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| 1 | Herbgenomics: A stepping stone for research into herbal medicine显示文摘From the prehistoric era until the publishing of the Compendium of Materia Medica and the first scientific Nobel Prize in the Chinese mainland for Tu's discovery on anti-malarial tablets,each milestone and stepping stone in the developmental history of herbal medicine involved intrepid exploration,bold hypothesis formulation,and cautious verification.After thousands of years of discovery and development,herbal research has entered a new era—the era of herbgenomics.Herbgenomics combines herbal and genomic research,bridging the gap between traditional herbal medicine and cutting-edge omics studies.Therefore,it provides a general picture of the genetic background of traditional herbs,enabling researchers to investigate the mechanisms underlying the prevention and treatment of human diseases from an omics perspective. | Haoyu Hu Xiaofeng Shen Baosheng Liao Lu Luo Jiang Xu Shilin Chen | 2019 | Science China(Life Sciences)2019，62，7： | 13 |
| 2 | A Comparative Analysis of the Chloroplast Genomes of Four Salvia Medicinal Plants显示文摘Herbgenomics is an emerging field of traditional Chinese medicine(TCM)research and development.By combining TCM research with genomics,herbgenomics can help to establish the scientific validity of TCM and bring it into wider usage within the field of medicine.Salvia Linn.(S.Linn.)is a large genus of Labiatae that includes important medicinal plants.In this herbgenomics study,the complete chloroplast(cp)genomes of two Salvia spp.—namely,S.przewalskii and S.bulleyana,which are used as a surrogate for S.miltiorrhiza—were sequenced and compared with those of two other reported Salvia spp.—namely,S.miltiorrhiza and S.japonica.The genome organization,gene number,type,and repeat sequences were compared.The annotation results showed that both Salvia plants contain 114 unique genes,including 80 protein-coding,30 transfer RNA(tRNA),and four ribosomal RNA(rRNA)genes.Repeat sequence analysis revealed 21 forward and 22 palindromic sequences in both Salvia cp genomes,and 17 and 21 tandem repeats in S.przewalskii and S.bulleyana,respectively.A synteny comparison of the Salvia spp.cp genomes showed a high degree of sequence similarity in the coding regions and a relatively high divergence of the intergenic spacers.Pairwise alignment and single-nucleotide polymorphism(SNP)analyses found some candidate fragments to identify Salvia spp.,such as the intergenic region of the trnV–ndhC,trnQ–rps16,atpI–atpH,psbA–ycf3,ycf1,rpoC2,ndhF,matK,rpoB,rpoA,and accD genes.All of the results—including the repeat sequences and SNP sites,the inverted repeat(IR)region border,and the phylogenetic analysis—showed that S.przewalskii and S.bulleyana are extremely similar from a genetic standpoint.The cp genome sequences of the two Salvia spp.reported here will pave the way for breeding,species identification,phylogenetic evolution,and cp genetic engineering studies of Salvia medicinal plants. | Conglian Liang Lei Wang Juan Lei Baozhong Duan Weisi Ma Shuiming Xiao Haijun Qi Zhen Wang Yaoqi Liu Xiaofeng Shen Shuai Guo Haoyu Hu Jiang Xu Shilin Chen | 2019 | Engineering2019，5，5： | 5 |
| 3 | Characterization of the target DNA sequence for the DNA-binding domain of zinc finger protein 191显示文摘抄写因素的 DNA 有约束力的性质上的研究在寻找这些因素调整的下游的基因是重要的。在现在的学习,我们在一个 Cy s2His2 类型抄写因素的 DNA 有约束力的性质上报导,锌手指蛋白质 191 (Zfpl91 ) ,它最新被发现了在老鼠起一个重要作用。由构造包含 Zfpl91 的 DNA 有约束力的域的熔化蛋白质,我们由在锌上决定蛋白质的有约束力的特性和依赖描绘了目标 DNA。数据证明 Zfpl91 的 DNA 有约束力的域能明确地绑在 TCAT 重复主题并且在目标 DNA 的多重有约束力的地点之中有合作效果。而且,有约束力的反应依赖于锌。这个工作在基因规定和开发在 Zfpl91 的角色上为进一步的研究提供一个基础。 | Haoyue Wang Ruilin Sun Guoxiang Liu Minghui Yao Jian Fei Hebai Shen | 2008 | Acta Biochimica et Biophysica Sinica2008，40，8： | 3 |
| 4 | Nuclear translocation of OsMFT1 that is impeded by OsFTIP1 promotes drought toleranee in rice显示文摘Drought is the leading environmental threat affecting crop productivity,and plants have evolved a series of mechanisms to adapt to drought stress.The FT-interacting proteins(FTIPs)and phosphatidylethanola mine.binding proteins(PEBPs)play key roles in developmental processes,whereas their roles in the regulation of stress response are still largely unknown.Here,we report that OsFTIP1 negatively regulates drought response in rice.We showed that OsFTIP1 interacts with rice MOTHER OF FT AND TFL1(OsMFT1),a PEBP that promotes rice tolerance to drought treatment.Further studies discovered that OsMFT1 interacts with two key drought-related transcription factors,OsbZIP66 and OsMYB26,regulating their binding capacity on drought-related genes and thereby enhancing drought toleranee in rice.Interestingly,we found that OsFTIP1 impedes the nucleocytoplasmic translocation of OsMFT1,implying that dynamic modulation of drought-responsive genes by the OsMFT1-OsMYB26 and OsMFT1-OsbZIP66 complexes is integral to OsFTIP1-modulated nuclear accumulation of OsMFT1.Our findings also suggest that OsMFT1 might act as a hitherto unknown nucleocytoplasmic trafficking signal that regulates drought tolerance in rice in response to environmental signals. | Ying Chen Jun Shen Liang Zhangi Haoyue Qi Lijia Yang Huanyu Wang Jiaxuan Wang Yuexing Wang Hao Du Zeng Tao Ting Zhao Pingchuan Deng Qingyao Shu Qian Qian Hao Yu Shiyong Song | 2021 | Molecular Plant2021，14，8： | 2 |
| 5 | in vitro study of DNA interaction with trichlorobenzenes by spectroscopic and voltammetric techniques显示文摘 | SHEN Haoyu SHAO Xiaoli XU Hua ct al | 2011 | Int J Electrochem Sci2011，6，3： | 1 |
| 6 | Electrochemical investigation of DNA interaction with melamine and its related compounds (MARCs)显示文摘 | SHEN Haoyu ZHENG Huimin ZHU Ning | 2010 | International Journal of Electrochemical Science2010，5，11： | 1 |
| 7 | in vitro study of DNA interaction with melamine and its related compounds显示文摘 | SHEN Haoyu LIU Yangqing GAO Jing | 2011 | DNA and Cell Biology2011，30，4： | 1 |
| 8 | Simultaneous screening and determination eight phthalares in plastic products for food use by sonication-assisted extraction/ GC-MS methods显示文摘 | SHEN Haoyu | 2005 | Talanta2005，66，3： | 1 |
| 9 | Rare double heterozygous mutations in antithrombin underlie hereditary thrombophilia in a Chinese family显示文摘 | Haoyu Deng Jiaquan Chen Hui Xie Yi Gu Kai Yuan Peng Wang Wei Shen Wei Liang Hao Zhang Jiwei Zhang Jun Xie Lan Zhang | 2013 | Journal of Thrombosis and Thrombolysis2013，，3： | 1 |
| 10 | Synthesis, characterization and biological activities of schiff base complexes derived from methyl-substituted salicylaldehyde and D-glucosamine,ML2显示文摘 | Huang Yonghua Shen Haoyu Long Shu | 2002 | Synthesis & Reactivity in Inorganic & Metal-Organic Chemistry2002，32，9： | 1 |
| 11 | Thixotropy of Aqueous Suspensions Containing Mg-AI Hydrotalcite-like Compound and Low-substituted Cationic Starch: Comparison between Oscillatory Shear and Thixotropic Loop Measurements显示文摘 | Li, Yan Bi, Haoyu Shen, Shuanglong | 2011 | Chinese Journal of Chemistry2011，29，6： | 1 |
| 12 | Application of dispersive solid-phase extraction and ultra- fast liquid chromatography-tandem quadrupole mass spec- trometry in food additive residue analysis of red wine 显示文摘 | Chen Xiaohong Zhao Yonggang Shen Haoyu | 2012 | Journal of Chromatography A2012，1263，： | 1 |
| 13 | Simultaneous screening and determination eight phthalates in plastic products for food use by sonication - assisited ex- traction/GC - MS methods 显示文摘 | SHEN Haoyu | 2005 | Talanta2005，66，3： | 1 |
| 14 | 50th anniversary of artemisinin:From the discovery to allele-aware genome assembly of Artemisia annua显示文摘Over the past half century,the fight against malaria has been a resounding success mainlydue to thediscoveryof artemisinin.According to the World Health Organization(WHO),morbidity and mortality due to malaria have been cut by half since the promotion of artemisinin-based combination therapy(WHO,2020). | Jiang Xu Baosheng Liao Ling Yuan Xiaofeng Shen Xuejiao Liao Jigang Wang Haoyu Hu Zhihai Huang Li Xiang Shilin Chen | 2022 | Molecular Plant2022，15，8： | 1 |
| 15 | Divergent responses of soil carbon and nitrogen pools to short-term nitrogen addition between two plantations in Northeast China显示文摘Nitrogen(N)deposition has a profound influence on forest soil carbon(C)and N pools,but there was no consensus on the responses of different C and N components in different forest types.In this study,a two-year simulated N deposition experiment with four levels of N(NH4NO3)-addition treatments(0,50,100,and 150 kg N/hm^(2)·a)were conducted in Larix gmelinii(LG)and Quercus mongolica(QM)plantation in Northeast China,in order to investigate the C and N pool dynamics under continuously enhanced N deposition.Soil organic carbon(SOC),soil total N(STN)and their active components(readily oxidizable C,ROC;dissolved organic C,DOC;microbial biomass C,MBC,dissolved organic N,DON;microbial biomass N,MBN)of the forest soil were measured monthly from May to October 2017.C and N contents in LG were observed higher than in QM.N addition had no effect on SOC and STN of LG,but significantly increased SOC and STN of QM at low N addition level.Low N addition generally raised active C components(ROC,DOC,and MBC)in both plantations,whereas high N addition did not significantly affect these components,or even decreased ROC in LG soil.Low N addition also increased STN and MBN of QM,while no significant change in STN and MBN of LG was observed.DON was directly affected by N addition and increased significantly with elevated N addition levels.The results indicated that N addition,especially of low rate,might enhance the C sequestration capacity of the forest soils and mitigate climate change. | Yedong Li Bo Wang Sen Dou Haoyue Shen Liyong Mei Yang Zhang Ximing Zeng Yaya Zhang Yameng Pei Haoye Ren Shimin Wu | 2019 | International Journal of Agricultural and Biological Engineering2019，12，6： | 1 |
| 16 | Simultaneous screening and determination eight phthalates in plastic products for food use by sonication-assisted extraction/GC-MS methods显示文摘 | SHEN Haoyu | 2005 | Talanta2005，66，： | 1 |
| 17 | Simultaneous screening and determination eight phthalates in plastic products for food use by sonication-assisited extraction/GC-MS methods显示文摘 | Shen Haoyu | 2005 | Talanta2005，66，3： | 1 |
| 18 | Synthesis, characterization and properties of ethylenedia- mine-functionalized Fe3 04 magnetic polymers for remov- al of Cr(Ⅵ) in wastewater显示文摘 | Zhao Yonggang Shen Haoyu Pan Shengdong | 2010 | Hazard Mater2010，182，13： | 1 |
| 19 | Preparation and characterization of amino-functionalized nano-Fe3 04 magnetic polymer adsorbents for removal of chromium(Ⅵ) ions显示文摘 | Zhao Yonggang Shen Haoyu Pan Shengdong | 2010 | Mater Sci2010，45，19： | 1 |
| 20 | Syn- thesis of NH2-functionalized nano-Fe3O4 magnetic poly- mer adsorbent and its application for the removal of Cr (Ⅵ) from industrial wastewater 显示文摘 | Zhao Yonggang Shen Haoyu Hu Meiqin | 2009 | Adv Mater Res2009，7982，： | 1 |
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