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您的检索式：作者名="Shijiu Chen"
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| 1 | The role of corneal endothelium in macular corneal dystrophy development and recurrence显示文摘Macular corneal dystrophy(MCD)is a progressive,bilateral stromal dystrophic disease that arises from mutations in carbohydrate sulfotransferase 6(CHST6).Corneal transplantation is the ultimate therapeutic solution for MCD patients.Unfortunately,postoperative recurrence remains a significant challenge.We conducted a retrospective review of a clinical cohort comprising 102 MCD patients with 124 eyes that underwent either penetrating keratoplasty(PKP)or deep anterior lamellar keratoplasty(DALK).Our results revealed that the recurrence rate was nearly three times higher in the DALK group(39.13%,9/23 eyes)compared with the PKP group(10.89%,11/101 eyes),suggesting that surgical replacement of the corneal endothelium for treating MCD is advisable to prevent postoperative recurrence.Our experimental data confirmed the robust m RNA and protein expression of CHST6 in human corneal endothelium and the rodent homolog CHST5 in mouse endothelium.Selective knockdown of wild-type Chst5 in mouse corneal endothelium(AC^(siChst5)),but not in the corneal stroma,induced experimental MCD with similar extracellular matrix synthesis impairments and corneal thinning as observed in MCD patients.Mice carrying Chst5 point mutation also recapitulated clinical phenotypes of MCD,along with corneal endothelial abnormalities.Intracameral injection of wild-type Chst5 rescued the corneal impairments in AC^(siChst5)mice and retarded the disease progression in Chst5 mutant mice.Overall,our study provides new mechanistic insights and therapeutic approaches for MCD treatment by highlighting the role of corneal endothelium in MCD development. | Bi-Ning Zhang Benxiang Qi Chunxiao Dong Bin Zhang Jun Cheng Xin Wang Suxia Li Xiaoyun Zhuang Shijiu Chen Haoyun Duan Dewei Li Sujie Zhu Guoyun Li Yihai Cao Qingjun Zhou Lixin Xie | 2024 | Science China(Life Sciences)2024，67，2： | 0 |
| 2 | Consumers' Perception of Risks,Awareness of Products and Willingness to Pay: A Case Study of Organic Milk显示文摘Based on survey data from Ji'nan city and some other cities in Shandong province,this paper conducted a research on consumers' perception degree of the food safety risk,and the awareness degree about organic food. Then taking organic milk as an example,the factors affecting the customers' buy willingness to pay for organic milk were analyzed by binary logit model and the willingness to pay was also calculated. The results show that the consumers' food safety risk perception degree is high,and the awareness about organic food is low. The consumers' age,level of education,whether the family has children below 12 years old,whether the family has a man( woman) older than 60years,health situation self-evaluation,organic food cognition and food safety risk perception have significant effect on customers' willingness to pay organic food. According to the calculation,the consumers were willing to pay a price premium of 60% for organic milk above ordinary milk. | Yingjun XU Shijiu YIN Mo CHEN Yang GAO | 2014 | Asian Agricultural Research2014，6，1： | 0 |
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