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| 1 | Regulatory B cells in autoimmune diseases显示文摘因为他们的能力, B 房间通常被认为是有免疫力的反应的积极管理者生产抗体,包括自身抗体。因为 B 房间用作介绍抗原的房间并且在有免疫力的回答施加另外的调节功能,抗体的生产便于最佳的 CD4 +T 房间激活。然而,某些 B 房间能否定地也由生产规章的 cytokines 并且直接经由 cell-to-cell 接触与病原的 T 房间交往调整有免疫力的反应。B 房间的这些类型被定义为规章的 B (Breg ) 房间。Breg 房间的规章的函数在发炎的鼠标模型被表明了,癌症,移植,并且特别地在 autoimmunity。在这评论,我们集中于在人的自体免疫的疾病导致发展的理解和 Breg 房间的功能和 B 房间的含意的最近的进展。 | Min Yang Ke Rui Shengjun Wang Liwei Lu | 2013 | Cellular & Molecular Immunology2013，10，2： | 32 |
| 2 | 有表面机械磨损处理辅助的合金钢强化渗硼动力学显示文摘用表面机械磨损处理(SMAT)在AISI H13钢上制备一层纳米结构的表面层。研究了这种SMAT试样的渗硼性能和粗晶粒对应物的比较。SMAT试样的硼扩散深度在600℃,2 h渗硼后的峰值是8μm,比粗晶粒试样深得多。在SMAT试样上用600℃接着更高温度的双重渗硼处理能合成厚得多的渗硼层。而且SMAT试样的活化能是1403 kJ/mol,比粗晶粒的209.4 kJ/mol低得多。结果表明,用双重渗硼处理的SMAT试样能明显增强渗硼动力学。而且热疲劳试验表明,具有优良抗氧化性和高温机械强度的渗硼层能有效延迟热疲劳裂纹的萌生,阻碍它们的传播。所以经双重渗硼处理的H13钢的热疲劳性能可以大大提升。 | Haopeng Yang Xiaochun Wu Zhe Yang Shengjun Pu Hongbin Wang | 2014 | 热处理技术与装备2014，35，2： | 7 |
| 3 | Application of Lactic Acid Bacteria(LAB) in Freshness Keeping of Tilapia Fillets as Sashimi显示文摘Aquatic products are extremely perishable food commodities. Developing methods to keep the freshness of fish represents a major task of the fishery processing industry. Application of Lactic Acid Bacteria(LAB) as food preservative is a novel approach. In the present study, the possibility of using lactic acid bacteria in freshness keeping of tilapia fillets as sashimi was examined. Fish fillets were dipped in Lactobacillus plantarum 1.19(obtained from China General Microbiological Culture Collection Center) suspension as LAB-treated group. Changes in K-value, APC, sensory properties and microbial flora were analyzed. Results showed that LAB treatment slowed the increase of K-value and APC in the earlier storage, and caused a smooth decrease in sensory score. Gram-negative bacteria dominated during refrigerated storage, with Pseudomonas and Aeromonas being relatively abundant. Lactobacillus plantarum 1.19 had no obvious inhibitory effect against these Gram-negatives. However, Lactobacillus plantarum 1.19 changed the composition of Gram-positive bacteria. No Micrococcus were detected and the proportion of Staphylococcus decreased in the spoiled LAB-treated samples. The period that tilapia fillets could be used as sashimi material extended from 24 h to 48 h after LAB treatment. The potential of using LAB in sashimi processing was confirmed. | CAO Rong LIU Qi CHEN Shengjun YANG Xianqing LI Laihao | 2015 | Journal of Ocean University of China2015，14，4： | 5 |
| 4 | Pharmacological Activation of RXR-a Promotes Hematoma Absorption via a PPAR-y-dependent Pathway After Intracerebral Hemorrhage显示文摘Endogenously eliminating the hematoma is a favorable strategy in addressing intracerebral hemorrhage(ICH).This study sought to determine the role of retinoid X receptor-ot(RXR-a)in the context of hematoma absorption after ICH.Our results showed that pharmacologically activating RXR-a with bexarotene significantly accelerated hematoma clearance and alleviated neurological dysfunction after ICH.RXR-ot was expressed in microglia/macro-phages,neurons,and astrocytes.Mechanistically,bexarotene promoted the nuclear translocation of RXR-a and PPAR-y,as well as reducing neuroinflammation by modulating microglia/macrophage reprograming from the Ml into the M2 phenotype.Furthermore,all the beneficial effects of RXR-a in ICH were reversed by the PPAR-y inhibitor GW9662.In conclusion,the pharmacological activation of RXR-a confers robust neuroprotection against ICH by accelerating hematoma clearance and repolarizing microglia/macrophages towards the M2 phenotype through PPAR-y-related mechanisms.Our data support the notion that RXR-ot might be a promising therapeutic target for ICH. | Chaoran Xu Huaijun Chen Shengjun Zhou Chenjun Sun Xiaolong Xia Yucong Peng Jianfeng Zhuang Xiongjie Fu Hanhai Zeng Hang Zhou Yang Cao Qian Yu Yin Li Libin Hu Guoyang Zhou Feng Yan Gao Chen Jianru Li | 2021 | Neuroscience Bulletin2021，37，10： | 4 |
| 5 | The Tibetan Plateau Surface–Atmosphere Coupling System and Its Weather and Climate Effects: The Third Tibetan Plateau Atmospheric Science Experiment显示文摘The Tibetan Plateau(TP) is a key area affecting forecasts of weather and climate in China and occurrences of extreme weather and climate events over the world. The China Meteorological Administration, the National Natural Science Foundation of China, and the Chinese Academy of Sciences jointly initiated the Third Tibetan Plateau Atmospheric Science Experiment(TIPEX-Ⅲ) in 2013, with an 8–10-yr implementation plan. Since its preliminary field measurements conducted in 2013, routine automatic sounding systems have been deployed at Shiquanhe, Gaize, and Shenzha stations in western TP, where no routine sounding observations were available previously. The observational networks for soil temperature and soil moisture in the central and western TP have also been established. Meanwhile, the plateau-scale and regional-scale boundary layer observations, cloud–precipitation microphysical observations with multiple radars and aircraft campaigns, and tropospheric–stratospheric air composition observations at multiple sites, were performed. The results so far show that the turbulent heat exchange coefficient and sensible heat flux are remarkably lower than the earlier estimations at grassland, meadow, and bare soil surfaces of the central and western TP. Climatologically, cumulus clouds over the main body of the TP might develop locally instead of originating from the cumulus clouds that propagate northward from South Asia. The TIPEX-Ⅲ observations up to now also reveal diurnal variations, macro-and microphysical characteristics, and water-phase transition mechanisms, of cumulus clouds at Naqu station. Moreover, TIPEX-Ⅲ related studies have proposed a maintenance mechanism responsible for the Asian 'atmospheric water tower' and demonstrated the effects of the TP heating anomalies on African, Asian, and North American climates. Additionally, numerical modeling studies show that the Γ distribution of raindrop size is more suitable for depicting the TP raindrop characteristics compared to the M–P distribution, the overestimation of sensible heat flux can be reduced via modifying the heat transfer parameterization over the TP, and considering climatic signals in some key areas of the TP can improve the skill for rainfall forecast in the central and eastern parts of China. Furthermore, the TIPEX-Ⅲ has been promoting the technology in processing surface observations, soundings, and radar observations, improving the quality of satellite retrieved soil moisture and atmospheric water vapor content products as well as high-resolution gauge–radar–satellite merged rainfall products, and facilitating the meteorological monitoring, forecasting, and data sharing operations. | Ping ZHAO Yueqing LI Xueliang GUO Xiangde XU Yimin LIU Shihao TANG Wenming XIAO Chunxiang SHI Yaoming MA Xing YU Huizhi LIU La JIA Yun CHEN Yanju LIU Jian LI Dabiao LUO Yunchang CAO Xiangdong ZHENG Junming CHEN An XIAO Fang YUAN Donghui CHEN Yang PANG Zhiqun HU Shengjun ZHANG Lixin DONG Juyang HU Shuai HAN Xiuji ZHOU | 2019 | Journal of Meteorological Research2019，33，3： | 4 |
| 6 | Tranexamic acid for acute intracerebral haemorrhage growth based on imaging assessment (TRAIGE): a multicentre, randomised, placebo- controlled trial显示文摘Background Studies show tranexamic acid can reduce the risk of death and early neurological deterioration after intracranial haemorrhage.We aimed to assess whether tranexamic acid reduces haematoma expansion and improves outcome in intracerebral haemorrhage patients susceptible to haemorrhage expansion.Methods We did a prospective,double-blind,randomised,placebo-controlled trial at 10 stroke centres in China.Acute supratentorial intracerebral haemorrhage patients were eligible if they had indication of haemorrhage expansion on admission imaging(eg,spot sign,black hole sign or blend sign),and were treatable within 8 hours of symptom onset.Patients were randomly assigned(1:1)to receive either tranexamic acid or a matching placebo.The primary outcome was intracerebral haematoma growth(>33% relative or>6 mL absolute)at 24 hours.Clinical outcomes were assessed at 90 days.Results Of the 171 included patients,124(72.5%)were male,and the mean age was 55.9±11.6 years.89 patients received tranexamic acid and 82 received placebo.The primary outcome did not differ significantly between the groups:36(40.4%)patients in the tranexamic acid group and 34(41.5%)patients in the placebo group had intracranial haemorrhage growth(OR 0.96,95% CI 0.52 to 1.77,p=0.89).The proportion of death was lower in the tranexamic acid treatment group than placebo group(8.1%vs 10.0%),but there were no significant differences in secondary outcomes including absolute intracranial haemorrhage growth,death and dependency.Conclusions Among patients susceptible to haemorrhage expansion treated within 8 hours of stroke onset,tranexamic acid did not significantly prevent intracerebral haemorrhage growth.Larger studies are needed to assess safety and efficacy of tranexamic acid in intracerebral haemorrhage patients. | Jingyi Liu Ximing Nie Hongqiu Gu Qi Zhou Haixin Sun Ying Tan Dacheng Liu Lina Zheng Jiahui Zhao Yan Wang Yibin Cao Haomeng Zhu Yunpeng Zhang Lijin Yi Yuehua Pu Miao Wen Zhonghua Yang Shengjun Sun Wenzhi Wang Xingquan Zhao Liping Liu Yongjun Wang | 2021 | Stroke & Vascular Neurology2021，6，2： | 3 |
| 7 | A Primal-Dual SGD Algorithm for Distributed Nonconvex Optimization显示文摘The distributed nonconvex optimization problem of minimizing a global cost function formed by a sum of n local cost functions by using local information exchange is considered.This problem is an important component of many machine learning techniques with data parallelism,such as deep learning and federated learning.We propose a distributed primal-dual stochastic gradient descent(SGD)algorithm,suitable for arbitrarily connected communication networks and any smooth(possibly nonconvex)cost functions.We show that the proposed algorithm achieves the linear speedup convergence rate O(1/(√nT))for general nonconvex cost functions and the linear speedup convergence rate O(1/(nT)) when the global cost function satisfies the Polyak-Lojasiewicz(P-L)condition,where T is the total number of iterations.We also show that the output of the proposed algorithm with constant parameters linearly converges to a neighborhood of a global optimum.We demonstrate through numerical experiments the efficiency of our algorithm in comparison with the baseline centralized SGD and recently proposed distributed SGD algorithms. | Xinlei Yi Shengjun Zhang Tao Yang Tianyou Chai Karl Henrik Johansson | 2022 | IEEE/CAA Journal of Automatica Sinica2022，9，5： | 3 |
| 8 | Haemostatic therapy in spontaneous intracerebral haemorrhage patients with high-risk of haematoma expansion by CT marker: a systematic review and meta- analysis of randomised trials显示文摘Background and purpose Current randomised controlled trials(RCTs)showed an uncertain benefit of haemostatic therapy on preventing haematoma expansion and improving the outcome in patients with intracerebral haemorrhage(ICH).This meta-analysis aims to systematically evaluate the effect of haemostatic agents on the prevention of haemorrhage growth in patients with high-risk spontaneous ICH predicted by CT signs in RCTs.Methods A comprehensive search of PubMed,EMBASE and Cochrane library from 1 January 2005 to 30 June 2021 was conducted.RCTs that compared haemostatic agents with placebo for the treatment of spontaneous patients with ICH with high-risk haemorrhage growth were included.The primary endpoint was haematoma expansion at 24 hours.Other major endpoints of interest included 90-day functional outcome and mortality.Results The meta-analysis included four RCTs that randomised 2666 patients with ICH with high-risk haemorrhage growth.Haemostatic therapy reduced the rate of haematoma expansion at a marginally statistically significant level when compared with placebo(OR 0.84;95% CI 0.70 to 1.00;p=0.051).Subgroup analysis for patients with black hole sign on CT revealed a significant reduction of haematoma expansion with haemostatic therapy(OR 0.61;95% CI 0.39 to 0.94;p=0.03).However,both the primary analysis and subgroup analyses showed that haemostatic therapy could not reduce the rate of poor functional outcome(modified Rankin Scale>3)or death.Conclusions Haemostatic therapy showed a marginally significant benefit in reducing early haematoma expansion in patients with high-risk spontaneous ICH predicted by markers on CT scan.However,no significant improvement in functional outcome or reduction of mortality was observed. | Ximing Nie Jingyi Liu Dacheng Liu Qi Zhou Wanying Duan Yuehua Pu Zhonghua Yang Miao Wen Haixin Sun Wenzhi Wang Shengjun Sun Hongqiu Gu Liping Liu | 2021 | Stroke & Vascular Neurology2021，6，2： | 2 |
| 9 | Intrauterine growth restriction alters nutrient metabolism in the intestine of porcine offspring显示文摘Background:Intrauterine growth restriction(IUGR)has negative impacts on the postnatal survival,growth and development of humans and animals,with not only on newborns but also adulthood.However,the characteristics for nutrient digestion and absorption in IUGR offspring are still largely unknown.Therefore,the normal birth weight(NBW)and IUGR growing pigs were used in this study to investigate their differences in nutrient utilization,with an expectition for further nutritional optimization of the IUGR offspring during their later life.Methods:Twelve IUGR and 12 NBW growing pigs were fitted with catheters in their portal vein to measure blood flow rate as well as nutrients and metabolites in plasma.The digestibilities of nutrients in different intestinal segments,and bacterial fermentation in the large intestine were examined to reveal the characteristics of nutrients utilization in IUGR versus NBW pigs.Results:The rate of portal venous blood flow did not differ beween IUGR and NBW pigs.Plasma concentrations of total cholesterol,triglycerides and glucose were much lower but those of urea were higher in the portal vein of IUGR pigs,compared with the NBW pigs.The ileal digestibility of dry matter,gross energy and starch were lower in IUGR pigs than in NBW pigs.IUGR increased hindgut microbial diversity and bacterial fermentation activity in the caecum.In vitro cross-fermentation of ileal digesta by caecal microbes of NBW and IUGR pigs showed that gas production was much higher for IUGR ileal digesta regardless of the source of caecal inocula.Conclusion:IUGR impairs the nutrient digestion and absorption in small intestine,reduces caecal microbial diversity and promotes bacterial fermentation in the large intestine during the growing phase.These findings aid in our understanding of nutrient metabolism in IUGR pigs and provide the basis for future nutritional interventions. | Tiantian Li Shimeng Huang Long Lei Shiyu Tao Yi Xiong Guoyao Wu Jie Hu Xiongkun Yuan Shengjun Zhao Bin Zuo Hongjian Yang Yingping Xiao Gang Lin Junjun Wang | 2021 | Journal of Animal Science and Biotechnology2021，12，2： | 2 |
| 10 | Microbial community structure analyses and cultivable denitrifier isolation of Myriophyllum aquaticum constructed wetland under low C/N ratio显示文摘With the rapid expansion of livestock production,the amount of livestock wastewater accumulated rapidly.Lack of biodegradable organic matter makes denitrification of livestock wastewater after anaerobic digestion more difficult.In this study,Myriophyllum aquaticum constructed wetlands(CWs)with efficient nitrogen removal performance were established under different carbon/nitrogen(C/N)ratios.Analysis of community composition reveals the change of M.aquaticum CWs in microbial community structure with C/N ratios.The proportion of Proteobacteria which is one of the dominant phyla among denitrifier communities increased significantly under low C/N ratio conditions.Besides,to obtain cultivable denitrifier that could be added into CWs in situ,33 strains belonging to phylum Proteobacteria were isolated from efficient M.aquaticum CWs,while the best-performing denitrification strain M3-1 was identified as Bacillus velezensis JT3-1(GenBank No.CP032506.1).Redundancy analysis and quadratic models showed that C/N ratio had significant effects on disposal of nitrate(NO_(3)^(−)-N)and the strains isolated could perform well in denitrification when C/N ratio is relatively low.In addition,they have relatively wide ranges of carbon sources,temperature and a high NO_(3)^(−)removal rate of 9.12 mg/(L·hr)at elevated concentrations of 800 mg/L nitrate.Thus,strains isolated from M.aquaticum CWs with low C/N ratio have a practical application value in the treatment of nitrate-containing wastewater.These denitrifying bacteria could be added to CWs to enhance nitrogen removal efficiency of CWs for livestock wastewater with low C/N ratio in the future. | Jialiang Zuo Lina Xu Jianlin Guo Shengjun Xu Shuanglong Ma Cancan Jiang Dongmin Yang Danhua Wang Xuliang Zhuang | 2023 | Journal of Environmental Sciences2023，，5： | 2 |
| 11 | Structure and electrochemical properties of La, F dual-doped LiLa_(0.01)Mn_(1.99)O_(3.99)F_(0.01) cathode materials显示文摘The cathode materials LiMn2O4 and rare earth elements La-doped or La and F dual-doped spinel lithium manganese oxides were synthesized by the citric acid-assisted sol-gel method. The synthesized samples were investigated by differential thermal analysis (DTA) and thermogravimetry (TG) measurements, X-ray diffraction (XRD), scanning electronic microscope (SEM), cyclic voltammetry (CV), and charge-discharge test. XRD data shows that all the samples exhibit the same pure spinel phase, and the LiLa0.01Mn1.99O3.99F0.01 and LiLa0.01Mn1.99O4 samples have smaller lattice parameters and unit cell volume than LiMn2O4. SEM indicates that LiLa0.01Mn1.99O3.99F0.01 has a slightly smaller particle size and a more regular morphology structure with narrow size distribution. The charge-discharge test reveals that the initial capacities of LiMn2O4, LiLa0.01Mn1.99O4, and LiLa0.01Mn1.99O3.99F0.01 are 129.9, 122.8, and 126.4 mAh·g-1, and the capacity losses of the initial values after 50 cycles are 14.5%, 7.6%, and 8.0%, respectively. The CVs show that the La and F dual-doped spinel displays a better reversibility than LiMn2O4. | Meng Chen Shengjun Li Chuang Yang | 2008 | Journal of University of Science and Technology Beijing2008，15，4： | 2 |
| 12 | N, O-doped carbon foam as metal-free electrocatalyst for efficient hydrogen production from seawater显示文摘Seawater electrolysis is the most promising technology for large scale hydrogen production due to the abundance and low cost of seawater in nature.However,compared with the traditional freshwater electrolysis,the issues of electrode poisoning and corrosion will occur during the seawater electrolysis process,and active and stable electrocatalysts for the hydrogen evolution reaction(HER)are thus highly desired.In this work,N,O-doped carbon foam in-situ derived from commercial melamine foam is proposed as a high-active metal-free HER electrocatalyst for seawater splitting.In acidic seawater,our catalyst shows high hydrogen generation performance with small overpotential of 161 mV at 10 mA·cm^(−2),a low Tafel slop of 97.5 mV·dec^(−1),and outstanding stability. | Qian Liu Shengjun Sun Longcheng Zhang Yongsong Luo Qin Yang Kai Dong Xiaodong Fang Dongdong Zheng Abdulmohsen Ali Alshehri Xuping Sun | 2022 | Nano Research2022，15，10： | 2 |
| 13 | Leptin Signaling Protects NK Cells from Apoptosis During Development in Mouse Bone Marrow显示文摘增加的证据在有免疫力的反应显示 leptin 的一个角色,但是发信号的 leptin 是否涉及在骨头髓(BM ) 调整 NK 房间开发,仍然保持大部分不清楚。在这研究,我们在在 prediabetic 的缺乏的 db/db 老鼠上演的 leptin 受体的 BM 描绘了 NK 房间区别和成熟。尽管 BM 细胞质类似于控制值, NK 房间的全部的数字严重地在变异的鼠标被减少。db/db BM 房间的流动 cytometric 分析揭示了在区别的各种各样的阶段开发 NK 房间的显著地减少的频率。显著地显示的 BM db/db NK 房间增加了 apoptosis,但是维持了正常房间骑车地位和 proliferative 能力。而且, recombinant leptin 能显著地在文化从野类型的老鼠提高 NK 房间的幸存。NK 房间上的进一步的检查功能的活动证明 db/db NK 房间与显著地增加的 IL-10 展出了正常内在的 cytotoxicity 生产。一起拿,我们的调查结果建议发信号的 leptin 经由在老鼠 BM 提高不成熟的 NK 房间的幸存调整 NK 房间开发。 | Cherry Kam Chun Lo Queenie Lai Kwan Lam Min Yang King-Hung Ko Lingyun Sun Rui Ma Shengjun Wang Huaxi Xu Sidney Tam Chang-You Wu Bo-Jiang Zheng Liwei Lu | 2009 | Cellular & Molecular Immunology2009，6，5： | 2 |
| 14 | Development of HEP-XXMF Series Hall Thrusters in BICE显示文摘Hall thruster is a type of electric propulsion thruster which is often regarded as a moderate specific impulse space propulsion technology and is used primarily for station keeping and orbit maintenance tasks. Magnetic field is the most important aspect in Hall thruster's design. Each time the performance improvement of Hall thrusters is accompanied with the regeneration of magnetic field design. Now, all the major space nations treat the magnetic field design as the key technology for Hall thrusters, and many Hall thrusters have emerged in recent years, for example, BPT-4000 and NASA-173 M. In China, based on magnetic focus technology, the Beijing Institute of Control Engineering(BICE) has been developing Hall thrusters ranged from hundreds of watts to 5 kilowatts, including the 1500 W HEP-100 MF and the 5 k W HEP-140 MF Hall thrusters. This paper briefly reviews the development of the HEP-XXMF series Hall thruster. The principle of the Hall thruster, the design methods and the current status of HEP-100 MF and HEP-140 MF are discussed in the paper. | HU Yantin HU Dawei WU Pengan LI Shengjun ZANG Juanwei MAO Wei SHAN Shihua YANG Jian | 2016 | Aerospace China2016，17，2： | 2 |
| 15 | Mechanism of sea ice formation based on comprehensive observation data in Liaodong Bay, China显示文摘Sea ice disaster is one of the principal natural hazards that affect some coastal areas of China,and the formation of ice cover in a wave field has important characteristics.However,analysis of the mechanism in which waves affect the thermodynamic process of sea ice is lacking,and the influence of waves is not taken into consideration in numerical models of sea ice,largely because of a lack of simultaneous observations of waves and sea ice.Using observational data of the sea ice cycle in the coastal waters of Liaodong Bay(China),we analyzed the characteristics of hydrology,meteorology,and sea ice thickness during the formation of sea ice,and explored the changes in the interrelationships among heat fluxes,waves,and sea ice under actual sea conditions.The results could provide a decision-making support as a reference to the establishment and improvement of China's early waming system to sea ice disasters,and the protection of ice drilling operations and production platform safety. | SHI Yongfang YANG Yongzeng TENG Yong SUN Meng YUN Shengjun | 2019 | Journal of Oceanology and Limnology2019，37，6： | 1 |
| 16 | A study of the construction and application of a Daubechies wavelet-based beam element显示文摘 | Junxing Ma Jijun Xue Shengjun Yang Zhengjia He | 2003 | Finite Elements in Analysis and Design2003，39，1： | 1 |
| 17 | A study of the construction and application of a Daubechies wavelet-based beam element 显示文摘 | Junxing Ma Jijun Xue Shengjun Yang Zhengjia He | 2003 | Finite Elements in Analysis and Design2003，39，10： | 1 |
| 18 | The construction of wavelet finite element and its application显示文摘 | CHEN Xuefeng YANG Shengjun HE Zhengjia | 2004 | Finite Elements in Analysis and Design2004，40，54： | 1 |
| 19 | The construction of wavelet finite element and its application显示文摘 | CHEN Xuefeng YANG Shengjun HE Zhengjia | 2004 | Finite Elements in Analysis and Design2004，40，： | 1 |
| 20 | Key technology of constructing the cut-off wall under the foundation with large depth soils layer in Tibet: Zhikong hydropower station 显示文摘 | LI Jianjun SHAO Shengjun YANG Chunming | 2011 | Electric Technology and Civil Engineer2011，，2224： | 1 |
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