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| 1 | Expression of HMGB2 indicates worse survival of patients and is required for the maintenance of Warburg effect in pancreatic cancer显示文摘高活动性组蛋白质(HMG ) 是第二很丰富的染色质蛋白质并且在活跃或不活跃的染色质域的建立施加全球 genomic 函数。通过和 nucleosomes,抄写因素,改变 nucleosome 机器和 histones 的相互作用, HMG 家庭蛋白质贡献响应快速的环境变化抄写调节的罚款。哺乳动物的高活动性组 B (HMGB ) 被领域用一条长酸的尾巴跟随了的二个双人脚踏车 HMG 盒子描绘。最近的研究证明 HMGB 的那高表情在许多癌症被发现了,例如前列腺,肾,卵巢、胃的癌症。然而,他们在胰腺的癌症的角色很少被报导了。在这研究,我们估计了 HMGB 蛋白质的诊断、预示的值,包括 HMGB1, HMGB2,和 HMGB3,在从癌症染色体地图集(TCGA ) 数据集的胰腺的癌症。我们的结果证明 HMGB2 在胰腺的癌症预言了差的预后。在 vitro,研究证明 silencing HMGB2 禁止了房间增长和生存能力。机械学地,我们的结果证明 silencing HMGB2 减少了组织缺氧可诱导的因素 1 (HIF1 ) 蛋白质水平和禁止的调停 HIF1 的 glycolysis 处理。进一步的分析显示包括 GLUT1, HK2,和 LDHA,指向 HIF1 的 glycolytic 基因都是预示的因素并且断然与 HMGB2 表示相关。一起拿,我们为胰腺的癌症发现了新预示、预兆的标记,并且在癌症在 glycolytic 控制使 HMGB2 的新奇函数清楚些。 | Xin Cai Hongjian Ding Yanxia Liu Gaofeng Pan Qingguo Li Zhen Yang Weiyan Liu | 2017 | Acta Biochimica et Biophysica Sinica2017，49，2： | 9 |
| 2 | Effect of Mixing on Properties and Microstructure of Magnesium Oxychloride Cement显示文摘This paper investigated the effect of mixing on the properties of magnesium oxychloride cement, such as apparent viscosity, setting time, compressive strength, and specific strength as well. The phase composition and crystallographic structure of the cement were determined by X-ray diffraction and scanning electron microscopy. The results indicate that the increases of stirring rate and mixing time change apparent viscosity distinctly, shorten setting time and enhance mechanical property. Magnesium oxychloride cement after mixing for 20 min exhibits the optimal mechanical performance. The effect of stirring rate on the phase composition of magnesium oxychloride cement dominates over the effect of mixing time. The increases of stirring rate and mixing time can increase the dispersion state and accelerate the neutralization, thus promoting the strength of magnesium oxychloride cement due to the formation of stable 5·1·8 phase, needle-like crystals and continuous crystalline structure in the whole cement matrix. The properties and microstructure of magnesium oxychloride cement at a stirring rate of 280 rpm are better than those at 140 rpm. | HE Zhenhui YANG Hongjian SONG Hui GUO Tao WU Songyi | 2016 | Journal of the Chinese Ceramic Society2016，，1： | 5 |
| 3 | Development of high-resolution multiple-SNP arrays for genetic analyses and molecular breeding through genotyping by target sequencing and liquid chip显示文摘Genotyping platforms,as critical supports for genomics,genetics,and molecular breeding,have been well implemented at national institutions/universities in developed countries and multinational seed companies that possess high-throughput,automatic,large-scale,and shared facilities.In this study,we integrated an improved genotyping by target sequencing(GBTS)system with capture-in-solution(liquid chip)technology to develop a multiple single-nucleotide polymorphism(mSNP)approach in which mSNPs can be captured from a single amplicon.From one 40K maize mSNP panel,we developed three types of markers(40K mSNPs,251K SNPs,and 690K haplotypes),and generated multiple panels with various marker densities(1K–40K mSNPs)by sequencing at different depths.Comparative genetic diversity analysis was performed with genic versus intergenic markers and di-allelic SNPs versus non-typical SNPs.Compared with the one-amplicon-one-SNP system,mSNPs and within-mSNP haplotypes are more powerful for genetic diversity detection,linkage disequilibrium decay analysis,and genome-wide association studies.The technologies,protocols,and application scenarios developed for maize in this study will serve as a model for the development of mSNP arrays and highly efficient GBTS systems in animals,plants,and microorganisms. | Zifeng Guo Quannv Yang Feifei Huang Hongjian Zheng Zhiqin Sang Yanfen Xu Cong Zhang Kunsheng Wu Jiajun Tao Boddupalli MPrasanna Michael SOlsen Yunbo Wang Jianan Zhang Yunbi Xu | 2021 | Plant Communications2021，2，6： | 5 |
| 4 | Independent Prognostic Value of High-sensitivity C-reactive Protein in Patients with Coronary Artery Ectasia显示文摘 | Yintang Wang Yang Wang Shijie You Hongjian Wang Dong Yin Kefei Dou Weihua Song | 2016 | Chinese Medical Journal2016，，21： | 4 |
| 5 | p53 isoform △113p53/△133p53 promotes DNA double-strand break repair to protect cell from death and senescence in response to DNA damage显示文摘在 DNA 双海滨的 p53 的禁止的角色裂缝(DSB ) 修理对它的压制肿瘤的性质似乎矛盾。p53 isoform Δ 113p53/Δ 133p53 是反对 p53 apoptotic 的 p53 目标基因活动。然而,它在 DNA 损坏修理的功能的信息正在缺乏。这里,我们报导那 Δ 113p53 表示被 γ 强烈导致; -irradiation, 然而并非由紫外照耀或热电震疗法。惊人地, Δ 113p53 支持 DNA DSB 修理小径包括相应再结合,非相应的结束加入并且单个海滨的退火。学习 Δ 的生物意义;在支持 DNA DSB 修理的 113p53,我们产生了 zebrafish Δ 113p53 经由抄写的 M/M 异种像使活跃之物的受动器核酸酶技术并且发现异种对 γ 更敏感;照耀。人的 ortholog, Δ 133p53,被 γ 仅仅也导致;照耀和功能修理支持 DNA DSB。Δ 133p53-knockdown 房间响应 γ 在以后的阶段在 G2 阶段被逮捕;照耀由于 unrepaired DNA DSB 的高水平,它最后导致了房间老朽。而且, Δ 113p53/Δ 133p53 经由 upregulating 支持 DNA DSB 修理由到在他们的倡导者的 p53 应答的元素的一种新奇类型的绑定的修理基因 rad51, lig4 和 rad52 的抄写。我们的结果表明那 Δ 113p53/Δ 133p53 是为由阻止 apoptosis 并且支持 DNA DSB 修理禁止房间老朽的 DNA 损坏应力的一个进化地保存的支持幸存的因素。我们的数据也建议 Δ 的正式就职;在正常房间或纸巾的 133p53 表示为癌症病人提供一个重要忍耐标记给放射疗法。 | Lu Gong Hongjian Gong Xiao Pan Changqing Chang Zhao Ou Shengfan Ye Le Yin Lina Yang Ting Tao Zhenhai Zhang Cong Liu David P Lane Jinrong Peng Jun Chen | 2015 | Cell Research2015，25，3： | 4 |
| 6 | First experimental constraints on WIMP couplings in the effective field theory framework from CDEX显示文摘We present weakly interacting massive particles(WIMPs) search results performed using two approaches of effective field theory from the China Dark Matter Experiment(CDEX), based on the data from both CDEX-1B and CDEX-10 stages. In the nonrelativistic effective field theory approach, both time-integrated and annual modulation analyses were used to set new limits for the coupling of WIMP-nucleon effective operators at 90% confidence level(C.L.) and improve over the current bounds in the low mχregion. In the chiral effective field theory approach, data from CDEX-10 were used to set an upper limit on WIMP-pion coupling at 90% C.L. We for the first time extended the limit to the m_(χ)<6 GeV/c^(2) region. | Yi Wang Zhi Zeng Qian Yue LiTao Yang KeJun Kang YuanJing Li Mehment Agartioglu HaiPeng An JianPing Chang JingHan Chen YunHua Chen JianPing Cheng Cheng Yi Chiang WenHan Dai Zhi Deng ChangHao Fang XinPing Geng Hui Gong QiuJu Guo XuYuan Guo HongJian He Li He ShengMing He JinWei Hu TuChen Huang HanXiong Huang HaiTao Jia LiPing Jia Xi Jiang HauBin Li JianMin Li Jin Li MingXuan Li RenMingJie Li Xia Li YuLan Li Bin Liao FongKay Lin ShinTed Lin ShuKui Liu YanDong Liu Yu Liu YuanYuan Liu ZhongZhi Liu Hao Ma YuCai Mao QiYuan Nie JinHua Ning Hui Pan NingChun Qi Jie Ren XiChao Ruan ChangSong Shang Vivek Sharma Ze She Lakhwinder Singh Monoj Kumar Singh TianXi Sun ChangJian Tang WeiYou Tang Yang Tian GuangFu Wang Li Wang Qing Wang Yu Chen Wang YunXiang Wang Zhen Wang Henry Tsz-King Wong ShiYong Wu YuCheng Wu HaoYang Xing Yin Xu Tao Xue YuLu Yan Nan Yi ChunXu Yu HaiJun Yu JianFeng Yue Ming Zeng BingTao Zhang Lei Zhang FengShou Zhang ZhenYu Zhang KangKang Zhao MingGang Zhao JiFang Zhou ZuYing Zhou JingJun Zhu | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，8： | 3 |
| 7 | KB4Rec:A Data Set for Linking Knowledge Bases with Recommender Systems显示文摘To develop a knowledge-aware recommender system,a key issue is how to obtain rich and structured knowledge base(KB)information for recommender system(RS)items.Existing data sets or methods either use side information from original RSs(containing very few kinds of useful information)or utilize a private KB.In this paper,we present KB4Rec v1.0,a data set linking KB information for RSs.It has linked three widely used RS data sets with two popular KBs,namely Freebase and YAGO.Based on our linked data set,we first preform qualitative analysis experiments,and then we discuss the effect of two important factors(i.e.,popularity and recency)on whether a RS item can be linked to a KB entity.Finally,we compare several knowledge-aware recommendation algorithms on our linked data set. | Wayne Xin Zhao Gaole He Kunlin Yang Hongjian Dou Jin Huang Siqi Ouyang Ji-Rong Wen | 2019 | Data Intelligence2019，1，2： | 3 |
| 8 | Anti-disturbance filter design for a class of stochastic systems with fading channels显示文摘Dear editor,As a significant topic in control and signal processing communities,the filtering problem has been attracting persistent research attention in the past few decades[1].In practical engineering,the parameter perturbations are unavoidable due mainly to exogenous disturbances,environmental changes and some other phenomena. | Yang LIU Zidong WANG Hongli DONG Hongjian LIU | 2020 | Science China(Information Sciences)2020，63，11： | 3 |
| 9 | Intrauterine growth restriction alters nutrient metabolism in the intestine of porcine offspring显示文摘Background:Intrauterine growth restriction(IUGR)has negative impacts on the postnatal survival,growth and development of humans and animals,with not only on newborns but also adulthood.However,the characteristics for nutrient digestion and absorption in IUGR offspring are still largely unknown.Therefore,the normal birth weight(NBW)and IUGR growing pigs were used in this study to investigate their differences in nutrient utilization,with an expectition for further nutritional optimization of the IUGR offspring during their later life.Methods:Twelve IUGR and 12 NBW growing pigs were fitted with catheters in their portal vein to measure blood flow rate as well as nutrients and metabolites in plasma.The digestibilities of nutrients in different intestinal segments,and bacterial fermentation in the large intestine were examined to reveal the characteristics of nutrients utilization in IUGR versus NBW pigs.Results:The rate of portal venous blood flow did not differ beween IUGR and NBW pigs.Plasma concentrations of total cholesterol,triglycerides and glucose were much lower but those of urea were higher in the portal vein of IUGR pigs,compared with the NBW pigs.The ileal digestibility of dry matter,gross energy and starch were lower in IUGR pigs than in NBW pigs.IUGR increased hindgut microbial diversity and bacterial fermentation activity in the caecum.In vitro cross-fermentation of ileal digesta by caecal microbes of NBW and IUGR pigs showed that gas production was much higher for IUGR ileal digesta regardless of the source of caecal inocula.Conclusion:IUGR impairs the nutrient digestion and absorption in small intestine,reduces caecal microbial diversity and promotes bacterial fermentation in the large intestine during the growing phase.These findings aid in our understanding of nutrient metabolism in IUGR pigs and provide the basis for future nutritional interventions. | Tiantian Li Shimeng Huang Long Lei Shiyu Tao Yi Xiong Guoyao Wu Jie Hu Xiongkun Yuan Shengjun Zhao Bin Zuo Hongjian Yang Yingping Xiao Gang Lin Junjun Wang | 2021 | Journal of Animal Science and Biotechnology2021，12，2： | 2 |
| 10 | On the sensor order in sequential integrated probability data association filter显示文摘The processing order of sensors with different detection probabilities and in different clutter densities in a multi-sensor system is investigated in this paper. A sequential implementation of the integrated probability data association (IPDA) algorithm under random set framework is derived. Under the assumptions of different detection probabilities and different clutter densities of individual sensor in a multi-sensor system, we reach the conclusion that the sequential IPDA filter depends on the order analyzing the target existence probability of varying sensor orders. Moreover, we obtain the optimal order of sensors for the sequential IPDA filter in terms of maximizing the target existence probability. The conclusions are demonstrated by simulation results. | WANG Yang JING ZhongLiang HU ShiQiang ZHANG HongJian WU JingJing | 2012 | Science China(Information Sciences)2012，55，3： | 2 |
| 11 | 参与辣椒素合成的DnaJ基因家族全表达谱分析显示文摘背景:DnaJ蛋白在植物发育和胁迫反应中发挥重要作用。近年来,通过对辣椒基因组全面的生信分析鉴定到76个DnaJ基因。但目前尚无辣椒DnaJ基因系统发育关系和表达谱的研究报道。因此,我们对不同组织、非生物胁迫和激素响应下辣椒DnaJ基因的系统发育关系和表达谱进行了系统的分析。结果:系统发育分析显示,辣椒DnaJ基因按序列同源性可分为7个亚族(Ⅰ、Ⅱ、Ⅲ、Ⅳ、Ⅴ、Ⅵ和Ⅶ亚族)。辣椒DnaJ基因在不同组织中的表达显示,38%(29/76)的辣椒DnaJ基因在至少一个组织中表达。结果表明,DnaJ基因在辣椒生长发育中具有潜在的关键作用。另外,为了解辛辣和非辛辣辣椒DnaJ基因在胎座中的表达差异,我们还利用RNA-Seq数据和qRT-PCR分析了辣椒DnaJ基因的表达模式。通过比较分析发现,8个基因在辛辣辣椒和非辛辣辣椒中的表达差异显著。CaDnaJs与胎座发育过程中参与辣椒素合成的基因共同表达。更重要的是,我们的研究揭示了这8个DnaJ基因可能受到胁迫(热、干旱和盐)的调控,同时也受到植物激素的调控(ABA,GA3,MeJA和SA)。结论:综上所述,部分在胎座中表达的DnaJ基因可能参与了植物在与刺激性相关化合物生物合成过程中对非生物胁迫的响应。本研究为辣椒DanJ基因的表达谱提供了广泛的认识,有助于我们对辣椒中的DnaJ基因功能认识。 | Fang Fanfei Liu Fawan Yang Xian Wan Hongjian Kang Yunyan 刘周斌(译) | 2020 | 辣椒杂志2020，，3： | 2 |
| 12 | Effective inhibition of human cytomegalovirus gene expression by DNA-based external guide sequences显示文摘调查是否 12 核苷酸基于 DNA 的 miniEGSs 罐头沉默人的 cytomegalovirus (HCMV ) 的表示 UL49 基因高效地,稳定地表示 UL49 基因的一根 HeLa 房间线被构造,通常认为的 miniEGSs (UL49-miniEGSs ) 是在稳定的房间线的 assayed。量的 RTPCR 和西方的污点结果在是有 UL49-miniEGSs 的 transfected 的 HeLa 房间在 UL49 表示水平显示出 67% 的减小。它与分别地是 1 和 7% 的嘲笑和控制 miniEGSs (TK-miniEGSs ) 的显著地不同。为了进一步证实基因沉默,与人的 RNase P 由 UL49-miniEGSs 指导了, UL49-miniEGSs 的异种被构造并且一修改了 5 种族被执行。数据证明基因表示由 UL49-miniEGSs 指导了的 UL49 的抑制是 P 依赖的 RNase,由 RNase P 的 UL49 mRNA 的劈开是地点特定。作为结果,基于 DNA 的 miniEGSs 的长度能沉默基因表示高效地仅仅是 12 nt。是显著地不到到目前为止知道的基因 inactivation 的任何另外的基于 oligonucleotide 的方法。MiniEGSs 可以为病毒的基因的抑制代表新奇指向基因的代理人,另外的人的疾病联系基因表示。 | Zhifeng Zeng Hongjian Li Yueqing Li Yanwei Cui Qi Zhou Yi Zou Guang Yang Tianhong Zhou | 2009 | Acta Biochimica et Biophysica Sinica2009，41，5： | 1 |
| 13 | Time-Delay Neural Network for the Prediction of Carbonation Tower's Temperature显示文摘 | Dan Shi Hongjian Zhang Liming Yang | 2003 | IEEE Transactions on Instrumentation and Measurement2003，52，4： | 1 |
| 14 | The impact of free-air CO 2 enrichment (FACE) and nitrogen supply on grain quality of rice显示文摘 | Lianxin Yang Yulong Wang Guichun Dong Hui Gu Jianye Huang Jianguo Zhu Hongjian Yang Gang Liu Yong Han | 2007 | Field Crops Research2007，，2： | 1 |
| 15 | Roles of cocatalysts in Pt–PdS/CdS with exceptionally high quantum efficiency for photocatalytic hydrogen production显示文摘 | Jinhui Yang Hongjian Yan Xiuli Wang Fuyu Wen Zhijun Wang Dayong Fan Jingying Shi Can Li | 2012 | Journal of Catalysis2012，，： | 1 |
| 16 | The impact of free-air CO 2 enrichment (FACE) and nitrogen supply on grain quality of rice显示文摘 | Lianxin Yang Yulong Wang Guichun Dong Hui Gu Jianye Huang Jianguo Zhu Hongjian Yang Gang Liu Yong Han | 2007 | Field Crops Research2007，，2： | 1 |
| 17 | TiO2-g-C3N4 composite materials for photocatalytic H2 evolution under visible light irradiation显示文摘 | YAN Hongjian YANG Haoxin | 2011 | J Alloys Compd2011，509，4： | 1 |
| 18 | Variation Analysis and Robust Fixture Design of a Flexible Fixturing System for Sheet Metal Assembly显示文摘 | Li Bing Yu Hongjian Yang Xiaojun | 2010 | Journal of Computing and Information Science in Engineering2010，132，041014： | 1 |
| 19 | Heat stress on calves and heifers: a review显示文摘The current review is designed with aims to highlight the impact of heat stress(HS) on calves and heifers and to suggest methods for HS alleviation. HS occurs in animals when heat gain from environment and metabolism surpasses heat loss by radiation, convection, evaporation and conduction. Although calves and heifers are comparatively heat resistant due to less production of metabolic heat and more heat dissipation efficiency, they still suffer from HS to some degree. Dry matter intake and growth performance of calves and heifers are reduced during HS because of redistributing energy to heat regulation through a series of physiological and metabolic responses, such as elevated blood insulin and protein catabolism. Enhanced respiration rate and panting during HS accelerate the loss of CO2, resulting in altered blood acid-base chemistry and respiratory alkalosis. HS-induced alteration in rumen motility and microbiota affects the feed digestibility and rumen fermentation. Decreased luteinizing hormone, estradiol and gonadotrophins due to HS disturb the normal estrus cyclicity, depress follicular development, hence the drop in conception rate. Prenatal HS not only suppresses the embryonic development by the impaired placenta, which results in hypoxia and malnutrition, but also retards the growth, immunity and future milk production of newborn calves. Based on the above challenges, we attempted to describe the possible impacts of HS on growth, health, digestibility and reproduction of calves and heifers. Likewise, we also proposed three primary strategies for ameliorating HS consequences. Genetic development and reproductive measures, such as gene selection and embryo transfers, are more likely long-term approaches to enhance heat tolerance. While physical modification of the environment, such as shades and sprinkle systems, is the most common and easily implemented measure to alleviate HS. Additionally, nutritional management is another key approach which could help calves and heifers maintain homeostasis and prevent nutrient deficiencies because of HS. | Jingjun Wang Jinghui Li Fengxia Wang Jianxin Xiao Yajing Wang Hongjian Yang Shengli Li Zhijun Cao | 2020 | Journal of Animal Science and Biotechnology2020，11，4： | 1 |
| 20 | TiO2-g-C3N4 composite materials for photocatalytic H2 evolution under visible light irradiation 显示文摘 | YAN Hongjian YANG Haoxin | 2011 | J Alloy Compd2011，509，4： | 1 |
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