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| 1 | H7N9 virulent mutants detected in chickens in China pose an increased threat to humans显示文摘 | Jianzhong Shi Guohua Deng Huihui Kong Chunyang Gu Shujie Ma Xin Yin Xianying Zeng Pengfei Cui Yan Chen Huanliang Yang Xiaopeng Wan Xiurong Wang Liling Liu Pucheng Chen Yongping Jiang Jinxiong Liu Yuntao Guan Yasuo Suzuki Mei Li Zhiyuan Qu Lizheng Guan Jinkai Zang Wenli Gu Shuyu Han Yangming Song Yuzhen Hu Zeng Wang Linlin Gu Wenyu Yang Libin Liang Hongmei Bao Guobin Tian Yanbing Li Chuanling Qiao Li Jiang Chengjun Li Zhigao Bu Hualan Chen | 2017 | Cell Research2017，27，12： | 70 |
| 2 | A seven-gene-deleted African swine fever virus is safe and effective as a live attenuated vaccine in pigs显示文摘African swine fever(ASF)is a devastating infectious disease in swine that is severely threatening the global pig industry.An efficacious vaccine is urgently required.Here,we used the Chinese ASFV HLJ/18 as a backbone and generated a series of genedeleted viruses.The virulence,immunogenicity,safety,and protective efficacy evaluation in specific-pathogen-free pigs,commercial pigs,and pregnant sows indicated that one virus,namely HLJ/18-7GD,which has seven genes deleted,is fully attenuated in pigs,cannot convert to the virulent strain,and provides complete protection of pigs against lethal ASFV challenge.Our study shows that HLJ/-18-7GD is a safe and effective vaccine against ASFV,and as such is expected to play an important role in controlling the spread of ASFV. | Weiye Chen Dongming Zhao Xijun He Renqiang Liu Zilong Wang Xianfeng Zhang Fang Li Dan Shan Hefeng Chen Jiwen Zhang Lulu Wang Zhiyuan Wen Xijun Wang Yuntao Guan Jinxiong Liu Zhigao Bu | 2020 | Science China(Life Sciences)2020，63，5： | 72 |
| 3 | Key technologies and equipment for a fully mechanized top-coal caving operation with a large mining height at ultra-thick coal seams显示文摘 | Jinhua Wang Bin Yu Hongpu Kang Guofa Wang Debing Mao Yuntao Liang Pengfei Jiang | 2015 | International Journal of Coal Science & Technology2015，2，2： | 57 |
| 4 | Understanding SARS-CoV-2-Mediated Inflammatory Responses: From Mechanisms to Potential Therapeutic Tools显示文摘Currently there is no effective antiviral therapy for SARS-CoV-2 infection, which frequently leads to fatal inflammatory responses and acute lung injury. Here, we discuss the various mechanisms of SARS-CoV-mediated inflammation. We also assume that SARS-CoV-2 likely shares similar inflammatory responses. Potential therapeutic tools to reduce SARS-CoV-2-induced inflammatory responses include various methods to block FcR activation. In the absence of a proven clinical FcR blocker, the use of intravenous immunoglobulin to block FcR activation may be a viable option for the urgent treatment of pulmonary inflammation to prevent severe lung injury. Such treatment may also be combined with systemic anti-inflammatory drugs or corticosteroids. However, these strategies, as proposed here, remain to be clinically tested for effectiveness. | Yajing Fu Yuanxiong Cheng Yuntao Wu | 2020 | Virologica Sinica2020，35，3： | 54 |
| 5 | Emergence and prevalence of naturally occurring lower virulent African swine fever viruses in domestic pigs in China in 2020显示文摘African swine fever virus(ASFV)has been circulating in China for more than two years,and it is not clear whether the biological properties of the virus have changed.Here,we report on our surveillance of ASFVs in seven provinces of China,from June to December,2020.A total of 22 viruses were isolated and characterized as genotype II ASFVs,with mutations,deletions,insertions,or short-fragment replacement occurring in all isolates compared with Pig/HLJ/2018(HLJ/18),the earliest isolate in China.Eleven isolates had four different types of natural mutations or deletion in the EP402R gene and displayed a nonhemadsorbing(non-HAD)phenotype.Four isolates were tested for virulence in pigs;two were found to be as highly lethal as HLJ/18.However,two non-HAD isolates showed lower virulence but were highly transmissible;infection with 106 TCID50 dose was partially lethal and caused acute or sub-acute disease,whereas 103 TCID50 dose caused non-lethal,sub-acute or chronic disease,and persistent infection.The emergence of lower virulent natural mutants brings greater difficulty to the early diagnosis of ASF and creates new challenges for ASFV control. | Encheng Sun Zhenjiang Zhang Zilong Wang Xijun He Xianfeng Zhang Lulu Wang Wenqing Wang Lianyu Huang Fei Xi Haoyue Huangfu Ghebremedhin Tsegay Hong Huo Jianhong Sun Zhijun Tian Wei Xia Xuewu Yu Fang Li Renqiang Liu Yuntao Guan Dongming Zhao Zhigao Bu | 2021 | Science China(Life Sciences)2021，64，5： | 46 |
| 6 | Palaeogeothermal response and record of the effusing of Emeishan basalts in the Sichuan basin显示文摘Thermal history of the Sichuan basin is reconstructed based on vitrinite reflectance from boreholes in the basin using a paleo-heat flow method.The results show that the Sichuan basin experienced a relatively low heat flow period in the Early Paleozoic,and an elevated paleo-heat flow,ranging 60-80 mW/m2 with a maximum as high as 100 mW/m2 around 259 Ma,from the beginning of the Late Paleozoic to the end of the early Permian,and a decreased paleo-heat flow from the late Permian to the late Triassic,and then maintained nearly stable to the present.The Late Paleozoic paleo-heat flow was quite high where there were extensive Emeishan flood basalts or concealed basalts which erupted between the early and the late Permian,such as the southwestern and northeastern areas of the Sichuan basin.According to the distribution of paleo-heat flow,it can be inferred that,the northeastern Sichuan basin was also influenced by the Emeishan magmatic activity during the Dongwu movement though there was lack of Emeishan flood basalts.In addition,the results of thermal history reconstruction of the Sichuan basin provide paleogeothermal evidence for the existence and onset of the Emaishan mantle plume. | ZHU ChuanQing XU Ming YUAN YuSon ZHAO YongQing SHAN JingNan HE ZhiGuo TIAN YunTao HU ShengBiao | 2010 | Chinese Science Bulletin2010，55，10： | 30 |
| 7 | Characteristics of coal re-oxidation based on microstructural and spectral observation显示文摘In order to investigate the characteristics of re-oxidation of residual coal in goafs in close coal seam mining,scanning electron microscope and infrared spectrometer are used to study the changes of coal microstructure and chemical reaction of functional groups of eight coal samples at different ranks.Result shows that after initial oxidation,the surface morphology of pore are different,and the porosity of coal is increased and the oxygen adsorption capacity of coal is improved.The change of coal molecular structure and presence of a large amount of active oxygen-containing functional groups lead to increasing tendency of coal to further oxidation.In addition,the higher lever of the initial oxidation is,the easier the re-oxidation occurs. | Liang Yuntao Tian Fuchao Luo Haizhu Tang Hui | 2015 | International Journal of Mining Science and Technology2015，25，5： | 21 |
| 8 | Compensation of ACE2 Function for Possible Clinical Management of 2019-nCoV-Induced Acute Lung Injury显示文摘The 2019-nCoV viral infection causes clusters of severe respiratory illness such as an acute respiratory distress syndrome(ARDS)similar to that caused by SARS-CoV(severe acute respiratory syndrome coronavirus)(Huang et al.2020).Both 2019-nCoV and SARS-CoV use the same receptor,ACE2(angiotensin converting enzyme 2). | Yuntao Wu | 2020 | Virologica Sinica2020，35，3： | 19 |
| 9 | Modeling,Control,and Protection of Modular Multilevel Converter-based Multi-terminal HVDC Systems:A Review显示文摘Multi-terminal direct current(MTDC)grids provide the possibility of meshed interconnections between regional power systems and various renewable energy resources to boost supply reliability and economy.The modular multilevel converter(MMC)has become the basic building block for MTDC and DC grids due to its salient features,i.e.,modularity and scalability.Therefore,the MMC-based MTDC systems should be pervasively embedded into the present power system to improve system performance.However,several technical challenges hamper their practical applications and deployment,including modeling,control,and protection of the MMC-MTDC grids.This paper presents a comprehensive investigation and reference in modeling,control,and protection of the MMC-MTDC grids.A general overview of state-of-the-art modeling techniques of the MMC along with their performance in simulation analysis for MTDC applications is provided.A review of control strategies of the MMC-MTDC grids which provide AC system support is presented.State-of-the art protection techniques of the MMCMTDC systems are also investigated.Finally,the associated research challenges and trends are highlighted. | Lei Zhang Yuntao Zou Jicheng Yu Jiangchao Qin Vijay Vittal George G.Karady Di Shi Zhiwei Wang | 2017 | CSEE Journal of Power and Energy Systems2017，3，4： | 17 |
| 10 | Effects of Slope Aspects on Soil Bacterial and Arbuscular Fungal Communities in a Boreal Forest in China显示文摘在 forested 环境的土壤 biogeochemical 性质和植物社区上的斜坡方面的效果广泛地被学习了;然而,倾斜对的方面影响大部分玷污微生物引起的社区遗体 unexamined,尽管有在生态系统工作的土壤生物区系的中央角色。在这研究,土壤细菌和 arbuscular mycorrhizal 真菌(AMF ) 的社区在更大的 Khingan 山的一个北方的森林里为斜坡方面(面对南方的方面,面对北方的方面和扁平的区域) 的三种类型用标注 pyrosequencing 被调查,中国。细菌并且 AMF 社区作文与斜坡方面不同。细菌的差异在面对北方的方面上是最低的,并且 AMF 差异在扁平的区域上是最低的。方面也在土壤 pH 和可得到的磷(P) 和灌木状的生物资源上有重要影响。土壤 pH 和 understory 灌木生物资源显著地与细菌的社区被相关,并且玷污可得到的 P 和灌木生物资源与 AMF 社区的显示出的重要关联。我们的结果建议了那个斜坡细菌的影响的方面和 AMF 社区,在植物社区和土壤化学药品性质由导致方面的变化调停了(例如, pH 和可得到的 P ) ,它在森林斜坡方面的效果上改进了知识在上未葬、地下社区。 | CHU Haiyan XIANG Xingjia YANG Jian Jonathan M. ADAMS ZHANG Kaoping LI Yuntao SHI Yu | 2016 | Pedosphere2016，26，2： | 15 |
| 11 | The next-generation sequencing technology and application显示文摘As one of the key technologies in biomedical research,DNA sequencing has not only improved its productivity with an exponential growth rate but also been applied to new areas of application over the past few years.This is largely due to the advent of newer generations of sequencing platforms,offering ever-faster and cheaper ways to analyze sequences.In our previous review,we looked into technical characteristics of the nextgeneration sequencers and provided prospective insights into their future development.In this article,we present a brief overview of the advantages and shortcomings of key commercially available platforms with a focus on their suitability for a broad range of applications. | Xiaoguang Zhou Lufeng Ren Qingshu Meng Yuntao Li Yude Yu Jun Yu | 2010 | Protein & Cell2010，1，6： | 13 |
| 12 | Progress in application of CFD techniques显示文摘Computational Fluid Dynamics (CFD) is an important branch of fluid mechanics, and will continue to play great roles on the design of aerospace vehicles, explora- tion of new concept vehicles and new aerodynamic technology. This paper will present the progress of CFD from point of view of engineering application in recent years at CARDC, including the software integration, grid technique, speeding up of convergence, unsteady fluid computation,etc., and also give some engineering application examples of CFD at CARDC. | CHEN ZuoBin JIANG Xiong ZHOU Zhu XIAO HanShan HUANG Yong MOU Bin XIAO ZhongYun LIU Gang WANG YunTao | 2008 | Science China(Technological Sciences)2008，51，7： | 13 |
| 13 | Effect of ammonium on nitrous oxide emission during denitrification with different electron donors显示文摘Nitrous oxide(N2O) emission during denitrification is receiving intensive attention due to its high potential to cause greenhouse effects.In this study,denitrifiers were acclimated in sequencing batch reactors with methanol or acetate as the electron donor and nitrate as the electron acceptor.The effects of ammonium on N2O emission were examined in batch experiments with various electron donors.With the addition of ammonium,N2O emission increased under all the examined conditions compared to experiments without ammonium addition.With different electron donors,the highest ratio of N2O emission to the removed oxidized nitrogen was 0.70% for methanol,5.34% for acetate,and 34.79% for polyhydroxybutyrate. | Guangxue Wu Xiaofeng Zhai Chengai Jiang Yuntao Guan | 2013 | Journal of Environmental Sciences2013，25，6： | 12 |
| 14 | Early prediction of pathological outcomes to neoadjuvant chemotherapy in breast cancer patients using automated breast ultrasound显示文摘Objective: Early assessment of response to neoadjuvant chemotherapy(NAC) for breast cancer allows therapy to be individualized.The optimal assessment method has not been established.We investigated the accuracy of automated breast ultrasound(ABUS) to predict pathological outcomes after NAC.Methods: A total of 290 breast cancer patients were eligible for this study.Tumor response after 2 cycles of chemotherapy was assessed using the product change of two largest perpendicular diameters(PC) or the longest diameter change(LDC).PC and LDC were analyzed on the axial and the coronal planes respectively.Receiver operating characteristic(ROC) curves were used to evaluate overall performance of the prediction methods.Youden's indexes were calculated to select the optimal cut-off value for each method.Sensitivity, specificity,positive and negative predictive values(PPV and NPV) and the area under the ROC curve(AUC) were calculated accordingly.Results: yp T0/is was achieved in 42 patients(14.5%) while yp T0 was achieved in 30 patients(10.3%) after NAC.All four prediction methods(PC on axial planes, LDC on axial planes, PC on coronal planes and LDC on coronal planes) displayed high AUCs(all>0.82), with the highest of 0.89 [95% confidence interval(95% CI), 0.83–0.95]when mid-treatment ABUS was used to predict final pathological complete remission(p CR).High sensitivities(85.7%–88.1%) were observed across all four prediction methods while high specificities(81.5%–85.1%) were observed in two methods used PC.The optimal cut-off values defined by our data replicate the WHO and the RECIST criteria.Lower AUCs were observed when mid-treatment ABUS was used to predict poor pathological outcomes.Conclusions: ABUS is a useful tool in early evaluation of p CR after NAC while less reliable when predicting poor pathological outcomes. | Xinguang Wang Ling Huo Yingjian He Zhaoqing Fan Tianfeng Wang Yuntao Xie Jinfeng Li Tao Ouyang | 2016 | Chinese Journal of Cancer Research2016，28，5： | 11 |
| 15 | Hydrocarbon generation characteristics and exploration prospects of Proterozoic source rocks in China显示文摘A large number of primary oil and gas reservoirs have been discovered in Proterozoic strata all over the globe.Proterozoic sequences are widely distributed in China, and the discovery of large Sinian-aged gas reservoirs in the Sichuan Basin and Mesoproterozoic liquid oil seepages in North China shows that attention should be paid to the exploration potential of Proterozoic strata. In this paper, the main controlling factors of Proterozoic source rocks are discussed. Principally, active atmospheric circulation and astronomical cycles may have driven intense upwelling and runoff to provide nutrients; oxygenated oceanic surface waters could have provided suitable environments for the organisms to thrive; volcanic activity and terrestrial weathering caused by continental break-up would have injected large amounts of nutrients into the ocean, leading to persistent blooms of marine organisms; and extensive anoxic deep waters may have created ideal conditions for the preservation of organic matter. Additionally, the appearance of eukaryotes resulted in diversified hydrocarbon parent material, which effectively improved the generation potential for oil and gas. Through the comparison of Formations across different cratons, seven sets of Proterozoic organic-rich source rocks have been recognized in China, which mainly developed during interglacial periods and are also comparable worldwide. The Hongshuizhuang and Xiamaling Formations in North China have already been identified previously as Mesoproterozoic source rocks. The early Proterozoic Changchengian System is highly promising as a potential source rock in the Ordos Basin. In the Upper Yangtze area, the Neoproterozoic Datangpo and Doushantuo Formations are extensively distributed, and represent the major source rocks for Sinian gas reservoirs in the Sichuan Basin. Moreover, the Nanhuan System may contain abundant shales with high organic matter contents in the Tarim Basin, although this possibility still needs to be verified. Indeed, all three cratons may contain source rocks of Proterozoic strata; thus, these strata represent major exploration targets worthy of great attention. | Wenzhi ZHAO Xiaomei WANG Suyun HU Shuichang ZHANG Huajian WANG Shuwei GUAN Yuntao YE Rong REN Tongshan WANG | 2019 | Science China Earth Sciences2019，62，6： | 9 |
| 16 | Genome of Plant Maca (Lepidium meyenil) Illuminates Genomic Basis for High-Altitude Adaptation in the Central Andes显示文摘Maca (Lepidium meyenii Walp, 2n = 8x = 64 ) ,属于 Brassicaceae 家庭,经济植物在秘鲁(4000-4500 m ) 在中央安第斯山脉岭被栽培。认为快速中央安第斯山脉高举发生 5-10 百万年以前(妈) ,一个进化问题关于象 maca 那样的植物怎么在一个短地质的时期以内获得高高度的改编产生。这里,我们报导 maca 的高质量的染色体集会,在里面它二仔细 spaced maca 特定的整个染色体的复制(WGD;6.7 妈) 被识别。在 maca 和密切相关的 Brassicaceae 种类之间的比较 genomic 分析揭示了经由 WGD 涉及不能生活的压力反应,荷尔蒙发信号小径,和第二等的代谢物生合成的 maca 基因和基因家庭的扩大。保留和许多复制基因的随后的功能的分叉可以说明词法、生理的变化(即,小叶形状和自我富饶) 在在高高度的环境的 maca。另外,一些复制 maca 基因在词法改编与功能被识别(即,叶卷应答) 并且不能生活的压力反应(即, GLYCINE 富有的 RNA 有约束力的蛋白质和 DNA-DAMAGE-REPAIR/TOLERATION 2 ) 在积极选择下面。一起, maca 染色体提供有用信息在安第斯山脉在植物的高高度的改编理解 WGD 的重要角色。 | Jing Zhang Yang Tian Liang Yan GuanghuiZhang Xiao Wang Yan Zeng Jiajin Zhang Xiao Ma Yuntao Tan Ni Long Yangzi Wang Yujin Ma Yuqi He Yu Xue Shumei Hao Shengchao Yang Wen Wang Liangsheng Zhang Yang Dong Wei Chen Jun Sheng | 2016 | Molecular Plant2016，9，7： | 9 |
| 17 | Calibration of a γ-Re_θ transition model and its validation in low-speed flows with high-order numerical method显示文摘Based on the Reynolds-averaged Navier–Stokes(RANS)equations and structured grid technology,the calibration and validation of γ-Re_θ transition model is preformed with fifth-order weighted compact nonlinear scheme(WCNS),and the purpose of the present work is to improve the numerical accuracy for aerodynamic characteristics simulation of low-speed flow with transition model on the basis of high-order numerical method study.Firstly,the empirical correlation functions involved in the γ-Re_θ transition model are modified and calibrated with experimental data of turbulent flat plates.Then,the grid convergence is studied on NLR-7301 two-element airfoil with the modified empirical correlation.At last,the modified empirical correlation is validated with NLR-7301 two-element airfoil and high-lift trapezoidal wing from transition location,velocity profile in boundary layer,surface pressure coefficient and aerodynamic characteristics.The numerical results illustrate that the numerical accuracy of transition length and skin friction behind transition location are improved with modified empirical correlation function,and obviously increases the numerical accuracy of aerodynamic characteristics prediction for typical transport configurations in low-speed range. | Wang Yuntao Zhang Yulun Li Song Meng Dehong | 2015 | Chinese Journal of Aeronautics2015，28，3： | 9 |
| 18 | Slip synergism of planar strike-slip fault during meta-instable state:Experimental research based on digital image correlation analysis显示文摘The meta-instable state(MIS)is the final stage before fault instability during stick-slip movement.Thus,identification of MIS is of great significance for assessing earthquake hazard in fault zones.A rock sample with a precut planar fault was loaded on a horizontally biaxial servo-controlled press machine to create stick-slip conditions.Digital images of the sample surface were taken by a high-speed camera at a rate of 1000 frames per second during the stick-slip motion and processed using a 2D digital image correlation method to obtain the displacement field.We define a synergism coefficient that describes the relative dispersion of the accumulative fault slip.The results reveal that:(1)a local pre-slip area spreads very slowly along the fault before the MIS develops.It extends at a higher but still slow speed during meta-instable state I(MIS-I).During the final^1.5%of MIS,in meta-instable state II(MIS-II),the local pre-slip area first extends at a speed of^0.9 m/s,and then expands out of the observed image area at a very high speed.These results indicate that the local pre-slip area transforms from a state of quasi-static extension in MIS-I to quasi-dynamic extension in MIS-II.(2)The synergism coefficient of the fault slip decreases to half of its original value in MIS-I and to a quarter of its original value in MIS-II.This continuous decrease of synergism coefficient indicates that the strengthening of fault slip synergism is a characteristic of MIS.(3)Furthermore,the unstable sliding stage includes three sliding processes:initial-,fast-,and adjusted-sliding.There are two pauses between the three sliding processes. | ZHUO YanQun GUO YanShuang JI YunTao MA Jin | 2013 | Science China Earth Sciences2013，56，11： | 8 |
| 19 | Pressure sintering of W-15wt.%Cu alloys prepared by mechanical alloying as a subsequent densification treatment method显示文摘The sintered W-15wt.%Cu alloys fabricated by mechanical alloying were re-sintered under pressure to increase the density and improve the properties of these alloys. The pressure was applied vertically along the axis of the sintered sample. Properties such as density, hardness, and bending strength were measured. The microstructures of the sintered bod- ies were observed. The results showed that the subsequent pressure sintering could increase the density of the sintered W-15wt.%Cu alloys. Their hardness, bending strength, and some other physical properties were also improved by this sub- sequent densification treatment. | LI Zhigang JIA Chengchang SUN Lan HE Yuntao FAN Shimin | 2006 | Rare Metals2006，25，2： | 8 |
| 20 | Molecular epidemiology demonstrates that imported and local strains circulated during the 2014 dengue outbreak in Guangzhou, China显示文摘The dengue virus(DENV) is a vital global public health issue. The 2014 dengue epidemic in Guangzhou, China, caused approximately 40,000 cases of infection and five deaths. We carried out a comprehensive investigation aimed at identifying the transmission sources in this dengue epidemic. To analyze the phylogenetics of the 2014 dengue strains, the envelope(E) gene sequences from 17 viral strains isolated from 168 dengue patient serum samples were sequenced and a phylogenetic tree was reconstructed. All 17 strains were serotype Ⅰ strains, including 8genotype Ⅰ and 9 genotype V strains. Additionally, 6 genotype Ⅰ strains that were probably introduced to China from Thailand before 2009 were widely transmitted in the 2013 and 2014 epidemics, and they continued to circulate until 2015, with one affinis strain being found in Singapore. The other 2 genotype Ⅰ strains were introduced from the Malaya Peninsula in 2014. The transmission source of the 9 genotype Ⅴ strains was from Malaysia in 2014. DENVs of different serotypes and genotypes co-circulated in the 2014 dengue outbreak in Guangzhou. Moreover, not only had DENV been imported to Guangzhou, but it had also been gradually exported, as the viruses exhibited an enzootic transmission cycle in Guangzhou. | Geng Li Pan Pan Qiuyan He Xiujuan Kong Kailang Wu Wei Zhang Yuntao Liu Huiting Huang Jianbo Liu Zhongde Zhang De Wu Xiaoping Lai Xiaohong Liu Jianguo Wu | 2017 | Virologica Sinica2017，32，1： | 7 |
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