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| 1 | Dual Functions of Microglia in Ischemic Stroke显示文摘Ischemic stroke is a leading cause of morbidity and mortality worldwide. Resident microglia are the principal immune cells of the brain, and the first to respond to the pathophysiological changes induced by ischemic stroke. Traditionally, it has been thought that microglial activation is deleterious in ischemic stroke, and therapies to suppress it have been intensively explored. However,increasing evidence suggests that microglial activation is also critical for neurogenesis, angiogenesis, and synaptic remodeling, thereby promoting functional recovery after cerebral ischemia. Here, we comprehensively review the dual role of microglia during the different phases of ischemic stroke, and the possible mechanisms controlling the post-ischemic activity of microglia. In addition, we discuss the dynamic interactions between microglia and other cells, such as neurons, astrocytes, oligodendrocytes,and endothelial cells within the brain parenchyma and the neurovascular unit. | Chuan Qin Luo-Qi Zhou Xiao-Tong Ma Zi-Wei Hu Sheng Yang Man Chen Dale B. Bosco Long-Jun Wu Dai-Shi Tian | 2019 | Neuroscience Bulletin2019，35，5： | 64 |
| 2 | Microvessel density is a prognostic marker of human gastric cancer显示文摘AIM: To investigate whether microvessel density (MVD) is related with prognosis in gastric cancer patients, and the expression of cyclooxygenase-2 (COX-2) and vessel endothelial growth factor (VEGF) so as to determine the possible role of COX-2 and VEGF in gastric cancer angiogenesis.METHODS: Forty-seven formalin-fixed paraffin-embedded tissue samples of gastric cancer were evaluated for COX-2, VEGF by immunohitochemical staining. To assess tumor angiogenesis, MVD was determined by immunohitochemical staining of endothelial protein factor Ⅷ-related antigen. The relationship among COX-2 and VEGF expression, MVD, and clinicopathologic parameters was analyzed. RESULTS: Among the 67 samples, high MVD was significantly associated with lymph node metastasis and poor survival. Multivariate survival analysis showed that MVD value and lymph node metastasis were independent prognostic factors. The expression rate of COX-2 and VEGF was significantly higher than that of the adjacent tissues. COX-2 and VEGF expression in gastric cancer was significantly correlated with tumor differentiation and depth of invasion, but not with survival. The mean MVD value of COX-2 or VEGF positive tumors was higher than that of COX-2 or VEGF negative tumors. A significant correlation was found between the expressions of COX-2and VEGF. CONCLUSION: MVD may be one of the important prognostic factors for gastric cancer patients. COX-2 and VEGF may play an important role in tumor progression by stimulating angiogenesis. VEGF might play a main role in the COX-2 angiogenic pathway. The inhibition of angiogenesis or COX-2, VEGF activity may have an important therapeutic benefit in the control of gastric cancer. | Hong-Chuan Zhao Rong Qin Xiao-Xin Chen Xia Sheng Ji-Feng Wu Dao-Bin Wang Gui-Hua Chen | 2006 | World Journal of Gastroenterology2006，12，47： | 25 |
| 3 | The divergent roles of autophagy in ischemia and preconditioning显示文摘 | Rui SHENG Zheng-hong QIN | 2015 | Acta Pharmacologica Sinica2015，36，4： | 25 |
| 4 | Outcomes and possible risk factors associated with axis alignment and rotational stability after implantation of the Toric implantable collamer lens for high myopic astigmatism显示文摘·AIM:To assess the visual outcomes and possible risk factors associated with axis alignment and rotational stability after implantation of Toric implantable collamer lens (TICL) for the correction of high myopic astigmatism. ·METHODS:In this prospective, nonrandomized clinical study, 54 consecutive eyes of 29 patients with high myopic astigmatism received TICL implantation. To evaluate postoperative axis deviation from the intended axis, a digital anterior segment photograph was taken. The ultrasound biomicroscopy(UBM) was used to observe footplate-position. ·RESULTS:After mean follow-up of 8.6 months, mean manifest refractive cylinder (MRC) decreased 79.3% from (-1.88±1.49)D preoperatively to (0.39±0.61)D postoperatively. MRC within 1.00D occurred in 68.5% (37/54) of eyes, whereas 48.1% (26/54) had MRC within 0.50D. Mean manifest refraction spherical equivalent (MRSE) changed from (-12.08±4.22)D preoperatively to (-0.41±0.61)D postoperatively. Uncorrected binocular vision of 20/20 or better occurred in 72.2%(39/54) of patients compared with binocular best-corrected visual acuity (BCVA) of 20/20 or better in 44.4% (24/54) preoperatively. The mean difference between intended and achieved TICL axes was (6.96±8.37)°. Footplates of TICLs were in the ciliary sulcus in 22 eyes (46.3%), below the ciliary sulcus in 32 eyes (53.7%). The angle of TICL rotation had significant correlation with the footplates-position (t =2.127; P =0.045) and the postoperative TICL vaulting (r =-0.516; P =0.000). ·CONCLUSION:The results of our study further support the safety, efficacy and predictability of TICL for the correct high myopic astigmatism. The footplate-position of TICL and vault value should be taken into consideration as two possible risks factors for TICL rotation. | Xun-Lun Sheng, De-Jun Zhu | 2012 | International Journal of Ophthalmology(English edition)2012，5，4： | 19 |
| 5 | Exogenous NADPH ameliorates myocardial ischemia–reperfusion injury in rats through activating AMPK/mTOR pathway显示文摘Our previous study shows that nicotinamide adenine dinucleotide phosphate(NADPH)plays an important role in protecting against cerebral ischemia injury.In this study we investigated whether NADPH exerted cardioprotection against myocardial ischemia/reperfusion(I/R)injury.To induce myocardial I/R injury,rats were subjected to ligation of the left anterior descending branch of coronary artery for 30 min followed by reperfusion for 2 h.At the onset of reperfusion,NADPH(4,8,16 mg·kg?1·d?1,iv)was administered to the rats.We found that NADPH concentrations in plasma and heart were signi?cantly increased at 4 h after intravenous administration.Exogenous NADPH(8?16 mg/kg)signi?cantly decreased myocardial infarct size and reduced serum levels of lactate dehydrogenase(LDH)and cardiac troponin I(cTn-I).Exogenous NADPH signi?cantly decreased the apoptotic rate of cardiomyocytes,and reduced the cleavage of PARP and caspase-3.In addition,exogenous NADPH reduced mitochondrial vacuolation and increased mitochondrial membrane protein COXIV and TOM20,decreased BNIP3L and increased Bcl-2 to protect mitochondrial function.We conducted in vitro experiments in neonatal rat cardiomyocytes(NRCM)subjected to oxygen–glucose deprivation/restoration(OGD/R).Pretreatment with NADPH(60,500 nM)signi?cantly rescued the cell viability and inhibited OGD/R-induced apoptosis.Pretreatment with NADPH signi?cantly increased the phosphorylation of AMPK and downregulated the phosphorylation of mTOR in OGD/R-treated NRCM.Compound C,an AMPK inhibitor,abolished NADPH-induced AMPK phosphorylation and cardioprotection in OGD/R-treated NRCM.In conclusion,exogenous NADPH exerts cardioprotection against myocardial I/R injury through the activation of AMPK/mTOR pathway and inhibiting mitochondrial damage and cardiomyocyte apoptosis.NADPH may be a potential candidate for the prevention and treatment of myocardial ischemic diseases. | Jiang Zhu Yi-fei Wang Xiao-ming Chai Ke Qian Ling-wei Zhang Peng Peng Pei-min Chen Jian-fang Cao Zheng-hong Qin Rui Sheng Hong Xie | 2020 | Acta Pharmacologica Sinica2020，41，4： | 19 |
| 6 | Simvastatin inhibited cardiac hypertrophy and fibrosis in apolipoprotein E-deficient mice fed a "Western-style diet" by increasing PPAR a and ~ expression and reducing TC, MMP-9, and Cat S levels显示文摘 | Yan-wen QIN Ping YE Ji-qiang HE Li SHENG Lu-ya WANG Jie DU | 2010 | Acta Pharmacologica Sinica2010，31，10： | 19 |
| 7 | The endoplasmic reticulum stress inhibitor salubrinal inhibits the activation of autophagy and neuroprotection induced by brain ischemic preconditioning显示文摘 | Bo GAO Xiang-yang ZHANG Rong HAN Tong-tong ZHANG Cheng CHEN Zheng-hong QIN Rui SHENG | 2013 | Acta Pharmacologica Sinica2013，34，5： | 19 |
| 8 | Characterization of Staphylococcus aureus Isolated from Clinical Specimens by Matrix Assisted Laser Desorption/Ionization Time-of-flight Mass Spectrometry显示文摘Objective To develop a matrix assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) approach to identify Staphylococcus aureus (S. aureus) and differentiate methicillin-resistant S. aureus (MRSA) from methicillin-sensitive S. aureus (MSSA). Methods A total of 100 S. aureus strains isolated from clinical specimens and farm workers were collected and analyzed by MALDI-TOF-MS. And data obtained were interpreted with biotyper software. Results Ninety-two strains were identified by MALDI-TOF-MS as S. aureus at a level of secure genus and probable species, and 4 strains were identified at probable genus after their cultivation, spectral collection and data preprocessing. One strain was identified as S. aureus with lower score. It was revealed that identification of S. aureus by MALDI-TOF-MS was highly correlated with typing by biochemical and serological methods with an accuracy as high as 97%. The biotyper cluster analysis showed that 100 isolates were divided into 2 types at the distance level of 400. Higher peak intensity in the mass of both 3784 Da and 5700 Da was observed in MRSA, whereas that was absent from MSSA. Conclusion MALDI-TOF-MS is considered as a simple, rapid and highly reproducible technique with high-throughput and accuracy for the identification of S. aureus and it can reliably differentiate MRSA from MSSA. | WANG Ye Ru CHEN Qian CUI Sheng Hui LI Feng Qin | 2013 | Biomedical and Environmental Sciences2013，26，6： | 14 |
| 9 | Roles of mechanosensitive channel Piezo 1/2 proteins in skeleton and other tissues显示文摘Mechanotransduction is a fundamental ability that allows living organisms to receive and respond to physical signals from both the external and internal environments.The mechanotransduction process requires a range of special proteins termed mechanotransducers to convert mechanical forces into biochemical signals in cells.The Piezo proteins are mechanically activated nonselective cation channels and the largest plasma membrane ion channels reported thus far.The regulation of two family members,Piezol and Piezo2#has been reported to have essential functions in mechanosensation and transduction in different organs and tissues.Recently,the predominant contributions of the Piezo family were reported to occur in the skeletal system,especially in bone development and mechano-stimulated bone homeostasis.Here we review current studies focused on the tissue-specific functions of Piezol and Piezo2 in various backgrounds with special highlights on their importance in regulating skeletal cell mechanotransduction.In this review,we emphasize the diverse functions of Piezol and Piezo2 and related signaling pathways in osteoblast lineage cells and chondrocytes.We also summarize our current understanding of Piezo channel structures and the key findings about PIEZO gene mutations in human diseases. | Lei Qin Tailin He Sheng Chen Dazhi Yang Weihong Yi Huiling Cao Guozhi Xiao | 2021 | Bone Research2021，9，4： | 14 |
| 10 | Hepatitis B virus and hepatitis C virus play different prognostic roles in intrahepatic cholangiocarcinoma: A meta-analysis显示文摘AIM: To identify the prognostic value of hepatitis B virus(HBV) and hepatitis C virus(HCV) infections in patients with intrahepatic cholangiocarcinoma.METHODS: A search was performed for relevant publications in Pub Med, EMBASE and Web of Science databases. The pooled effects were calculated from the available information to identify the relationship between HBV or HCV infection and the prognosis and clinicopathological features. The χ2 and I2 tests were used to evaluate heterogeneity between studies. Pooled hazard ratios(HRs) with 95% confidence intervals(CIs) were calculated by a fixed-effects model, if no heterogeneity existed. If there was heterogeneity, a random-effects model was applied.RESULTS: In total, 14 studies involving 2842 cases were enrolled in this meta-analysis. The patients with HBV infection presented better overall and diseasefree survival, and the pooled HRs were significant at 0.76(95%CI: 0.70-0.83) and 0.78(95%CI: 0.66-0.94), respectively. Additionally, our study revealed that HCV infection was correlated with shortened overall survival in comparison with the control group(HR = 2.64, 95%CI: 1.77-3.93). We also found that HBV infection occurred more frequently in male patients [odds ratio(OR) = 1.91, 95%CI: 1.06-3.44] and was correlated with higher levels of serum aspartate transaminase(AST) and alpha-fetoprotein(AFP)(OR = 1.93, 95%CI: 1.11-3.35; OR = 3.86, 95%CI: 2.58-5.78) and a lower level of serum carbohydrate antigen 19-9(CA19-9)(OR = 0.47, 95%CI: 0.34-0.65). Moreover, HBV infection was associated with cirrhosis(OR = 6.44, 95%CI: 4.33-9.56), a higher proportion of capsule formation(OR = 6.04, 95%CI: 3.56-10.26), and a lower rate of lymph node metastasis(OR = 0.39, 95%CI: 0.25-0.58). No significant publication bias was seen in any of the enrolled studies.CONCLUSION: HBV infection may indicate a favorable prognosis in patients with intrahepatic cholangiocarcinoma, while HCV infection suggests a poor prognosis. | Zheng Wang Yuan-Yuan Sheng Qiong-Zhu Dong Lun-Xiu Qin | 2016 | World Journal of Gastroenterology2016，22，10： | 12 |
| 11 | Expression of cyclooxygenase-2 in gastric cancer and its relation to liver metastasis and long-term prognosis显示文摘AIM: To investigate the expression of cyclooxygenase-2(COX-2) in gastric cancer and its relation with the liver metastasis and prognosis.METHODS: Expression of COX-2 mRNA and protein was examined in gastric cancer and its paired substantial normal tissue by semi-quantitative reverse transcriptionpolymerase chain reaction and immunohistochemistry.The relation between COX-2 expression and prognosis was investigated in 195 cases.RESULTS: The expression of COX-2 mRNA in gastric cancer tissue was significantly higher than that in normal tissue in 47 cases (w= 792, P<0.01). The COX-2 mRNA in pT3-4 tissue expressed higher than that in pT1-2tissue (w = 204, P<0.05). The positive expression rate of COX-2 protein was 57.9% (113/195). The COX-2expression was significantly related to histological type,lymphnode metastasis, venous invasion and liver metastasis (P<0.05). No relation was found between COX-2 expression and invasion depth, peritoneal metastasis and International Union against Cancer TNMstage. The multiple regression analysis showed that the COX-2 expression and venous invasion were obviously associated with liver metastasis (P<0.05). However,there was no significant correlation between COX-2immunoreactivity and prognosis.CONCLUSION: COX-2 may play an important role in the development of gastric cancer, and the over-expression of COX-2 protein may be a high risk factor for liver metastasis. | Ji-Ren Yu Yi-Jun Wu Qi Qin Ke-Zheng Lu Sheng Yan Xiao-Sun Liu Shu-Sen Zheng | 2005 | World Journal of Gastroenterology2005，11，31： | 12 |
| 12 | Rubus chingii Hu: an overview of botany, traditional uses,phytochemistry, and pharmacology显示文摘Rubus chingii Hu, a member of the rosaceae family, is extensively distributed in China and Japan. Its unripe fruits(Fupenzi in Chinese) have a long history of use as an herbal tonic in traditional Chinese medicine for treating various diseases commonly associated with kidney deficiency, and they are still in use today. Phytochemical investigations on the fruits and leaves of R. chingii indicate the presence of terpenoids, flavonoids, steroids, alkaloids, phenylpropanoids, phenolics, and organic acids. Extracts or active substances from this plant are reported to have various pharmacological properties, including antioxidant, anti-inflammatory, antitumor, antifungal, antithrombotic, antiosteoporotic, hypoglycemic, and central nervous system-regulating effects. This review provides up-to-date information on the botanical characterizations, traditional usages, chemical constituents, pharmacological activities, toxicity,and quality control of R. chingii. Possible directions for future research are also briefly proposed. This review aims to supply fundamental data for the further study of R. chingii and contribute to the development of its clinical use. | SHENG Jia-Yun WANG Si-Qi LIU Kao-Hua ZHU Bo ZHANG Qiao-Yan QIN Lu-Ping WU Jian-Jun | 2020 | Chinese Journal of Natural Medicines2020，18，6： | 12 |
| 13 | Buyang Huanwu Decoction fraction protects against cerebral ischemia/reperfusion injury by attenuating the inflammatory response and cellular apoptosis显示文摘Buyang Huanwu Decoction fraction extracted from Buyang Huanwu Decoction contains saponins of Astragalus, total paeony glycoside and safflower flavones. The aim of this study was to demonstrate the neuroprotective effect and mechanism of Buyang Huanwu Decoction fraction on ischemic injury both in vivo and in vitro. In vivo experiments showed that 50-200 mg/kg Buyang Huanwu Decoction fraction reduced infarct volume and pathological injury in ischemia/reperfusion rats, markedly inhibited expression of nuclear factor-κB and tumor necrosis factor-α and promoted nestin protein expression in brain tissue. Buyang Huanwu Decoction fraction (200 mg/kg) exhibited significant effects, which were similar to those of 100 mg/kg Ginkgo biloba extract. In vitro experimental results demonstrated that 10-100 mg/L Buyang Huanwu Decoction fraction significantly improved cell viability, decreased the release of lactate dehydrogenase and malondialdehyde levels, and inhibited the rate of apoptosis in HT22 cells following oxygen-glucose deprivation. Buyang Huanwu Decoction fraction (100 mg/L) exhibited significant effects, which were similar to those of 100 mg/L Ginkgo biloba extract. These findings suggest that Buyang Huanwu Decoction fraction may represent a novel, protective strategy against cerebral ischemia/reperfusion injury in rats and oxygen-glucose deprivation-induced damage in HT22 cells in vitro by attenuating the inflammatory response and cellular apoptosis. | Yulian Jin Liuyi Dong Changqing Wu Jiang Qin Sheng Li Chunyan Wang Xu Shao Dake Huang | 2013 | Neural Regeneration Research2013，8，3： | 11 |
| 14 | The effects of autophagy on vascular endothelial cells induced by airborne PM2.5显示文摘The purpose of this study was to examine the direct toxicity of PM2.5 collected from Beijing on human umbilical vein endothelial cells(HUVEC). A Cell Counting Kit 8(CCK8) assay demonstrated that PM2.5 exposure decreased the proliferation of HUVECs in a dosedependent manner. We also found that PM2.5 exposure induced autophagy in HUVECs, as evidenced by:(1) an increased number of double-membrane vesicles;(2) enhanced conversion and punctuation of the microtubule-associated protein light chain 3(LC3); and(3) decreased levels of the selective autophagy substrate p62 in a time-dependent manner.Furthermore, promoting autophagy in PM2.5-exposed HUVECs with rapamycin increased the cell survival rate, whereas inhibiting autophagy via 3-methyladenine significantly decreased cell survival. These results demonstrate that PM2.5 exposure can induce cytotoxicity and autophagy in HUVECs and that autophagy play a protective role against PM2.5-induced cytotoxicity. The findings of the present study imply a direct toxic effect of PM2.5 on HUVECs and provide novel insight into the mechanism of cardiovascular diseases caused by PM2.5 exposure. | Zhixiang Zhou Tong Shao Mengnan Qin Xiaoyan Miao Yu Chang Wang Sheng Fengshang Wu Yunjiang Yu | 2018 | Journal of Environmental Sciences2018，30，4： | 11 |
| 15 | An overview of design for CSNS/RCS and beam transport显示文摘The China Spallation Neutron Source (CSNS) is the first accelerator-based pulsed neutron source in China. Its accelerators are made up of an 80 MeV H- linac, a Rapid Cycling Synchrotron (RCS) and two beam transport lines. RCS accumulates and accelerates protons to the design energy of 1.6 GeV, and extracts high energy beam to strike the target. The overview of RCS is presented, and the key problems of the physics design are discussed. The two beam transport lines, from linac to RCS and from RCS to the target, are also introduced. | WANG Sheng AN YuWen FANG ShouXian HUANG Nan LIU WeiBin LIU YuDong QIN Qing QIU Jing WANG Na XU Gang XU ShouYan YU ChengHui | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，S2： | 11 |
| 16 | Comparison of immediate and followup results between transradial and transfemoral approach for percutaneous coronary intervention in true bifurcational lesions显示文摘在为在分叉的经皮的冠的干预(一种总线标准) 的 transradial 和 transfemoral 途径之间的功效和安全的背景 A 比较没被做。这研究评估了 transradial 一种总线标准(TRI ) 的可行性并且在 bifurcations.Methods 把立即、紧跟的结果与 transfemoral 一种总线标准(TFI ) 作比较有分叉的 134 个连续病人从 2004 年 4 月在我们的医院里与打印机控制语言被对待到 2005 年 10 月。这些,在 TFI 组在 TRI 组和 74 个病人(101 损害) 有 60 个病人(88 损害) 。分叉类型根据因斯蒂图特·卡迪奥瓦苏莱雷·帕里斯·苏德 Classification.Results TRI 组的意见被分类有的更小的 stent 直径((3. | YANG Yue-jin XU Bo CHEN Ji-lin KANG Sheng QIAO Shu-bin QIN Xue-wen YAO Min CHEN Jue WU Yong-jian LIU Hai-bo YUAN Jin-qing YOU Shi-jie LI Jian-jun DAI Jun GAO Run-lin | 2007 | Chinese Medical Journal2007，，7： | 11 |
| 17 | LiFePO_4 doped with magnesium prepared by hydrothermal reaction in glucose solution显示文摘与镁做的锂铁磷酸盐(LiFePO4 ) 热水地在水溶液作为碳先锋与葡萄糖从商业 LiOH, FeSO4, H3PO4 和 MgSO4 被综合。样品被 X 光检查粉末衍射描绘,扫描电子显微检查法和骑车的经常的费用分泌物。结果证明综合粉末在与从葡萄糖的焦糖反应生产的碳先锋涂的 situ。在环境温度(28 ± 2 ° C ) ,准备的 LiFePO4 的电气化学的表演展出 135 mAh g 的高排出量 ? 1 在 5C 和超过 90 的 98% 的好能力保留骑车。优秀电气化学的表演应该与在碳和主要的 LiFePO4 之间的亲密接触被相关,源于,导致 LiFePO4 的电导率的增加并且二级粒子在里面 situ 积炭的形成先锋 / 碳。 | Xiu Qin Ou Guang Chuan Liang Jin Sheng Liang Sheng Zhao Xu Xia Zhao | 2008 | Chinese Chemical Letters2008，19，3： | 10 |
| 18 | Synergistic effects of prostaglandin E1 and lithium in a rat model of cerebral ischemia显示文摘瞄准:热吃惊蛋白质(HSP ) 是细胞的幸存的重要管理者并且对服的局部缺血施加 neuroprotective 效果。前列腺素 El (PGE1 ) 和锂被报导了保护神经原免于是化学家损害。如果锂能加强,现在的学习被承担检验对服的局部缺血的 PGE1 的 neuroprotection,并且如果合作效果发生在 HSP 的水平。方法:大脑局部缺血被永久中间的服的动脉吸藏(pMCAO ) 在老鼠导致。老鼠立即是有为 2 d 和 PGE1 的一个单个静脉内的政府的锂的下的注射的 pretreated 在以后化学家侮辱。每个组的 Cerebrocortical 血流动仔细在外科的操作以后在局部缺血, 5 min, 15 min, 30 min 和 60 min 的发作以前被监视。身体温度以前被测量,在 pMCAO 的发作以后的 5 min, 2 h 和 24 h。梗塞体积,大脑浮肿和马达行为赤字被分析 24 h 在以后化学家侮辱。Cytoprotective HSP70 并且他我在 ipsilateral 半球的条纹弦音器的 oxygenase-1 (HO-1 ) 被弄污的免疫检测。从 ipsilateral 半球的条纹弦音器的大脑节是有 anti-HSP70 抗体和 4,6-diamidino-2-phenylindole (DAPI ) 的双 labeled。结果:有 PGE1 的处理(8 和 16 μg/kg, iv ) 或锂(0.5 mEq/kg, sc ) 独自减少的梗塞体积,神经病学的赤字和大脑浮肿在老鼠由焦点的服的局部缺血导致了。而且,当 PGE1 和锂一起被给时,更大的 neuroprotection 被观察。显著地,在调整 cytoprotective 上面, HSP70 和 HO-1 蛋白质铺平的 PGE1 和锂的合作管理。结论:锂和 PGE1 可以在服的局部缺血的处理施加 synergistic 效果并且可以因此为击的处理有潜在的临床的价值。 | Rong HAN Bo GAO Rui SHENG Li-sha ZHANG Hui-lin ZHANG Zhen-lun GU Zheng-hong QIN | 2008 | Acta Pharmacologica Sinica2008，29，10： | 10 |
| 19 | Antitumor effects of Chi-Shen extract from Salvia miltiorrhiza and Paeoniae radix on human hepatocellular carcinoma cells显示文摘目的:从鼠尾草植物 miltiorrhiza 和 Paeoniae radix.Methods 的水溶性的混合物调查 Chi-Shenextract ( CSE )的 antihepatocellular 癌效果: HepG2 房间( hepatocellular 癌房间线)的生长上的 CSE 的 Theeffect 被学习by3-( 4,5 ) -2,5-diphenyltetrazohum 溴化物 assay.Apoptosis 通过氮蒽橘子( AO )被检测并且染色的乙烯 dibromide ( EB )和 DNA 破碎试金。房间周期 ofHepG2 房间上的 CSE 的效果被染色方法的 propidium 碘化物学习。caspases-3 的激活, -8and-9 被免疫分析工具包检验。Bcl-2 家庭和 p53 的抄写是检测 byRT-PCR.Results : 我们的数据表明 CSE 强烈在导致 manner.CSE 的房间死亡被考虑是由观察 typicalapoptotic 的 apoptotic 的 dose-andtime-dependent 导致了 HepG2 房间死亡由 AO/EB 染色和 DNA 破碎试金的词法变化。 HepG2cell 死亡的正式就职被 apoptosis 的正式就职为 sub-G1 比例增加引起, Bcl-2 的 thedownregulation ,起来 Bax 和 p53 的规定,并且 caspases-3 and-9pathways.Conclusion 的激活:这些结果清楚地证明 CSE 能禁止 HepG2 房间和原因 apoptosis.Moreover 的增长, CSE 的反癌症效果与 Bcl-2 家庭小径和在 HepG2 房间的 caspases-3 and-9 的激活有关。 | Sheng HU Shi-min CHEN Xiao-kuan LI Rui QIN Zhi-nan MEI | 2007 | Acta Pharmacologica Sinica2007，28，8： | 10 |
| 20 | Dioxygen Affinities and Catalytic Epoxidation Performanceof Transition-Metal Hydroxamates显示文摘Hydroxamicacidsandtheirderivativesareeasilysynthesizedandhavebeenextensivelyusedasanalyticreagentsandmedicinesl'2.Besides,palladiumhydroxamateswereemployedtocatalyzeolefinspreparingunsaturatedestersbymeansofmolecularoxygen'.Hydroxamicacidcanformsquar... | Hua YANG Sheng Ying QIN Xiao Xia LU(Department of Chemistry, Sichuan University, Chengdu 610064) | 1999 | Chinese Chemical Letters1999，10，1： | 9 |
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