetitive elements.We confirmed a WGD event that occurred very close to the time of the split between the Magnoliales and Laurales.Functional enrichment of the Magnolia-specific and expanded gene families highlighted genes involved in the biosynthesis of secondary metabolites,plant–pathogen interactions,and responses to stimuli,which may improve the ecological fitness and biological adaptability of the lineage.Phylogenomic analyses revealed a sister relationship of magnoliids and Chloranthaceae,which are sister to a clade comprising monocots and eudicots.The genome sequence of M.biondii could lead to trait improvement,germplasm conservation,and evolutionary studies on the rapid radiation of early angiosperms. | Shanshan Dong Min Liu Yang Liu Fei Chen Ting Yang Lu Chen Xingtan Zhang Xing Guo Dongming Fang Linzhou Li Tian Deng Zhangxiu Yao Xiaoan Lang Yiqing Gong Ernest Wu Yaling Wang Yamei Shen Xun Gong Huan Liu Shouzhou Zhang | 2021 | Horticulture Research2021，8，1： | 4 |
| 10 | High nitrogen stainless steel drug-eluting stent-Assessment of pharmacokinetics and preclinical safety in vivo显示文摘Pharmacokinetic analyses were performed using 20 pigs for 120-days implantation,while one sirolimus-eluting stent was implanted into one of their coronary artery.At different time points,the residual sirolimus on the stent,delivered locally(to artery wall),regionally(to adjacent and downstream muscle)and systemically(to plasma and visceral organs),was detected throughout 120 days.Preclinical safety evaluation was performed using 32 pigs for 180-days implantation to study the safety of metal platform material and the effectiveness of sirolimus eluting coating on the HNS stent.The neointima area,restenosis rate and inflammatory grade for HNS and control group stents were detected and analyzed.Approximately 80%sirolimus was eluted from the sirolimuseluting stents after 30-days implantation in vivo.Additionally,there was sustained sirolimus in the artery wall,cardiac muscle and heart throughout 120-days implantation,and sirolimus accumulated to the peak at 90-days implantation.It was inferred that the sirolimus eluting stent in this study was covered by neointima before 90-days implantation,indicating that the sirolimus eluting coating on the HNS stent was safe and effective.Very little sirolimus was distributed in visceral organs after 14-days implantation.HNS sirolimus-eluting stent exhibited lower restenosis rate and lower inflammatory grade than control group,which verified that the sirolimus-eluting coating design in this study was reasonable and practical.In addition,there were no significant difference in restenosis rate and inflammatory score between HNS bare-metal stent and drug-eluting stents,illustrating that HNS has good bio-compatibility and is suitable to use as coronary artery stent material. | Shanshan Chen Zhifeng Yao Yongbiao Guan Hui Yang M.Babar Shahzad Yizhe Wu Bingchun Zhang Li Shen Ke Yang | 2020 | Bioactive Materials2020，5，4： | 3 |
| 11 | A New Global Solar-induced Chlorophyll Fluorescence(SIF)Data Product from TanSat Measurements显示文摘The Chinese Carbon Dioxide Observation Satellite Mission(TanSat)is the third satellite for global CO2 monitoring and is capable of detecting weak solar-induced chlorophyll fluorescence(SIF)signals with its advanced technical characteristics.Based on the Institute of Atmospheric Physics Carbon Dioxide Retrieval Algorithm for Satellite Remote Sensing(IAPCAS)platform,we successfully retrieved the TanSat global SIF product spanning the period of March 2017 to February 2018 with a physically based algorithm.This paper introduces the new TanSat SIF dataset and shows the global seasonal SIF maps.A brief comparison between the IAPCAS TanSat SIF product and the data-driven SVD(singular value decomposition)SIF product is also performed for follow-up algorithm optimization.The comparative results show that there are regional biases between the two SIF datasets and the linear correlations between them are above 0.73 for all seasons.The future SIF data product applications and requirements for SIF space observation are discussed. | Lu YAO Dongxu YANG Yi LIU Jing WANG Liangyun LIU Shanshan DU Zhaonan CAI Naimeng LU Daren LYU Maohua WANG Zengshan YIN | 2021 | Advances in Atmospheric Sciences2021，38，3： | 3 |
| 12 | Electrodeposition and Characterization of Polyaniline Film显示文摘Polyaniline film was prepared by electrochemical method in an acidic solution of aniline. The micromor phology of the polyaniline film was transformed to three-dimensional network structure instead of little particles while the deposition time was extended. The peak wavelength of the photoluminescence spectrum was 491 nm. The luminous intensity increased with the extension of deposition time, and so did the electrochemical activity. | WANG Hong-zhi, ZHANG Peng, ZHANG Wei-guo and YAO Su-wei Shanshan Research Office of Surface Technology, College of Chemical Engineering, Tianjin University, Tianjin 300072, P. R. China | 2012 | Chemical Research in Chinese Universities2012，28，1： | 3 |
| 13 | Clinical Prediction Models for Hepatitis B Virus-related Acute-on-chronic Liver Failure:A Technical Report显示文摘Background and Aims:It is critical but challenging to predict the prognosis of hepatitis B virus-related acute-on-chronic liver failure(HBV-ACLF).This study systematically summarized and evaluated the quality and performance of available clinical prediction models(CPMs).Methods:A keyword search of articles on HBV-ACLF CPMs published in PubMed from January 1995 to April 2020 was performed.Both the quality and performance of the CPMs were assessed.Results:Fifty-two CPMs were identified,of which 31 were HBV-ACLF specific.The modeling data were mostly derived from retrospective(83.87%)and single-center(96.77%)cohorts,with sample sizes ranging from 46 to 1,202.Three-month mortality was the most common endpoint.The Asian Pacific Association for the Study of the Liver consensus(51.92%)and Chinese Medical Association liver failure guidelines(40.38%)were commonly used for HBV-ACLF diagnosis.Serum bilirubin(67.74%),the international normalized ratio(54.84%),and hepatic encephalopathy(51.61%)were the most frequent variables used in models.Model discrimination was commonly evaluated(88.46%),but model calibration was seldom performed.The model for end-stage liver disease score was the most widely used(84.62%);however,varying performance was reported among the studies.Conclusions:Substantial limitations lie in the quality of HBV-ACLF-specific CPMs.Disease severity of study populations may impact model performance.The clinical utility of CPMs in predicting short-term prognosis of HBV-ACLF remains to be undefined. | Xia Yu Yi Lu Shanshan Sun Huilan Tu Xianbin Xu Kai Gong Junjie Yao Yu Shi Jifang Sheng | 2021 | Journal of Clinical and Translational Hepatology2021，9，6： | 3 |
| 14 | Graphene/RuO2 nanocrystal composites as sulfur host for lithium-sulfur batteries显示文摘An optimized graphene/RuO2/S composite is prepared by hydrothermal growth of RuO2 particles on graphene oxide sheets as the positive electrode for rechargeable lithium-sulfur batteries. The electrode with 6.1 wt% RuO2 nanocrystals and a high sulfur content of 79.0 wt% delivers an optimal electrochemical performance with high residual capacities of 508 mAh g-1 after 200 cycles and 389 m Ah g-1 after800 cycles at 1 C with a low capacity decay of 0.054%. The RuO2 nanocrystals promote the redox reaction kinetics and facilitate the transformation of sulfur chemistry, leading to large improvements in reversibility and rate capability of the composite electrode. The density functional theory calculations signify the formation of Li–O and Ru–S bonds through chemical interactions between RuO2 and Li polysulfides while the adsorption energies between graphene and polysulfide species are much higher in the presence of RuO2 than that of the neat graphene acting alone. These discoveries support the efficient entrapment of polysulfides by the composite electrode to the benefit of enhanced cyclic stability of the battery. | Jian-Qiu Huang Jiaqiang Huang Woon Gie Chong Jiang Cui Shanshan Yao Baoling Huang Jang-Kyo Kim | 2019 | Journal of Energy Chemistry2019，28，8： | 2 |
| 15 | Kilometers Long Graphene-Coated Optical Fibers for Fast Thermal Sensing显示文摘The combination of optical fiber with graphene has greatly expanded the application regimes of fiber optics,from dynamic optical control and ultrafast pulse generation to high precision sensing.However,limited by fabrication,previous graphene-fiber samples are typically limited in the micrometer to centimeter scale,which cannot take the inherent advantage of optical fibers—longdistance optical transmission.Here,we demonstrate kilometers long graphene-coated optical fiber(GCF)based on industrial graphene nanosheets and coating technique.The GCF shows unusually high thermal diffusivity of 24.99 mm^(2) s^(-1) in the axial direction,measured by a thermal imager directly.This enables rapid thermooptical response both in optical fiber Bragg grating sensors at one point(18-fold faster than conventional fiber)and in long-distance distributed fiber sensing systems based on backward Rayleigh scattering in optical fiber(15-fold faster than conventional fiber).This work realizes the industrial-level graphene-fiber production and provides a novel platform for two-dimensional material-based optical fiber sensing applications. | Yiyong Guo Bing Han Junting Du Shanshan Cao Hua Gao Ning An Yiwei Li Shujie An Zengling Ran Yue Lin Wencai Ren Yunjiang Rao Baicheng Yao | 2021 | Research2021，，1： | 2 |
| 16 | Nonpharmaceutical interventions contribute to the control of COVID-19 in China based on a pairwise model显示文摘Nonpharmaceutical interventions(NPIs),particularly contact tracing isolation and household quarantine,play a vital role in effectively bringing the Coronavirus Disease 2019(COVID-19)under control in China.The pairwise model,has an inherent advantage in characterizing those two NPIs than the classical well-mixed models.Therefore,in this paper,we devised a pairwise epidemic model with NPIs to analyze COVID-19 outbreak in China by using confirmed cases during February 3rde22nd,2020.By explicitly incorporating contact tracing isolation and family clusters caused by household quarantine,our model provided a good fit to the trajectory of COVID-19 infections.We calculated the reproduction number R=1.345(95%CI:1.230-1.460)for Hubei province and R=1.217(95%CI:1.207-1.227)for China(except Hubei).We also estimated the peak time of infections,the epidemic duration and the final size,which are basically consistent with real observation.We indicated by simulation that the traced high-risk contacts from incubated to susceptible decrease under NPIs,regardless of infected cases.The sensitivity analysis showed that reducing the exposure of the susceptible and increasing the clustering coefficient bolster COVID-19 control.With the enforcement of household quarantine,the reproduction number R and the epidemic prevalence declined effectively.Furthermore,we obtained the resumption time of work and production in China(except Hubei)on 10th March and in Hubei at the end of April 2020,respectively,which is broadly in line with the actual time.Our results may provide some potential lessons from China on the control of COVID-19 for other parts of the world. | Xiao-Feng Luo Shanshan Feng Junyuan Yang Xiao-Long Peng Xiaochun Cao Juping Zhang Meiping Yao Huaiping Zhu Michael Y.Li Hao Wang Zhen Jin | 2021 | Infectious Disease Modelling2021，6，1： | 2 |
| 17 | Feasibility of Booster Vaccination in High-Risk Populations for Controlling Coronavirus Variants—China,2021显示文摘Introduction:Vaccination booster shots are completely necessary for controlling breakthrough infections of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)in China.The study aims to estimate effectiveness of booster vaccines for high-risk populations(HRPs).Methods:A vaccinated Susceptible-Exposed-Symptomatic-Asymptomatic-Recovered/Removed(SEIAR)model was developed to simulate scenarios of effective reproduction number(Reff)from 4 to 6.Total number of infectious and asymptomatic cases were used to evaluated vaccination effectiveness.Results:Our model showed that we could not prevent outbreaks when covering 80%of HRPs with booster unless Reff=4.0 or the booster vaccine had efficacy against infectivity and susceptibility of more than 90%.The results were consistent when the outcome index was confirmed cases or asymptomatic cases.Conclusions:An ideal coronavirus disease 2019(COVID-19)booster vaccination strategy for HRPs would be expected to reach the initial goal to control the transmission of the Delta variant in China.Accordingly,the recommendation for the COVID-19 booster vaccine should be implemented in HRPs who are already vaccinated and could prevent transmission to other groups. | Kangguo Li Zeyu Zhao Hongjie Wei Jia Rui Jiefeng Huang Xiaohao Guo Yichao Guo Shiting Yang Guzainuer Abudurusuli Li Luo Xingchun Liu Yao Wang Jingwen Xu Yuanzhao Zhu Meng Yang TianlongYang Weikang Liu Bin Deng Chan Liu Zhuoyang Li Peihua Li Shanshan Yu Zimei Yang Yanhua Su Benhua Zhao Yan Niu Tianmu Chen | 2021 | China CDC weekly2021，3，50： | 2 |
| 18 | Flavor characteristics of lapsang souchong and smoked lapsang souchong, a special chinese black tea with pine smoking process显示文摘 | YAO Shanshan GUO Wenfei LU Yi | 2005 | Agric Food Chem2005，53，： | 1 |
| 19 | Rheological be harlots of nylon 6/silica modified melamine cyanurate non-halo gen flame retardant composites显示文摘 | Wei Shanshan Yao Feng Xu Xiangyang | 2013 | Journal of Nanoseience and Nanotechnology2013，13，3： | 1 |
| 20 | Piceatannol enhances Beclin-1 activity to suppress tumor progression and its combination therapy strategy with everolimus in gastric cancer显示文摘The effects and regulation of Beclin-1-an autophagy-related protein-have not been fully defined, however, a negative correlation has been reported between Beclin-1 expression and carcinogenesis. Meanwhile, no compound has been shown to directly inhibit its activity. Here, we evaluate piceatannol, a naturally occurring polyphenolic compound, as a potential targeting agonist of Beclin-1, to assess its efficacy as an antitumor agent against gastric cancer. More specifically, we determine the effects of piceatannol treatment on cell viability using a monitoring system and colony forming assay. Piceatannol was found to efficiently inhibit the proliferation of several human gastric cancer cell lines. Autophagic flux is increased by piceatannol treatment, and correlates with inhibition of cell proliferation and colony formation. Additionally, microscale thermophoresis and surface plasmon resonance results show a direct interaction between piceatannol and Beclin-1, which reduces the phosphorylation activity of Beclin-1 at the Ser-295 site. Notably, piceatannol impairs the binding of Beclin-1 to Bcl-2 and enhances the recruitment of binding of UV radiation resistance-associated gene protein, which further triggers Beclin-1-dependent autophagy signaling. An increase in autophagic activity via treatment with the mTOR inhibitor, everolimus, effectively sensitizes piceatannol-induced antitumor effects. Xenograft models confirmed that piceatannol inhibits tumor development and elicits a potent synergistic effect with everolimus in vivo. Taken together, the findings of this study strongly support the application of combinatorial piceatannol and everolimus therapy in future clinical trials for gastric cancer patients. | Longtao Huangfu Xiaoyang Wang Shanshan Tian Junbing Chen Xueying Wang Biao Fan Qian Yao Gangjian Wang Cong Chen Jing Han Xiaofang Xing Jiafu Ji | 2023 | Science China(Life Sciences)2023，66，2： | 1 |
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