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| 1 | Combination of graphene oxide and platelet-rich plasma improves tendon-bone healing in a rabbit model of supraspinatus tendon reconstruction显示文摘The treatment of rotator cuff tear is one of the major challenges for orthopedic surgeons.The key to treatment is the reconstruction of the tendon-bone interface(TBI).Autologous platelet-rich plasma(PRP)is used as a therapeutic agent to accelerate the healing of tendons,as it contains a variety of growth factors and is easy to prepare.Graphene oxide(GO)is known to improve the physical properties of biomaterials and promote tissue repair.In this study,PRP gels containing various concentrations of GO were prepared to promote TBI healing and supraspinatus tendon reconstruction in a rabbit model.The incorporation of GO improved the ultrastructure and mechanical properties of the PRP gels.The gels containing 0.5 mg/ml GO(0.5 GO/PRP)continuously released transforming growth factor-b1(TGF-b1)and platelet-derived growth factor(PDGF)-AB,and the released TGF-b1 and PDGF-AB were still at high concentrations,1063.451 pg/ml and814.217 pg/ml,respectively,on the 14th day.In vitro assays showed that the 0.5 GO/PRP gels had good biocompatibility and promoted bone marrow mesenchymal stem cells proliferation and osteogenic and chondrogenic differentiation.After 12 weeks of implantation,the magnetic resonance imaging,microcomputed tomography and histological results indicated that the newly regenerated tendons in the 0.5 GO/PRP group had a similar structure to natural tendons.Moreover,the biomechanical results showed that the newly formed tendons in the 0.5 GO/PRP group had better biomechanical properties compared to those in the other groups,and had more stable TBI tissue.Therefore,the combination of PRP and GO has the potential to be a powerful advancement in the treatment of rotator cuff injuries. | Dingsu Bao Jiacheng Sun Min Gong Jie Shi Bo Qin Kai Deng Gang Liu Shengqiang Zeng Zhou Xiang Shijie Fu | 2021 | Regenerative Biomaterials2021，8，6： | 4 |
| 2 | Sonocatalytic hydrogen/hole-combined therapy for anti-biofilm and infected diabetic wound healing显示文摘It is a great challenge to effectively eradicate biofilm and cure biofilm-infected diseases because dense extracellular polymeric substance matrix prevents routine antibacterial agents from penetrating into biofilm.H_(2)is an emerging energy-regulating molecule possessing both high biosafety and high tissue permeability.In this work,we propose a concept of sonocatalytic hydrogen/hole-combined’inside/outside-cooperation’anti-biofilm for promoting bacteria-infected diabetic wound healing based on two-dimensional piezoelectric nanomaterials.Proof-of-concept experiments using C_(3)N_(4)nanosheets as a representative piezoelectric catalyst with wide band gap and high biosafety have verified that sonocatalytically generated H_(2)and holes rapidly penetrate into biofilm to inhibit bacterial energy metabolism and oxidatively deprive polysaccharides/NADH in biofilm to destroy the bacterial membrane/electron transport chain,respectively,inside/outside-cooperatively eradicating biofilm.A bacteria-infected diabetic wound model is used to confirm the excellent in vivo antibacterial performance of sonocatalytic hydrogen/hole-combined therapy,remarkably improving bacteria-infe cted diabetic wound healing.The proposed strategy of sonocatalytic hole/hydrogen-combined’inside/outside-cooperation’will make a highway for treatment of deep-seated biofilm infection. | Qingqing Xu Shengqiang Chen Lingdong Jiang Chao Xia Lingting Zeng Xiaoqing Cai Zhaokui Jin Shucun Qin Wenjiang Ding Qianjun He | 2023 | National Science Review2023，10，5： | 2 |
| 3 | Inflammatory risk stratification individualizes anti-inflammatory pharmacotherapy for acute type A aortic dissection显示文摘The systemic benefits of anti-inflammatory pharmacotherapy vary across cardiovascular diseases in clinical practice.We aimed to evaluate the application of artificial intelligence to acute type A aortic dissection(ATAAD)patients to determine the optimal target population who would benefit from urinary trypsin inhibitor use(ulinastatin).Patient characteristics at admission in the Chinese multicenter 5A study database(2016-2022)were used to develop an inflammatory risk model to predict multiple organ dysfunction syndrome(MODS). | Hong Liu Haiyang Li Lu Han Yingyuan Zhang Ying Wu Liang Hong Jinong Yang Jisheng Zhong Yuqi Wang Dongkai Wu Guoliang Fan Junquan Chen Shengqiang Zhang Xingxing Peng Zhihua Zeng Zhiwei Tang Zhanjie Lu Lizhong Sun Sichong Qian Yongfeng Shao Hongjia Zhang on behalf of the Additive Anti-inflammatory Action for Aortopathy&Arteriopathy(A)Investigators | 2023 | The Innovation2023，4，4： | 0 |
| 4 | A Toarcian Ocean Anoxic Event record from an open-ocean setting in the eastern Tethys: Implications for global climatic change and regional environmental perturbation显示文摘The Early Toarcian“Oceanic Anoxic Event”(T-OAE)is recorded by marked disruption to both the climate system and marine ecosystems.Here,we present intergraded high-resolution carbon-isotope data(δ^(13)C),bulk geochemistry,mineral characterization from an open-ocean setting in the eastern Tethys.With these data,we(1)construct the high-resolution record of the T-OAE from an open-ocean setting in the eastern Tethys;(2)show that the T-OAE in the Sewa succession was marked by coarser-grained deposits associated with high-energy conditions within the otherwise low-energy claystone deposits that likely linked to a globally increased supply of clastic sediments into marginal and deeper marine basin;(3)propose that the low C_(org):P_(total) ratios,in combination with bioturbated structure and depletion or slight enrichment in redox-sensitive trace elements of V,Mo,and U suggest a long-term oxygenation event throughout the T-OAE interval at the Sewa succession,and hence,anoxia may not play a fundamental role during the Toarcian negative CIE in this setting;(4)exhibit that a warming and more humid climate began at the start of the T-OAE,and many episodic changes in sediment provenance throughout the T-OAE interval occurred at this location;and(5)suggest that accumulation of organic-matter sediments during the T-OAE is generally controlled by global climatic changes,but a regional environmental perturbation also might influence the preservation of organic matter. | Xiugen FU Jian WANG Huaguo WEN Chunyan SONG Zhongwei WANG Shengqiang ZENG Xinglei FENG Hengye WEI | 2021 | Science China Earth Sciences2021，64，11： | 0 |
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