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| 1 | Diagnosis and therapy of primary undifferentiated embryonal sarcoma of the liver显示文摘Primary undifferentiated embryonal sarcoma (UES)of the liver,also called malignant mesenchymoma of the liver,is a rare hepatic malignancy.It arises from the mesoderm and comprises more than two types of sarcomas.UES can occur at any site of the body;common sites include the retroperitoneum and the lower extremities.Only a few cases of UES have been reported worldwide.1 In this study,we retrospectively examined the clinical data of 11 patients with UES between January 2000 and November 2011 at the People's Liberation Army General Hospital. | Lyu Shaocheng Shi Xianjie Liang Yurong Gu Wanqing Ji Wenbin Luo Ying Lu Fang Xu Mingyue | 2014 | Chinese Medical Journal2014，，8： | 7 |
| 2 | Physicochemical and tribological properties of gemini-type halogen-free dicationic ionic liquids显示文摘A series of new halogen-free dicationic ionic liquids(ILs)with different alkyl chain lengths were prepared,and the relationship between the alkyl chain length,physicochemical and tribological properties of ILs,and their role as neat lubricant for steel–steel friction pairs,was investigated.Evaluation of stability during hydrolysis and copper strip corrosion test results show that synthetic ILs are stable and not corrosive to metal contacts,due to the halogen-free anions.The friction and wear test results indicate that ILs with long alkyl chains have excellent friction-reducing and anti-wear properties,especially at high temperatures.Based on the surface three-dimensional(3D)profiles,electrical contact resistance,scanning electron microscopy(SEM),energy dispersive X-ray spectroscopy(EDS),and the X-ray photoelectron spectrometry(XPS)analysis of the worn surfaces of steel discs,we can conclude that the efficiency of ILs is due to the formation of high quality tribofilms that consist of both tribochemical reaction and ordered absorption films. | Qiangliang YU Chaoyang ZHANG Rui DONG Yijun SHI Yurong WANG Yanyan BAI Jiaying ZHANG Meirong CAI Feng ZHOU Weimin LIU | 2021 | Friction2021，9，2： | 3 |
| 3 | Epithelial-Mesenchymal Transitions and the Expression of Twist in MCF-7/ADR, Human Multidrug-Resistant Breast Cancer Cells显示文摘0BJECTIVE To study the expression levels of Twist and epithelialmesenchymal transitions in multidrug-resistant MCF-7/ADR breast cancer cells, and to study the relationship between multidrug resistance (MDR) and metastatic potential of the cells. METHODS RT-PCR, immunohistochemical and Western blotting methods were used to examine the changes of expression levels of the transcription factor Twist, E-cadherin and N-cadherin in the MCF-7 breast cancer cell line and its multidrug-resistant variant, MCF-7/ADR. RESULTS In MCF-7 cells, the expression of E-cadherin can be detected, but there is no expression of Twist or N-cadherin. In MCF-7/ADR cells, E-cadherin expression is lost, but the expression of two other genes was significantly positive. CONCLUSION Epithelial-mesenchymal transitions induced by Twist, may have a relationship with enhanced invasion and metastatic potential during the development of multidrug-resistant MCF-7/ADR breast cancer cells. | Fei Zhang Yurong Shi Lin Zhang Bin Zhang Xiyin Wei Yi Yang Rui Wang Ruifang Niu | 2007 | Chinese Journal of Clinical Oncology2007，4，1： | 2 |
| 4 | Synthesis and characterization of YNbTiO 6 :Dy 3+ phosphor显示文摘 | Yurong Shi Yuhua Wang Zhigang Yang | 2010 | Journal of Alloys and Compounds2010，，6： | 1 |
| 5 | A novel red phosphor Ca12Al14O32Cl2:Eu3+for near UV white light emitting diodes显示文摘 | YANG Zhigang ZHAO Zhengyan SHI Yurong | 2013 | Materials Research Bulletin2013，48，： | 1 |
| 6 | Simulta- neous determination of positional isomers of benzene- diols by capillary zone electrophoresis with square wave amperometric detection 显示文摘 | Xie Tianyao Liu Qiwen Shi Yurong | 2006 | J Chromatogr A2006，1109，2： | 1 |
| 7 | Novel synthesis method of YAG:Ce3+micron-sized powders and its luminescence properties显示文摘 | DING Xin SHI Yurong ZHU Ge | 2014 | Materials Chemistry and Physics2014，147，： | 1 |
| 8 | Tunable magneto-Seebeck effect in Co_(2)FeSi/MgO/Co_(2)FeSi heterostructure via optimized interfacial engineering显示文摘Enhancing the tunneling magneto-Seebeck(TMS) ratio and uncovering its underlying mechanism are greatly demanded in spin caloritronics.The magnitude and sign of the TMS effect depend on the type of atom and the stacking order of atoms at the interfaces.Herein,we demonstrate that TMS ratios can be effectively manipulated by altering heterogonous or homogeneous interface through decoration on the CoFeSi(001) surface inserted on the MgO insulating layers.The maximum TMS ratio of pure Co_(2)/O termination is 4565% at 800 K.Notably,the TMS ratio of the FeSi/O termination has two peak values,of which the maximum could reach up to-3290% at 650 K.By comparing two different atom arrangements at the interface,we reveal that the sign and symbol of the TMS ratio can be controlled by the temperature and different atomic configurations at the Co_(2)FeSi/MgO interface.Furthermore,the spin-Seebeck coefficient up to ~150 μV/K is also possible when we select suitable terminations and temperatures.These findings will provide useful insights into how to control the sign and symbol of the TMS ratio and accordingly stimulate the development field of magneto-thermoelectric power and spin caloritronic devices based on the magneto-Seebeck effect in Heusler-based metallic multilayers. | Jingyu Li Xianbiao Shi Yurong Jin Le Ma Liuming Wei Chi Zhang Hang Li Peng-Fei Liu | 2024 | Science China(Physics,Mechanics & Astronomy)2024，67，3： | 0 |
| 9 | Synthesis of size-controlled hollow Fe3O4 nanospheres and their growth mechanism显示文摘Size-controlled hollow Fe3O4 nanospheres were synthesized via a one-pot hydrothermal method as a function of reaction time and sodium citrate,polyacrylamide,and urea content.Multiple characterization techniques such as scanning and transmission electron microscopy and Raman spectroscopy were employed to investigate the crystal structure and morphology of the obtained nanospheres.The Fe3O4 nanosphere formation mechanism was elucidated from analyzing the characterization data.High levels of sodium citrate and longer reaction times were observed to increase the diameter of the nanospheres until hollow structures formed.Furthermore,polyacrylamide and urea promoted the formation of hollow structures.The hollow-structured Fe3O4 nanospheres exhibited high magnetization saturation values in the range of 48.8-58.7 emu/g.The facile synthesis method described herein,to generate size-controlled Fe3O4 nanospheres with tailored properties,demonstrates potential across a wide range of fields from drug-delivery and stealth devices,to environmental and energy applications. | Lei Shi Yurong He Yanwei Hu Xinzhi Wang Baocheng Jiang Yimin Huang | 2020 | Particuology2020，18，2： | 0 |
| 10 | Bio-inspired Recyclable Carbon Interface for Solar Steam Generation显示文摘Solar power,as one of renewable energy,holds potential application for producing steam which relies on high-temperature liquid by traditional methods.Herein,steam was generated by a bio-inspired strategy derived from the plants transpiration using a Printed Recyclable Carbon Membrane(PRCM).The membrane structure facilitated the concentration of carbon particles for the photoreaction and the heat generation for water evaporation,thereby improving the photo-thermal conversion efficiency.The PRCM achieved the best steady evaporation efficiency of 51.9%,which was 5.6 times higher than the value for water and recycling tests were demonstrated.The carbon particles were separated from the water under the magnetism action,a convenient approach that avoided secondary pollution resulting from the disintegration of the PRCM.Rapid preparation,low cost,and reusability of the printed carbon membrane allow for photo-thermal applications such as solar steam generation and seawater desalination. | Lei Shi Xinzhi Wang Yanwei Hu Yurong He Yuying Yan | 2020 | Journal of Bionic Engineering2020，17，2： | 0 |
| 11 | Cathepsin B S-nitrosylation promotes ADAR1-mediated editing of its own mRNA transcript via an ADD1/MATR3 regulatory axis显示文摘Genetic information is generally transferred from RNA to protein according to the classic“Central Dogma”.Here,we made a striking discovery that post-translational modification of a protein specifically regulates the editing of its own mRNA.We show that S-nitrosylation of cathepsin B(CTSB)exclusively alters the adenosine-to-inosine(A-to-I)editing of its own mRNA.Mechanistically,CTSB S-nitrosylation promotes the dephosphorylation and nuclear translocation of ADD1,leading to the recruitment of MATR3 and ADAR1 to CTSB mRNA.ADAR1-mediated A-to-I RNA editing enables the binding of HuR to CTSB mRNA,resulting in increased CTSB mRNA stability and subsequently higher steady-state levels of CTSB protein.Together,we uncovered a unique feedforward mechanism of protein expression regulation mediated by the ADD1/MATR3/ADAR1 regulatory axis.Our study demonstrates a novel reverse flow of information from the post-translational modification of a protein back to the post-transcriptional regulation of its own mRNA precursor.We coined this process as“Protein-directed EDiting of its Own mRNA by ADAR1(PEDORA)”and suggest that this constitutes an additional layer of protein expression control.“PEDORA”could represent a currently hidden mechanism in eukaryotic gene expression regulation. | Zhe Lin Shuang Zhao Xuesong Li Zian Miao Jiawei Cao Yurong Chen Zhiguang Shi Jia Zhang Dongjin Wang Shaoliang Chen Liansheng Wang Aihua Gu Feng Chen Tao Yang Kangyun Sun Yi Han Liping Xie Hongshan Chen Yong Ji | 2023 | Cell Research2023，33，7： | 0 |
| 12 | Impacts of CMEs on Earth Based on Logistic Regression and Recommendation Algorithm显示文摘Coronal mass ejections(CMEs)are one of the major disturbance sources of space weather.Therefore,it is of great significance to determine whether CMEs will reach the earth.Utilizing the method of logistic regression,we first calculate and analyze the correlation coefficients of the characteristic parameters of CMEs.These parameters include central position angle,angular width,and linear velocity,which are derived from the Large Angle and Spectrometric Coronagraph(LASCO)images.We have developed a logistic regression model to predict whether a CME will reach the earth,and the model yields an F1 score of 30%and a recall of 53%.Besides,for each CME,we use the recommendation algorithm to single out the most similar historical event,which can be a reference to forecast CMEs geoeffectiveness forecasting and for comparative analysis. | Yurong Shi Jingjing Wang Yanhong Chen Siqing Liu Yanmei Cui Xianzhi Ao | 2022 | Space(Science & Technology)2022，，1： | 0 |
| 13 | Down-Regulation of CXCR4 Expression by siRNA Inhibits Invasive Ability of Breast Cancer Cells显示文摘OBJECTIVE To investigate the efficiency of gene silencing by CXCR4- siRNAs (small interfering RNA), and to examine the invasive ability and the expression of other metastatic-associated genes in siRNA-treated breast cancer cells. METHODS Three siRNAs were designed and cloned into the pSilenc ? 3.1-H1 neo vector. The reconstructed plasmids were purified and trans- fected into the T47D breast cancer cell line, which highly expressed CXCR4. The amount of CXCR4 expression in the transfected cells was measured by flow cytometry and Real-time PCR. Cell invasive ability was evaluated us- ing 24-well Matrigel invasion chambers. In addition, the expression of other metastatic-associated genes, such as E-cad, IGFBP-5, FN and MMP-2, was assessed by Real-time PCR. RESULTS The suppression rates of CXCR4 mRNA expression reached 95.7%, 85.9% and 98.3%compared with control-siRNA cells in the 3 CXCR4- siRNA T47D cells respectively. FCM assays for CXCR4 protein expression showed a similar inhibitory effect. The invasion indexes of these CXCR4- siRNA cells were 0.037, 0.290 and 0.188 respectively compared with control- siRNA cells. After treatment of the cells with CXCR4-siRNA, the expression of E-cad showed an upward tendency and that of IGFBP-5 had a downward trend, while alteration in expression of FN and MMP2 varied without a con- sistant effect. CONCLUSION CXCR4 plays an important role in modulating migra- tion of human breast cancer cells. Small interfering RNA can significantly silence the CXCR4 gene in the human T47D breast cancer cell line. The results of this study strengthen the need for further research on novel gene therapy against breast cancer metastasis. | Lin Zhang Rui Wang Yurong Shi Yi Yang Xiyin Wei Zhi Yao Ruifang Niu | 2007 | Chinese Journal of Clinical Oncology2007，4，4： | 0 |
| 14 | The Effect of Twist Expression on Angiogenesis in Hepatocellular Carcinoma显示文摘OBJECTIVE Hepatocellular carcinoma (HCC) is a hypervascular tumor for which angiogenesis plays an important role in its progression. The aim of this study was to investigate the expression of TWIST and VEGF and determine their roles in angiogenesis of HCC. METHODS Expression Twist and VEGF mRNA was determined by real-time RT-PCR in 30 pairs of hepatocellular carcinoma and matched non-cancerous tissues. Immunohistochemistry was carried out to analyze the protein expression of Twist and VEGF in 40 hepatocellular carcinoma cases. Staining of endothelial cells for CD34 was used to evaluate the microvessel density (MVD). RESULTS We found that the HCC specimens showing positive Twist expression in tumor cells had a higher microvessel density than those without Twist expression. Furthermore, we found that overexpression of the Twist protein positively correlated with up-regulation of VEGF in the HCC tissues (r=0.479, P=0.002). CONCLUSION Our results demonstrate that Twist may play an important role in the angiogenesis of HCC and a high-level of Twist expression may be related to the malignant potential of tumor cells. | Gangmin Xi Lin Zhang Zhongli Zhan Lihua Zhang Xiyin Wei Yi Yang Yurong Shi Fei Zhang Ruifang Niu | 2006 | Chinese Journal of Clinical Oncology2006，3，6： | 0 |
| 15 | Proteasome Inhibitors Sensitize Hepatocellular Carcinoma Cells to TRAIL显示文摘OBJECTIVE To investigate the effect of proteasome inhibition on the sensitivity of carcinoma cells to TRAIL-inducing apoptosis, and to study the mechanism of the response. METHODS Human hepatocellular carcinoma cells, pretreated with the proteasome inhibitor, MG132, were cotreated with TRAIL. Western blot assays, immunoprecipitation and RT-PCR were performed to test the expression of the Bcl-2 family proteins and Bax mRNA. RESULTS We found that (i) proteasome inhibition sensitized the human hepatocellular carcinoma cells to TRAIL; and (ii) resulted in Bax accumulation before release of cytochrome C and induction of apoptosis. These results were associated with the ability of proteasome inhibitors to overcome Bcl-2-mediated antiapoptotic function; (iii) Bax is regulated by an ubiquitin/proteasome-dependent degradation pathway. CONCLUSION Proteasome inhibition sensitized hepatocellular carcinoma cells to TRAIL by the inhibition of the ubiquitin/proteasome-mediated Bax degradation pathway. | Qingfeng Sheng Yurong Shi Qiang Li Jihui Hao Ruifang Niu Xiyin Wei Yi Yang Lin Zhang | 2006 | Chinese Journal of Clinical Oncology2006，3，6： | 0 |
| 16 | Physical and Mechanical Properties of Catalpa bungei Clones and Estimation of the Properties by Near-Infrared Spectroscopy显示文摘Air-dry density,modulus of rupture(MOR),modulus of elasticity(MOE),compressive strength parallel to grain,and hardness of Catalpa bungei clones were investigated in this study with feasibility of predicting these properties by near infrared(NIR)spectroscopy.The best candidate Luoqiu 3'has been selected from three clones based on wood physical and mechanical property indices.Lower values of wood physical and mechanical properties have been found in the corewood compared to the outerwood.There were significant positive correlations between the air-dry density and mechanical properties.Information from Cross section for air dry density,compressive strength parallel to grain,and hardness yielded prediction models with better effects,along with the best MOR and MOE modeling effects resulted from average sections'spectra collection.Multiplicative scatter correction(MSC)+Savitzky-Golay(S-G)smoothing method has been proved to be the most applicable way.In addition,the predictions from five point sampling method were slightly better than three point one.Overall,results suggest NIR spectroscopy was viable to predict the physical and mechanical properties of C bungei dones with methods developed in this study proved effective in preliminary screening. | Rui Wang Lanlan Shi Yurong Wang | 2022 | Journal of Renewable Materials2022，10，12： | 0 |
| 17 | RNA sequencing-based optimization of biological lipid droplets for sonodynamic therapy to reverse tumor hypoxia and elicit robust immune response显示文摘Mitochondria-targeted sonodynamic therapy(SDT)is a promising strategy to inhibit tumor growth and activate the anti-tumor immune responses.Identifying the mechanisms underlying mitochondria-targeted SDT,further optimizing its efficacy,developing novel sonosensitizer carriers with good biocompatibility pose major challenges to the clinical practice of SDT.In this study,we investigated the mechanisms of mitochondria-targeted SDT and demonstrated that it suppressed the mitochondrial electron transport chain(ETC)in pancreatic cancer cells through RNA-sequencing analysis.Based on these findings,we constructed the functional lipid droplets(LDs)(CPI-613/IR780@LDs),which combined mitochondria-targeted SDT with the tricarboxylic acid(TCA)cycle inhibitor CPI-613.CPI-613/IR780@LDs synergistically inhibited the TCA cycle and the ETC of mitochondrial aerobic respiration to reduce oxygen consumption and increase reactive oxygen species(ROS)generation at the tumor site,thus enhancing the efficacy of SDT in hypoxic pancreatic cancer.Moreover,the combination of mitochondria-targeted SDT and anti-PD-1 antibody exhibited excellent tumor inhibition and activated anti-tumor immune responses by increasing tumorinfiltrating CD8+T cells and reducing regulatory T cells,synergistically arresting the growth of both primary and metastatic pancreatic tumors.Meanwhile,lipid droplets are cell-derived biological carriers with natural mitochondrial targeting ability and can achieve efficient hydrophobic drug loading through active phagocytosis.Therefore,the functional lipid droplet-based SDT combined with anti-PD-1 antibody holds great potential in the clinical treatment of hypoxic pancreatic cancer. | Zhan Shi Xue Wang Jiali Luo Yiqing Zeng Qing Wen Yurong Hong Tao Zhang Pintong Huang | 2023 | Nano Research2023，16，5： | 0 |
| 18 | Flexible radio-frequency micro electro-mechanical switch towards the applications of satellite communications显示文摘This paper presents a flexible radio-frequency microelectromechanical system(RF MEMS)switch integrated on cyclo-olefin polymer(COP)substrate using a modified surface MEMS processing technology,which could be used in the 17-19 GHz frequency band of satellite communication.Through systematic simulation analysis,it is found that flexible RF MEMS switch can achieve certain bending radius by miniaturizing the electronic dimension,without degrading the RF performance.It is demonstrated that the RF characteristics of flexible RF MEMS switch with special anchor structural design,fabricated by modified surface MEMS processing,are not sensitive to bending deformation under the curvature of 0 mm^(-1),0.05 mm^(-1),0.10 mm^(-1).Furthermore,the range of bending curvature which will affect the RF characteristics is given through systematic simulation.The flexible RF MEMS switch with high process compatibility and stable RF performance is believed to be promising candidates for future microwave communications and other consumer electronics. | Yingli Shi Chao Zhou Zibo Cao Yurong He Jingwen Guo Chunxin Li Qianhong Wu Kui Liang Yanzhao Li Yuan Lin | 2022 | npj Flexible Electronics2022，6，1： | 0 |
| 19 | Screening a Novel Human Breast Cancer- Associated Antigen from a cDNA Expression Library of Breast Cancer显示文摘 | Shuhua Yang Lin Zhong Ruifang Niu Defa Wang Yurong Shi Xiyin Wei Yi Yang | 2005 | Chinese Journal of Clinical Oncology2005，2，5： | 0 |
| 20 | Clonal Analysis of Peripheral Papilloma and Cancerous Cells of the Breast显示文摘OBJECTIVE Because almost al malignancies represent monoclonal proliferations,we have studied the clonal status of peripheral papil omas (peri-PM),ductal carcinomas in situ(DCIS),and normal breast tissues to explore a reliable way to distinguish benign and malignant(or pre-malignant) cases previously diagnosed morphologically. METHODS Twenty-six cases of peri-PM,25 cases of peri-PM with atypical ductal hyperplasia(ADH),27 cases of DCIS,16 cases of developed canceration and 20 specimens of normal tissue were examined in the study.The clonal status of these tissues was studied using an assay based on inactivation mosaicism of the lenth-polymorphic X-chromosomes at the androgen receptor(AR)locus. RESULTS Loss of polymorphism at the AR locus was found in all DCIS cases and 10 cases(10/25,40.0%)of peri-PM with ADH,indicating the monoclonality of the tumors.Twenty-four out of 26(92.3%)cases with peri-PM and 19 specimens of normal tissue were shown to be polyclonal.In 16 cases of developed canceration,identical X chromosome inactivation(monoclonal alterations)was observed from both the peri-PM with ADH part,and the DCIS part in each case. CONCLUSION These results contribute to the understanding of the genetic changes of peri-PM,and confirm the peri-PM withADH as a precancerous lesion of the breast.Clonal analysis might be a useful modality to screen high-risk cases from precancerous lesions or to distinguish between benign hyperplasia and early carcinoma. | Qi Yu Yun Niu Yong Yu Xiumin Ding Yurong Shi | 2007 | Chinese Journal of Clinical Oncology2007，4，6： | 0 |
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