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| 1 | Gender associates with both susceptibility to infection and pathogenesis of SARS-CoV-2 in Syrian hamster显示文摘Epidemiological studies of the COVID-19 patients have suggested the male bias in outcomes of lung illness.To experimentally demonstrate the epidemiological results,we performed animal studies to infect male and female Syrian hamsters with SARS-CoV-2.Remarkably,high viral titer in nasal washings was detectable in male hamsters who presented symptoms of weight loss,weakness,piloerection,hunched back and abdominal respiration,as well as severe pneumonia,pulmonary edema,consolidation,and fibrosis.In contrast with the males,the female hamsters showed much lower shedding viral titers,moderate symptoms,and relatively mild lung pathogenesis.The obvious differences in the susceptibility to SARS-CoV-2 and severity of lung pathogenesis between male and female hamsters provided experimental evidence that SARS-CoV-2 infection and the severity of COVID-19 are associated with gender. | Lunzhi Yuan Huachen Zhu Ming Zhou Jian Ma Rirong Chen Yao Chen Liqiang Chen Kun Wu Minping Cai Junping Hong Lifeng Li Che Liu Huan Yu Yali Zhang Jia Wang Tianying Zhang Shengxiang Ge Jun Zhang Quan Yuan Yixin Chen Qiyi Tang Honglin Chen Tong Cheng Yi Guan Ningshao Xia | 2021 | Signal Transduction and Targeted Therapy2021，6，4： | 3 |
| 2 | Improved characteristics and protective efficacy in an animal model of E. coli -derived recombinant double-layered rotavirus virus-like particles显示文摘 | Tingdong Li Haijun Lin Yue Zhang Min Li Daning Wang Yaojian Che Yinbin Zhu Shaowei Li Jun Zhang Shengxiang Ge Qinjian Zhao Ningshao Xia | 2014 | Vaccine2014，，： | 2 |
| 3 | Persisting lung pathogenesis and minimum residual virus in hamster after acute COVID-19显示文摘Dear Editor,Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has infected more than 200 million people,causing coronavirus disease 2019(COVID-19)worldwide.Lungs are the primary target organ of SARS-CoV-2 infection.The mild COVID-19 cases develop symptoms of fever,fatigue,muscle weakness,chest pain,headache and cough(Chen et al.,2020;Wang et al.,2020;Zhu et al.,2020),while severe COIVD-19 cases might have pneumonia,breathing difficulties,multiple organ failure and death(Chen et al.,2020;Wang et al.,2020;Zhu et al.,2020).Both the clinicians and researchers have largely focused on the acute phase of COVID-19,but the long-term health consequences of the COVID-19 patients after clinical recovery remain less investigated.Several clinical cohorts demonstrated that some patients discharged from hospital still experience symptoms including fatigue,muscle weakness,chest pain,cough and breathing difficulties(Carfi et al.,2020;Lim et al.,2020;Huang et al.,2021).Moreover,severely impaired pulmonary diffusion capacities and abnormal chest imaging manifestations were observed in some convalescent patients(Huang et al.,2021).Surprisingly,residual virus(An et al.,2020;Yao et al.,2020;Kim et al.,2021)were detected in some convalescent patients. | Lunzhi Yuan Huachen Zhu Ming Zhou Jian Ma Rirong Chen Liuqin Yu Wenjia Chen Wenshan Hong Jia Wang Yao Chen Kun Wu Wangheng Hou Yali Zhang Shengxiang Ge Yixin Chen Quan Yuan Qiyi Tang Tong Cheng Yi Guan Ningshao Xia | 2022 | Protein & Cell2022，13，1： | 1 |
| 4 | Swine as a Principal Reservoir of Hepatitis E Virus That Infects Humans in Eastern China 显示文摘 | Yingjie Zheng Shengxiang Ge Ningshao Xia | 2006 | The Journal of Infectious Diseases2006，193，： | 1 |
| 5 | Development of a fluorescent probe hydrolysis-insulated isothermal PCR for rapid and sensitive on-site detection of African swine fever virus显示文摘Dear Editor,African swine fever virus(ASFV),the sole member of the family Asfarviridae,is the causative agent of African swine fever(ASF),a viral disease that leads to high mortality in domestic pigs.Since firstly identified in Kenya in the 1920s,ASFV has been prevalent in Africa,Europe,and Russian Federation(Sanchez et al.,2019).Recently,ASFV was introduced to Asian countries including China,Mongolia,Vietnam,Cambodia,Laos and South Korea,which lead to huge economic losses to local pig industries(Li and Tian,2018;Gaudreault and Richt,2019).The first case of ASFV in China was reported in August 2018(Zhou et al.,2018). | Tianli Zou Junhua Deng Xiangdong Li Shiyin Zhang Lingyan Chen Liying Hao Jinshan Zhuang Heng Wang Guihong Zhang Shengxiang Ge Kegong Tian | 2022 | Virologica Sinica2022，37，3： | 0 |
| 6 | Low-Carbon Routing Based on Improved Artificial Bee Colony Algorithm for Electric Trackless Rubber-Tyred Vehicles显示文摘Trackless rubber-tyerd vehicles are the core equipment for auxiliary transportation in inclined-shaft coal mines,and the rationality of their routes plays the direct impact on operation safety and energy consumption.Rich studies have been done on scheduling rubber-tyerd vehicles driven by diesel oil,however,less works are for electric trackless rubber-tyred vehicles.Furthermore,energy consumption of vehicles gives no consideration on the impact of complex roadway and traffic rules on driving,especially the limited cruising ability of electric trackless rubber-tyred vehichles(TRVs).To address this issue,an energy consumption model of an electric trackless rubber-tyred vehicle is formulated,in which the effects from total mass,speed profiles,slope of roadways,and energy management mode are all considered.Following that,a low-carbon routing model of electric trackless rubber-tyred vehicles is built to minimize the total energy consumption under the constraint of vehicle avoidance,allowable load,and endurance power.As a problem-solver,an improved artificial bee colony algorithm is put forward.More especially,an adaptive neighborhood search is designed to guide employed bees to select appropriate operator in a specific space.In order to assign onlookers to some promising food sources reasonably,their selection probability is adaptively adjusted.For a stagnant food source,a knowledge-driven initialization is developed to generate a feasible substitute.The experimental results on four real-world instances indicate that improved artificial bee colony algorithm(IABC)outperforms other comparative algorithms and the special designs in its three phases effectively avoid premature convergence and speed up convergence. | Yinan Guo Yao Huang Shirong Ge Yizhe Zhang Ersong Jiang Bin Cheng Shengxiang Yang | 2023 | Complex System Modeling and Simulation2023，3，3： | 0 |
| 7 | Infection,pathology and interferon treatment of the SARS-CoV-2 Omicron BA.1 variant in juvenile,adult and aged Syrian hamsters显示文摘The new predominant circulating SARS-CoV-2 variant,Omicron,can robustly escape current vaccines and neutralizing antibodies.Although Omicron has been reported to have milder replication and disease manifestations than some earlier variants,its pathogenicity in different age groups has not been well elucidated.Here,we report that the SARS-CoV-2 Omicron BA.1 sublineage causes elevated infection and lung pathogenesis in juvenile and aged hamsters,with more body weight loss,respiratory tract viral burden,and lung injury in these hamsters than in adult hamsters.Juvenile hamsters show a reduced interferon response against Omicron BA.1 infection,whereas aged hamsters show excessive proinflammatory cytokine expression,delayed viral clearance,and aggravated lung injury.Early inhaled IFN-α2b treatment suppresses Omicron BA.1 infection and lung pathogenesis in juvenile and adult hamsters.Overall,the data suggest that the diverse patterns of the innate immune response affect the disease outcomes of Omicron BA.1 infection in different age groups. | Lunzhi Yuan Huachen Zhu Peiwen Chen Ming Zhou Jian Ma Xuan Liu Kun Wu Rirong Chen Qiwei Liu Huan Yu Lifeng Li Jia Wang Yali Zhang Shengxiang Ge Quan Yuan Qiyi Tang Tong Cheng Yi Guan Ningshao Xia | 2022 | Cellular & Molecular Immunology2022，19，12： | 0 |
| 8 | New discovery of high-affinity SARS-CoV-2 spike S2 protein binding peptide selected by PhIP-Seq显示文摘Dear Editor,Theworld had suffered pandemics of COVID-19 caused by SARS-CoV-2.At the time ofwriting,COVID-19 is still widely spreading inmany countries and regions,and by June 14,2022,totally 532,887,351 cases,including 6,307,021 deaths,were reported globally(WHO,http://gffzze7c39cdc9e894ca6sp9ubv0xqqp0o60uk.ffgz.tsg.suse.edu.cn/table).Powerful measures,such as prophylactic and therapeutic interventions against the virus,are in urgent need for COVID-19 control and prevention.The spike protein,which is expressed on the virus surface,is the key determinant of viral-host interaction(Ng et al.,2021)and mediates the virus entry. | Mengyuan Chen Shuizhen He Hualong Xiong Dongxu Zhang Shaojuan Wang Wangheng Hou Xiaomei Zhu Jin Wang Yang Huang Congming Hong Yubin Wu Ruoyao Qi Tianying Zhang Quan Yuan Tingdong Li Yixin Chen Shiyin Zhang Shengxiang Ge Jun Zhang Ningshao Xia | 2022 | Virologica Sinica2022，37，5： | 0 |
| 9 | Nanoparticle-based multivalent human antibodies offer potent and broad neutralization against Omicron sublineages显示文摘Dear Editor As of January 2023,coronavirus disease 2019(COVID-19)induced by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has caused more than 6.7 million deaths,with SARS-CoV-2 variants continuing to alter the trajectory of the COVID-19 pandemic.Indeed,the prevalence of the newly emergent Omicron sublineages,particularly BA.4/5 and XBB,has highlighted the critical need for the design and production of broadly potent neutralization antibodies to efficiently combat SARS-CoV-2 variants.Neutralizing antibodies(nAbs)XMA01,XMA04,and XMA09,which target noncompeting antigenic sites in RBD(receptor binding domain),exhibit high neutralization potency against earlier disease variants(Supplementary Fig.1a–d),as previously reported by us. | Yizhen Wang Feibo Song Siling Wang Miaolin Lan Tingdong Li Huilin Guo Yali Zhang Shengxiang Ge Zizheng Zheng Ningshao Xia | 2023 | Signal Transduction and Targeted Therapy2023，8，9： | 0 |
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