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| 1 | Alisol B 23-acetate-induced HepG2 hepatoma cell death through mTOR signaling-initiated G_1 cell cycle arrest and apoptosis: A quantitative proteomic study显示文摘Objective: The present study aimed to investigate the molecular events in alisol B 23-acetate(ABA) cytotoxic activity against a liver cancer cell line.Methods: First, we employed a quantitative proteomics approach based on stable isotope labeling by amino acids in cell culture(SILAC) to identify the different proteins expressed in HepG2 liver cancer cells upon exposure to ABA. Next, bioinformatics analyses through DAVID and STRING on-line tools were used to predict the pathways involved. Finally, we applied functional validation including cell cycle analysis and Western blotting for apoptosis and mTOR pathway-related proteins to confirm the bioinformatics predictions.Results: We identified 330 different proteins with the SILAC-based quantitative proteomics approach. The bioinformatics analysis and the functional validation revealed that the mTOR pathway, ribosome biogenesis, cell cycle, and apoptosis pathways were differentially regulated by ABA. G1 cell cycle arrest, apoptosis and mTOR inhibition were confirmed.Conclusions: ABA, a potential mTOR inhibitor, induces the disruption of ribosomal biogenesis. It also affects the mTOR-MRP axis to cause G1 cell cycle arrest and finally leads to cancer cell apoptosis. | Ji Xia Qiang Luo Shengbin Huang Fuquan Jiang Lin Wang Guanghui Wang Jingjing Xie Jie Liu Yang Xu | 2019 | Chinese Journal of Cancer Research2019，31，2： | 2 |
| 2 | Electrical Characteristics of Plasma Plume During Pulse Wave Laser Welding显示文摘To detect the real-time plasma plume during pulse wave Nd:YAG laser welding, experimental studies were conducted based on asynchronous signal acquisition system. The electrical signals of the laser-induced plasma plume were obtained by a passive acquisition system. The plume was directly observed and recorded using synchronous high-speed camera. The results showed that the waveform of the signals was in accordance with the periodical laser power. The signals decreased after the laser was turned on and fl uctuated relatively steadily on the stable stage and then increased to 0 V after the laser beam was turned off . The decreasing time of the electrical signals was roughly 1.0 ms, and it decreased with the increasing peak power. However, the average power had insignifi cant eff ect on the signal decreasing time. | Tong Liu Lijun Yang Shengbin Zhao Yiming Huang | 2019 | Transactions of Tianjin University2019，25，4： | 0 |
| 3 | Utility-optimal random access control in wireless multi-hop networks with queuing constraints显示文摘In this paper,a model of network utility maximization(NUM)is presented for random access control in multi-hop wireless networks.Diferent from the classical NUM framework,our model considers the queueing stability.We propose a distributed iterative prices and link probabilities adaption algorithm by using dual decomposition techniques,which only requires limited message passing,but converges to the global optimum of the total network utility.Numerical results and simulation comparison validate our conclusion. | TAN YunMeng ZHAO Yang LIAO ShengBin WU ZhuoHua | 2013 | Science China(Information Sciences)2013，56，10： | 0 |
| 4 | Identifi cation of Molecular Flipping of an Asymmetric Tris(phthalocyaninato)Lutetium Triple-Decker Complex by Scanning Tunneling Microscopy/Spectroscopy显示文摘The assembling behavior and electronic properties of asymmetric tris(phthalocyaninato)lutetium triple-decker sandwich complex molecules(Lu2Pc3)on highly oriented pyrolytic graphite(HOPG)surfaces have been studied by scanning tunneling microscopy/spectroscopy(STM/STS)methods.Phase transitions were observed at different bias polarities,involving an ordered packing arrangement with fourfold symmetry at negative bias and an amorphous arrangement at positive bias.Molecular switching behaviour for individual Lu2Pc3 molecules was reported here according to the bias-polarity-induced flipping phenomena and the peak shift in dI/dV versus V curves at different voltage scanning directions.The sensitive response of the strong intrinsic molecular dipole to an external electric field is proposed to be responsible for molecular switching of Lu_(2)Pc_(3)at the solid/liquid interface. | Xianghua Kong Shengbin Lei Yanlian Yang Ke Deng Guicun Qi Chen Wang | 2009 | Nano Research2009，2，3： | 0 |
| 5 | Prediction of natural fracture in shale oil reservoir based on R/S analysis and conventional logs显示文摘Investigation into natural fractures is extremely important for the exploration and development of low-permeability reservoirs.Previous studies have proven that abundant oil resources are present in the Upper Triassic Yanchang Formation Chang 7 oil-bearing layer of the Ordos Basin,which are accumulated in typical low-permeability shale reservoirs.Natural fractures are important storage spaces and flow pathways for shale oil.In this study,characteristics of natural fractures in the Chang 7 oil-bearing layer are first analyzed.The results indicate that most fractures are shear fractures in the Heshui region,which are characterized by high-angle,unfilled,and ENE-WSW-trending strike.Subsequently,natural fracture distributions in the Yanchang Formation Chang 7 oil-bearing layer of the study area are predicted based on the R/S analysis approach.Logs of AC,CAL,ILD,LL8,and DEN are selected and used for fracture prediction in this study,and the R(n)/S(n)curves of each log are calculated.The quadratic derivatives are calculated to identify the concave points in the R(n)/S(n)curve,indicating the location where natural fracture develops.Considering the difference in sensitivity of each log to natural fracture,gray prediction analysis is used to construct a new parameter,fracture prediction indicator K,to quantitatively predict fracture development.In addition,fracture development among different wells is compared.The results show that parameter K responds well to fracture development.Some minor errors may probably be caused by the heterogeneity of the reservoir,limitation of core range and fracture size,dip angle,filling minerals,etc. | Haoran XU Wei JU Xiaobing NIU Shengbin FENG Yuan YOU Hui YANG Sijia LIU Wenbo LUAN | 2021 | Frontiers of Earth Science2021，15，3： | 0 |
| 6 | Influence of Wetland Self-purification Capacity on the Utilization of Water Resources——A Case Study of the Project for Recycling Yanshan River Water显示文摘[Objective] The study aims to resolve water resource problem availably. [Method] On the basis of wetland self-purification capacity, Yanshan River water was purified by Xixi Wetland,and the feasibility of using treated Yanshan River water for urban greening and watering road was analyzed. [Result]Compared with direct utilization of tap water,it is more economic to recycle Yanshan River water purified by Xixi Wetland for urban greening and watering road,with obvious economic,ecological and social benefits,so it is an effective method to address shortage of water resources and is worth spreading. [Conclusion]It is feasible to use Yanshan River water purified by Xixi Wetland for urban greening and watering road. | Dongtao Yang Liping Xie Shengbin Zhu Langying Qian Zuyou Wen Chang Gao | 2013 | Meteorological and Environmental Research2013，4，2： | 0 |
| 7 | Two-dimensional covalent organic frameworks for electrocatalysis:Achievements,challenges,and opportunities显示文摘Covalent organic frameworks(COFs)represent an emerging class of crystalline porous polymers with high porosity,good stability,and adjustable structure,and their excellent characteristics lay a solid foundation for electrocatalysis.This review systematically introduces the design principles of the catalytic sites in two-dimensional(2D)COF-based electrocatalysts and analyzes the relationship between 2D COF structure and their electrocatalytic performances.In particular,the recent progress in the field of 2D COFs as electrocatalysts is comprehensively summarized.Finally,we discuss the current shortcomings and challenges on tailoring 2D COF for high-performance electrocatalysts in details,and look forward to promoting more researches on 2D COF-based electrocatalysts. | Ruoyu Zhao Teng Wang Junjun Li Yongxia Shi Man Hou Yong Yang Zhicheng Zhang Shengbin Lei | 2023 | Nano Research2023，16，7： | 0 |
| 8 | Long-term Toxicity of Maxing Erchen Zhike Granules显示文摘[Objectives]To study the long-term toxicity of Maxing Erchen Zhike granules to rats after intragastric administration,so as to provide reference for its preclinical safety evaluation.[Methods]Total 80 rats were randomly and evenly divided into high-dose group(1.2 mL/100 g,120 g/kg),middle-dose group(96.0 g/kg),low-dose group(72.0 g/kg)and blank control group.The rats in the treatment groups were administered with corresponding doses of Maxing Erchen Zhike granules,and those in the blank control group were given with equal-amount normal saline.The administration lasted for 30 consecutive days.During the experiment,the rats'feed intake,activity,feces and other conditions and toxicity reactions were observed every day.After 24 h of the last administration,12 rats(half male and half female)were randomly selected from each group.Each of the rats was anesthetized with 10%chloral hydrate solution(0.3 mL/100 g)through intraperitoneal injection and subjected to abdominal aorta blood collection(two tubes)for hematological examination and blood biochemical examination(serum).Then,the main organs of the rats were weighed,and pathological examinations were performed.After that,the main organs were weighed and pathological examination was performed.The remaining rats in each group were discontinued and observed for 14 d.On the 15th d,they were subjected to the same treatment,and the body weight,organ coefficients,hematological indices,blood biochemical indices and pathological indices were examined.[Results]After 30 d of administration,there was no abnormality in the appearance and behavior of the animals.There was no significant difference in the daily consumption of feed among the groups,and there was no special case of weight gain.Among the blood biochemical indices,the ALB and ALT levels of each administration group were significantly different from those of the blank control group(P<0.05).The results of histopathological examination show that there was one case of interstitial pneumonia in each of the high-dose group,middle-dose group and blank control group.After 14 d that the administration was stopped,one case of focal myocarditis appeared in the high-dose group,and one case of interstitial pneumonia appeared in the middle-dose group.[Conclusions]Maxing Erchen Zhike granules are safe to be administered to rats at 100 times the clinical dose.and there should be no safety hazards clinically when used at conventional doses. | Jiabao MA Zhenyuan WEI Shuang WU Jiahuan WEI Shengbin CHEN Jinhua LIU Zhengteng YANG | 2020 | Medicinal Plant2020，11，5： | 0 |
| 9 | Highly interconnected macroporous MBG/PLGA scaffolds with enhanced mechanical and biological properties via green foaming strategy显示文摘In this study,mesoporous bioactive glass particles(MBGs) are incorporated into poly(lactic-co-glycolic acid)(PLGA) to fabricate highly interconnected macroporous composite scaffolds with enhanced mechanical and biological properties via a developed supercritical carbon dioxide(scCO_(2)) foaming method Scaffolds show favorable highly interconnected and macroporous structure through a high foaming pressure and long venting time foaming strategy.Specifically,scaffolds with porosity from 73% to 85%,pore size from 120 μm to 320 μm and interconnectivity of over 95% are controllably fabricated at MBG content from 0 wt% to 20 wt%.In comparison with neat PLGA scaffolds,composite scaffolds perform improved strength(up to 1.5 folds) and Young's modulus(up to 3 folds).The interconnected macroporous structure is beneficial to the ingrowth of cells.More importantly,composite scaffolds also provide a more promising microenvironment for cellular proliferation and adhesion with the release of bioactive ions.Hopefully,MBG/PLGA scaffolds developed by the green foaming strategy in this work show promising morphological,mechanical and biological features for tissue regeneration. | Chaobo Song Jiapeng Zhang Shuang Li Shengbin Yang Eryi Lu Zhenhao Xi Lian Cen Ling Zhao Weikang Yuan | 2021 | Chinese Journal of Chemical Engineering2021，34，1： | 0 |
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