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| 1 | Resting-state connectivity in the default mode network and insula during experimental low back pain显示文摘Functional magnetic resonance imaging studies have shown that the insular cortex has a significant role in pain identification and information integration, while the default mode network is associated with cognitive and memory-related aspects of pain perception. However, changes in the functional connectivity between the default mode network and insula during pain remain unclear. This study used 3.0 T functional magnetic resonance imaging scans in 12 healthy subjects aged 24.8 ± 3.3 years to compare the differences in the functional activity and connectivity of the insula and default mode network between the baseline and pain condition induced by intramuscular injection of hypertonic saline. Compared with the baseline, the insula was more functionally connected with the medial prefrontal and lateral temporal cortices, whereas there was lower connectivity with the posterior cingulate cortex, precuneus and inferior parietal lobule in the pain condition. In addition, compared with baseline, the anterior cingulate cortex exhibited greater connectivity with the posterior insula, but lower connectivity with the anterior insula, during the pain condition. These data indicate that experimental low back pain led to dysfunction in the connectivity between the insula and default mode network resulting from an impairment of the regions of the brain related to cognition and emotion, suggesting the importance of the interaction between these regions in pain processing. | Shanshan Zhang Wen Wu Guozhi Huang Ziping Liu Shigui Guo Jianming Yang Kangling Wang | 2014 | Neural Regeneration Research2014，9，2： | 3 |
| 2 | STRENGTH AND DUCTILITY OF Ni-Cu-BASE ALLOY MONEL K-500显示文摘STRENGTHANDDUCTILITYOFNi-Cu-BASEALLOYMONELK-500Wang;ZhixingXie;ShishuLiu;ShiguiYuan;ChaoYang;Hongcai(DepartmentofMaterialsSci... | Wang Zhixing Xie Shishu Liu Shigui Yuan Chao Yang Hongcai(Department of Materials Science and EngineeringNortheastern University, Shenyang 110006) | 1995 | 中国有色金属学会会刊:英文版1995，5，1： | 3 |
| 3 | From SARS to MERS: evidence and speculation显示文摘 | Hainv Gao Hangping Yao Shigui Yang Lanjuan Li | 2016 | Frontiers of Medicine2016，10，4： | 3 |
| 4 | Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterisation of viral genome显示文摘 | Yu Chen Weifeng Liang Shigui Yang Nanping Wu Hainv Gao Jifang Sheng Hangping Yao Jianer Wo Qiang Fang Dawei Cui Yongcheng Li Xing Yao Yuntao Zhang Haibo Wu Shufa Zheng Hongyan Diao Shichang Xia Yanjun Zhang Kwok-Hung Chan Hoi-Wah Tsoi Jade Lee-Lee Teng We | 2013 | 2013 (9881)2013，，9881： | 2 |
| 5 | Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterisation of viral genome显示文摘 | Yu Chen Weifeng Liang Shigui Yang Nanping Wu Hainv Gao Jifang Sheng Hangping Yao Jianer Wo Qiang Fang Dawei Cui Yongcheng Li Xing Yao Yuntao Zhang Haibo Wu Shufa Zheng Hongyan Diao Shichang Xia Yanjun Zhang Kwok-Hung Chan Hoi-Wah Tsoi Jade Lee-Lee Teng We | 2013 | The Lancet2013，，9881： | 1 |
| 6 | Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterisation of viral genome显示文摘 | Yu Chen Weifeng Liang Shigui Yang | 2013 | The Lancet2013，381，9881： | 1 |
| 7 | Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterisation of viral genome 显示文摘 | Chen Yu Liang Weifeng Yang Shigui | 2013 | Lancet2013，381，9881： | 1 |
| 8 | Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterisation of viral genome显示文摘 | Yu Chen Weifeng Liang Shigui Yang Nanping Wu Hainv Gao Jifang Sheng Hangping Yao Jianer Wo Qiang Fang Dawei Cui Yongcheng Li Xing Yao Yuntao Zhang Haibo Wu Shufa Zheng Hongyan Diao Shichang Xia Yanjun Zhang Kwok-Hung Chan Hoi-Wah Tsoi Jade Lee-Lee Teng We | 2013 | The Lancet2013，，9881： | 1 |
| 9 | Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterisation of viral genome显示文摘 | Yu Chen Weifeng Liang Shigui Yang Nanping Wu Hainv Gao Jifang Sheng Hangping Yao Jianer Wo Qiang Fang Dawei Cui Yongcheng Li Xing Yao Yuntao Zhang Haibo Wu Shufa Zheng Hongyan Diao Shichang Xia Yanjun Zhang Kwok-Hung Chan Hoi-Wah Tsoi Jade Lee-Lee Teng We | 2013 | The Lancet2013，，9881： | 1 |
| 10 | Genetic variation of the genus Kengyilia by ISSR markers显示文摘We investigated the genetic variation within 32 accessions distributed to 14 species and one variety by using ISSR(inter-simple sequence repeat)markers.The results showed that genetic variation was relatively higher among the accessions.A total of 593 bands were amplified by 12 ISSR primers,of which 535 bands(90.2%)were polymorphic.Eleven to 80 polymorphic bands were amplified from each prime,with an average of 44.6 bands.The interspecies GS(genetic similarity)value ranged from 0.430 to 0.866,and the average was 0.620.Cluster analysis showed that all accessions could be classified into 4 groups by ISSR markers.The different accessions in a species were clustered together,but they had genetic variation in molecular levels.There was obvious interspecies genetic variation.Species with similar morphological characteristics and from the same areas or neighboring geographical regions were clustered together and had close relationships.ISSR markers are useful in analyzing interspecies variation in Kengyilia. | Li ZHANG Yonghong ZHOU Chunbang DING Ruiwu YANG Shigui LIU | 2008 | Frontiers in Biology2008，3，2： | 0 |
| 11 | Wide grain 4,encoding an alpha-tubulin,regulates grain size by affecting cell expansion in rice显示文摘Rice is one of the three most important food crops in the world.Increasing rice yield is an effective way to ensure food security.Grain size is a key factor affecting rice yield;however,the genetic and molecular mechanisms regulating grain size have not been fully investigated.In this study,we identified a rice mutant,wide grain 4-D(wg4-D),that exhibited a significant increase in grain width and a decrease in grain length.Histological analysis demonstrated that WG4 affects cell expansion thereby regulating grain size.MutMap-based gene mapping and complementary transgenic experiments revealed that WG4 encodes an alpha-tubulin,OsTubA1.A SNP mutation in WG4 affected the arrangement of cortical microtubules and caused a wide-grain phenotype.WG4 is located in nuclei and cytoplasm and expressed in various tissues.Our results provide insights into the function of tubulin in rice and identifies novel targets the regulation of grain size in crop breeding. | Yi Liu Lianan Guo Guoli Qu Yang Xiang Xu Zhao Hua Yuan Ting Li Liangzhu Kang Shiwen Tang Bin Tu Bingtian Ma Yuping Wang Shigui Li Weilan Chen Peng Qin | 2023 | The Crop Journal2023，11，6： | 0 |
| 12 | A Severe Seasonal Influenza Epidemic During 2017–2018 in China After the 2009 Pandemic Influenza: A Modeling Study显示文摘Influenza viruses continue to cause epidemics worldwide every year.However,due to the lack of an effective assessment for the severity of influenza epidemics,it was extremely difficult to take preventative measures.Data were extracted from infectious diseases reports from 2011–2018.Joinpoint regression model and susceptible-exposed-infectious-recovered model were built to understand the characteristics and processes of the epidemic.The reported incidence of influenza was 1,913,698 from January 2011 to February 2018,with an average-yearly-reported-incidence-rate of 19.21 per 100,000.However,there had been a substantial nationwide epidemic of influenza after September 2017,when the average yearly reported incidence rate was 87.29 per 100,000 and an annual percentage change of 48.1%.The hemagglutinin genes of most influenza A(H1N1 and H3N2)viruses from the period of the epidemic had lower homology to those before August 2017.All the hemagglutinin of the recommended A(H3N2,H1N1)and B(Victoria)viruses for vaccines 2017/2018 had low matches with the epidemic viruses.The basic reproduction number was 1.53.The vaccination benefit was linearly related to vaccination coverage,while the quarantine measure had only significantly benefited when over 60%of the quarantined population.The most severe epidemic of influenza in China since 2011 occurred during the period from September 2017 to February 2018.Compared to quarantine,influenza vaccination is more effective way to prevent influenza,and strategies to increase vaccination coverage should be taken for the prevention of severe epidemics of influenza. | Xiaofang Fu Yuqing Zhou Jie Wu Xiaoxiao Liu Cheng Ding Chenyang Huang Min Deng Dongyan Shi Chencheng Wang Kaijin Xu Jingjing Ren Bing Ruan Lanjuan Li Shigui Yang | 2019 | Infectious Microbes & Diseases2019，1，1： | 0 |
| 13 | Predicting the Incident Cases of Emerging Infectious Disease Using a Bayesian Probability Model--China,February 2020显示文摘What is already known about this topic?The exact number of incident cases of emerging infectious diseases on a daily basis is of great importance to the disease control and prevention,but it is not directly available from the current surveillance system in time.What is added by this report?In this study,a Bayesian statistical method was proposed to estimate the posterior parameters of the gamma probability distribution of the lag time between the onset date and the reporting time based on the surveillance data.And then the posterior parameters and corresponding cumulative gamma probability distribution were used to predict the actual number of new incident cases and the number of unreported cases per day.The proposed method was used for predicting COVID-19 incident cases from February 5 to February 26,2020.The final results show that Bayesian probability model predictions based on data reported by February 28,2020 are very close to those actually reported a month later.What are the implications for public health practice?This research provides a Bayesian statistical approach for early estimation of the actual number of cases of incidence based on surveillance data,which is of great value in the prevention and control practice of epidemics. | Yewu Zhang Xiaofeng Wang Yanfei Li Siyu Wu Ming Wan Xuemei Su Shigui Yang Hanjiang Lai Zhongwei Jia Jiaqi Ma | 2020 | China CDC weekly2020，2，52： | 0 |
| 14 | Zero-Shot Medical Image Retrieval for Emerging Infectious Diseases Based on Meta-Transfer Learning--Worldwide,2020显示文摘Introduction:Due to the increasing number of medical images,image retrieval has become an important technique for medical image analytics.Although many content-based image retrieval methods have been proposed,the retrieval of images in datasets related to emerging/new infectious diseases still remain a challenge-mostly due to the lack of historical data.As a result,the current retrieval models have limited functionality in helping doctors make accurate diagnoses of new diseases.Methods:In this paper,we propose a zero-shot retrieval model based on meta-learning and ensemble learning,which can obtain a model with stronger generalizability without using any relevant training data,and thus performs well on new types of test data.Results:The experimental results showed that the proposed method is 3% to 5% higher than the traditional method,which means that our model can retrieve relevant medical images more accurately for newly emerging data types and provide doctors with more effective assistance.Discussion:When a new infectious disease occurs,doctors can use the proposed zero-shot retrieval model to retrieve all relevant cases,quickly find the common problems of patients,find the locations of the new infections,and determine its infectivity as soon as possible.The proposed method is a new computeraided decision support technology for emerging infectious diseases. | Yuying Zhao Hanjiang Lai Jian Yin Yewu Zhang Shigui Yang Zhongwei Jia Jiaqi Ma | 2020 | China CDC weekly2020，2，52： | 0 |
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