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| 1 | Diagnosis and Treatment of Keloids and Hypertrophic Scars—Japan Scar Workshop Consensus Document 2018显示文摘There has been a long-standing need for guidelines on the diagnosis and treatment of keloids and hypertrophic scars that are based on an understanding of the pathomechanisms that underlie these skin fibrotic diseases.This is particularly true for clinicians who deal with Asian and African patients because these ethnicities are highly prone to these diseases.By contrast,Caucasians are less likely to develop keloids and hypertrophic scars,and if they do,the scars tend not to be severe.This ethnic disparity also means that countries vary in terms of their differential diagnostic algorithms.The lack of clear treatment guidelines also means that primary care physicians are currently applying a hotchpotch of treatments,with uneven outcomes.To overcome these issues,the Japan Scar Workshop(JSW)has created a tool that allows clinicians to objectively diagnose and distinguish between keloids,hypertrophic scars,and mature scars.This tool is called the JSW Scar Scale(JSS)and it involves scoring the risk factors of the individual patients and the affected areas.The tool is simple and easy to use.As a result,even physicians who are not accustomed to keloids and hypertrophic scars can easily diagnose them and judge their severity.The JSW has also established a committee that,in cooperation with outside experts in various fields,has prepared a Consensus Document on keloid and hypertrophic scar treatment guidelines.These guidelines are simple and will allow even inexperienced clinicians to choose the most appropriate treatment strategy.The Consensus Document is provided in this article.It describes(1)the diagnostic algorithm for pathological scars and how to differentiate them from clinically similar benign and malignant tumors,(2)the general treatment algorithms for keloids and hypertrophic scars at different medical facilities,(3)the rationale behind each treatment for keloids and hypertrophic scars,and(4)the body site-specific treatment protocols for these scars.We believe that this Consensus Document will be helpful for physicians from all over the world who treat keloids and hypertrophic scars. | Rei Ogawa Sadanori Akita Satoshi Akaishi Noriko Aramaki-Hattori Teruyuki Dohi Toshihiko Hayashi Kazuo Kishi Taro Kono Hajime Matsumura Gan Muneuchi Naoki Murao Munetomo Nagao Keisuke Okabe Fumiaki Shimizu Mamiko Tosa Yasuyoshi Tosa Satoko Yamawaki Shinichi Ansai Norihisa Inazu Toshiko Kamo Reiko Kazki Shigehiko Kuribayashi | 2019 | Burns & Trauma2019，7，1： | 31 |
| 2 | Neointimal coverage of sirolimus-eluting stents 6 months and 12 months after implantation: evaluation by optical coherence tomography显示文摘背景:光连贯断层摄影术(10 月) 是有约 10 microm 的分辨率的一种新成像形式并且能被采用设想 intracoronary 特征。Sirolimus-eluting stents (SES ) 由于在斯滕特氏印模膏神气上的推迟的 re-endothelialization 产生迟了的血栓,它可以导致尖锐心肌的梗塞或死亡。这研究被设计在培植以后与 10 月 6 日月和 12 个月评估 SES 的 re-endothelialization 和 neointimal 范围。方法:在学习注册的 36 个病人的一个总数在 SES 培植以后经历了 10 月检查 6 月(17 个病人) 和 12 个月(19 个病人) 。到 SES 神气上的容器墙和 neointimal 范围的神气并置被 10 月结果评估:46 SES 和 6561 口神气被分析。在 6 个月, 3041 口神气(98.7%) 是好添的, 39 口神气(1.3%) 是 malapposed。在 12 个月, 3434 口神气(98.6%) 是好添的, 47 口神气(1.4%) 是 malapposed。而且,仅仅在 6 个月(18.2%) 的 4SES 和在 12 个月(41.7%) 的 10 SES 被 neointimal 生长充分盖住。在 6 个月和 12 个月盖住分析神气的平均 neointimal 厚度是(42+/-28 ) microm 并且(88+/-32 ) microm 分别地。与 neointimal 厚度 <100 microm 在 12 个月(45.6%) 在 6 个月(72.1%) 和 1461 口神气有 1989 口神气。结论:10 月能在 SES 神气上设想神气并置到容器墙和 neointimal 范围。在 6 月、 12 月的后续考试,大多数神气被薄 neointima 盖住,但是很少全部 SES 显示出完整的范围。为了面对揭开的斯滕特氏印模膏阻止 late-stent 血栓,炫耀,更长双的反血小板药治疗应该被推荐。 | YAO Zhu-hua Tetsuo Matsubara Tsuyoshi Inada Yasuyoshi Suzuki Takahiko Suzuki | 2008 | Chinese Medical Journal2008，，6： | 9 |
| 3 | Role of cortical spreading depression in the pathophysiology of migraine显示文摘A migraine is a recurring neurological disorder characterized by unilateral,intense,and pulsatile headaches.In one-third of migraine patients,the attacks are preceded by a visual aura,such as a slowly-propagating scintillating scotoma.Migraine aura is thought to be a result of the neurovascular phenomenon of cortical spreading depression(SD),a self-propagating wave of depolarization that spreads across the cerebral cortex.Several animal experiments have demonstrated that cortical SD causes intracranial neurogenic inflammation around the meningeal blood vessels,such as plasma protein extravasation and pro-inflammatory peptide release.Cortical SD has also been reported to activate both peripheral and central trigeminal nociceptive pathways.Although several issues remain to be resolved,recent evidence suggests that cortical SD could be the initial trigger of intracranial neurogenic inflammation,which then contributes to migraine headaches via subsequent activation of trigeminal afferents. | Yilong Cui Yosky Kataoka Yasuyoshi Watanabe | 2014 | Neuroscience Bulletin2014，30，5： | 4 |
| 4 | Detection of Loop-Mediated Isothermal Amplification Reaction by Turbidity Derived from Magnesium Pyrophosphate Formation显示文摘 | Yasuyoshi Mori Kentaro Nagamine Norihiro Tomita Tsugunori Notomi | 2001 | Biochemical and Biophysical Research Communications2001，，1： | 3 |
| 5 | Loop-mediated isothermal amplification (LAMP): a rapid, accurate, and cost-effective diagnostic method for infectious diseases显示文摘 | Yasuyoshi Mori Tsugunori Notomi | 2009 | Journal of Infection and Chemotherapy2009，，2： | 3 |
| 6 | Development of TiO 2 powder-coated food packaging film and its ability to inactivate Escherichia coli in vitro and in actual tests显示文摘 | Chamorn Chawengkijwanich Yasuyoshi Hayata | 2008 | International Journal of Food Microbiology2008，，3： | 2 |
| 7 | Loop-mediated isothermal amplification (LAMP): recent progress in research and development显示文摘 | Yasuyoshi Mori Hidetoshi Kanda Tsugunori Notomi | 2013 | Journal of Infection and Chemotherapy2013，，3： | 2 |
| 8 | Real-time turbidimetry of LAMP reaction for quantifying template DNA显示文摘 | Yasuyoshi Mori Masataka Kitao Norihiro Tomita Tsugunori Notomi | 2003 | Journal of Biochemical and Biophysical Methods2003，，2： | 2 |
| 9 | Expression of Matrix Metalloproteinase-7 on Cancer Cells and Tissue Endothelial Cells in Renal Cell Carcinoma: Prognostic Implications and Clinical Significance for Invasion and Metastasis显示文摘 | Yasuyoshi Miyata Takahisa Iwata Kojiro Ohba | 2006 | Clin Cancer Res2006，12，23： | 1 |
| 10 | Antifungal activity of TiO2 photocatalysis against Penieillium expansum in vitro and in fruit tests显示文摘 | Chamorn Maneerat Yasuyoshi Hayata | 2006 | Food microbiology2006，107，： | 1 |
| 11 | The distribution of fibronectin and laminin in the murine periodontal membrane, indicating possible functional role in the apical migration of the junctional epithelium 显示文摘 | Takako S Yasuyoshi O Mizuho K | 1996 | Archs oral Biol1996，41，89： | 1 |
| 12 | Efficient computational algorithms for trajectory control of free-flying space robots with multiple arms 显示文摘 | Yasuyoshi Y Takeshi T Tsuneo Y | 1993 | IEEE Transactions on Robotics and Automation1993，9，5： | 1 |
| 13 | A new conceptualization for Mikulicz’s disease as an IgG4-related plasmacytic disease显示文摘 | Motohisa Yamamoto Hiroki Takahashi Mikiko Ohara Chisako Suzuki Yasuyoshi Naishiro Hiroyuki Yamamoto Yasuhisa Shinomura Kohzoh Imai | 2006 | Modern Rheumatology2006，，6： | 1 |
| 14 | Antifungal activity of TiO2 photocatalysis against Penicillium expansum in vitro and in fruit tests显示文摘 | Chamorn M Yasuyoshi H | 2006 | International Journal of Food Microbiology2006，107，2： | 1 |
| 15 | Plasterlor movement and enlargement of the spinal cord after cervical laminoplasty显示文摘 | Ikuo Aita Koichiro hayashi Yasuyoshi wadano | 1998 | Bone Joint Surg1998，80，： | 1 |
| 16 | Lomerizine, a Ca^2+ channel blocker, reduces glutamate-lnduced neurotoxicity and ischemia/reperfusim damage in rat retina显示文摘 | Torin N Akaike A Yasuyoshi H | 2000 | Exp Eye Res2000，70，4： | 1 |
| 17 | Lead-free Piezoceramics 显示文摘 | Yasuyoshi Saito Hisaaki Takao Toshihiko Tani | 2004 | Nature2004，432，： | 1 |
| 18 | Determination of amikacin in human plasma by high-performance capillary electrophoresis with fluorescence detection显示文摘 | Shigeyuki O Yasuyoshi M | 1996 | Journal of Chromatography B:Biomedical Sciences and Applications1996，686，2： | 1 |
| 19 | Mitochondrial cytochrome C release and caspase-3-like protease activation during indomethacin-induced apoptosis in rat gastric mucosal cells显示文摘 | Yasuyoshi F Tatsuya M Masachika K | 2000 | Soc Exp Biol Med2000，224，： | 1 |
| 20 | Dynamic characteristics of novel two-DOF resonant actuator by vector Transactions on Magnetics, 2012, control显示文摘 | Takamichi Yoshimoto Yasuyoshi Asai Tomoshiro Ota | 2012 | IEEE2012，48，11： | 1 |
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