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| 1 | Diagnosis and Treatment of Keloids and Hypertrophic Scars—Japan Scar Workshop Consensus Document 2018显示文摘There has been a long-standing need for guidelines on the diagnosis and treatment of keloids and hypertrophic scars that are based on an understanding of the pathomechanisms that underlie these skin fibrotic diseases.This is particularly true for clinicians who deal with Asian and African patients because these ethnicities are highly prone to these diseases.By contrast,Caucasians are less likely to develop keloids and hypertrophic scars,and if they do,the scars tend not to be severe.This ethnic disparity also means that countries vary in terms of their differential diagnostic algorithms.The lack of clear treatment guidelines also means that primary care physicians are currently applying a hotchpotch of treatments,with uneven outcomes.To overcome these issues,the Japan Scar Workshop(JSW)has created a tool that allows clinicians to objectively diagnose and distinguish between keloids,hypertrophic scars,and mature scars.This tool is called the JSW Scar Scale(JSS)and it involves scoring the risk factors of the individual patients and the affected areas.The tool is simple and easy to use.As a result,even physicians who are not accustomed to keloids and hypertrophic scars can easily diagnose them and judge their severity.The JSW has also established a committee that,in cooperation with outside experts in various fields,has prepared a Consensus Document on keloid and hypertrophic scar treatment guidelines.These guidelines are simple and will allow even inexperienced clinicians to choose the most appropriate treatment strategy.The Consensus Document is provided in this article.It describes(1)the diagnostic algorithm for pathological scars and how to differentiate them from clinically similar benign and malignant tumors,(2)the general treatment algorithms for keloids and hypertrophic scars at different medical facilities,(3)the rationale behind each treatment for keloids and hypertrophic scars,and(4)the body site-specific treatment protocols for these scars.We believe that this Consensus Document will be helpful for physicians from all over the world who treat keloids and hypertrophic scars. | Rei Ogawa Sadanori Akita Satoshi Akaishi Noriko Aramaki-Hattori Teruyuki Dohi Toshihiko Hayashi Kazuo Kishi Taro Kono Hajime Matsumura Gan Muneuchi Naoki Murao Munetomo Nagao Keisuke Okabe Fumiaki Shimizu Mamiko Tosa Yasuyoshi Tosa Satoko Yamawaki Shinichi Ansai Norihisa Inazu Toshiko Kamo Reiko Kazki Shigehiko Kuribayashi | 2019 | Burns & Trauma2019，7，1： | 31 |
| 2 | Promoted differentiation of cynomolgus monkey ES cells into hepatocyte-like cells by co-culture with mouse fetal liver-derived cells显示文摘AIM: To explore whether a co-culture of cynomolgus monkey embryonic stem (cES) cells with embryonic liver cells could promote their differentiation into hepatocytes. METHODS: Mouse fetal liver-derived cells (MFLCs) were prepared as adherent cells from mouse embryos on embryonic d (ED) 14, after which undifferentiated cES cells were co-cultured with MFLCs. The induction of cES cells along a hepatic lineage was examined in MFLC- assisted differentiation, spontaneous differentiation, and growth factors (GF) and chemicals-induced differentiations (GF-induced differentiation) using retinoic acid, leukemia inhibitory factor (LIF), FGF2, FGF4, hepatocyte growth factor (HGF), oncostatin M (OSM), and dexamethasone. RESULTS: The mRNA expression of α-fetoprotein, albumin (ALB), α-1-antitrypsin, and hepatocyte nuclear factor 4α was observed earlier in the differentiating cES cells co-cultured with MFLCs, as compared to cES cells undergoing spontaneous differentiation and those subjected to GF-induced differentiation. The expression of cytochrome P450 7a1, a possible marker for embryonic endoderm-derived mature hepatocytes, was only observed in cES cells that had differentiated in a co-culture with MFLCs. Further, the disappearance of Oct3/4, a representative marker of an undifferentiated state, was noted in cells co-cultured with MFLCs, but not in those undergoing spontaneous or GF-induced differentiation. Immunocytochemical analysis revealed an increased ratio of ALB-immunopositive cells among cES cells co-cultured with MFLCs, while glycogen storageand urea synthesis were also demonstrated. CONCLUSION: MFLCs showed an ability to induce cES cells to differentiate toward hepatocytes. The co-culture system with MFLCs is a useful method for induction of hepatocyte-like cells from undifferentiated cES cells. | Ko Saito Masahide Yoshikawa Yukiteru Ouji Kei Moriya Mariko Nishiofuku Shigehiko Ueda Noriko Hayashi Shigeaki Ishizaka Hiroshi Fukui | 2006 | World Journal of Gastroenterology2006，12，42： | 11 |
| 3 | Evaluation of a strawberry-harvesting robot in a field test显示文摘 | Shigehiko Hayashi Kenta Shigematsu Satoshi Yamamoto Ken Kobayashi Yasushi Kohno Junzo Kamata Mitsutaka Kurita | 2009 | Biosystems Engineering2009，，2： | 4 |
| 4 | Robotic harvesting system for eggplants 显示文摘 | Shigehiko HAYASHI Katsunobu GANNO Yukit- sugu ISHII | 2002 | JARQ2002，36，3： | 1 |
| 5 | Robotic harvesting system for eggplants显示文摘 | Shigehiko Hayashi Katsunobu Ganno Yukitsugu Ishii | 2002 | JARQ2002，36，3： | 1 |
| 6 | Evaluation of a strawberry-harvesting robot in a field test 显示文摘 | Shigehiko Hayashi Kenta Shigematsu Satoshi Yamamoto | 2010 | Biosystems Engineering2010，105，2： | 1 |
| 7 | Evaluation of a strawberry-harvesting robot in a field test显示文摘 | Shigehiko Hayashi Kenta Shigematsu Satoshi Yamamoto Ken Kobayashi Yasushi Kohno Junzo Kamata Mitsutaka Kurita | 2009 | Biosystems Engineering2009，，2： | 1 |
| 8 | EXPRESSION OF UROKINASE-TYPE PLASMINOGEN ACTIVATOR, UROKINASE-TYPE PLASMINOGEN ACTIVATOR RECEPTOR AND PLASMINOGEN ACTIVATOR INHIBITORS IN PATIENTS WITH RENAL CELL CARCINOMA: CORRELATION WITH TUMOR ASSOCIATED MACROPHAGE AND PROGNOSIS显示文摘 | KOJIRO OHBA YASUYOSHI MIYATA SHIGERU KANDA SHIGEHIKO KOGA TOMAYOSHI HAYASHI HIROSHI KANETAKE | 2005 | The Journal of Urology2005，，2： | 1 |
| 9 | Robotic harvesting system for eggplants 显示文摘 | Shigehiko Hayashi Katsunobu GANNO Yukitsugu ISHII | 2002 | JARQ2002，36，3： | 1 |
| 10 | Evaluation of a strawberry-harvesting robot in a field test显示文摘 | Shigehiko Hayashi Kenta Shigematsu Satoshi Yamamoto | | 0，，02： | 1 |
| 11 | Evaluation of a strawberryharvesting robot in a field test显示文摘 | Shigehiko Hayashi Kenta Shigematsxi | 2010 | Biosystems Engineering2010，105，2： | 1 |
| 12 | Emissions in combustion of lean methane-air and biomass-air mixtures supported by primary hot burned gas in a multi-stage gas turbine combustor显示文摘 | Sadamasa Adachi Atushi Iwamoto Shigeru Hayashi Hideshi Yamada Shigehiko Kaneko | 2006 | Proceedings of the Combustion Institute2006，，2： | 1 |
| 13 | Robotic harvesting system for eggplants显示文摘 | Shigehiko Hayashi Katsunobu Ganno Yukitsugu Ishii | 2002 | JARQ2002，36，3： | 1 |
| 14 | Robotic harvesting system for eggplants 显示文摘 | Shigehiko Hayashi Katsunobu Ganno Yukitsugu Ishii | 2002 | Japan Agricultural Research Quarterly2002，36，3： | 1 |
| 15 | Robotic harvesting system for eggplants 显示文摘 | Shigehiko Hayashi Katsunobu Ganno Yukitsugu Ishii | 2002 | JARQ2002，36，3： | 1 |
| 16 | Robotic harvesting system for eggplants显示文摘 | Shigehiko Hayashi Katsunobu Ganno Yukitsugu Ishii | 2002 | JARQ2002，36，3： | 1 |
| 17 | Robotic harvesting system for eggplants显示文摘 | Shigehiko HAYASHI Katsunobu GANNO Yukitsugu ISHII | 2002 | JARQ2002，36，3： | 1 |
| 18 | Robotic Harvesting System for Eggplants 显示文摘 | Shigehiko Hayashi Katsunobu Ganno Yukitsugu Ishii | 2002 | JARQ2002，36，3： | 1 |
| 19 | Robotic harvesting system for eggplants显示文摘 | Shigehiko Hayashi Katsunobu Ganno Yukitsugu Ishii | 2002 | JARQ2002，36，3： | 1 |
| 20 | Robotic Harvesting System for Eggplantsp 显示文摘 | Shigehiko HAYASHI Katsunobu GANNO Yukitsugu ISHII | 2002 | JARQ2002，36，3： | 1 |
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