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| 1 | The Tea Tree Genome Provides Insights into Tea Flavor and Independent Evolution of Caffeine Biosynthesis显示文摘茶是世界有巨大的经济、药用、文化的重要性的最旧、很流行的包含咖啡因的饮料。这里,我们在场第一个高质量的核苷酸序列充满重复(80.9%) ,栽培的茶树山茶 sinensis 的 3.02-Gb 染色体。我们证明茶树的一种非常地大的染色体尺寸从一些 LTR retrotransposon 家庭的慢、稳定、长期的扩大被结果。除了一个最近的整个染色体的复制事件,基因的系特定的扩大把新陈代谢的生合成与 flavonoid 联系了被发现,它提高 catechin 生产,萜烯酶激活,和应力公差,为茶风味和改编的重要特征。我们相对可可子和咖啡表明一个独立人士和茶咖啡因合成小径的快速的进化。在 25 山茶种类之中的比较研究表明那更高的表情大多数 flavonoid- 和咖啡因铺平 -- 然而并非 theanine 相关的基因贡献 catechins 和咖啡因的增加的生产并且因此提高处理茶的适用性和茶质量。这些新奇调查结果为进一步的 metabolomic 和典型生合成小径的功能的 genomic 精炼铺平道路并且将帮助开发将最后满足并且吸引世界范围的更多的茶喝酒者的茶风味的一个更多样化的集合。 | En-Hua Xia Hai-Bin Zhang Jun Sheng Kui Li Qun-Jie Zhang Changhoon Kim Yun Zhang Yuan Liu Ting Zhu Wei Li Hui Huang Yan Tong Hong Nan Cong Shi Chao Shi Jian-Jun Jiang Shu-Yan Mao Jun-Ying Jiao Dan Zhang Yuan Zhao You-Jie Zhao Li-Ping Zhang Yun-Long Liu Ben-Ying Liu Yue Yu Sheng-Fu Shao De-Jiang Ni Evan E. Eichler Li-Zhi Gao | 2017 | Molecular Plant2017，10，6： | 113 |
| 2 | Effects of glycyrrhetinic acid on collagen metabolism of hepatic stellate cells at different stages of liver fibrosis in rats显示文摘INTRODUCTIONLiver fibrosis is a dynamic course leading tocirrhosis from a various chronic liver diseases. Thepathological basis of fibrosis is the disturbance ofproduction and degradation of the extracellularmatrix (ECM), which causes accumulation of ECMin the liver[1,2]. | Ji Yao Wang Qi Sheng Zhang Ji Sheng Guo Mei Yu Hu Department of Gastroenterology, Zhongshan Hospital, Medical Center, Fu Dan University Shanghai Medical University), Shanghai 200032, China | 2001 | World Journal of Gastroenterology2001，7，1： | 29 |
| 3 | Morphological observation and rbcL gene sequences studies of two new species,Grateloupia dalianensis H.W.Wang et D.Zhao,sp.nov.and G.yinggehaiensis H.W.Wang et R.X.Luan,sp.nov.(Halymeniaceae,Rhodophyta) from China显示文摘A few species in the genus Grateloupia (Halymeniaceae,Rhodophyta) have been investigated in detail with respect to morphological observations and molecular analyses.In this study,the authors document the vegetative and reproductive structures of two new species of Grateloupia,G.dalianensis H.W.Wang et D.Zhao,sp.nov.and G.yinggehaiensis H.W.Wang et R.X.Luan,sp.nov.They both have the morphological character that carpogonial ampullae and auxiliary cell ampullae are the simple Grateloupia-type.The two species can be distinguished from other species of the genus by their distinctive morphological features respectively.Based on ribulose-1,5-bisphosphate carboxylase/oxygenase (rbcL) gene sequences,the phylogenetic tree obtained in the study indicated that they are both embedded within the Grateloupia clade.G.dalianensis clusters a subclade with G.asiatica,and G.yinggehaiensis forms a single monophyletic subclade with G.hawaiiana. | ZHAO Dan WANG Hongwei SHENG Yingwen LV Jianzhou LUAN Rixiao | 2012 | Acta Oceanologica Sinica2012，31，2： | 20 |
| 4 | 4-Hydroxybenzyl-substituted amino acid derivatives from Gastrodia elata显示文摘Seven new 4-hydroxybenzyl-substituted amino acid derivatives(1-7), together with 11 known compounds, were isolated from an aqueous extract of the rhizomes of Gastrodia elata Blume.Their structures were determined by spectroscopic and chemical methods. Compounds 1-3 are pyroglutamate derivatives containing 4-hydroxybenzyl units at the N atom and 4-7 are the first examples of natural products with the 4-hydroxybenzyl unit linked via a thioether bond to 2-hydroxy-3-mercaptopropanoic acid(4-6) and 2-hydroxy-4-mercaptobutanoic acid(7), which would be biogenetically derived from cysteine and homocysteine, respectively. The structures of 1 and 2 were verified by synthesis, while the absolute configurations of 4, 5 and 7 were assigned using Mosher's method based on the MPA determination rule of ΔδRS values. The known compound 4-(hydroxymethyl)-5-nitrobenzene-1,2-diol(8) exhibited activity against Fe^(2+)-cysteine induced rat liver microsomal lipid peroxidation with IC_(50) values of 9.99×10^(-6) mol/L. | Qinglan Guo Yanan Wang Sheng Lin Chenggen Zhu Minghua Chen Zhibo Jiang Chengbo Xu Dan Zhang Huailing Wei Jiangong Shi | 2015 | Acta Pharmaceutica Sinica B2015，5，4： | 18 |
| 5 | Organic anion transporting polypeptide-1B1 haplotypes in Chinese patients显示文摘瞄准:在搬运 polypeptide-1B1 的器官的阴离子检测 388G >A 和 521T >C 变体等位基因(OATP1B1,编码基因 SLCO1B1 ) 基因。方法:111 个健康志愿者在我们的学习为 OATP1B1 等位基因被屏蔽。PCR 限制碎片长度多型性被用来鉴别 388G >A 多型性和一个 1 步 tetra 教材方法为 521T >C 变化的决心被开发。结果:在中国人口的 388G >A 和 521T >C 变体等位基因的频率分别地是 73.4% 和 14.0% 。SLCO1B1 *1b 和 *15 haplotypes 的频率分别地是 59.9% 和 14.0% 。结论:SLCO1B1 *1b 和 SLCO1B1 *15 变体在中国人口是相对普通的。他们的频率类似于那在从那在白种人和黑人日本,却显著地不同。 | Lin-yong XU Yi-jing HE Wei ZHANG Sheng Deng Qing LI Wei-xia ZHANG Zhao-qian LIU Dan WANG Yuan-fei HUANG Hong-hao ZHOU Zhen-qiu SUN | 2007 | Acta Pharmacologica Sinica2007，28，10： | 18 |
| 6 | Characteristics of interior noise of a Chinese high-speed train under a variety of conditions显示文摘目的:研究高速列车在不同速度(260~385 km/h)、无砟和有砟轨道以及明线和隧道运行时的车内噪声特性,为高速列车车内减振降噪和车体低噪声设计提供科学依据。创新点:系统分析高速列车在不同运行条件下的车内噪声总值变化、空间分布、频谱特性和声源贡献,掌握车内噪声随列车运行速度的变化规律、轨道型式和隧道混响对车内噪声的影响,研究轮轨噪声、气动噪声和弓网噪声对车内噪声的作用。方法:1.根据不同的列车运行速度,分析车内噪声的变化规律;通过进一步对比头尾车运行时,不同测点位置的噪声总值、显著频率和声源贡献,研究气动作用对车内噪声的影响。2.针对不同轨道型式,分析车内噪声的差异特性;通过进一步对比不同速度下的前、后转向架上方车内噪声测点(其中一个还位于受电弓下方)的噪声总值、显著频率和声源贡献,研究有砟和无砟轨道、弓网噪声对车内噪声的影响以及速度因素的作用。3.对于隧道运行,分析不同速度下在明线和隧道运行时的车内噪声总值和显著频率,研究隧道混响对车内噪声的影响以及速度因素的作用。结论:1.TC01车无论作为头车或尾车运行,车内观光区的噪声均主要受气动作用影响。2.随着列车运行速度的提高,轨道型式的不同对车内噪声的影响有所降低。3.隧道混响对中间车的影响要高于头车。 | Jie ZHANG Xin-biao XIAO Xiao-zhen SHENG Rong FU Dan YAO Xue-song JIN | 2017 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2017，18，8： | 10 |
| 7 | MicroRNA in vivo precipitation identifies miR-151-3p as a computational unpredictable miRNA to target Stat3 and inhibits innate IL-6 production显示文摘MicroRNAs(miRNAs)function as important regulators in the immune response and inflammation.Several approaches have been reported to computationally predict miRNAs and their potential targets.However,there are still many miRNA–target interactions that are unpredictable by using the current computational algorithms.We established a miRNA in vivo precipitation method(miRIP)to identify unpredictable miRNAs with definite targets in these cells.Because Stat3 is a well-known transcription factor involved in innate immunity and inflammation,we utilized the miRIP method to identify miRNAs that bind Stat3 mRNA in macrophages.Among the captured miRNAs,miR-151-3p was confirmed to interact with Stat3 mRNA 3′-UTR and downregulate the Stat3 protein levels.LPS stimulation decreased miR-151-3p expression,thereby increasing IL-6 production.Therefore,we found that miR-151-3p inhibited LPS-induced IL-6 production by targeting Stat3.These data further confirmed miRIP as an efficient method to identify unpredictable miRNAs and explore miRNAs-mediated regulation in innate immunity and inflammation. | Xiang Liu Xiaoping Su Sheng Xu Huamin Wang Dan Han Jiangxue Li Mingyan Huang Xuetao Cao | 2018 | Cellular & Molecular Immunology2018，15，2： | 8 |
| 8 | Images for diagnosis Sarcomatoid carcinoma of the renal pelvis in duplex kidney显示文摘肾的骨盆的 Sarcomatoid 过渡房间癌是一个稀罕的瘤,仅仅 14 个插图丰富的例子以前报导了。双肾是尿道的最普通的先天的反常,与约 2% 的发生。在双肾的肾的骨盆的瘤形成是稀罕的。我们报导了癌其 sarcomatoid 与两个肾的单位的膀胱手铐切除外科与肾盂积水膨出,和全部的 nephroureterectomy 从复制肾的骨盆的上面的部分发源的一个案例被执行。因为肾的骨盆的 sarcomatoid 癌的稀罕性质和它对辅助治疗的反应的明显的缺乏,做早诊断和早激进的外科改进幸存是必要的。为经常、勤奋的监视或对待的建筑群强调需要是重要的有在有瘤形成的风险的情况下的任何一个一半的肾盂积水膨出的双肾。 | CHEN Ge-ming CHEN Shan-wen XIA Dan LI Jun YAN Sheng JIN Bai-ye | 2011 | Chinese Medical Journal2011，，13： | 8 |
| 9 | Mechanism of Chaihu Shugan Powder(柴胡疏肝散) for Treating Depression Based on Network Pharmacology显示文摘Objective:To analyze the effective components of Chinese medicine(CM)contained in Chaihu Shugan Powder(柴胡疏肝散,CSP)in the treatment of depressive disorders and to predict its anti-depressant mechanism by network pharmacology.Methods:Absorption,distribution,metabolism,excretion,and toxicity calculation method was used to screen the active components of CSP.Traditional Chinese Medicine System Pharmacological Database Analysis Platform and text mining tool(GoPuMed database)were used to predict and screen the active ingredients of CSP and anti-depressive targets.Through Genetic Association Database,Therapeutic Target Database,and PharmGkb database targets for depression were obtained.Cytoscape3.2.1 software was used to establish a network map of the active ingredients-targets of CSP,and to analyze gene function and metabolic pathways through Database for Annotation,Visualization and Integrated Discovery and the Omicshare database.Results:The 121 active ingredients and 15 depression-related targets which were screened from the database can exert antidepressant effects by improving the neural plasticity,growth,transfer condition and gene expression of neuronal cell,and the raise of the expression of gap junction protein.The 15 targets passed 14 metabolic pathways,mainly involved in the regulation of neurotransmitters(5-hydroxytryptamine,dopamine and epinephrine),inflammatory mediator regulation of TRP channels,calcium signaling pathway,cyclic adenosine monophosphate signaling pathway and neuroactive ligand-receptor interaction and other signal channels to exert anti-depressant effects.Conclusion:This article reveals the possible mechanism of CSP in the treatment of depression through network pharmacology research,and lays a foundation for further target studies. | LIU Yuan-yue HU Dan FAN Qi-qi ZHANG Xiao-hao ZHU Yi-cheng NI Miao-yan WANG Yan-ming ZHANG Lan-kun SHENG Lei | 2020 | Chinese Journal of Integrative Medicine2020，26，12： | 6 |
| 10 | Dynamic monitoring of the cytotoxic effects of protoberberine alkaloids from Rhizoma Coptidis on HepG2 cells using the xCELLigence system显示文摘AIM: To investigate the cytotoxic effects of the six protoberberine alkaloids(PAs) from Rhizoma Coptidis on HepG2 cells. METHOD: A systematic screening was conducted to investigate the dynamic response of HepG2 cells to the PAs using the impedance-based xCELLigence system. Cisplatin was selected as the positive control. The real time, concentration-response curves and the 50% inhibitory concentrations(IC50) were acquired to evaluate the anticancer activity of the PAs. RESULTS: All of the six PAs inhibited cell growth and induce death in HepG2 cells in a time- and concentration-dependent manner. The IC50 values of cisplatin, berberine, columbamine, coptisine, epiberberine, jatrorrhizine, and palmatine were 5.13, 42.33, 226.54, 36.90, 302.72, 383.54, and 456.96 μg·mL-1, respectively. The results obtained using the xCELLigence system corresponded well with those of the conventional methods. CONCLUSION: The xCELLigence system is a reliable and efficient tool for real-time screening of the cytotoxic effect of compounds in cell-based in vitro assays. Coptisine and berberine, with methylenedioxy group at C2 and C3 on the phenyl ring showed stronger effect.than the other four PAs. However, compared with cisplatin, the six PAs didn't show obvious cytotoxic effect on HepG2 cells.These results provided some useful data for the evaluation of the anticancer compounds, and the clinical application of traditional Chinese medicine. | ZHANG Le-Le MA Li-Na YAN Dan ZHANG Cong-En GAO Dan XIONG Yin SHENG Fei-Ya DONG Xiao-Ping XIAO Xiao-He | 2014 | Chinese Journal of Natural Medicines2014，12，6： | 6 |
| 11 | Integrated genomic analysis identifies deregulated JAK/STAT-MYC-biosynthesis axis in aggressive NK-cell leukemia显示文摘好攻击的 NK 房间白血病(ANKL ) 是在从亚洲的人之中是更流行的 NK 房间瘤的一种稀罕形式并且中央并且南美洲。病人们通常在天以内死到月,甚至在收到迅速的治疗学的管理以后。这里,我们由集成整个染色体执行了 ANKL 的第一全面研究, transcriptome 并且定序指向,象功能的试金一样的 cytokine 数组。在 JAK-STAT 小径的变化在 48% 被识别(14/29 ) ANKL 病人,当细胞外的 STAT3 激发器 IL10 被 56 褶层的一般水准提高时(P < 0.0001 ) 在检查的所有病人的血浆。另外的经常变异的基因包括的 TP53 (34%) , TET2 (28%) , CREBBP (21%) 和 MLL2 (21%) 。耐心的 NK 白血病房间在多重新陈代谢的小径显示出 STAT3 phosphorylation, MYC 表示和 transcriptional 活动的突出的激活。机能上地, STAT3 激活和 MYC 表示为 ANKL 房间的增长和幸存是批评的。发信号的 STAT 调整了发信号的 MYC 抄写节目,和两 STAT, MYC 抄写被要求维持核苷酸合成和 glycolysis 的激活。一起, JAK-STAT 小径在 ANKL 为 genomic 改变和 IL10 刺激代表一个主要目标。这最新发现的 JAK/STAT-MYC-biosynthesis 轴可以在对待白血病的这种子类型为新奇治疗学的策略的发展提供机会。 | Liang Huang Dan Liu Na Wang Shaoping Ling Yuting Tang Jun Wu Lingtong Hao Hui Luo Xuelian Hu Lingshuang Sheng Lijun Zhu Di Wang Yi Luo Zhen Shang Min Xiao Xia Mao Kuangguo Zhou Lihua Cao Lili Dong Xinchang Zheng Pinpin Sui Jianlin He Shanlan Mo Jin Yan Qilin Ao Lugui Qiu Hongsheng Zhou Qifa Liu Hongyu Zhang Jianyong Li Jie Jin Li Fu Weili Zhao Jieping Chen Xin Du Guoliang Qing Hudan Liu Xin Liu Gang Huang Ding Ma Jianfeng Zhou Qian-fei Wang | 2018 | Cell Research2018，28，2： | 5 |
| 12 | Complete disassociation of adult pancreas into viable single cells through cold trypsin-EDTA digestion显示文摘The in vitro isolation and analysis of pancreatic stem/progenitor cells are necessary for understanding their properties and function; however, the preparation of high-quality single-cell suspensions from adult pancreas is prerequisite. In this study, we applied a cold trypsin-ethylenediaminetetraacetic acid (EDTA) digestion method to disassociate adult mouse pancreata into single cells. The yield of single cells and the viability of the harvested cells were much higher than those obtained via the two commonly used warm digestion methods. Flow cytometric analysis showed that the ratio of ductal or BCRP1-positive cells in cell suspensions prepared through cold digestion was consistent with that found in vivo. Cell culture tests showed that pancreatic epithelial cells prepared by cold digestion maintained proliferative capacity comparable to those derived from warm collagenase digestion. These results indicate that cold trypsin-EDTA digestion can effectively disassociate an adult mouse pancreas into viable single cells with minimal cell loss, and can be used for the isolation and analysis of pancreatic stem/progenitor cells. | Dan LI Shi-yun PENG Zhen-wu ZHANG Rui-cheng FENG Lu LI Jie LIANG Sheng TAI Chun-bo TENG | 2013 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2013，14，7： | 5 |
| 13 | Childhood BMI and Adult Obesity in a Chinese Sample:A 13-Year Follow-up Study显示文摘Objective Obesity is recognized as a significant risk factor for diabetes and hypertension. The present study aimed to examine the associations between adults' obesity risk and childhood and parental obesity. Methods A total of 204 children aged 6-17 years were recruited in 2002 with an average follow-up period of 13.2 years. Height and body weight were measured by trained staffs. Overweight and obesity were defined based on the Chinese standard for children and adults. T-test, analysis of variance, and Chi-square analysis were used for single factor analysis. Multiple linear and logistic regression analyses were used to perform multifactor analysis. Results The percentage of non-obese children who grew up to be non-obese adults was 62.6%, and that of obese children who grew up to be obese adults was 80.0%. There was a significant association between childhood body mass index(BMI) and adulthood BMI with a β regression coefficient of 3.76 [95% confidence interval(CI): 1.36-6.16], and between childhood obesity and adulthood obesity with an odds ratio of 5.76(95% CI: 1.37-24.34). There was no statistical difference between parental obesity at baseline and children's adulthood obesity, after adjustment of confounders. Male participants and those aged 10.0-13.0 years had a higher risk of adulthood obesity with odds ratios of 2.50(95% CI: 1.12-5.26) and 3.62(95% CI: 1.17-11.24), respectively. Conclusion Childhood obesity is an important predictor of adulthood obesity. | LIU Dan HAO Yun Xia ZHAO Ting Zhi SONG Peng Kun ZHAI Yi PANG Shao Jie ZHAO Yan Fang ZHANG Mei WANG Zhuo Qun MI Sheng Quan WANG Yu Ying ZHANG Jian ZHAO Wen Hua | 2019 | Biomedical and Environmental Sciences2019，32，3： | 5 |
| 14 | Myofiber necroptosis promotes muscle stem cell proliferation via releasing Tenascin-C during regeneration显示文摘Necroptosis,a form of programmed cell death,is characterized by the loss of membrane integrity and release of intracellular contents,the execution of which depends on the membrane-disrupting activity of the Mixed Lineage Kinase Domain-Like protein(MLKL)upon its phosphorylation.Here we found myofibers committed MLKL-dependent necroptosis after muscle injury.Either pharmacological inhibition of the necroptosis upstream kinase Receptor Interacting Protein Kinases 1(RIPK1)or genetic ablation of MLKL expression in myofibers led to significant muscle regeneration defects.By releasing factors into the muscle stem cell(MuSC)microenvironment,necroptotic myofibers facilitated muscle regeneration.Tenascin-C(TNC),released by necroptotic myofibers,was found to be critical for MuSC proliferation.The temporary expression of TNC in myofibers is tightly controlled by necroptosis;the extracellular release of TNC depends on necroptotic membrane rupture.TNC directly activated EGF receptor(EGFR)signaling pathway in MuSCs through its N-terminus assembly domain together with the EGF-like domain.These findings indicate that necroptosis plays a key role in promoting MuSC proliferation to facilitate muscle regeneration. | Shen'ao Zhou Wei Zhang Gaihong Cai Yingzhe Ding Caixia Wei Sheng Li Yu Yang Jie Qin Dan Liu Hao Zhang Xiexiang Shao Jianhua Wang Hongye Wang Wenjun Yang Huating Wang She Chen Ping Hu Liming Sun | 2020 | Cell Research2020，30，12： | 4 |
| 15 | Downregulation of mi R ‐101 in gastric cancer correlates with cyclooxygenase‐2 overexpression and tumor growth显示文摘 | Xiao‐Pu He Yun Shao Xiao‐Lin Li Wei Xu Guo‐Sheng Chen Huan‐Huan Sun Hai‐Chen Xu Xian Xu Dan Tang Xi‐Feng Zheng Yi‐Ping Xue Guo‐Chang Huang Wei‐Hao Sun | 2012 | FEBS J2012，，22： | 4 |
| 16 | A morphological and molecular assessment of the genus Sinotubimorpha (Halymeniaceae, Rhodophyta)显示文摘 | Ying-Wen SHENG Wen ZHANG Dan ZHAO Hong-Wei WANG | 2012 | Journal of Systematics and Evolution2012，50，2： | 3 |
| 17 | A Near Infrared Cyanine-Based Fluorescent Probe for Highly Selectively Detecting Glutathione in Living Cells显示文摘包含 thiol 组的氨基酸在把生物氧化作为减小平衡起重要作用。由于 biothiols 的重要细胞的功能,开发有效方法检测 biothiols 在是必要的复杂化生物系统。在这个工作,我们发展了一基于花青荧光灯探查作为一个检测的组利用 thioether,它出现了荧光灯“刺激”向 GSH 和它的反应能被用作 biomarker 决定细胞的 GSH。 | Xiaole Sheng Dan Chen Meijiao Cao Yufeng Zhang Xie Han Xiaoqiang Chen Shenghua Liu Haiyan Chen Jun Yin | 2016 | Chinese Journal of Chemistry2016，34，6： | 3 |
| 18 | A New Coordination Polymer Built of 4-(5H-tetrazol)-benzoic Acid and 3,5-Dimethyl-1H,1,2,4-Triazole Showing a Rarely Observed(3,5)-Connected lhh Topology: Synthesis, Structure, CO_2 Adsorption and Luminescent Property显示文摘A three-dimensional coordination polymer,namely {[Zn_2(tzba)(dmtrz)(OH)]·3H_2O}_n(1,H_2tzba = 4-(5H-tetrazol)benzoic acid,Hdmtrz = 3,5-dimethyl-lH,l,2,4-triazole),was hydrothermally synthesized and characterized by single-crystal X-ray diffraction.It crystallizes in monoclinic system,P2_1/c space group with a = 8.018(11),b = 21.04(3),c = 11.069(14) A,β=91.26(3)°,V= 1867(4) A^3,Z = 4,D_c = 1.729 g/cm^3,F(000) = 984,μ= 2.614 mm^(-1),R(F^2 > 2σ(F^2)) =0.0612 and wR(F^2) = 0.1533.Topological analysis reveals that compound 1 is a(3,5)-connected structure with a Schlafli symbol of(4~2.6)(4~2.6~5.8~3),which is a rarely observed lhh topology.In addition,the CO_2 adsorption performance and luminescent property of 1 have also been studied. | SHENG Dong-Hai DAN Wen-Yan LUO Gen-Xiang DENG Ming-Li | 2016 | Chinese Journal of Structural Chemistry2016，35，2： | 3 |
| 19 | An Energy Ratio Feature Extraction Method for Optical Fiber Vibration Signal显示文摘在光纤维警告前系统(OFPS ) 的侵入事件被划分成是有害侵入事件和无害的干扰事件的二种类型。目前,事件的这二种类型的信号特征抽取方法通常从时间领域的看法被设计。然而,为不同有害侵入事件的时间域特征的差别不是明显的,它不能详细反映他们的差异。我们发现不同侵入信号的光谱分发有明显的差别。为这个原因,侵入信号被转变成频率域。在这份报纸,有害侵入事件的一个精力比率特征抽取方法上被拉。第一,侵入信号被预先处理并且力量光谱密度(PSD ) 被计算。然后,不同频率乐队的精力比率被计算,并且侵入事件的每种类型的相应特征向量进一步被形成。线性判别式分析(LDA ) 分类器被用来在纸识别有害侵入事件。试验性的结果证明算法改进侵入信号的识别率,并且进一步验证算法的可行性和有效性。 | Zhiyong SHENG Xinyan ZHANG Yanping WANG Weiming HOU Dan YANG | 2018 | Photonic Sensors2018，8，1： | 2 |
| 20 | Acrylamide-induced Subacute Neurotoxic Effects on the Cerebral Cortex and Cerebellum at the Synapse Level in Rats显示文摘Objective To investigate acrylamide(ACR)-induced subacute neurotoxic effects on the central nervous system(CNS) at the synapse level in rats. Methods Thirty-six Sprague Dawley(SD) rats were randomized into three groups,(1) a 30 mg/kg ACR-treated group,(2) a 50 mg/kg ACR-treated group, and(3) a normal saline(NS)-treated control group. Body weight and neurological changes were recorded each day. At the end of the test, cerebral cortex and cerebellum tissues were harvested and viewed using light and electron microscopy. Additionally, the expression of Synapsin Ⅰ and P-Synapsin Ⅰ in the cerebral cortex and cerebellum were investigated. Results The 50 mg/kg ACR-treated rats showed a significant reduction in body weight compared with untreated individuals(P < 0.05). Rats exposed to ACR showed a significant increase in gait scores compared with the NS control group(P < 0.05). Histological examination indicated neuronal structural damage in the 50 mg/kg ACR treatment group. The active zone distance(AZD) and the nearest neighbor distance(NND) of synaptic vesicles in the cerebral cortex and cerebellum were increased in both the 30 mg/kg and 50 mg/kg ACR treatment groups. The ratio of the distribution of synaptic vesicles in the readily releasable pool(RRP) was decreased. Furthermore, the expression levels of Synapsin Ⅰ and P-Synapsin Ⅰ in the cerebral cortex and cerebellum were decreased in both the 30 mg/kg and 50 mg/kg ACR treatment groups. Conclusion Subacute ACR exposure contributes to neuropathy in the rat CNS. Functional damage of synaptic proteins and vesicles may be a mechanism of ACR neurotoxicity. | ZHANG Bin SHAO Hua WANG Xiu Hui CHEN Xiao LI Zhong Sheng CAO Peng ZHU Dan YANG Yi Guang XIAO Jing Wei LI Bin | 2017 | Biomedical and Environmental Sciences2017，30，6： | 2 |
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